• Title/Summary/Keyword: Process analytical technology

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Process analytical technology (PAT): new paradigm for the state-of-the-art analytical technology (공정분석기술: 첨단 분석기술의 새로운 패러다임)

  • Kim, Jong-Yun;Park, Yong Joon;Yeon, Jei-Won;Woo, Young-Ah;Kim, Hyo-Jin;Song, Kyuseok
    • Analytical Science and Technology
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    • v.21 no.5
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    • pp.345-363
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    • 2008
  • Process analytics has been already widely utilized in a large-scale continuous production line such as petroleum industries for several decades. Although the process analytics has a long history, a concept of "Process Analytical Technology (PAT)" has been rapidly adopted as a new paradigm for the process monitoring in the production process of various industries. In this review, current status and recent developments of PAT in various research bodies have been introduced, including the introduction of various types of analytical instruments, chemometrics tools, and perspectives and future applications of PAT as well as the fundamentals on PAT such as terminology and its historical background.

Process analytical technology (PAT): field applications and current status in pharmaceutical industries (공정분석기술: 제약산업에서의 기술개발 사례 및 현황)

  • Woo, Young-Ah;Kim, Jong-Yun;Park, Yong Joon;Yeon, Jei-Won;Song, Kyuseok;Kim, Hyo-Jin
    • Analytical Science and Technology
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    • v.22 no.1
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    • pp.35-43
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    • 2009
  • The goal of PAT (Process Analytical Technology) is to build quality into products through better understanding and control of manufacturing processes, rather than merely testing the quality of the end product. Pharmaceutical manufacturers are trying to develop and implement new technologies in pharmaceutical production and quality control for real-time measurements of critical product and process parameters. Characterization of manufacturing process through experimental design, for evaluation of the effect of product and process variables, represents an integral part of the PAT framework. However, the publications regarding real PAT application to pharmaceutical process are very limited and the technologies are confidential as well. In this review, the case studies related to PAT are shown with real applications from a pharmaceutical company. Additionally, various applications of PAT on the developing stage are introduced with high analytical technologies for the improvement of quality control on manufacturing process.

An Analytical Expression for Current Gain of an IGBT

  • Moon, Jin-Woo;Chung, Sang-Koo
    • Journal of Electrical Engineering and Technology
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    • v.4 no.3
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    • pp.401-404
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    • 2009
  • A simple analytical expression for a current gain of IGBT is derived in terms of the device parameters as well as a gate length dependent parameter, which allows for the determination of the current components of the device as a function of its gate length. The analytical results are compared with those from simulation results. A good agreement is found.

Selecting optimized mix proportion of bagasse ash blended high performance concrete using analytical hierarchy process (AHP)

  • Praveenkumar, S.;Sankarasubramanian, G.;Sindhu, S.
    • Computers and Concrete
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    • v.23 no.6
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    • pp.459-470
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    • 2019
  • Apart from strength properties, durability, toughness and workability are also important criteria in defining the performance of a concrete structure. Hence "High Performance Concrete (HPC)" is introduced. It is different from high strength concrete and can have various applications. In this paper, the properties (Mechanical and Durability) of High Performance Concrete blended with bagasse ash at 5%, 10%, 15% and 20% are studied. However, it is difficult to analyze the performance based on different properties obtained from different experiments. Hence it is necessary to combine all the criteria/properties into a single value to obtain a result by a technique called Analytical Hierarchy Process (AHP).It is an effective tool for dealing with complex decision making, and may aid the decision maker to set priorities and make the best decision. In addition, the AHP incorporates a useful technique for checking the consistency of the decision maker?s evaluations, thus reducing the bias in the decision making process.

An Analytical Methodology for Evaluating Radiological Protection Alternatives Using Analytical Hierarchy Process (계층화 의사결정법을 이용한 방사선방호선택 대안결정에 관한 해석적 방법론)

  • Sa, Sang-Duk;Narita, Masakuni
    • Journal of Radiation Protection and Research
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    • v.19 no.2
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    • pp.99-107
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    • 1994
  • This study aims to introduce a prescriptive methodology to comprehensively support the analysis of decision process by the use of Saaty's Analytical Hierarchy Process for the optimization of radiation protection. The analytical Hierarchy Process for the optimization of radiation protection. The analytical process for the problem of selecting options among given protection alternatives is illustrated with the data of the uranium mine example in ICRP Publ. 55. This technique, unlike other conventional selection method, is considered to provide a useful tool for the protection manager with respect to its ease of use and simplification in the choice of optimal alternative associated with radiological protection.

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Development of Process Analytical Technology (PAT) for Total Quality Innovation on Pharmaceutical Processes (의약품 제조공정에서의 전사적 품질혁신을 위한 공정분석기술 개발)

  • Shin, Sang-Mun;Park, Kyung-Jin;Choi, Yong-Sun;Lee, Sang-Kil;Choi, Guang-Jin;Kwon, Byung-Soo;Cho, Byung-Rae
    • Journal of Pharmaceutical Investigation
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    • v.37 no.6
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    • pp.329-338
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    • 2007
  • The quality assurance issue of drug products is more important than the general product because it is highly related to the human health and life. In this reason, the regulatory guide lines have continuously been intensified all around the world. In order to achieve effective quality assurance and real-time product release (RTPR) of drug products, process analytical technology (PAT), which can analyze and control a manufacturing process, has been proposed from the United States. With the PAT process, we can obtain significant process features of materials, quality characteristics and product capabilities from a raw material to the final product in the real-time procedure. PAT can also be utilized to process validation using information system that can analyze the risk of drug products through out an entire product life-cycle. In this paper, we first offered a new concept for the off-line process design methods to prepare the improved quality assurance restrictions and a real-time control method by establishing an information system. We also introduced an automatic inspection system by obtaining surrogate variables based on drug product formulations. Finally, we proposed an advanced PAT concept using validation and feedback principles through out the entire life-cycle of drug product manufacturing processes.

Experience of Theory and Practice of the Process of Implementing Information Technologies in the Educational Environment

  • Melnyk, Yaroslav;Drapak, Halyna;Sverdlyk, Zoriana;Tsilyna, Maryna;Varenko, Volodymyr;Boichuk, Nelia
    • International Journal of Computer Science & Network Security
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    • v.21 no.4
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    • pp.75-79
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    • 2021
  • The article covered theoretical aspects use of information and communication technologies in teaching. Information and communication technologies are technologies that allow you to search, process and assimilate information from various sources, including the Internet. This is the presentation of information in electronic form, its processing and storage, the use of the computer, a variety of programs. The use of information and communication technologies in the work of a student gives an increase in motivation for learning; increased cognitive interest; evaluate their learning activities, identify the problems of their own educational activities; the formation of cognitive independence of students.

A Sufficient Condition for the Independence of Non-Stationary Demand Process and Inventory Position Process under < Q, r > Systems

  • Sung, C.S.
    • Journal of Korean Institute of Industrial Engineers
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    • v.8 no.1
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    • pp.22-28
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    • 1982
  • Under a continuous-review inventory system, the inventory position process was proved to be asymptotically independent of the general renewal demand processes, when the two processes form an asymptotic unimodel joint distribution. The analytical technique implemented through this work seems to be more like general, and so the periodic-review system can be similarly investigated. In conclusion, the results may be evaluated to direct to the analytical analyses of some inventory systems which have been treated under some restrictions on demand processes.

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