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http://dx.doi.org/10.12925/jkocs.2019.36.2.676

Synthesis and Structural Characterization of β-Carboline Compounds  

Byeon, Hong-Ju (Department of Biotechnology, Korea National University of Transportation)
Han, Min-Hui (Department of Biotechnology, Korea National University of Transportation)
Moon, Gi-Seong (Department of Biotechnology, Korea National University of Transportation)
Jung, Kyung-Hwan (Department of Biotechnology, Korea National University of Transportation)
Lee, Hyang-Yeol (Department of Biotechnology, Korea National University of Transportation)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.2, 2019 , pp. 676-684 More about this Journal
Abstract
The Pictet-Spengler reactions have widely known for the organic synthesis or biosynthesis of biologically active compounds, tetrahydro-${\beta}$-carbolines. We have developed the simple and efficient synthetic method for the synthesis of ${\beta}$-carbolines in water. Their chemical structures were characterized by nmr and UPLC/MS/QTOF. Calculated masses of compound 1 ($C_{17}H_{17}N_2$ 249.1392), 2 ($C_{17}H_{23}N_2$ 255.1861), 3 ($C_{19}H_{21}N_2O_3$ 325.1552) and 4 ($C_{19}H_{19}N_2O$ 279.1497) were almost identical with the detected masses of compound 1 (249.1315), 2 (255.1789), 3 (325.1460) and 4 (279.1364) respectively. Those synthesized four compounds showed strong antibiotic activity against the common E. coli.
Keywords
${\beta}$-carbolines; Pictet-Spengler reaction; anti-microbial effect;
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