Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

THE REVIEW OF TRANSMISSION OF INFECTIOUS DISEASE IN HUMAN TISSUE TRANSPLANTATION: PHASE II. ALLOGENIC SOFT TISSUES

동종조직이식술시 전염성질환의 이환가능성에 대한 고찰 II: 동종연조직

  • Lee, Eun-Young (Dept. of Oral and Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Kim, Kyoung-Won (Dept. of Oral and Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Um, In-Woong (Korea Tissue Bank)
  • 이은영 (충북대학교 의과대학 구강악안면외과학교실, 의학연구소) ;
  • 김경원 (충북대학교 의과대학 구강악안면외과학교실, 의학연구소) ;
  • 엄인웅 (한국조직은행)
  • Published : 2007.05.31
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Abstract

Implantation of allografts has increased widely with not only the availability of many allogenic bone but also allogenic soft tissues. The aim of tissue banking is to provide surgeons with safe tissues compatible with their intended clinical application. The incidence of tissue transplant-transmitted infection is unknown and can only be inferred from prospective studies. The possibility of donor-to-recipient disease transmission through soft tissue transplantation can be considered by reviewing the risk associated with other transplanted hard tissues. Viral, bacterial, and fungal infections have been transmitted via transplantation of soft tissue allografts such as skin, cornea, dura, pericardium. fascia lata, and heart valves. Corneas have transmitted rabies, Creutzfeldt-Jakob disease (CJD), hepatitis B (HBV), cytomegalovirus (CMV), herpes simplex virus (HSV), bacteria, and fungi. Heart valves have been implicated in transmitting tuberculosis, hepatitis B. HIV-1 and CMV. CJD has been transmitted by dura and pericardium transplants. Skin has transmitted CMV, bacteria, and fungi. Cadaveric skin, pericardium, dura, and fascia lata have been used in dental patients with intra-oral soft tissue injuries and GBR. This study is review of the considering transmission of infectious disease in allogenic soft tissues and guidelines of reducing the risk. Prior to use, many tissues are exposed to antibiotics, disinfectants, and sterilants, which further reduce or remove the risk of transmitted disease. Because some soft tissue grafts cannot be subjected to sterilization steps, the risk of infectious disease transmission remains and thorough donor screening and testing is especially important.

Keywords

References

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