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http://dx.doi.org/10.22246/jikm.2019.40.3.458

A Review of Domestic Research on Traditional Korean Medicine for Alcoholic Liver Disease  

Cho, Na-kyung (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Lee, Yu-ri (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Kim, Kyung-soon (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Choi, Hong-sik (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Kim, Seung-mo (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Back, Young-doo (Dept. of Biomedical Laboratory Science, Daegu Health College)
Moon, Byung-kwon (Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University)
Publication Information
The Journal of Internal Korean Medicine / v.40, no.3, 2019 , pp. 458-477 More about this Journal
Abstract
Objectives: This study aimed to investigate the trend in the research on alcoholic liver disease (ALD) using Korean traditional medicine. Methods: This review was conducted using six electronic databases (NDSL, KMBASE, Koreantk, KISS, KISTI, and KoreaMed) with no restrictions in year. The search terms were "alcoholic liver disease", "alcoholic fatty liver", "alcoholic hepatitis", "alcoholic cirrhosis", "herbal medicine", "acupuncture" and "traditional medicine". The searched studies were analyzed according to the type of research. Results: After screening, 37 studies were selected among 552. The types of studies were as follows: 8 in vivo studies, 17 case reports, 7 case series, 1 assessment scale study, 1 randomized controlled trial, and 3 research reviews. The in vivo studies reported the efficacy and its mechanism in the animal phase of single or complex herbal medicine. In the clinical research, interventions such as herbal medicine and acupuncture were most commonly used for ALD treatment. Conclusions: We analyzed the trends in ALD treatment using Korean traditional medicine through this review. The results showed that Korean traditional medicine could be an effective method for ALD treatment. Conducting related in-depth studies, such as well-designed randomized controlled trial based on the results of experimental research, is necessary.
Keywords
alcoholic liver disease; traditional medicine; review;
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Times Cited By KSCI : 20  (Citation Analysis)
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1 Hong SH. Clinical report and study on Alcoholic Liver Disease. The journal of Korean Acupuncture & Moxibustion Society 1999;16(3):15-24.
2 Jeong YE, Cho YS, Baek JH, Kim JD. A Case of Korean Medicine for Alcoholic Liver Disease Patients with Fatigue and Dizziness. J Int Korean Med 2018;39(2):224-9.   DOI
3 World Health Organization. https://www.who.int/news-room/fact-sheets/detail/alcohol
4 Kim DG. Alcohol consumption and drinking conditions. (the title was translated from 알코올소비량과음주실태.) Kiri Korea Insurance Research Institute an aging population review 17. 2018-01-08 Available from: URL:http://www.kiri.or.kr/html/perioList.asp?mStep=09&part=perio&Cate1_num=173&vVol=17
5 Bae JH, Joo SH, An SY, Jang EG, Kim YC, Lee JH. A Case Study of Two Alcoholic Liver Cirrhosis Patients. J Int Korean Med 2018;39(2):176-83.   DOI
6 Jun JH, Kim YC, Lee JH, Woo HJ. The Effects of Chungganhaeju-tang(Qingganjiejiu-tang) on Alcoholic Liver Damages by Applying Proteomics. J Int Korean Med 2008;29(2):469-89.
7 Lee JE, Lee JH. Experimental Study of Chungganhaeju-tang (Qingganjiejiu-tang) on Oxidative Stress. J Int Korean Med 2011;32(2):188-202.
8 Merdians & Acupoints Compilation Committee of Korean Medical Colleges. Principles of meridians & acupoints : a guidebook for college students. Daejeon: Jongryenamu; 2012, p. 64-7, 213-6, 918-21, 998-9.
9 Hong SH, Kwon OS, Kim SH, Kim HJ, Kim KT, Park SE, et al. Effects of Injinoryung-San on Alcoholic Hepatitis. Korean J Oriental Physiology & Pathology 2008;22(1):204-8.
10 Choi SH, Chang MW, Park SA, Lim SM, An JJ, Jo HK, et al. Two Cases report of Chungganplus (Gamichunggan-tang) for Hepatitic C patient and Alcoholic Hepatitis patient with Cerebral-infarction. Herbal formula science 2008;16(2):243-54.
11 Jeong EW, Cho YS, Kim HS, Kim SY, Lee SK. Chunggangunbi-tang-gamibang's Effect on Alcoholic Liver Cirrhosis with Ascites. Herbal formula science 2007;15(2):161-9.
12 Zheng CX, Yim DS, Lee SY. The Effects of Ka-Mi-Chung-Gan-Tang on Rat with Alcoholic Fatty Liver. Kor K Parmacogn 2004;35(3):229-32.
13 Lee TH, Cho HS, Lee HY, Park JH, Lee YK, Kim SK. A case of Intracerebral Hemorhage with Alcoholic liver disease. Journal of Pharmacopuncture 2003;6(3):81-6.   DOI
14 Lee JH, Park SM, Kim YC, Woo HJ. A Clinical Study of the Effects of Chungganhaeju-tang on Alcoholic Fatty Liver. J Korean Oriental Med 2001;22(4):107-13.
15 Kim BH. The Effects of Scutellaria Radix Extract on the Alcohol-Induced Fatty Acid Synthesis of Liver in Rats. J Korean Med Obes Res 2018;18(1):19-26   DOI
16 Baik TH, Lee DS. Non-traumatic Spontaneous Gastrocnemius Muscle Blood Stasis Associated with Alcoholic Liver Cirrhosis. Korean J Oriental Physiology & Pathology 2012;26(5):778-83.
17 Rho EJ, Lee JH. A Clinical Report of Chronic Alcoholic Liver Disease treated by Zhizihoupo Tang. J of KMediACS 2011;3(1):13-22.
18 Kim BK, Yang WK, Park YC, Jung GY, Shin EJ, Do SG, et al. Effect of SAL5 on chronic ethanol-induced fatty liver model. Kor J Herbol 2018;33(1):17-26.   DOI
19 Kim TH, Ahn HY, Kim YW, Sim SY, Seo KI, Cho YS. Hepatoprotective Effect of Bacillus subtilis-fermented Silkworm (BombyxmoriL.) Extract on an Alcoholic Fatty Liver in Rats. Journal of Life Science 2018;28(6):697-707.   DOI
20 Kim BH. The Effects of Injinsaryung-san on Rat with Alcoholic Fatty Liver. Herbal formula science 2018;26(2):113-22.   DOI
21 Kim TR, Lim HC, Lee DE, Jang YJ, Jeon SY. A Case Report of Alcoholic Liver Disease with Lower Limb Weakness. J Int Korean Med 2017;38(6):1068-75.   DOI
22 Kang KW, Lee JH. A Case of Alcoholic Liver Cirrhosis Treated with Injinoryeong-san. J Int Korean Med 2016;37(1):135-42.   DOI
23 Choi GY, Kum SY, Kim BW, Jee HC, Sun SH, Lee SG. Case Report of Ascites in Alcoholic Liver Cirrhosis. Korean J. Oriental Physiology & Pathology 2009;23(5):1161-5.
24 Kwon JY, Kim YJ, Park JK, Kong KH, Go HY. A Case Report of Suggested Liver Dysfunction by Atorvastatin Treated with Saenggangeonbi-tang. J Int Korean Med 2017;38(5):548-54.   DOI
25 Kim J, Heo SJ, Yang EJ, Seo JW, Kim EY. A Case Report of ascites in Liver cirrhosis treated with Saenggangeonbi-tang. J Int Korean Med 2010;31(106):299-305.
26 Kim JJ, Seo BI, Choi HS, Kim SM, Woo CH, Koo JS, et al. Preventive Effects of Daekumeumja on Fatty Degeneration of Liver and Immunosuppression Induced by Alcohol. Korean journal of oriental medicine 2010;16(2):167-79.
27 Kim HY, Jang SY, Yoon KM, Im EY, Yoo HJ, Choi GH, et al. A Clinical Report on 1 case of the Jaundice Caused by the Alcoholic Liver Disease. The Journal of East-West Medicine 2009;34(2):37-44.
28 Kim JE, Park SE, Lee JW, Son HY, Lee BG, Sin CK, et al. A Study of Syndrome Differentiation Types of Alcoholic Liver Disease. J Int Korean Med 2009;30(110):93-9.
29 Shin YJ, Ko SJ, Jang WS, Jeon JY, Seol JK, Baek DG, et al. Clinical study of Alcoholic Liver Disease Treated with Sodalgeonbi-tang. J Int Korean Med 2009;30(110):43-8.
30 Jeong YE, Kim JD, Kang SB, Kim SM. A Case Report of Patient with Acute Alcoholic Hepatitis and Renal Dysfunction. J Korean Med Obes Res 2016;16(2):138-43.   DOI
31 Kim EH, Chung JO. Protective effects of Cirsium setidens ethanolic extracts against alcoholic fatty liver injury in rats. J Nutr Health 2016;49(6):420-8.   DOI
32 Han MK, Kim KS, Choi HS, Joo JH. The Clinical Report of Flank Pain Induced by Alcoholic Liver Cirrhosis with Soshihotang-gamibang. The Journal of East-West Medicine 2015;40(3):47-53.
33 Kasper DL, Fauci AS, Hauser S, Longo D, Jameson JL, Loscalzo J. Harrison's Principles of Internal Medicine, 19th edition. New York: McGraw-Hill Professional Publishing; 2017, p. 2877-96.
34 Kim JE, Park SE, Lee JW, Son HY, Lee BG, Sin CK, et al. Study to Develop the Pattern Identification Questionnaire for Alcoholic Hepatitis. Korean J Oriental Physiology & Pathology 2009;23(5):958-63.
35 Shin YS, Kim JS, Choi KS, Han YH. A Clinical Report of Ascites Induced by Alcholic Liver Cirrhosis with Saenggangeonbi-tang. J Int Korean Med 2008;29(105):140-6.
36 Felix S, Christian D, Jochen H, Ramon B. Pathophysiology and Management of Alcoholic Liver Disease: Update 2016. Gut and Live 2017;11(2):173-88.   DOI
37 Shin YS, Cho SH, Kim NU, Han YH. Clinical Report of Acute Cholecystitis with Gagamsaenggantang. Korean J Oriental Physiology & Pathology 2009;23(6):1465-9.
38 Kim JY Protective Effect of Citrus unshiu Peel Extract on Ethanol-Induced Fatty Liver in Rats. J Korean Soc Food Sci Nutr 2014;43(2):187-93.   DOI
39 Hwang SJ, Choi HS, Kim SM, Woo CH. Effects of Saengkankeonbi-tang on Prevention of Hyperlipidemia and Liver Damage Induced by Alcohol. Kor J Herbology 2009;24(4):9-15.
40 Seo YH, Kim JD, Choi HY, Jung TY. Case Report of Suggested Alcoholic Hepatitis Treated with Saenggangeonbi-tang and Kongjin-Dan. The Journal of East-West Medicine 2011;36(4):83-9.
41 Kwak MA, Lee JH, Woo HJ. Effects of Chungganhaeju-tang(Qingganjiejiu-tang) on Alcohol Metabolism and Alcoholic Liver Damages. J Korean Med 2000;21(1):68-76.
42 Lee JH, Pack SM, Kim YC, Woo HJ. A Clinical Study of the Effects of Chungganhaeju-tang on Alcoholic Fatty Liver. J Korean Med 2001;22(4):107-13.
43 Han CW, Kim YC, Lee JH, Wpp HJ. The Effects of Chungganhaeju-tang(Qingganjiejiu-tang) on $NF{\kappa}B$ Activation and Apoptosis of Kupffer Cells. J Int Korean Med 2004;25(1):59-70.
44 Lee E, Ko H. Saenggangeonbi-tang's Effect on Alcoholic Liver Cirrhosis - 1 case. J Korean Oriental Med 2000;21(3):213-9.
45 Lee YY, Son KC, Choi BL, Seo SH, Yoo HS, Choi WJ, et al. The Clinical Report about Patients with Alcoholic Liver Disease given Gamichunggan-san. J Int Korean Med 2001;22(4):414-9.
46 Cheon YS, Won JH, Kim TG, Bae NG, Ryu ST, Kim YH, et al. The effects of Injinsugunomija Extract on Liver Function Test of Alcoholic Liver Disease and Viral Hepatitis Patients. J Int Korean Med 2001;22(3):291-8.
47 Yeo EK, Kim DW, Jun CY, Han YH, Park JH. A Alcoholic Liver Disease Patient Case with Diabetes Mellitus. J Int Korean Med 2000;21(4):649-53.
48 Han SS, Son CG. The study on Oriental and Western medical of Liver cirrhosis(Fibrosis) pathological system. Journal of Hawhwa Medicine 2000;9(1):379-86.
49 Ko H. Alcoholic Liver disease complicated with ascites in three patients using a herbal medicine (CheungganHaeju-tang). J Int Korean Med 1999;20(1):263-73.
50 Kim JD. The study on Oriental and Western medical of Alcoholic Liver Disease(the title was translated from 알코올성 肝疾患의 東西醫學的考察) J Int Korean Med 1996;17(1):1-7.   DOI
51 Sukhpreet Singh, Natalia A Osna, Kusum K Kharbanda Treatment options for alcoholic and non-alcoholic fatty liver disease: A review. World J Gastroenterol 2017;23(36):6549-70.   DOI
52 Jung YJ, Lee JH, Kim YC, Woo HJ. The Effects of Chungganhaeju-tang(Qingganjiejiu-tang) on Alcoholic Liver Damages by Applying Proteomics. J Int Korean Med 2007;28(1):68-78.
53 Yoon SH. Response of Kagamseanggantang on the Liver Function in Alcoholic Liver Diseases. J Korean Oriental Med 1993;14(2):348-54.
54 The Korean Association for the Study of the Liver. KASL clinical practice guidelines for liver cirrhosis. Seoul: The Korean Association for the Study of the Liver; 2013, p. 18-20.