• The Korean journal of internal medicine
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• v.33 no.6
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• pp.1224-1233
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• 2018

Background/Aims: The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity. Methods: In this 24-week, phase 3, randomized, double-blind, placebo-controlled trial, eligible patients (n = 127) were randomized 2:1 to subcutaneous CZP + methotrexate (MTX; 400 mg at week 0, 2, and 4 followed by 200 mg every 2 weeks) or placebo + MTX. Results: At week 24, the American College of Rheumatology criteria for 20% (ACR20) response rate was significantly greater with CZP + MTX than with placebo (66.7% vs. 27.5%, p < 0.001). Differences in ACR20 response rates for CZP vs. placebo were significant from week 1 (p < 0.05) and remained significant through week 24. The CZP group reported significant improvement in physical function and disability compared to the placebo group (p < 0.001) at week 24, as assessed by Korean Health Assessment Questionnaire-Disability Index (KHAQ-DI). Post hoc analysis indicated that the proportion of patients who had ACR70 responses, Disease Activity Score 28 (DAS28) low disease activity, and DAS28 remission at week 24 was greater in CZP + MTX-treated patients who achieved a decrease in DAS28 ${\geq}1.2$ (43.8%) at week 4 than in nonresponders. Among 18 (22.2%) and 14 patients (35.0%) in CZP and placebo groups who had latent tuberculosis (TB), none developed active TB. Most adverse events were mild or moderate. Conclusions: CZP treatment combined with MTX in active RA patients with moderate to severe disease activity and an inadequate response to MTX resulted in rapid onset of efficacy, which is associated with better clinical outcome at week 24 and has an acceptable safety profile, especially in an intermediate TB-burden population.

• Korean Journal of Radiology
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• v.19 no.6
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• pp.1089-1098
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• 2018

Objective: To investigate the diagnostic yield of contrast-enhanced computed tomography (CT) in Crohn's disease (CD) patients presenting with acute severe lower gastrointestinal bleeding (LGIB), and the role of CT in predicting the risk of rebleeding. Materials and Methods: A consecutive series of 110 CD patients presenting with acute severe LGIB between 2005 and 2016 were analyzed. Among them, 86 patients who had undergone contrast-enhanced CT constituted the study cohort. The diagnostic yield of CT for detecting contrast extravasation was obtained for the entire cohort and compared between different CT techniques. In a subgroup of 62 patients who had undergone CT enterography (CTE) and showed a negative result for extravasation on CTE, the association between various clinical and CTE parameters and the risk of rebleeding during subsequent follow-up was investigated using Cox regression analysis. Results: The diagnostic yield of CT was 10.5% (9 of 86 patients). The yield did not significantly differ between single-phase and multiphase examinations (p > 0.999), or between non-enterographic CT and CTE (p = 0.388). Extensive CD (adjusted hazard ratio [HR], 3.27; 95% confidence interval [CI], 1.09-9.80; p = 0.034) and bowel wall-to-artery enhancement ratio (adjusted HR, 2.81; 95% CI, 1.21-6.54; p = 0.016) were significantly independently associated with increased rebleeding risks, whereas anti-tumor necrosis factor-${\alpha}$ therapy after the bleeding independently decreased the risk of rebleeding (adjusted HR, 0.26; 95% CI, 0.07-0.95; p = 0.041). Conclusion: The diagnostic yield of contrast-enhanced CT was not high in CD patients presenting with acute severe LGIB. Nevertheless, even a negative CTE may be beneficial as it can help predict the risk of later rebleeding.

• The Journal of Internal Korean Medicine
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• v.40 no.3
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• pp.458-477
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• 2019

Objectives: This study aimed to investigate the trend in the research on alcoholic liver disease (ALD) using Korean traditional medicine. Methods: This review was conducted using six electronic databases (NDSL, KMBASE, Koreantk, KISS, KISTI, and KoreaMed) with no restrictions in year. The search terms were "alcoholic liver disease", "alcoholic fatty liver", "alcoholic hepatitis", "alcoholic cirrhosis", "herbal medicine", "acupuncture" and "traditional medicine". The searched studies were analyzed according to the type of research. Results: After screening, 37 studies were selected among 552. The types of studies were as follows: 8 in vivo studies, 17 case reports, 7 case series, 1 assessment scale study, 1 randomized controlled trial, and 3 research reviews. The in vivo studies reported the efficacy and its mechanism in the animal phase of single or complex herbal medicine. In the clinical research, interventions such as herbal medicine and acupuncture were most commonly used for ALD treatment. Conclusions: We analyzed the trends in ALD treatment using Korean traditional medicine through this review. The results showed that Korean traditional medicine could be an effective method for ALD treatment. Conducting related in-depth studies, such as well-designed randomized controlled trial based on the results of experimental research, is necessary.

• Korean Journal of Heritage: History & Science
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• v.49 no.4
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• pp.64-79
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• 2016

The purpose of the present study is to clarify the process of change to the pond at the Jongmyo Shrine(宗廟), from the Joseon Dynasty period to the modern and contemporary era. The consequent research results can be summarized as follows. The first record of the Jongmyo pond is confirmed in the "Annals of King Sejong(世宗實錄)". The pond, which was being constructed at the time, refers to the current upper pond(上池). A pair of islets(雙島) were constructed during the Sukjong(肅宗) period, with several trees planted on the middle islet(中池). The middle pond is thick with lotuses. In particular, the middle island on the middle pond subsequently changed into a single island(單島), which is likely to be related to the pond expansion during the reign of Youngjo(英祖). When the lower pond(下池), involving dualistic arrangement, was constructed in the modern and contemporary era, the pond of the Jongmyo Shrine underwent a drastic transformation phase. The lower pond was constructed before 1947 at the latest, and when the right side of the lower pond was filled in the mid 1980s, the dualistically arranged lower pond became a unified type of lower pond. On the other hand, the bank protections of the upper and middle ponds were constructed with earth, but was subsequently modified into its current form using stone.

• KIPS Transactions on Software and Data Engineering
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• v.10 no.8
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• pp.287-300
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• 2021

Collaborative Cyber-Physical Systems (CCPS) are those systems that contain tightly coupled physical and cyber components, massively interconnected subsystems, and collaborate to achieve a common goal. The safety of a single Cyber-Physical System (CPS) can be achieved by following the safety standards such as ISO 26262 and IEC 61508 or by applying hazard analysis techniques. However, due to the complex, highly interconnected, heterogeneous, and collaborative nature of CCPS, a fault in one CPS's components can trigger many other faults in other collaborating CPSs. Therefore, a safety assurance technique based on fault criticality analysis would require to ensure safety in CCPS. This paper presents a Fault Criticality Matrix (FCM) implemented in our tool called CPSTracer, which contains several data such as identified fault, fault criticality, safety guard, etc. The proposed FCM is based on composite hazard analysis and content-based relationships among the hazard analysis artifacts, and ensures that the safety guard controls the identified faults at design time; thus, we can effectively manage and control the fault at the design phase to ensure the safe development of CPSs. To justify our approach, we introduce a case study on the Platooning system (a collaborative CPS). We perform the criticality analysis of the Platooning system using FCM in our developed tool. After the detailed fault criticality analysis, we investigate the results to check the appropriateness and effectiveness with two research questions. Also, by performing simulation for the Platooning, we showed that the rate of collision of the Platooning system without using FCM was quite high as compared to the rate of collisions of the system after analyzing the fault criticality using FCM.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.15 no.2
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• pp.23-36
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• 2005

The main obstacle hindering the wide deployment of identity-based cryptosystem is that the entity responsible for creating the private key has too much power. As a result, private keys are no longer private. One obvious solution to this problem is to apply the threshold technique. However, this increases the authentication computation, and communication cost during the key issuing phase. In this paper, we propose a new effi ient model for issuing multiple private keys in identity-based encryption schemes based on the Weil pairing that also alleviates the key escrow problem. In our system, the private key of a user is divided into two components, KGK (Key Description Key) and KUD(Key Usage Desscriptor), which are issued separately by different parties. The KGK is issued in a threshold manner by KIC (Key Issuing Center), whereas the KW is issued by a single authority called KUM (Key Usage Manager). Changing KW results in a different private key. As a result, a user can efficiently obtain a new private key by interacting with KUM. We can also adapt Gentry's time-slot based private key revocation approach to our scheme more efficiently than others. We also show the security of the system and its efficiency by analyzing the existing systems.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.2
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• pp.163-170
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• 2021

This study was conducted to create a technology to remove acne bacteria with human-friendly materials. First, the Cutibacterium acnes (C. acnes) were adsorbed to the mica disc to grow, and then the biofilm was checked through an atomic microscope to see if the biofilm had grown. Based on the topographic image, the shape changed round, the size was 17% longer on average, and the phase value of the resonance frequency separating materials was observed as a single value, the biofilm grown by covering the extracellular polymeric substrate (EPS). As a result of processing 50 mM of amino acids in the matured biofilm, the concentration of C. acnes decreased when valine, serine, arginine and leucine were treated. Scanning with nanoindentation and AFM contact modes confirmed that the hardness of biofilms treated with Valine (Val) increased. This indicates that an AFM tip measured cell which may have more solidity than that of EPS. The experiment of fluorescent tagged to EPS displays an existence of EPS at the condition of 10 mM Val, but an inhibition of growth of EPS at the 50 mM Val. Number of C. acnes was also reduced above 10 mM of Val. Weak adhesion of biofilm generated from an inhibition of EPS formation seems to induce decrease of C. acnes. Accordingly, we elucidated that Val has an efficiency which eliminates C. acnes by approach of an inhibition of EPS.

• Korean Journal of Remote Sensing
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• v.38 no.3
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• pp.251-263
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• 2022

This paper presents an idea of ScanSAR image formation. For image formation of ScanSAR that utilizes the burst mode for raw signal acquisition, most conventional single burst methods essentially require a step of azimuth stitching which contributes to radiometric and phase distortions to some extent. Time-domain cross correlation could replace SPECAN which is most popularly used for ScanSAR processing. The core idea of the proposed method is that it is possible to relieve the necessity of azimuth stitching by an extension of Doppler bandwidth of the reference function to the burst cycle period. Performance of the proposed method was evaluated by applying it to the raw signals acquired by a spaceborne SAR system, and results satisfied all image quality requirements including 3 dB width, peak-to-sidelobe ratio (PSLR), compression ratio,speckle noise, etc. Image quality of ScanSAR is inferior to that of Stripmap in all aspects. However, it is also possible to improve the quality of ScanSAR image competitive to that of Stripmap if focused on a certain parameter while reduced qualities of other parameters. Thus, it is necessary for a ScanSAR processor to offer a great degree of flexibility complying with different requirements for different applications and techniques.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.35 no.3
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• pp.297-302
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• 2022

We investigated the origin of magnetic behaviors induced by an asymmetric spin exchange interaction in Fe-site engineered lead iron niobate [Pb(Fe_1/2Nb_1/2)O₃, PFN], which exhibits a room-temperature multiferroicity. The magnitude of spin exchange interaction was regulated by the introduced transition metals with a distinct Bohr magneton, i.e., Cr, Co, and Ni. All compositions were found to have a single-phase perovskite structure keeping their ferroelectric order except for Cr introduction. We discovered that the incorporation of each transition metal imposes a distinct magnetic behavior on the lead iron niobate system; antiferro-, hard ferro-, and soft ferromagnetism for Cr, Co, and Ni, respectively. This indicates that orbital occupancy and interatomic distance play key roles in the determination of magnetic behavior rather than the magnitude of the individual Bohr magneton. Further investigations are planned, such as X-ray absorption spectroscopy, to clarify the origin of magnetic properties in this system.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.6
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• pp.371-383
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• 2021

Steel-concrete single-leaf blast-resistant doors, having steel box and slab inside, are installed on the wall using supporting members such as hinges and latches. Several studies have been conducted on their deflection behavior in the same direction as that of the blast pressure, but studies on their deflection behavior in the opposite direction, that is, studies on negative deflection behavior are relatively insufficient. In this study, we conducted a parameter analysis using finite element analysis on blast-resistant doors, on their rebound behavior in the negative deflection phase. Results revealed that the plastic deformation of the door, and the change in momentum and kinetic energy during rebound, were major factors influencing the rebound behavior. Greater rebound force was developed on the supporting members in the impulsive region, than in the quasi-static region; due to the characteristics in the impulsive region, where the kinetic energy developed relatively greater than the strain energy. In the design process, it is necessary to consider excessive deformation that could occur in the supporting members as the rebound behavior progresses. Additionally, it was found that in the case of steel-concrete blast doors, the rebound force increased relatively more, when the effects of both rebound and negative blast pressure contributed to the negative deflection of the door. Since conditions for the occurrence of this superposition effect could vary depending on structural characteristics and explosion conditions, further investigation may be required on this topic.