Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Down-regulation of inducible nitric oxide synthase and tumor necrosis factor-a expression by Bisphenol A via nuclear factor-kB inactivation in macrophages

  • Kim, Ji-Young (Department of Pharmacy and Research Center for Proteineous Materials. Chosun University) ;
  • Jeong, Hye-Gwang (Department of Pharmacy and Research Center for Proteineous Materials. Chosun University)
  • Published : 2002.10.01
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Abstract

Bisphenol A ［BPA. 2.2-bis(4-hydroxyphenyl)propane］ is reported to have estrogenic activity: however. its influence on cytokine production or immune system function remains unclear. In this study. we investigated the effects of BPA on the production of nitric oxide (NO) and tumor necrosis factor-a (TNF-a), and on the level of inducible nitric oxide synthase (iNOS) and TNF-a gene expression in mouse macrophages. BPA alone did not affect NO or TNF-a production. (omitted)

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