• Mass Spectrometry Letters
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• v.12 no.2
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• pp.41-46
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• 2021

Collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD) are the widely used fragmentation technique in mass spectrometry-based proteomics studies. Understanding the fragmentation pattern from the tandem mass spectra using statistical methods helps to implement efficient spectrum analysis algorithms. The study characterizes the frequency of occurrence of multi-charged fragment ions and their neutral loss events of doubly and triply charged peptides in the CID and HCD spectrum. The dependency of the length of the fragment ion on the occurrence of multi-charged fragment ion is characterized here. Study shows that the singly charged fragment ions are generally dominated in the doubly charged peptide spectrum. However, as the length of the product ion increases, the frequency of occurrence of charge 2 fragment ions increases. The y- ions have more tendencies to generate charge 2 fragment ions than b- ions, both in CID and HCD spectrum. The frequency of occurrence of charge 2 fragment ion peaks is prominent upon the dissociation of the triply charged peptides. For triply charged peptides, product ion of higher length occurred in multiple charge states in CID spectrum. The neutral loss peaks mostly exist in charge 2 states in the triply charged peptide spectrum. The b-ions peaks are observed in much less frequency than y-ions in HCD spectrum as the length of the fragment increases. Isotopic peaks are occurred in charge 2 state both in doubly and triply charged peptide's HCD spectrum.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.47 no.3
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• pp.209-215
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• 2021

Objectives: Vascular malformation (VM) of the tongue can cause true macroglossia in children. Reduction glossectomy provides primary relief when sclerotherapy has failed or is not possible. In this study, we evaluated the surgical role in functional outcome of reduction glossectomy performed for VM of the tongue. Patients and Methods: We evaluated the functional and surgical outcomes of seven children who were treated at a tertiary care centre in Southern India between 2013 and 2018. Results: Six children underwent median glossectomy, while one child underwent lateral glossectomy. Functional assessment was performed at least 2 years after the date of surgery. At the time of assessment, speech was comprehensible for three children and was occasionally unintelligible in four children. Taste and swallowing were normal in all seven children. Six children exhibited a minimal residual lesion after surgery, of which only one was symptomatic. Residual lesions were managed with sclerotherapy (n=3), observation (n=2), or repeat surgery (n=1). Conclusion: Reduction glossectomy in children with macroglossia secondary to VMs has acceptable outcomes in terms of cosmesis and speech, with no gastronomic restriction.

• Earthquakes and Structures
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• v.22 no.2
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• pp.109-120
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• 2022

Older or damaged structures can require significant retrofit to ensure they perform well in subsequent earthquakes. Supplemental damping devices are used to achieve this goal, but increase base shear forces, foundation demand, and cost. Displacement reduction without increasing base shear is possible using novel semi-active and recently-created passive devices, which offer energy dissipation in selected quadrants of the force-displacement response. Combining these devices with large, strictly passive energy dissipation devices can offer greater, yet customized response reductions. Supplemental damping to reduce response without increasing base shear enables a net-zero base shear approach. This study evaluates this concept using two incremental dynamic analyses (IDAs) to show displacement reductions up to 40% without increasing base shear, more than would be achieved for either device alone, significantly reducing the risk of response exceeding the unaltered structural case. IDA results lead to direct calculation of reductions in risk and annualized economic cost for adding these devices using this net-zero concept, thus quantifying the trade-off. The overall device assessment and risk analysis method presented provides a generalizable proof-of-concept approach, and provides a framework for assessing the impact and economic cost-benefit of using modern supplemental energy dissipation devices.

• Research in Mathematical Education
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• v.26 no.3
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• pp.167-202
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• 2023

A central problem of mathematics teaching worldwide is probably the insufficient adaptive handling of tasks-especially in computational practice phases and modeling tasks. All students in a classroom must often work on the same tasks. In the process, the high-achieving students are often underchallenged, and the low-achieving ones are overchallenged. This publication uses different modeling of the tennis serve as an example to show a possible solution to the problem and develops and discusses one adaptive task each for middle school, high school, and college using three mathematical models of the tennis serve each time. From model to model within the task, the complexity of the modeling increases, the mathematical or physical demands on the students increase, and the new modeling leads to more realistic results. The proposed models offer the possibility to address heterogeneous learning groups by their arrangement in the surface structure of the so-called parallel adaptive task and to stimulate adaptive mathematics teaching on the instructional topic of mathematical modeling. Models A through C are suitable for middle school instruction, models C through E for high school, and models E through G for college. The models are classified in the specific modeling cycle and its extension by a digital tool model, and individual modeling steps are explained. The advantages of the presented models regarding teaching and learning mathematical modeling are elaborated. In addition, we report our first teaching experiences with the developed parallel adaptive tasks.

• Nuclear Engineering and Technology
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• v.56 no.3
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• pp.933-940
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• 2024

A macroscopic cross section generation model was developed for the conceptual horizontal, compact high temperature gas reactor (HC-HTGR). Because there are many sources of spectral effects in the design and analysis of the core, conventional LWR methods have limitations for accurate simulation of the HC-HTGR using a neutron diffusion core neutronics simulator. Several super-cell model configurations were investigated to consider the spectral effect of neighboring cells. A new history variable was introduced for the existing library format to more accurately account for the history effect from neighboring nodes and reactivity control drums. The macroscopic cross section library was validated through comparison with cross sections generated using full core Monte Carlo models and single cell cross section for both 3D core steady-state problems and 2D and 3D depletion problems. Core calculations were then performed with the AGREE HTR neutronics and thermal-fluid core simulator using super-cell cross sections. With the new history variable, the super-cell cross sections were in good agreement with the full core cross sections even for problems with significant spectrum change during fuel shuffling and depletion.

• Journal of Periodontal and Implant Science
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• v.54 no.3
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• pp.139-148
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• 2024

Purpose: The objective of this study was to demonstrate the suitability of cone-beam computed tomography (CBCT) for in vivo research in periodontology, with implications for oral implantology, facial traumatology, and all disciplines involved in treating patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ). Methods: Halves of the jaws of 9 Swiss mountain sheep, assigned to a control group (n=3), an osteoporosis group (n=3) and a zoledronate-exposed group (n=3), were examined. Clinical and radiological evaluations were conducted using CBCT imaging to assess whether periodontitis and bone defects were observed to a significant extent after surgical tooth extraction. Results: In contrast to the control and osteoporosis groups, the zoledronate group exhibited significant residual bone defects following tooth extraction (P<0.05). CBCT more objectively revealed these effects and enabled a numerical evaluation (in mm³). Conclusions: Evaluating residual defects in bone blocks from sheep using CBCT analysis was found to be as effective as a clinical examination conducted by specialists in oral and maxillofacial surgery. The strong correlation between radiological findings and clinical conditions suggests that CBCT may become increasingly important in the future, particularly in periodontological research related to BRONJ.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.6 no.3
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• pp.63-74
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• 1986

A methodology for the probabilistic determination of active storage capacity of an impounding reservoir is proposed with due considerations to the durations and return periods of the low flow series at the reservoir site. For more reliable probabilistic analysis the best-fit stochastic generation model of Monte Carlo type was first selected for the generation of monthly flow series, the models tested being the Month Carlo Model based on the month-by-month flow series (Monte Carlo-A Type), Monte Carlo Model based on the standardized sequential monthly flow series (Monte Carlo-B Type), and the Thomas-Fiering Model. Monte Carlo-B Model was final1y selected and synthetic monthly flows of 200 years at Hong Cheon dam site were generated. With so generated 200 years' monthly flows partial duration series of low flows were developed for various durations. Each low flow series was further processed by a nonsequential mass analysis for specified draft rates. This mass analysis furnished the storage-draft-recurrence interval relationship which gives the reservoir storage requirement for a specified water demand from the reservoir during a drought of given return period. Illustrations are given on the application of these results in analyzing the water supply capacity of a particlar reservoir, existing or proposed.

• Water for future
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• v.18 no.3
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• pp.253-264
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• 1985

Basically, there are two ways viewing the reservoir storage-yield relationship., The most common viewpoint is the determination of the storage required at a given reservoir to supply a required yield. This type of problem is usually encountered in the planning and early design phases of a reservoir. The second viewpoint is the determination of yield from a given amount of storage. This often occurs in the final design phases or in re-evaluation of an existing reservoir for a more comprehensive analysis. The purpose of this study is to improve the present methodology estimating the storage-yield relationship for a reservoir design or a reservoir operation. The Residual Mass curve Technique, the slightly modified version of Low Flow Techniques and the Transition Probability Matrix Technique are reviewed and examined for the best fit technique to find the reservoir storage-yield realtionship. The historical data during 1917~1940 at the proposed Hongchun damsite and the synthetic data simulated by Thomas-Fiering model are utilized to examine the reservoir storge-yield relationship with three techniques in detail. After the three techniques which estimate the reservoir storage-yield relationship were reviewed extensively, it was concluded that the Residual Mass Curve Technique and the slightly modified version of Low Flow Techniques were suitable for a preliminary design, but the Transition Probability Matrix Technique Provided satisfactory results as a final design technique because it reflected the variation of a monthly yield as well as seasonlly.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.3
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• pp.678-684
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• 2013

This paper describes a low-power baseband circuit for SAW-less LTE-Advanced transmitters. The proposed transmitter baseband circuit consists of a 2nd-order Tow-Thomas type active RC-LPF and a 1st-order passive RC LPF. It can provide a 7 multi-channel cut-off frequencies and wide gain control range of -41 dB ~ 0 dB with a 1-dB step. The proposed 2nd-order active RC-LPF adopts an op-amp in which three other sub-op amps are in parallel connected to reduce DC current for different cutoff frequency. In addition, each sub-op amp adopts both Miller and feed-forward phase compensation method to achieve an UGBW of more than 1-GHz with a small DC power consumption. The proposed baseband circuit is implemented in 65-nm CMOS technology, consuming DC power from 6.3 mW to 24.1 mW from a 1.2V supply voltage for each different cut-off frequency.

• Maritime Security
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• v.2 no.1
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• pp.71-123
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• 2021

Seoul is under increasing pressure to choose between the US-led IndoPacific Strategy (IPS) and China's Belt and Road Initiative (BRI). Accordingly, this paper undertakes a detailed appraisal of the IPS and the BRI in the context of Korea's national policy imperatives. Based on a study of network structure by Daniel Nexon and Thomas Wright (2007), the present study seeks to identify a particular network structure within the IPS and the BRI. Through this analysis, the relationship between the core and the participant states will be addressed. Awareness of specific configurations of the IPS and the BRI is important as these reveal what participant states can expect from each network. According to Nexon and Wright, there are four types of network structure: unipolar anarchy, hegemonic order, constitutional order, and imperial order. Based on this, we argue that the IPS has a constitutional order and the BRI has an imperial order. Therefore, we suggest to Seoul that participating in the IPS may make more room for an independent foreign policy than would a BRI partnership with China. South Korea would benefit by participating in the IPS in terms of its national security, striking a favourable regional balance of power.