• Korean Journal of Occupational Health Nursing
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• v.29 no.4
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• pp.228-234
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• 2020

Purpose: This study aimed to identify the past and present status of occupational safety and health education in Korea and to explore future plans for these fields. Methods: We summarized past empirical or theoretical literature. Results: Occupational safety and health education strive to protect workers' health and create healthy workplaces by solving various problems such as workers' occupational diseases and mental health in the rapidly changing occupational environment. For occupational safety and health education to be effectively utilized in occupational sites, a live education that can be applied to the field should be provided. The need for education to explore and develop the ability to prepare for new hazards, including infectious diseases such as COVID-19, has increased. Conclusion: It is believed that the occupational health education element of the new era will be occupational health education. This focus will develop the ability to closely assess and predict the collective, organizational, and personal responses of affected workplaces and the impact of occupational health sciences.

• Journal of the Korean Society of Visualization
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• v.18 no.2
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• pp.10-17
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• 2020

The curvature of wound boundaries has been identified as a key modulator that determines a type of force responsible for cell migration. While several studies report how certain curvatures of the boundary correlate with the rate at which the wound closes, it remains unclear how these curvatures are spatiotemporally formed to regulate the healing process. We investigated the dynamic changes in the boundary curvatures by visualizing cell migration patterns. Locally, cells at the convex boundary continuously move forward with transmitting kinetic responses behind to the cells away from the boundary, and cells at the concave boundary exhibit dramatic contracting motion, like a purse-string, when they accumulate enough negative curvatures to gain the thrust toward the void. Globally, the dynamics of boundary geometries are controlled by the diffusive flow of cells driven by the density gradient between the wound area and the cell layer.

• Journal of Mechanical Science and Technology
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• v.17 no.8
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• pp.1140-1147
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• 2003

We have examined the effect on neck-muscle activation of altering whole body posture. A Rhesus monkey (Macaca mulatta) was trained to produce sinusoidal (0.25 Hz) head tracking movements in the sagittal plane when seated with trunk and head vertical or while standing in the quadrupedal position. Video-fluoroscopic images of cervical vertebral motion, and electromyographic (EMG) responses were recorded simultaneously. Results demonstrated that vertebral motion varied with body posture, occurring synchronously between all joints in the upright position and primarily at skull-$C_1$ when in the quadrupedal position. Muscle EMG activation was significantly greater (P<0.001) in the quadrupedal position than when upright for all muscles except semispinalis cervicis. Peak activation of all the muscles occurred prior to peak head extension in the quadrupedal position, suggesting synchronous activity between muscles. Data suggest that, when upright, muscles were activated in functional groupings defined by their anatomical arrangement. In the quadrupedal position, gravity acting on the horizontally oriented head produced greater activation and a collective response of the muscles.

• International Journal of Internet, Broadcasting and Communication
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• v.15 no.4
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• pp.9-20
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• 2023

In the aftermath of the COVID-19 pandemic, the importance of collective efforts in promoting health preventive behaviors is accentuated, bringing sociopolitical factors into focus. To fully capture psychological drivers of health preventive behaviors in risk situations, anchored on the Model of Risk Information Seeking and Processing (RISP; Griffin, Dunwoody, and Neuwirth 1999), in retrospect of the recent COVID-19 pandemic, we explored whether and how individuals' vaccination behaviors are predicted by RISP-related variables (information insufficiency, affective responses, perceived information gathering capacity, subjective norms) and one's political identity. Findings from a survey of 705 adult participants in the U.S. showed that the effects of one's risk information insufficiency on his or her information seeking and affective response regarding the pandemic, which is also related to their risk susceptibility perceptions. More importantly, the impact of political identity on one's perceived risk susceptibility, and its association with vaccination behaviors are also identified. The findings of this study provide valuable insights for the development of effective health communication strategies for preventive health behaviors.

• International Journal of Vascular Biomedical Engineering
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• v.2 no.2
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• pp.1-9
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• 2004

The history of studies in biology regarding reactive oxygen species (ROS) is approximately 40 years. During the initial 30 years, it appeared that these studies were mainly focused on the toxicity of ROS. However, recent studies have identified another action regarding oxidative signaling, other than toxicity of ROS. Basically, it is suggested that ROS are reactive, and degenerate to biomolecules such as DNA and proteins, leading to deterioration of cellular functions as an oxidative stress. On the other hand, recent studies have shown that ROS act as oxidative signaling in cells, resulting in various gene expressions. Recently ROS emerged as critical signaling molecules in cardiovascular research. Several studies over the past decade have shown that physiological effects of vasoactive factors are mediated by these reactive species and, conversely, that altered redox mechanisms are implicated in the occurrence of metabolic and cardiovascular diseases ROS is a collective term often used by scientist to include not only the oxygen radicals($O2^{-{\cdot}},\;{^{\cdot}}OH$), but also some non-radical derivatives of oxygen. These include hydrogen peroxide, hypochlorous acid (HOCl) and ozone (O3). The superoxide anion ($O2^{-{\cdot}}$) is formed by the univalent reduction of triplet-state molecular oxygen ($^3O_2$). Superoxide dismutase (SOD)s convert superoxide enzymically into hydrogen peroxide. In biological tissues superoxide can also be converted nonenzymically into the nonradical species hydrogen peroxide and singlet oxygen ($^1O_2$). In the presence of reduced transition metals (e.g., ferrous or cuprous ions), hydrogen peroxide can be converted into the highly reactive hydroxyl radical (${^{\cdot}}OH$). Alternatively, hydrogen peroxide may be converted into water by the enzymes catalase or glutathione peroxidase. In the glutathione peroxidase reaction glutathione is oxidized to glutathione disulfide, which can be converted back to glutathione by glutathione reductase in an NADPH-consuming process.

• Parasites, Hosts and Diseases
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• v.50 no.4
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• pp.301-308
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• 2012

In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of $CD19^+$ B cells was observed as early as week 1 post-infection while $CD4^+/CD8^+$ T cells were down-regulated. Accumulation of $Mac1^+$ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-${\alpha}$ mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-$1{\beta}$ expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-${\beta}$ were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-${\beta}$ and IL-4 during the early stages of infection.

• Journal of Electrical Engineering and Technology
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• v.9 no.3
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• pp.827-834
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• 2014

In order to meet the low voltage ride-through requirement in a grid code, a wind power plant (WPP) has to stay connected to a grid, supporting the voltage recovery for a grid fault. To do this, a plant-level controller as well as a wind generator (WG) controller is essential. The dynamic response of a WPP should be analyzed in order to design a plant-level controller. The dynamic response of a WPP for a grid fault is the collective response of all WGs, which depends on the wind speed approaching the WG. Thus, the dynamic response of a WPP should be analyzed by taking the wake effect into consideration, because different wind speeds at WGs will result in different responses of the WPP. This paper analyzes the response of a doubly fed induction generator (DFIG)-based offshore WPP with a grid fault taking into account the wake effect. To obtain the approaching wind speed of a WG in a WPP, we considered the cumulative impact of multiple shadowing and the effect of the wind direction. The voltage, reactive power, and active power at the point of common coupling of a 100 MW DFIG-based offshore WPP were analyzed during and after a grid fault under various wind and fault conditions using an EMTP-RV simulator. The results clearly demonstrate that not considering the wake effect leads to significantly different results, particularly for the reactive power and active power, which could potentially lead to incorrect conclusions and / or control schemes for a WPP.

• Molecules and Cells
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• v.43 no.1
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• pp.23-33
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• 2020

NF-κB signaling through both canonical and non-canonical pathways plays a central role in immune responses and inflammation. NF-κB-inducing kinase (NIK) stabilization is a key step in activation of the non-canonical pathway and its dysregulation implicated in various hematologic malignancies. The tumor suppressor, p53, is an established cellular gatekeeper of proliferation. Abnormalities of the TP53 gene have been detected in more than half of all human cancers. While the non-canonical NF-κB and p53 pathways have been explored for several decades, no studies to date have documented potential cross-talk between these two cancer-related mechanisms. Here, we demonstrate that p53 negatively regulates NIK in an miRNA-dependent manner. Overexpression of p53 decreased the levels of NIK, leading to inhibition of the non-canonical NF-κB pathway. Conversely, its knockdown led to increased levels of NIK, IKKα phosphorylation, and p100 processing. Additionally, miR-34b induced by nutlin-3 directly targeted the coding sequences (CDS) of NIK. Treatment with anti-miR-34b-5p augmented NIK levels and subsequent non-canonical NF-κB signaling. Our collective findings support a novel cross-talk mechanism between non-canonical NF-κB and p53.

• Asia-Pacific Journal of Business
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• v.15 no.2
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• pp.1-22
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• 2024

Purpose - The Chinese fan community includes a significant number of young and middle-aged individuals, playing a crucial role in emotional mobilization and social engagement. In recent years, the impact of Celebrity Pairing or Character Pairing (CP) on Weibo has grown notably, partly due to features like Super Topics and Hot Searches. This phenomenon has enhanced fan engagement, resulting in heightened participation in discussions and interactions on the platform. Our study targets CP fans of movies and television dramas on Weibo and aims to identify the factors that drive their emotional sharing. Design/methodology/approach - The research methodology integrates Self-Determination Theory and Social Sharing of Emotion Theory within the EASI (Emotion, Attachment, and Social Integration) model. This approach aims to uncover how CP fans meet their emotional needs via social media and determine the factors influencing their sharing intentions and behaviours. Data were collected through online surveys, yielding 504 valid responses Findings - The analysis, performed with SPSS and Smart PLS software, reveals that self-determination, interpersonal relationships, and social media tolerance significantly affect fans' intentions to share content. Specifically, intrinsic motivation, driven by self-determination, is a critical factor in CP fans' propensity to share content, highlighting the importance of 'inward socialization.' Additionally, the study finds that external factors, like the social media environment, play a more minor role than internal motivators. Research implications or Originality - This research enhances quantitative research methodologies by identifying intrinsic and extrinsic motivations that satisfy the emotional needs of CP fans. It distinguishes between individual, interpersonal, and collective/social factors as motivational elements, providing insights into the emotional and psychological needs of the Chinese movie and TV drama fan community.

• Journal of Animal Science and Technology
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• v.44 no.4
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• pp.427-442
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• 2002

Conjugated linoleic acid(CLA) is a collective term for a group of positional (c8, c10; c9, c11; c10, c12, and c11, c13) and geometric(cis,cis; cis,trans; trans,cis; and trans,trans) isomers of octadecadienoic acid (linoleic acid) with conjugated double bond system. CLA has been shown to have a variety of biological effects. Major effects of CLA on health, such as anti-cancer, anti-oxidation, anti-atherosclerosis and improving immuno-responses, might be derived or partially derived from the alternated lipid metabolism after CLA feeding. Most of studies on the effect of CLA on fat metabolism are concentrated on rats, mice, pigs and other mammals. The CLA inhibited carcinogen-induced neoplasia in several animal models and inhibited the proliferation of human malignant melanoma, colorectal and breast cancer cells and CLA reduced the atherosclerosis. Several studies have determined the antioxidant property of CLA; however, the property still remains controversial. Some of the studies have shown that CLA acted as an antioxidant, whereas some other studies have demonstrated that CLA might be a prooxidant. Several studies suggested that CLA could reduce fat accumulation in mammals. CLA was suggested to promote muscle growth and reduce fat deposition in mouse, and improve feed efficiency in rats. CLA has been shown to inhibit the activity of stearoyl-CoA reductase. CLA also reduced the content of arachidonic acid. Since arachidonic acid, and eicosapentaenoic acid (EPA) and docosahexenoic acid (DHA) are synthesized by different pathways, reducing the synthesis of arachidonic acid may not mean reducing that of EPA and DHA. Many sutdies have been shown biological effects of CLA. Therefore, further research is needed to answer the following questions: 1) how to synthesize the new CLA by new methods, 2) why CLA has shown biological effects, 3) how to increase CLA effects in animal products.