• The Korean Journal of Mycology
• /
• v.9 no.3
• /
• pp.153-155
• /
• 1981

Attempts were made to investigate on sterols of Cryptoporus volatus (Pk.) Hubb.. Its carpophores were collected in Gyeong Gi Province and extracted with a mixture of chloroform and methanol. From the extract eight spots were detected by T.L.C.. One of the spots was identified as ergosterol by T.L.C., G.L.C. and chemical tests.

• Journal of Microbiology and Biotechnology
• /
• v.20 no.1
• /
• pp.78-81
• /
• 2010

Four compounds were isolated from the culture broth of Volvariella bombycina and they were identified as ergosta-4,6,8(14),22-tetraene-3-one (1), ergosterol peroxide (2), indole-3-carboxaldehyde (3), and indazole (4) by interpretation of spectroscopic data. Among them, compound 2 exhibited melanogenesis inhibitory effect in cultured B16 mouse melanoma cells.

• Archives of Pharmacal Research
• /
• v.17 no.1
• /
• pp.1-4
• /
• 1994

From the stems of Solanum lyratum Thunb.(Solanaceae), two sesquiterpenoids together with two 5$\alpha$, 8$alpha-epidioxy sterols have been isolated and identified as atractylenolide I, dehydrocarissone, engosterol peroxide, 9, 11-dehydroergosterol peroxide. These compounds never previously isolated from this genus.

• Korean Journal of Pharmacognosy
• /
• v.45 no.2
• /
• pp.101-106
• /
• 2014

Marine-derived microbes have yielded a variety of metabolites so far. In the course of the project to find metabolites from marine microbes, an isolate of Penicillium glabrum (SF 5317) was selected for chemical investigation. A large scale culture of this strain in PDA media was extracted with an organic solvent and the extract was subjected to a serious of chromatography, which led to six metabolites. Their chemical structures were elucidated as sulochrin (1), questin (2), questinol (3), ergosterol (4), 3-methyldesmethoxyyangonin (5), and hydroxysulochrin (6) on the basis of spectroscopic data. To the best of our knowledge, this is the second isolation of compounds 5 and 6 in nature and especially 6 is isolated from Penicillium sp. for the first time.

• The Korean Journal of Mycology
• /
• v.8 no.1
• /
• pp.25-28
• /
• 1980

Attempts were made to investigate sterol components of Calvatia saccatum (Vahl.) Fr. which grows wildly in Korea. Its carpophores were collected in Gyeong Gi Province and extracted with chloroform and methanol. Two compounds were isolated from the extract and one of these compounds was identified as ergosterol by TLC, GLC and chemical tests.

• The Korean Journal of Mycology
• /
• v.8 no.2
• /
• pp.101-106
• /
• 1980

To investigate constituents of Lampteromyces japonicus (Kawam.) Singer which grows wildly in Korea, the carpophores of the fungus were collected in Gyeong Gi. Province and analyzed for sterols and amino acids by gas chromatography and an amino acid autoanalyzer. The results showed that it contained stigmasterol and ergosterol and that it contained eleven free amino acids. These free amino acids were also determined quantitatively. Furthermore, sixteen amino acids were identified in the total amino acid fraction of the fruiting body.

• Journal of Microbiology and Biotechnology
• /
• v.20 no.11
• /
• pp.1521-1523
• /
• 2010

Bioassay-guided fractionation of a methanol extract of Ganoderma lucidum gave a pure cholesterol esterase inhibitor. On the basis of spectroscopic analysis and comparison with data from the literature, the structure of this compound was identified as $5{\alpha},8{\alpha}$-epidioxyergosta-6,22-dien-$3{\bet}$-ol (compound I). This compound inhibited cholesterol esterase activity with an $IC_{50}$ value of $42{\mu}M$. Lineweaver-Burk plot analysis revealed that compound I is a noncompetitive inhibitor. The findings of this study suggest that compound I may be the active principle of the hypocholesterolemic effect of Ganoderma lucidum.

• Journal of Pharmaceutical Investigation
• /
• v.28 no.4
• /
• pp.241-247
• /
• 1998

Ketoconazole is an imidazole antifungal agent which inhibits the biosynthesis of fungal cellmembrane ergosterol and has immunosuppressive properties in vitro. Biphenyl dimethyl dicarboxylate (PMC) has been utilized for antioxidative action and for liver-protective purposes. Studies were undertaken to investigate effects of biphenyl dimethyl dicarboxylate (PMC) on the immunosuppression of ketoconazole in ICR mice. In the combination of PMC and ketoconazole, as compared with the treatment of ketoconazole alone, there were significant increases in activities of natural killer (NK) cells and phagocytes along with circulation leukocytes. The elevation of serum glutamic-pyruvic transaminase (S-GPT) and total protein levels caused by ketoconazole were reduced by the combination of PMC and ketoconazole. In addition, lower serum albumin and albumin/globulin (A/G) ratio were also increased to normal level.

• The Korean Journal of Mycology
• /
• v.6 no.1
• /
• pp.53-56
• /
• 1978

The carpophores of Mycroporus affinis (Blume et Nees) Kuntze which grows wildly in Korea were collected in the Gyeong Gi Province and extracted with chloroform and methanol. Two compounds were isolated from the extract and one of these compounds was identified as ergosterol by T.L.C., G.L.C. and chemical tests.

• The Korean Journal of Mycology
• /
• v.7 no.2
• /
• pp.87-90
• /
• 1979

Attempts were made to investigate sterol components of Schizophyllum commune Fr. which is one of medicinal fungi and grows wildly in Korea. Its carpophores were collected in Mountain Gwanak and extracted with chloroform and methanol. A sterol was isolated and identified as ergosterol by TLC, GLC and chemical tests.