• Biomolecules & Therapeutics
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• v.26 no.5
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• pp.432-438
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• 2018

Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This study investigates whether treatment with the Evodia rutaecarpa aqueous extract (ERAE) from berries and its major molecular component, evodiamine, can reduce the adverse caffeine-induced sleep-related and excitation effects. We combined measurements from the pentobarbital-induced sleep test, the open field test, and the locomotor activity test in mice that had been dosed with caffeine. We found that ERAE and evodiamine administration reduced the degree of caffeine-induced sleep disruption during the sleep test. Additionally, we found that evodiamine significantly inhibits caffeine-induced excitation during the open field test, as well as decreasing hyperlocomotion in the locomotor activity test. Additional in vitro experiments showed that caffeine administration decreased the expression of ${\gamma}$-aminobutyric acid $(GABA)_A$ receptor subunits in the mouse hypothalamus. However, evodiamine treatment significantly reversed this expression reduction. Taken together, our results demonstrate that ERAE and its major compound, evodiamine, provide an excellent candidate for the treatment or prevention of caffeine-induced sleep disturbances and excitatory states, and that the mechanism of these beneficial effects acts, at least in part, through the $GABA_A$-ergic system.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.11a
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• pp.235-238
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• 2006

For high-speed aircraft and high-speed civil transport planes, certain structural skin components are subjected to very large acoustic loads in an elevated thermal environment. In this study, we used the single-mode Fokker-Panck distribution to predict displacements of isotropic plates subject to thermo-acoustic combined load. The single mode was formulated to predict the nonlinear dynamic responses of postbuckled plates under acoustic random excitation. Acoustic random excitation was used with Gauss distribution. Some important effects of the snap-through motion on the dynamic responses of the postbuckled plates are described.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.6 no.3
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• pp.96-102
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• 1997

Eigenvalue analysis of vibration mode and an analysis by frequency response among the methods of predicting gear noise are related with transmitting sound of vibration. In this study we intended to reduce the vibration noise of differential gear by reducing torque fluctuation of drive pinion shaft which causes vibration noise of differential gear in rear wheel drive vehicles. For this we developed multi-degree of freedom analysis model in which mass moment of inertia and torsional spring combined and we examined the influence of torsional vibration of driveline elements by performing forced vibration analysis of engine excitation torque. We studied the methods for reducing torsional vibration of driveline according to the design factor of propeller shaft and examined the effects reducing vibration in differential gear by applying flexible coupling.

• Journal of KSNVE
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• v.7 no.5
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• pp.853-860
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• 1997

For this study, the multi-degree of freedom analysis model of torsional vibration was developed. This model is combined with mass moment of inertia and torsional spring in two wheel drive and four wheel drive vehicle. We compared and analyzed torsional vibration characteristics by natural frequencies and mode shapes which are obtained by free vibration analysis of this model. And we studied torsional vibration contribution of driveline elements by performing the forced vibration analysis of engine excitation torque. The validity of this model is demonstrated by the field test. The reduction effect of the torsional vibration along the driveline design factor is presented by the analytical results.

• Journal of Ocean Engineering and Technology
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• v.7 no.1
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• pp.73-80
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• 1993

본 연구에서는 장주형 해양구조물의 횡방향 진동에 대한 파라메트릭 가진 효과를 고찰하였다. 먼저, 장주형 해양구조물의 횡방향 운동에 대한 4계 편미방지배방정식을 비선형 Mathieu 방정식으로 유도하였다. 비선형 mathieu 방정식의 해를 구하여 장주형 해양구조물의 동적 반응 특성을 해석하였다. 유체 비선형 감쇠력은 불안정 조건하에 있는 파라메트릭 진동의 반응크기를 제한 하는데 중요한 역활을 한다. 파라메트릭 진동의 경우 가장 큰 반응크기는 Mathieu 안정차트의 첫번째 불안정 구간에서 일어난다. 반면에, 파라메트릭 진동과 강제진동의 결합 진동인 경우, 가장 큰 반응 크기는 두번째 불안정 구간에서 발생된다. 파라메트릭 가진으로 인한 장주형 해양구조물의 횡방향 운동은 동적조건에 따라 subharmonic, superharmonic 또는 chaotic 운동이 되기도 한다.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 1998.10a
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• pp.12-19
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• 1998

Response spectrum analysis method is widely used for seismic analysis of building structure. Analysis of structural vibration for equipment, machine and moving loads are executed by time history analysis. This method is very complex, difficult and tedious. In this study, maximum response of structure for this case are simply and fast. calculated by mode shape and response spectrum for excitation. At first, Response spectrum and time history analysis for some earthquake is carried and investigate the error of maximum displacement response for R. S. A. Secondly, The process for response spectrum analysis in excitation are calculated, and maximum model response are combined by CQC (Complete Quadratic Combination) methods. Finally, Combining maximum displacement response is compared with one of time history analysis.

• Wind and Structures
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• v.1 no.1
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• pp.59-66
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• 1998

The vibrations of bodies subjected to fluid flow can cause modifications in the flow conditions, giving rise to interaction forces that depend primarily on displacements and velocities of the body in question. In this paper the linearized equations of motion for bodies of arbitrary prismatic or cylindrical cross-section in two-dimensional cross-flow are presented, considering the three degrees of freedom of the body cross-section. By restraining the rotational motion, equations applicable to circular tubes, pipes or cables are obtained. These equations can be used to determine stability limits for such structural systems when subjected to non uniform cross-flow, or to evaluate, under the quasi static assumption, their response to vortex or turbulent excitation. As a simple illustration, the stability of a pipe subjected to a bidimensional flow in the direction normal to the pipe axis is examined. It is shown that the approach is extremely powerful, allowing the evaluation of fluid-structure interaction in unidimensional structural systems, such as straight or curved pipes, cables, etc, by means of either a combined experimental-numerical scheme or through purely numerical methods.

• Structural Engineering and Mechanics
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• v.76 no.5
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• pp.619-629
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• 2020

In current study, surface/interface effects for pull-in voltage and viscous fluid velocity effects on dimensionless natural frequency (DNF) of fluid-conveying piezoelectric nanosensor (FCPENS) subjected to direct electrostatic voltage DC with nonlinear excitation, harmonic force and also viscoelastic foundation (visco-pasternak medium and structural damping) are investigated using Gurtin-Murdoch surface/interface (GMSIT) theory. For this analysis, Hamilton's principles, the assumed mode method combined with Lagrange-Euler's are used for the governing equations and boundary conditions. The effects of surface/interface parameters of FCPENS such as Lame's constants (λI,S, μI,S), residual stress (τ0I,S), piezoelectric constants (e31psk,e32psk) and mass density (ρI,S) are considered for analysis of dimensionless natural frequency respect to viscous fluid velocity u̅f and pull-in voltage V̅DC.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.10
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• pp.1029-1037
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• 2015

Recently, the importance of rotordynamic stability has been increased because of the tendency to employ ultra-high speeds in rotating machinery. In particular, the dynamic characteristics of gas bearings for high-speed rotating machinery need to be identified at various excitation frequencies to predict the rotor's behavior. In this study, we perform dynamic loading tests for gas-foil bearings (GFBs) to determine the bump foil structure and an air-film combined bump-foil structure for varying excitation frequencies. We calculate the dynamic characteristics from the measured force and displacement data. The air film is generated by a pressurized air supply. Based on the results, the stiffness coefficients of the bump structure and the air-film combined bump structure increased, while the damping coefficients decreased at increasing excitation frequencies. Further, the stiffness and damping coefficients of the air-film combined structure show lower values than those of the bump structure. Consequently, we identify the frequency-dependent dynamic characteristics of the bump structure and the effect of gas film on the dynamic characteristics of GFBs. Furthermore, to reveal the effectiveness of the proposed method, we perform experiments and discuss two methods of extracting the dynamic characteristics from the measured data.

• Structural Engineering and Mechanics
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• v.81 no.6
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• pp.691-703
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• 2022

To obtain the seismic response of lead-cored rubber, shape memory alloy (SMA)-rubber isolation Plate-shell Integrated Concrete Liquid-Storage Structure (PSICLSS), based on a PSICLSS in a water treatment plant, built a scale experimental model, and a shaking table test was conducted. Discussed the seismic responses of rubber isolation, SMA-rubber isolation PSICLSS. Combined with numerical model analysis, the vibration characteristics of rubber isolation PSICLSS are studied. The results showed that the acceleration, liquid sloshing height, hydrodynamic pressure of rubber and SMA-rubber isolation PSICLSS are amplified when the frequency of seismic excitation is close to the main frequency of the isolation PSICLSS. The earthquake causes a significant leakage of liquid, at the same time, the external liquid sloshing height is significantly higher than internal liquid sloshing height. Numerical analysis showed that the low-frequency acceleration excitation causes a more significant dynamic response of PSICLSS. The sinusoidal excitation with first-order sloshing frequency of internal liquid causes a more significant sloshing height of the internal liquid, but has little effect on the structural principal stresses. The sinusoidal excitation with first-order sloshing frequency of external liquid causes the most enormous structural principal stress, and a more significant external liquid sloshing height. In particular, the principal stress of PSICLSSS with long isolation period will be significantly enlarged. Therefore, the stiffness of the isolation layer should be properly adjusted in the design of rubber and SMA-rubber isolation PSICLSS.