• Biomolecules & Therapeutics
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• v.1 no.1
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• pp.98-102
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• 1993

The therapeutic effectiveness of adenine arabinoside(tora-A) and its conjugate of prednisone(BR-8702-AP) was compared in Herpes simplex Virus Type 1 (HSV-1) infected BALB/C mice. The BALB/C mouse was infected with HSV-1(700 PFU/mouse) intranasally. Among mice infected intranasally with virus, a mortality rate of 100% was observed. On the oral administration of non-toxic doses of ara-A or BR-8702-AP(125 mg /kg/day) for 5 consecutive days 2 hours after virus infection, the tora-A was highly effective in reducing mortality to 0% (P<0.001) and BR-8702-AP was also effective in reducing mortality to 15% (P<0.01). In this model infection, the virus was first replicated in the lung and transmitted to the brain. Both arts-A and BR-8702-AP did not inhibit the viral replication in the lung, but they inhibited the viral transmission to the brain. However, the BR-8702-AP was less effective than the aria-A to prevent transmission of virus to brain. Therefore, the reduced mortality due to tora-A or BR-8702-AP therapy was associated with inhibition of viral transmission to brain.

• IMMUNE NETWORK
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• v.14 no.4
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• pp.187-200
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• 2014

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are the most common cause of genital ulceration in humans worldwide. Typically, HSV-1 and 2 infections via mucosal route result in a lifelong latent infection after peripheral replication in mucosal tissues, thereby providing potential transmission to neighbor hosts in response to reactivation. To break the transmission cycle, immunoprophylactics and therapeutic strategies must be focused on prevention of infection or reduction of infectivity at mucosal sites. Currently, our understanding of the immune responses against mucosal infection of HSV remains intricate and involves a balance between innate signaling pathways and the adaptive immune responses. Numerous studies have demonstrated that HSV mucosal infection induces type I interferons (IFN) via recognition of Toll-like receptors (TLRs) and activates multiple immune cell populations, including NK cells, conventional dendritic cells (DCs), and plasmacytoid DCs. This innate immune response is required not only for the early control of viral replication at mucosal sites, but also for establishing adaptive immune responses against HSV antigens. Although the contribution of humoral immune response is controversial, $CD4^+$ Th1 T cells producing IFN-${\gamma}$ are believed to play an important role in eradicating virus from the hosts. In addition, the recent experimental successes of immunoprophylactic and therapeutic compounds that enhance resistance and/or reduce viral burden at mucosal sites have accumulated. This review focuses on attempts to modulate innate and adaptive immunity against HSV mucosal infection for the development of prophylactic and therapeutic strategies. Notably, cells involved in innate immune regulations appear to shape adaptive immune responses. Thus, we summarized the current evidence of various immune mediators in response to mucosal HSV infection, focusing on the importance of innate immune responses.

• Journal of Korea Multimedia Society
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• v.11 no.3
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• pp.398-403
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• 2008

Data broadcasting is a mechanism to transmit information to clients in simplex transmission environments. In this mechanism, server transmits to repeat all information to all users and users use a necessary data when the data is transmitted. Therefore users are waiting the necessary data until the data is transmitted. It is important to reduce user's waiting time. Server schedules the data to reduce waiting time. In this paper, we study efficient data scheduling algorithm. The result shows that the performance of the proposed method is increased 13 percent compared to the method considering only request frequency.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 2006.07a
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• pp.331-331
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• 2006

• The Journal of Korean Institute of Communications and Information Sciences
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• v.18 no.11
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• pp.1785-1796
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• 1993

Thanks to the data processing facilities of modern digital computers, the performances of radar has been promoted greatly as one of the main components of command and control systems along with the computer communications. In this study, radar data integrating and processing systems were designed for the data processing of various information from many kinds of radar in a single data processing system. The performance of the data integrating system was analyzed by applying queueing theory. A radar data integrating network was designed for synchronous relational operations among the information processing systems and the transmission characteristics were also analysed by specific models for each system. The designed data integrating systems can be divided into a simplex type and a distributed multiplex type.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.528-532
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• 2019

The dorsal root ganglion (DRG) was isolated from mouse embryos and Schwann cells and neuronal cells were cultured in vitro. The neurons and Schwann cells were cultured separately and the two kinds of cells were cultured together for three weeks. Generation of myelination was confirmed by transmission electron microscope and confocal microscope using a myelinaion protein, myelin protein zero (MPZ) antibody. The sindbis virus was infected for three days in the myelinated culture cells and then demyelination was carried out. The process of demyelination was also confirmed by transmission electron microscopy and confocal microscopy using myelin protein zero (MPZ) antibody. The study was supported by a Basic Research Program through the National Research Foundation (NRF) funded by the Ministry of Science and Technology, ICT and Future Plans (NRF-2016R1A2B4016552 and 2017R1A2B3005753).

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1999.05a
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• pp.266-271
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• 1999

The purpose in this study has to development the system on increasing operation of old-typed transceiver for solve the question that limited allocation frequencies and continuesly icreasment of traffic. Therefore, we are desigened the remote control system that has the function for variable channels, PTT and monitoring of transmission power and frequencies. Exchange of control data is to hold in common the twist two-wire or telephone line for the voice transmission. The H/W is consist of FSK and MCS-51 processor which are up-down control of channel, n control and monitoring display by serial data transmission. According to the simplex traffic operation is designed the algorithm of serial data transmission by sequential transmission sequence and protocol. The S/W of sequential transmission sequence is designed to usefully the intergrated communications system which is able to connection between the multi-transceiver and multi-terminal by master processor.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.50 no.10
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• pp.480-488
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• 2001

This paper presents a technique that can obtain an optimal solution for the Security-Constrained Economic Dispatch (SCED) problems using the Interior Point Method (IPM) while taking into account of the power flow constraints. The SCED equations are formulated by using only the real power flow equations from the optimal power flow. Then an algorithm is presented that can linearize the SCED equations based on the relationships among generation real power outputs, loads, and transmission losses to obtain the optimal solutions by applying the linear programming (LP) technique. The objective function of the proposed linearization algorithm are formulated based on the fuel cost functions of the power plants. The power balance equations utilize the Incremental Transmission Loss Factor (ITLF) corresponding to the incremental generation outputs and the line constraints equations are linearized based on the Generalized Generation Distribution Factor (GGDF). Finally, the application of the Primal Interior Point Method (PIPM) for solving the optimization problem based on the proposed linearized objective function is presented. The results are compared with the Simplex Method and the promising results ard obtained.

• Journal of Power Electronics
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• v.12 no.5
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• pp.787-799
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• 2012

Real and reactive power flows on a transmission line interact inherently. This situation degrades power flow controller performance when independent real and reactive power flow regulation is required. In this study, a quasi multi-pulse interline power flow controller (IPFC), consisting of eight six-pulse voltage source converters (VSC) switched at the fundamental frequency is proposed to control real and reactive power flows dynamically on a transmission line in response to a sequence of set-point changes formed by unit-step reference values. It is shown that the proposed hybrid fuzzy-PI commanded IPFC shows better decoupling performance than the parameter optimized PI controllers with analytically calculated feed-forward gains for decoupling. Comparative simulation studies are carried out on a 4-machine 4-bus test power system through a number of case studies. While only the fuzzy inference of the proposed control scheme has been modeled in MATLAB, the power system, converter power circuit, control and calculation blocks have been simulated in PSCAD/EMTDC by interfacing these two packages on-line.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.29 no.3
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• pp.262-267
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• 2007

Implantation of allografts has increased widely with not only the availability of many allogenic bone but also allogenic soft tissues. The aim of tissue banking is to provide surgeons with safe tissues compatible with their intended clinical application. The incidence of tissue transplant-transmitted infection is unknown and can only be inferred from prospective studies. The possibility of donor-to-recipient disease transmission through soft tissue transplantation can be considered by reviewing the risk associated with other transplanted hard tissues. Viral, bacterial, and fungal infections have been transmitted via transplantation of soft tissue allografts such as skin, cornea, dura, pericardium. fascia lata, and heart valves. Corneas have transmitted rabies, Creutzfeldt-Jakob disease (CJD), hepatitis B (HBV), cytomegalovirus (CMV), herpes simplex virus (HSV), bacteria, and fungi. Heart valves have been implicated in transmitting tuberculosis, hepatitis B. HIV-1 and CMV. CJD has been transmitted by dura and pericardium transplants. Skin has transmitted CMV, bacteria, and fungi. Cadaveric skin, pericardium, dura, and fascia lata have been used in dental patients with intra-oral soft tissue injuries and GBR. This study is review of the considering transmission of infectious disease in allogenic soft tissues and guidelines of reducing the risk. Prior to use, many tissues are exposed to antibiotics, disinfectants, and sterilants, which further reduce or remove the risk of transmitted disease. Because some soft tissue grafts cannot be subjected to sterilization steps, the risk of infectious disease transmission remains and thorough donor screening and testing is especially important.