• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2009년도 정보통신설비 학술대회
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• pp.364-366
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• 2009

광 바이오 센서 시스템에서 Trans-Impedance amplifier (TIA)는 광검출기로부터 입력단으로 들어오는 미세한 전기 신호를 원하는 신호레벨까지 증폭하는 역할을 한다. TIA는 광 바이오 센서 시스템의 감도 (sensitivity)를 결정하는 매우 중요한 회로로 저잡음, 저전력, 낮은 입력 임피던스 등의 특성이 요구되어진다. 본 논문에서는 광 바이오 센서 시스템에서 요구되어 지는 저전력, 저잡음 성능을 구현하기 위하여 regulated cascode (RGC) TIA를 설계하였다. 본 연구에서는 기존 common gate (CG) 기법의 TIA에서 전류원 역할을 하는 current source를 저항으로 대체하고, local feedback stage를 이용하는 RGC TIA를 저잡음, 저전력 특성 및 회로 면적 감소의 장점을 갖도록 설계하였다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.1107-1108
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• 2008

The purpose of this study is to develope a computer mouse using the head movements and eye blink in order to help the disability persons who can't move the hands or foot because of car accident or cerebral apoplexy. The mouse is composed of two gyro-sensors and photo sensor. The gryo-sensors detect the head horizontal and vertical angular velocities, respectively. The photo sensor detect the eye blink to perform click, double click, and to reset the head position. In the results, we could control the mouse points in real time using the proposed system.

• Bulletin of the Korean Chemical Society
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• 제26권2호
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• pp.278-280
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• 2005

To obtain cytochrome $c_3$ labeled with a stable isotope, the conditions of cultivation and the composition of medium for DvMF were examined. The growth of DvMF was steady and reproducible under purging with $N_2$ and under pH control. DvMF was able to go on a defined medium without natural products. The composition of medium containing a small amount of $NH_4C$l as sole nitrogen source was established. Then, uniformly $^{15}N$labeled cytochrome $c_3$ was obtained during the culture of DvMF in a defined medium with $^{15}NH_4$Cl; it was confirmed by $^1H-^{15}N$ HMQC.

• Bulletin of the Korean Chemical Society
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• 제32권12호
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• pp.4377-4381
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• 2011

In this study, real-time and label-free methods for monitoring the enzymatic reaction of urease, which releases ammonia through the hydrolysis of urea in an aqueous solution, were developed using a liquid crystal (LC)-based pH sensor. Nematic liquid crystal 4-cyano-4'-pentylbiphenyl (5CB), doped with 4'-pentyl-biphenyl-4-carboxylic acid (PBA), exhibited a shift in optical appearance from bright to dark when it was in contact with ammonia generated from the enzymatic reaction between urease and urea. This optical change was attributed to the anchoring transitions of LCs caused by hydrophobic interactions between the tails of deprotonted PBA ($PBA^-$) molecules and the LCs at the aqueous/LC interface. This novel technique holds great promise for the sensitive detection of urease along with its substrates and inhibitors.

• 센서학회지
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• 제17권1호
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• pp.23-28
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• 2008

In order to measure bio-signals, it is desirable to build a fully implantable system which connects directly to neural pathways or body tissue. A design scheme for fully implementable measurement system is proposed in this paper. Consisting of an implanted module and an external system, the proposed scheme delivers power and data between the two modules. The external module sends power via inductive link using a simple H-bridge type oscillator. Also, the implanted module sends measured data to the external system utilizing R/F communication technique at a frequency of ISM band. A stable communication and operation is achieved as the two types of channels are separated. Implemented in a compact size enough to be implanted in human body, the system exhibits good performance in experimental studies.

• Bulletin of the Korean Chemical Society
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• 제34권1호
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• pp.237-242
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• 2013

This experiment was conducted for the purpose of developing such a sensor that can quickly sense dopamine concentration by using chitosan-gold nanoshell. Chitosan nano particles were reacted with gold nano particles so as to synthesize chitosan-gold nanoshell, and the size of the synthesized product was about 150 nm. When dopamine was reacted with chitosan-gold nanoshell, the size of it was not definitely changed, but dopamine was well reacted with chitosan-gold nanoshell, and it generated SERS (surface-enhanced Raman scattering), which led to a clear difference in the intensity of Raman scattering within the range of dopamine concentration (1 mM-10 mM). When Raman scattering was intensity marked on chitosan-gold nanoshell by employing a calibration curve according to dopamine concentration, a straight line whose margin of error was narrow was earned.

• Transactions on Electrical and Electronic Materials
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• 제14권5호
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• pp.273-277
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• 2013

A unified potentiostat circuit for both $O_2$- and $H_2O_2$- based electrochemical glucose sensors was proposed and its function was verified by circuit simulations and measurement results of a fabricated chip. This circuit consisted of an operational amplifier, a comparator and current mirrors. The proposed circuit was fabricated with a $0.13{\mu}m$ thick oxide CMOS process and an active area of $360{\mu}m{\times}100{\mu}m$. The measurements revealed an input operation range from 0.5 V to 1.6 V in the $H_2O_2$- based bio-sensor and from 1.7 V to 2.6 V in the $O_2$- based bio-sensor with a supply voltage of 3.3 V. The evaluation results showed that the proposed potentiostat circuit is suitable for measuring the electrochemical cell currents of both $O_2$- and $H_2O_2$- based glucose sensors.

• 로봇학회논문지
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• 제2권4호
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• pp.317-326
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• 2007

Recently, robotic automation in clinical laboratory becomes of keen interest as a fusion of bio and robotic technology. In this paper, we present a new robotic platform for clinical tests suitable for small or medium sized laboratories using mobile robots. The mobile robot called Mobile Agent is designed as transfer system of blood samples, reagents, microplates, and any instruments. Also, the developed mobile agent can perform diverse tests simultaneously based on its cooperative and distributed ability. The driving circuits for the mobile agent are embedded in the robot, and each mobile agent communicates with other agents by using Bluetooth communication. The RFID system is used to recognize patient information. Also, the magnetic hall sensor is embedded to remove and compensate the cumulated error of locomotion at the bottom of mobile agent. The proposed mobile agent can be easily used for various applications because it is designed to be compatible with general software development tools. The Mobile agents are manufactured, and feasibility of the robot and localization of the agents using magnetic hall sensor are validated by preliminary experiments.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.43-43
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• 2010

We have characterized the parametric and functional properties of live cell and cancer cell according to plasma treatment conditions using Atmospheric Pressure (AP) Plasma with uniquely designed low temperature arc-free unit. AP plasma system showed very highly efficient capabilities of reacting and interfacing directly with live and cancer cells. The parametric results with the types of gases, applied power, applied gap, and process times on cells will be presented in accordance with functional studies of the works. The growth of cancer cells is directly influenced by AP plasma exposure with evaluating plasma conditions in several human cancer cells and understanding how plasma exposure alters molecular signaling pathways. The cells exhibit a slower or faster growth rates compared with untreated cells, depending on the cell types. These results strongly support the conclusion that alterations in one or more of each gene are responsible, at least in part, for plasma-induced apoptosis in cancer cells. In addition, it also will be presented that AP plasma has an important role for the improvement of sensor performance due to excellent interface property between enzyme and metal electrode for bio sensor manufacturing process.

• BioChip Journal
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• 제12권4호
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• pp.340-347
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• 2018

$F{\ddot{o}}rster$ resonance energy transfer (FRET) is extremely sensitive to the separation distance between the donor and the acceptor which is ideal for probing such biological phenomena. Also, FRET-based probes have been developing for detecting an unamplified, low-abundance of target DNA. Here we describe the development of FRET based DNA sensor based on an accumulated QD system for detecting KRAS G12D mutation which is the most common mutation in cancer. The accumulated QD system consists of the polystyrene beads which surface is modified with carboxyl modified QDs. The QDs are sandwich-hybridized with DNA of a capture probe, a reporter probe with Texas-red, and a target DNA by EDC-NHS coupling. Because the carboxyl modified QDs are located closely to each other in the accumulated QDs, these neighboring QDs are enough to transfer the energy to the acceptor dyes. Therefore the FRET factor in the bead system is enhancing by the additional increase of 29.2% as compared to that in a single QD system. These results suggest that the accumulated nanobead probe with conjugated QDs can be used as ultrasensitive DNA nanosensors detecting the mutation in the various cancers.