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http://dx.doi.org/10.5806/AST.2008.21.5.345

Process analytical technology (PAT): new paradigm for the state-of-the-art analytical technology  

Kim, Jong-Yun (Korea Atomic Energy Research Intitute)
Park, Yong Joon (Korea Atomic Energy Research Intitute)
Yeon, Jei-Won (Korea Atomic Energy Research Intitute)
Woo, Young-Ah (Korea United Pharm. Inc.)
Kim, Hyo-Jin (Department of Pharmacy, Dongduk Women's)
Song, Kyuseok (Korea Atomic Energy Research Intitute)
Publication Information
Analytical Science and Technology / v.21, no.5, 2008 , pp. 345-363 More about this Journal
Abstract
Process analytics has been already widely utilized in a large-scale continuous production line such as petroleum industries for several decades. Although the process analytics has a long history, a concept of "Process Analytical Technology (PAT)" has been rapidly adopted as a new paradigm for the process monitoring in the production process of various industries. In this review, current status and recent developments of PAT in various research bodies have been introduced, including the introduction of various types of analytical instruments, chemometrics tools, and perspectives and future applications of PAT as well as the fundamentals on PAT such as terminology and its historical background.
Keywords
Process analytical technology; process analytical chemistry; chemometrics; design of experiment; process monitoring; process analytics;
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1 Y. Arikawa, Analytical Sciences, 17, i571-i573(2001)   DOI   ScienceOn
2 J. Workman, M. Koch and D. Veltkamp, Anal. Chem., 77, 3789-3806(2005)   DOI   ScienceOn
3 J. Workman, M. Koch and D. Veltkamp, Anal. Chem., 75, 2589-2876(2003)
4 M. Birch, S. J. Fussell, P. D. Higginson, N. McDowall and I. Marziano, Org. Process Res. Dev., 9(3), 360-364(2005)   DOI   ScienceOn
5 M. J. Kim, H. Chung, Y. Woo and M. S. Kemper, Anal. Chim. Acta., 587, 190-197(2007)
6 R. D. McDowall, Analyt. Chim. Acta., 391, 149-158(1999)   DOI   ScienceOn
7 K. H. Norris and J. R. Hart, Proc. 1963 Intern. Symp. on Humidity and Moisture in Liquids and Solids, Direct Spectrophotometric Determination of Moisture Content of Grains and Seeds, A. Wexler(Ed.), Reinhold, New York, 19(1965)
8 Y.-A. Woo and H.-J. Kim, Microchem. J., 78, 167-173(2004)   DOI   ScienceOn
9 J. Kim, J. Noh, H. Chung, Y.-A. Woo, M. S. Kemper and Y. Lee, Anal. Chim. Acta., 598, 280-285(2007)   DOI   ScienceOn
10 IAEA-TECDOC-1459, Technical data on nucleonic gauges, IAEA, Vienna, Austria (2005)
11 T.-J. Kim, Y.-H. Cho, I.-K. Choi, J.-G. Kang, K. Song and K.-Y. Jee, J. Nucl. Mater., 375(2), 275-279(2008)   DOI   ScienceOn
12 '원자력산업 적용 첨단 방사화학 기술' 워크샵, 춘계한국원자력학회, 2008
13 J. R. McConell, K. P. Barton, M. A. LaPack and M. A. DesJardin, Org. Process Res. Dev., 6, 700-705(2004)   DOI   ScienceOn
14 K. L. Vora, G. Buckton and D. Clapham, Eur. J. Pharm. Sci., 22, 97-105(2004)   DOI   ScienceOn
15 C.-K. Lai and C. C. Cooney, J. Pharm. Sci., 93(1), 60-70(2004)   DOI   ScienceOn
16 N. Wang, N. Zhang and M. Wang, Computers and Electronics in Agriculture, 50, 1-14(2006)   DOI   ScienceOn
17 K. Lundstedt-Enkel, J. Gabrielsson, H. Olsman, E. Seifert, J. Pettersen, P. M. Lek, A. Boman and T. Lundstedt, Chemometrics and Intelligent Laboratory Systems, 84, 201-207(2006)   DOI   ScienceOn
18 P. Barrett, B. Smith, J. Worlitschek, V. Bracken, B. O'Sullivan and D. O'Grady, Org. Process Res. Dev., 9, 348-355(2005)   DOI   ScienceOn
19 G. Fevotte, J. Calas, F. Puel and C. Hoff, Int. J. Pharm., 273, 159-169(2004)   DOI   ScienceOn
20 E. Verpoorte, Electrophoresis, 23, 677-712(2002)   DOI   ScienceOn
21 Y.-A. Woo, J.-W. Ahn, I.-K. Chun and H.-J. Kim, Anal. Chem., 73, 4964-4971(2001)   DOI   ScienceOn
22 R. B. Shah, M. A. Tawakkul and M. A. Khan, J. Pharm. Sci., 96, 1356-1365(2007)   DOI   ScienceOn
23 K. Thurow, B. Gode, U. Dingerdissen and N. Stoll, Org. Process Res. Dev., 8, 970-982(2004)   DOI   ScienceOn
24 C. Cimander and C.-F. Mandenius, J. Chem. Technol. Biotechnol., 77, 1157-1168(2002)   DOI   ScienceOn
25 N. E. Mathis, Measurement of Thermal Conductivity Anisotropy in Polymer Materials, Chemical Engineering Department, Fredericton, N. B, Canada, 1996
26 P. D. Coates, S. E. Barnes, M. G. Sibley, E. C. Brown, H. G. M. Edward and I. J. Scowen, Polymer, 44, 5937- 5949(2003)   DOI   ScienceOn
27 D. R. Unger and F. J. Muzzio, J. AIChE., 45(12), 2477-2486(1999)   DOI   ScienceOn
28 P.-A. Auroux, D. Iossifidis, D. R. Reyes and A. Manz, Anal. Chem., 74, 2637-2652(2002)   DOI   ScienceOn
29 S. Martini, C. Bertoli, M. L. Herrera, I. Neeson and A. Marangoni, JAOCS, 82(5), 305-312(2005)   DOI   ScienceOn
30 K. A. Bakeev (Ed.), 'Process Analytical Technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries Blackwell Publishing Professional', Wiley Blackwell, Ames, IA, 2005
31 K. Huikko, R. Kostiainen and T. Kotiaho, Eur. J. Pharm. Sci., 20, 149-171(2003)   DOI   ScienceOn
32 J. Bo Holm-Nielsen, C. K. Dahl and K. H. Esbensen, Chemometrics and Intelligent Laboratory Systems, 83, 114-126(2006)   DOI   ScienceOn
33 M. Halstensen, P. de Bakker and K. H. Esbensen, Chemometrics and Intelligent Laboratory Systems, 84, 88-97(2006)   DOI   ScienceOn
34 K. J. Clevett, 'Process Analyzer Technology', John Wiley & Sons, New York, 1986
35 J. P. Chauvel, W. W. Henslee and L. A. Melton, Anal. Chem., 74, 381A-384A(2002)
36 M. Daszykowski and B. Walczak, Trends in Analytical Chemistry., 25(11), (2006)
37 P. Gemperline, G. Puxty, M. Maeder, D. Walker, F. Tarczynski and M. Bosserman, Anal. Chem., 76, 2575-2582(2004)   DOI   ScienceOn
38 R. A. Crocombe, spectrosc. eur., 16(3), 16-19(2004)
39 Y.-A. Woo, H.-R. Lim, H.-J. Kim and H. Chung, J. Pharm. Biomed. Anal., 33, 1049-1057(2003)   DOI   ScienceOn
40 P. Mougin, A. Thomas, D. Wilkinson, G. White, K. J. Roberts, N. Herrmann, R. Jack and R. Tweedie, J. AIChE., 49(2), 373-378(2003)   DOI   ScienceOn
41 대한화학회, 화학용어술어집 개정 5판, 2007
42 Z. Shi, R. P. Cogdill, S. M. Short and C. A. Anderson, J. Pharm. Biomed. Anal., 47, 738-745(2008)   DOI   ScienceOn
43 M. J. Kim, H. Chung, Y. Woo and M. S. Kemper, Anal. Chim. Acta., 579, 209-216(2006)   DOI   ScienceOn
44 C. -K. Lai, D. Holt, J. C. Leung, C. L. Cooney, G. K. Raju and P. Hansen, J. AIChE., 47(11), 2618-2622(2001)   DOI   ScienceOn
45 T. Pan and E. M. Sevick-Muraca, Anal. Chem., 74, 4228-4234(2002)   DOI   ScienceOn
46 Z. Sun, Y. Huang and E. M. Sevick-Muraca, Rev. Sci. Instrum., 73, 383-393(2002)   DOI   ScienceOn
47 B. Lavine and J. Workman, Anal. Chem., 80, 4519-531(2008)   DOI   ScienceOn
48 J. Workman, M. Koch and D. Veltkamp, Anal. Chem., 79, 4345-4364(2007)   DOI   ScienceOn
49 F. McLennan and B. R. Kowalski (Eds.), 'Process Analytical Chemistry', Chapman & Hall, London, 1995
50 C. H. Legge, J. Chem. Educ., 79(2), 173-178(2002)   DOI   ScienceOn
51 F. Alba, G. M. Crawley, J. Fatkin, D. M. J. Higgs and P. G. Kippax, Phsiochem. Eng. Asp., 15, 495-502(1999)
52 G. S. Constable, A. J. Lesser and E. B. Coughlin, J. Polym. Sci. Part B: Polym. Phys. 41, 1323-1333(2003)   DOI   ScienceOn
53 T. Davies, P. Lampen, M. Fiege, T. Richter and T. Frohlich, Spectrosc. Eur., 15(5), 25-28(2003)
54 T. Chapman, Nature, 421, 661-666(2003)   PUBMED
55 M.-S. Hwang, S.-H. Cho, H. Chung and Y.-A. Woo, J. Pharm. Biomed. Anal., 38, 210-215(2005)   DOI   ScienceOn
56 D. Brennan, J. Alderman and L. Sattler, B. O'Connor, Measurement, 33, 67-4(2003)   DOI   ScienceOn
57 S. J. Lee and S. Y. Lee, Appl. Microbiol. Biotechnol., 64, 289-299(2004)   DOI
58 R. Belchamber, Spectrosc. Eur., 15(6), 26-27(2003)
59 J. L. Lippert and S. C. Switalski, Uncalibrated in-line Raman data as a lower cost process consistency tool for a multi-product process control, IFPAC, Arlington, VA (2004)
60 정용주, 연제원, 김원호, 한국특허등록 0629609(2006)
61 E. Martinelli, C. Falconi, A. D'Amico and C. Di Natale, Sens. Actuators B, 95, 132-139(2003)   DOI   ScienceOn
62 S. Barthe and R. W. Rousseau, Chem. Eng. Tech., 29, 206-211(2006)   DOI   ScienceOn
63 F. Sistare, L. St. Pierre Berry and C. A. Mojica, Org. Process Res. Dev., 9, 332-336(2005)   DOI   ScienceOn
64 G. Macaloney, J. W. Hall, M. J. Rollins, I. Draper, K. B. Anderson, J. Preston, B. G. Thomson and B. McNeil, Bioprocess Eng., 17, 157-167(1997)
65 T. Pan, D. Barber, D. Coffin-Beach, Z. Sun and E. M. Sevick-Muraca, J. Pharm. Sci., 93, 635-645(2004)   DOI   ScienceOn
66 J. Workman, K. E. Creasy, S. Doherty, L. Bond, M. Koch, A. Ullman and D. Veltkamp, Anal. Chem., 73, 2705-2718(2001)   DOI   ScienceOn
67 Z. Sun, S. Torrance, F. K. Mcneil-Watson and E. M. Sevick-Muraca, Anal. Chem., 75, 1720-1725(2003)   DOI   ScienceOn
68 S. D. Brown, Appl. Spectrosc., 49, 14A-31A(1995)
69 J. B. Callis, D. L. Illman and B. R. Kowalski, Anal. Chem., 59, 624A(1987)   DOI
70 M. T. Rube and D. J. Eustace, Anal. Chem., 62, 65A(1990)   DOI
71 S. S. Sekulic, H. W. Ward III, D. R. Brannegan, E. D. Stanley, C. L. Evans, S. T. Sciavolino, P. A. Hailey and P. K. Aldridge, Anal. Chem., 68, 509-513(1996)   DOI   ScienceOn
72 Guidance for Industry, PAT: A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary, Medicine (CVM), Office of Regulatory Affairs (ORA), Pharmaceutical CGMPs, September 2004. URL: http://www.fda.gov/cder/guidance/6419fnl.htm
73 H. Hotelling, J. Educ. Psychol., 24, 417-441(1933)   DOI
74 S. J. Doherty and A. J. Lange, Trends in Analytical Chemistry, 25(11), (2006)
75 R. G. Brereton, 'Chemometrics: Data Analysis for the Laboratory and Chemical Plant', Wiley, Chichester, UK, 2003