Browse > Article

Chemical Constituents from Marine-derived Fungus Penicillium glabrum  

Min, Jin-Young (School of Biotechnology, Yeungnam University)
Park, So Yeon (School of Biotechnology, Yeungnam University)
Shim, Sang Hee (School of Biotechnology, Yeungnam University)
Publication Information
Korean Journal of Pharmacognosy / v.45, no.2, 2014 , pp. 101-106 More about this Journal
Abstract
Marine-derived microbes have yielded a variety of metabolites so far. In the course of the project to find metabolites from marine microbes, an isolate of Penicillium glabrum (SF 5317) was selected for chemical investigation. A large scale culture of this strain in PDA media was extracted with an organic solvent and the extract was subjected to a serious of chromatography, which led to six metabolites. Their chemical structures were elucidated as sulochrin (1), questin (2), questinol (3), ergosterol (4), 3-methyldesmethoxyyangonin (5), and hydroxysulochrin (6) on the basis of spectroscopic data. To the best of our knowledge, this is the second isolation of compounds 5 and 6 in nature and especially 6 is isolated from Penicillium sp. for the first time.
Keywords
Penicillium glabrum; Cultures; Hydroxysulochrin; 3-Methyldesmethoxyyangonin; Questin;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Huang, K. X., Iwakami, N., Fujii, I., Ebizuka, Y. and Sankawa, U. (1995) Transformations of Penicillium islandicum and Penicillium frequentans that produce anthraquinonerelated compounds. Curr. Genet. 28: 580-584.   DOI
2 Smetanina, O. F., Yurchenko, A. N., Kalinovsky, A. I., Pushilin, M. A., Slinkina, N. N., Yurchenko, E. A. and Afiyatullov, S. (2011) 4-Methoxy-3-methylgoniothalamin from marine-derived fungi of the genus Penicillium. Russ. Chem. B. 60: 760-763.   DOI
3 Assante, G., Camarda, L. and Nasini, G. (1980) Secondary mold metabolites. IX. Structure of a new bianthrone and of three new secoanthraquinones from Aspergillus wentii Wehmer. Gazz. Chim. Ital. 110: 629-631.
4 Gauthier, T., Wang, X., Dos, S., Joice, S., Athanasios, F., Souria, T., Cecile, C., Marie Pierre, A., Nicolas, L., Isabelle, P. O. and Olivier, P. (2012) Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells. PLoS One 7: e29906.   DOI
5 Song, X.-Q., Zhang, X., Han, Q.-J., Li, X.-B., Li, G., Li, R.-J., Jiao, Y., Zhou, J.-C. and Lou, H.-X. (2013) Xanthone derivatives from Aspergillus sydowii, an endophytic fungus from the liverwort Scapania ciliata S. Lac, and their immunosuppressive activities. Phytochem. Lett. 6: 318-321.   DOI   ScienceOn
6 Wang, W., Zhu, T., Tao, H., Lu, Z., Fang, Y., Gu, Q. and Zhu, W. (2007) Two new cytotoxic quinone type compounds from the halotolerant fungus Aspergillus variecolor. J. Antibiot. 60: 603-607.   DOI   ScienceOn
7 Hammerschmidt, L., Wray, V., Lin, W., Kamilova, E., Proksch, P. and Aly, A.H. (2012) New styrylpyrones from the fungal endophyte Penicillium glabrum isolated from Punica granatum. Phytochem. Lett. 5: 600-603.   DOI   ScienceOn
8 Marianski, S. and Marianski, A. (2009) The Art of Making Fermented Sausages. 47, Bookmagic, Florida.
9 Nicoletti, R., Buommino, E., De Filippis, A., Lopez-Gresa, M., Manzo, E., Carella, A., Petrazzuolo, M. and Tufano, M. A. (2009) Bioprospecting for antagonistic Penicillium strains as a resource of new antitumor compounds. World J. Microb. Biot. 24: 185-195.
10 Nevarez, L., Vasseur, V., Le Madec, A., Le Bras, M. A., Coroller, L., Leguerinel, I. and Barbier, G. (2009) Physiological traits of Penicillium glabrum strain LCP 08.5568, a filamentous fungus isolated from bottled aromatized mineral water. Int. J. Food Microbiol. 130: 166-71.   DOI   ScienceOn
11 Inamori, Y., Kato, Y., Kubo, M., Kamiki, T., Takemoto, T. and Nomoto, K. (1983) Studies on metabolites prodced by Aspergillus terreus var. aureus. I. Chemical structures and antimicrobial activities of metabolites isolated from culture broth. Chem. Pharm. Bull. 31: 4543-4548.   DOI   ScienceOn
12 Kimura, Y., Kozawa, M., Baba, K. and Hata, K. (1983) New constitutents of roots of Polygonum cupidatum. J. Med. Plants Res. 48: 164-168.   DOI   ScienceOn
13 He, X. and Liu, R.H. (2008) Phytochemicals of apple peels: isolation, structure elucidation, and their antiproliferative and antioxidant activities. J. Agric. Food. Chem. 56: 9905-9910.   DOI   ScienceOn
14 Shimada, A., Shiokawa, C., Kusano, M., Fujioka, S. and Kimura, Y. (2003) Hydroxysulochrine, a tea pollen growth inhibitor from the fungus Aureobasidium sp. Biosci. Biotechnol. Biochem. 67: 442-444.   DOI   ScienceOn
15 Kirk, P. M., Cannon, P. F., Minter, D. W. and Stalpers, J. A. (2008) Dictionary of the Fungi (10th ed.), 505, CABI, Wallingford.
16 Rifkind, D. and Freeman, G. (2005) The Nobel Prize Winning Discoveries in Infectious Diseases. 43-46, Academic Press, London.
17 Broadbent, D., Mabelis, R. P. and Spencer, H. (1975) 3,6,8-Trihydroxy-1-methylxanthone-an antibacterial metabolite from Penicillium patulum. Phytochemistry 14: 2082-2083.   DOI   ScienceOn
18 Shimada, A., Shiokawa, C., Kusano, M., Fujioka, S. and Kimura, Y. (2003) Hydroxysulochrin, a tea pollen growth inhibitor from the fungus Aureobasidium sp. Biosci. Biotech. Bioch. 67: 442-444.   DOI   ScienceOn
19 Kim, M.-Y., Son, J. H., Jang, J.-H., Ahn, J. S. and Oh, H. (2012) Two new botcinin derivatives encountered in the studies of secondary metabolites from the marine-derived fungus Botryotinia sp. SF-5275. J. Antibiot. 65: 161-164.   DOI   ScienceOn