• Journal of Digital Convergence
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• v.17 no.10
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• pp.209-221
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• 2019

Cooperating with a supplier with professional skills is necessary to achieve performance in the development of the innovative products. It is also important to improve development competence and share knowledge. This study empirically analyzed the effect of participant's Job Competence and Leadership Competence on Knowledge Sharing, and the effect of Purchaser Interdependence on Supplier Absorption Capacity. The purpose of the study is to confirm that Knowledge Sharing between Development Participant and Supplier contributes to Performance and to demonstrate the need for a cooperative relationship with the Supplier. A survey was conducted on the product development participants to confirm the relationship between the factors using a Structural Equation Model. As a result of the hypothesis test, the better the Individual Competence of the development participants, the better the Knowledge Sharing Activity, and then Knowledge Sharing and Interdependence are the main factor in the Absorption Capacity of the Supplier. The results of this study can contribute to improving the Supplier Absorption Capacity in the product development projects in which high technology is converged. In the future, we will study the effects of the project support activities of related departments for Performance.

• 한국노년학
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• v.38 no.3
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• pp.481-499
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• 2018

The purpose of this study is to examine the impacts of smartphone use on structured social network types in the Korean elderly population. Data was derived from the 2014 survey of living conditions and welfare needs of Korean older persons collected by Korea Institute for Health and Social Affairs. A total of 4,180 participants were selected for the Propensity Score Matching (PSM) analysis. Based on propensity score estimates, the 491 smartphone users (treatment group) and 491 featurephone users (control group) were matched. Ordinary Least Squares (OLS) regression analysis was conducted to examine the relationship between smartphone use and structural social network types. The results showed that among retired older adults, people using smartphone had significantly better structured social networks than those using featurephone even after controlling for covariates. Smartphone users had the higher levels of social contact and social activity. These findings suggested empirical evidence that using smartphone positively affects structured social networks, which might be used as the basis for designing intervention programs to promote social networks and social engagement of retired older adults.

• The Journal of Korean society of community based occupational therapy
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• v.9 no.1
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• pp.15-24
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• 2019

Objective : The purpose of this study is to investigate the relationship between the leisure experience, leisure identity, depression, and self-respect of the elderly with sleep disorders through leisure activities. Methods : The elderly with sleep disorders were applied for more than 4 weeks from March to July, 2018. Depression, self-respect, and sleep quality before and after the application of leisure activities were analyzed by the corresponding sample t test. The leisure experience, leisure identity, and change in leisure activities were analyzed by SEM(structural wearing model analysis through confirmatory factor analysis. Results : The results of this study are as follows. First, there was a significant difference in depression level before and after leisure activities (p = .000). Second, there was no significant difference in self-respect before and after leisure activities (p = .182). Third, there was a significant difference in the quality of sleep before and after leisure activities (p = .000). Fourth, the effects of leisure experience, leisure identity, and change on leisure activities showed that leisure experience influenced leisure identity and change. However, leisure identity affected depression and sleep quality among the factors of change. Conclusion : A decrease in the quality of sleep that can occur in the elderly can affect the quality of life. It was found through experiments that the leisure activities of elderly people with sleep disorder can bring about positive changes in depression level and sleep quality of the elderly.

• Korean Journal of Biological Psychiatry
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• v.26 no.1
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• pp.22-31
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• 2019

Objectives Previous studies have revealed inconsistent results on amygdala volume in adult bipolar disorder (BD) patients compared to healthy controls (HC). Since the amygdala encompasses multiple subregions, the subtle volume changes in each amygdala nucleus might have not been fully reflected in the measure of the total amygdala volume, causing discrepant results. Thus, we aimed to investigate volume changes in each amygdala subregion and their association with subtypes of BD, lithium use and clinical status of BD. Methods Fifty-five BD patients and 55 HC underwent T1-weighted structural magnetic resonance imaging. We analyzed volumes of the whole amygdala and each amygdala subregion, including the anterior amygdaloid area, cortico-amygdaloid transition area, basal, lateral, accessory basal, central, cortical, medial and paralaminar nuclei using the atlas in the FreeSurfer. The volume difference was analyzed using a one-way analysis of covariance with individual volumes as dependent variables, and age, sex, and total intracranial volume as covariates. Results The volumes of whole right amygdala and subregions including basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area in the right amygdala of BD patients were significantly smaller for the HC group. No significant volume difference between bipolar I disorder and bipolar II disorder was found after the Bonferroni correction. The trend of larger volume in medial nucleus with lithium treatment was not significant after the Bonferroni correction. No significant correlation between illness duration and amygdala volume, and insignificant negative correlation were found between right central nucleus volume and depression severity. Conclusions Significant volume decrements of the whole amygdala, basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area were found in the right hemisphere in adult BD patients, compared to HC group. We postulate that such volume changes are associated with altered functional activity and connectivity of amygdala nuclei in BD.

• Korean Journal of Construction Engineering and Management
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• v.20 no.5
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• pp.83-94
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• 2019

Recently, the proportion of overseas orders of domestic construction companies is increasing, and the global market demands management transparency on corporate social responsibility activities. Therefore, domestic companies are faced with the need to systematically prepare for social responsibility activities. The purpose of this study was to examine whether CSR activities have a moderating effect on the relationship between organizational trust, job satisfaction, turnover intention and contract type. This study analyzed the effect of CSR activities on organizational trust, job satisfaction and turnover intention. The study targets regular and irregular workers in construction companies who promote CSR activities through the homepage, public service ad, and media. The questionnaire distributed 300 copies online. The final valid sample is 255 (145 Regular and 110 Irregular). Empirical analysis used a structural equation model. The results of the study are as follows. First, in CSR activities, economic responsibility, philanthropic responsibility and ethical responsibility had a positive (+) effect on organizational trust. Second, organizational trust had a positive (+) effect on job satisfaction in CSR activities. Finally, the magnitude of the Moderate effect of the type of labor contract according to the group classification showed that the CSR activity on organizational trust had many regular employees with economic responsibility. Also, organizational trust in job satisfaction was found to be large in regular employees. The results of this study can be a guide to CSR activities of construction companies in terms of organizational effectiveness.

• 한국노년학
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• v.32 no.4
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• pp.1013-1023
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• 2012

This study aims to identify the effect of the mental health and leisure competence of senior citizen through participation in archery activity on satisfaction in their life. To achieve the purpose, the study interviewed members of the Archery and Sports Association living in Gwangju, Jeonnam and Jeonbuk using a questionnaire and collected 328 valid responses. The questions as measuring instruments such as leisure competence, depression, self-esteem, and satisfaction level which were developed by previous studies were revised for this study. For a statistics, a frequency analysis, a descriptive analysis, a correlation analysis, and a structural model analysis were conducted. As a result, first, the higher self-esteem of the subjects, the more they participated in archery and were satisfied with their life. Second, the lower depression they had, the more they participated in archery and were satisfied with their life. Third, as leisure competence of the subjects was not a main factor of archery participation, the related assumption was rejected. The mental health of the senior citizen such as self-esteem and depression was a factor of participation in archery and their satisfaction with their life grew higher through participation in archery.

• Journal of the Korean Applied Science and Technology
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• v.36 no.2
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• pp.676-684
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• 2019

The Pictet-Spengler reactions have widely known for the organic synthesis or biosynthesis of biologically active compounds, tetrahydro-${\beta}$-carbolines. We have developed the simple and efficient synthetic method for the synthesis of ${\beta}$-carbolines in water. Their chemical structures were characterized by nmr and UPLC/MS/QTOF. Calculated masses of compound 1 ($C_{17}H_{17}N_2$ 249.1392), 2 ($C_{17}H_{23}N_2$ 255.1861), 3 ($C_{19}H_{21}N_2O_3$ 325.1552) and 4 ($C_{19}H_{19}N_2O$ 279.1497) were almost identical with the detected masses of compound 1 (249.1315), 2 (255.1789), 3 (325.1460) and 4 (279.1364) respectively. Those synthesized four compounds showed strong antibiotic activity against the common E. coli.

• Molecules and Cells
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• v.44 no.1
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• pp.26-37
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• 2021

Human papillomaviruses (HPVs) cause cellular hyperproliferation-associated abnormalities including cervical cancer. The HPV genome encodes two major viral oncoproteins, E6 and E7, which recruit various host proteins by direct interaction for proteasomal degradation. Recently, we reported the structure of HPV18 E7 conserved region 3 (CR3) bound to the protein tyrosine phosphatase (PTP) domain of PTPN14, a well-defined tumor suppressor, and found that this intermolecular interaction plays a key role in E7-driven transformation and tumorigenesis. In this study, we carried out a molecular analysis of the interaction between CR3 of HPV18 E7 and the PTP domain of PTPN21, a PTP protein that shares high sequence homology with PTPN14 but is putatively oncogenic rather than tumor-suppressive. Through the combined use of biochemical tools, we verified that HPV18 E7 and PTPN21 form a 2:2 complex, with a dissociation constant of 5 nM and a nearly identical binding manner with the HPV18 E7 and PTPN14 complex. Nevertheless, despite the structural similarities, the biological consequences of the E7 interaction were found to differ between the two PTP proteins. Unlike PTPN14, PTPN21 did not appear to be subjected to proteasomal degradation in HPV18-positive HeLa cervical cancer cells. Moreover, knockdown of PTPN21 led to retardation of the migration/invasion of HeLa cells and HPV18 E7-expressing HaCaT keratinocytes, which reflects its protumor activity. In conclusion, the associations of the viral oncoprotein E7 with PTPN14 and PTPN21 are similar at the molecular level but play different physiological roles.

• Korean Journal of Food Science and Technology
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• v.52 no.6
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• pp.595-603
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• 2020

To elucidate the structure-function relationship of polysaccharides obtained from Colocasia esculenta, the immuno-stimulating polysaccharide, CE-4a was purified to homogeneity from the crude polysaccharide (CE) extracted from the corms of C. esculenta by two subsequent column chromatographies using DEAE-Sepharose FF and Sephadex G-100, and analysis of their immuno-stimulatory activities and structure were conducted. CE-4a showed an increase in anti-complementary activity in a dose-dependent fashion. The molecular mass was estimated to be 182.4 kDa, which mainly consisted of galactose (43.5%) and mannose (18.2%). Methylation analysis indicated that CE-4a comprised at least 10 different glycosyl linkages, such as terminal Galp, 3-linked Galp, and 4-linked Manp, as well as a characteristic linkage, 2,4,6-branched Manp residue. To analyze the fine structure of CE-4a, it was sequentially digested using endo-α-(1→4)-polygalacturonase, exo-α-galactosidase and endo-β-1,4-D-mannanase. These analyses suggested that CE-4a is to be a highly branched galactomannan with a (1→4)-mannan backbone and galactopyranosyl oligosaccharide side chains.

• Journal of the Korean Applied Science and Technology
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• v.38 no.1
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• pp.228-240
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• 2021

This study was conducted with the goal of establishing a foothold for lifelong sports as well as establishing golf as a desirable leisure activity through the analysis of the relationship between golf participants' coach support, resilience and self-rated health. To achieve the goal of this study, a total of 300 questionnaires were distributed and 300 copies were collected back. Out of those returned questionnaires, insincerely replied or double-replied questionnaires were excluded and finally 278 questionnaires were analyzed for this study. For analysis of the data, frequency analysis, exploratory factor analysis, reliability analysis, confirmatory factor analysis, correlation analysis, and structural equating modeling were conducted using SPSS 18.0 and AMOS 18.0. Main findings were as follows: First coach support had a positive effect on resilience. Second, resilience had a positive effect on self-rated health. Third, coach support had a positive effect on self-rated health. Fourth, resilience mediated the relationship between golf participant coach support and self-rated health. Therefore, golf instructors should achieve specialization and diversification of educational programs through continuous learning about various teaching methods.