• Biomolecules & Therapeutics
• /
• v.22 no.5
• /
• pp.467-473
• /
• 2014

The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly decreased the spontaneous alterations in Y-maze test and step-through latency in passive avoidance test, whereas increased time spent to find the hidden platform in Morris water maze test compared with the sham control group. In contrast, oral administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the expression of brain-derived neurotrophic factor (BDNF) in the cortex and hippocampus via promoting activation of cAMP response element binding protein (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning and memory impairment possibly through activation of CREB and up-regulation of BDNF levels, thereby exhibiting a cognition-enhancing potential.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.9 no.11
• /
• pp.4483-4501
• /
• 2015

In this paper, we investigate a security transmission scheme at the physical layer for cooperative wireless relay networks in the presence of a passive eavesdropper. While the security scheme has been previously investigated with perfect channel state information(CSI) in the presence of a passive eavesdropper, this paper focuses on researching the robust cooperative relay beamforming mechanism for wireless relay networks which makes use of artificial noise (AN) to confuse the eavesdropper and increase its uncertainty about the source message. The transmit power used for AN is maximized to degrade the signal-to-interference-plus-noise-ratio (SINR) level at the eavesdropper, while satisfying the individual power constraint of each relay node and worst-case SINR constraint at the desired receiver under a bounded spherical region for the norm of the CSI error vector from the relays to the destination. Cooperative beamforming weight vector in the security scheme can be obtained by using S-Procedure and rank relaxation techniques. The benefit of the proposed scheme is showed in simulation results.

• Journal of Aerospace System Engineering
• /
• v.8 no.3
• /
• pp.6-13
• /
• 2014

A passive launch and on-orbit vibration isolator using SMA(Shape Memory Alloy) washer for both the structural safety of the micro-vibration source by attenuating the transmitted force under launch loads and the micro-vibration isolation during their on-orbit operation has been proposed, which does not require the additional launch locking mechanism. To measure the characteristics of SMA mesh washer, we performed compressive loading tests with a single SMA mesh washer and a vibration isolator using SMA mesh washer. The numerical equivalent model of vibration isolator using SMA mesh washer composed of two spring and viscous damping elements has been verified that both stiffness and viscous damping varied with respect to compressed deformations. In addition, the effectiveness of launch loads and micro-vibration reduction has been investigated through the dynamic characteristics measurement test of cooler assembly combined with passive vibration isolator.

• 한국IT서비스학회:학술대회논문집
• /
• 2008.11a
• /
• pp.127-130
• /
• 2008

Recently, a wide variety of research on the knowledge-based industries, which are considered a key area of social science research, has been conducted. In this light, this study examines a case of knowledge diffusion taken from the IT service field. The IT service industry has been considered difficult to diffuse due to its unique technological regimes and sophisticated market demand. In particular, the established public service systems have limited markets and encompass national characteristics, thereby making their international diffusion difficult. However, despite these limitations, the automated customs system ASYCUDA has been distributed successfully and is now operating in about 100 countries, making the case very unusual. Using various industrial innovation models, and an analysis of lead markets, with regard to ASYCUDA, this research examines patterns of technological learning activities by actors, characteristics of the lead markets, and paths of technology transfer. The findings indicate that when active technology providers attempt to streamline and standardize the technology to make it suitable for the characteristics of the initial technology application areas(lead markets), this helps to diffuse the technology to passive recipients and the surrounding nations. The findings also confirm that south-south cooperation in the acquired technologies was of considerable help in sharing knowledge among the passive technology recipients, and that the active technology providers' programmed, well-organized technology assistance was a key driving force behind technology transfer and diffusion between the surrounding nations.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.21 no.2
• /
• pp.127-133
• /
• 2008

The purpose of this study is to investigate the seismic performance of both exterior precast concrete cladding panels and their connections on steel frame, when these cladding systems are considered as the structural components. The degrees of their participation of lateral stiffness to the main building are evaluated in terms of different heights of the cladding panels. Considering the cladding system as an integrated building provides additional lateral stiffness, as well as a mechanism for energy dissipation and this system can be used as one of an advanced passive seismic control system. Hysteresis behaviors of connectors are modeled and integrated into a nonlinear finite element analysis program, ABAQUS. The results show that connections play the most important role in structural cladding system and they improve seismic performance of overall building response.

• Journal of the Korean Society of Safety
• /
• v.28 no.3
• /
• pp.123-128
• /
• 2013

The Advanced Power Reactor Plus(APR+), which is a GEN III+ reactor based on the APR1400, is being developed in Korea. In order to enhance the safety of the APR+, a passive auxiliary feedwater system(PAFS) has been adopted in the APR+. The PAFS replaces the conventional active auxiliary feedwater system(AFWS) by introducing a natural driving force mechanism while maintaining the system function of cooling the primary side and removing the decay heat. As the PAFS completely replaces the conventional AFWS, it is required to verify the cooling capacity of PAFS for the core damage frequency(CDF) evaluation. For this reason, this paper discusses the cooling performance of the PAFS during transient accidents. The test case and scenarios were picked from the result of the sensitivity analysis in APR+ Probabilistic Safety Assessment(PSA). The analysis was performed by the best estimate thermal-hydraulic code, RELAP5/.MOD3.3. This study shows that the plant maintains the stable state without the core damages under the given test scenarios. The results of PSA considering this analysis' results shows that the CDF values are decreased. The analysis results can be used for more realistic and accurate performance of a PSA.

• Journal of Food Hygiene and Safety
• /
• v.29 no.4
• /
• pp.356-362
• /
• 2014

Allergic diseases have increased rapidly over the past decades, affecting an estimated 20~30% of the population in developed countries. In this study, we investigated whether or not a typical costal sand dune plant Carex pumila (CPE) suppresses the activation of mast cells and IgE-mediated allergic response in vitro and in vivo. As the results, the extract of Carex pumila inhibited antigen-stimulated degranulation in RBL-2H3 cells and Bone marrow-derived mast cells (BMMCs), and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. CPE also suppressed the production of pro-inflammatory cytokines, TNF-${\alpha}$ and IL-4, in antigen-stimulated mast cells. As its mechanism of action, CPE inhibited the activation of Syk in $Fc{\varepsilon}RI$-mediated signalling pathway, and that of LAT, a downstream adaptor molecule of Syk, in a dose-dependent manner. CPE also suppressed the activation of mitogen-activated protein (MAP) kinases, p38, ERK1/2, JNK, and Akt. Altogether, CPE inhibited mast cell activation and IgE-mediated allergic response by antigen through suppressing the activation of Syk. These results suggest that CPE may be useful for the treatment of allergic diseases.

• Korean Journal of Pharmacognosy
• /
• v.49 no.4
• /
• pp.298-304
• /
• 2018

Malus sieboldii is a dicotyledonous plant that grows widely in Jeju Island and Ganghwa Island in Korea. Malus sieboldii has been known as a detoxifying and antioxidant plant, but study on allergic diseases is not known. In this study, we investigated the effect of Malus sieboldii extract (MSE) on the activation of mast cells, which is well known to be a critical causative cell to induce allergic diseases. As a result of our experiments, MSE inhibited the degranulation and inflammatory cytokine secretion from mast cells by antigen stimulation. As the mechanism of MSE in mast cells, it inhibited the activation of Syk kinase, a essential signaling protein activated by antigen, and further inhibited activation of $PLC{\gamma}$ and MAP kinase(P38, ERK1/2, and JNK). Furthermore, in vivo animal studies showed that MSE significantly inhibited IgE-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis in a dose-dependent manner. Taken together, the results of this study showed for the first time that MSE inhibited IgE-mediated allergic responses by suppressing Syk kinase in mast cells. Therefore, it could be considered that MSE is worth developing as an anti-allergic material.

• Nuclear Engineering and Technology
• /
• v.53 no.1
• /
• pp.304-313
• /
• 2021

Nickel base Alloy X-750, which is used as fastener parts in light-water reactor (LWR), has experienced many failures by environmentally assisted cracking (EAC). In order to improve the reliability of passive components for nuclear power plants (NPP's), it is necessary to study the failure mechanism and to predict crack growth behavior by developing a probabilistic failure model. In this study, The Bayesian inference was employed to reduce the uncertainties contained in EAC modeling parameters that have been established from experiments with Alloy X-750. Corrosion fatigue crack growth rate model (FCGR) was developed by fitting into Paris' Law of measured data from the several fatigue tests conducted either in constant load or constant ΔK mode. These parameters characterizing the corrosion fatigue crack growth behavior of X-750 were successfully updated to reduce the uncertainty in the model by using the Bayesian inference method. It is demonstrated that probabilistic failure models for passive components can be developed by updating a laboratory model with field-inspection data, when crack growth rates (CGRs) are low and multiple inspections can be made prior to the component failure.

• Journal of Energy Engineering
• /
• v.25 no.1
• /
• pp.56-68
• /
• 2016

Extensive researches have been carried out for enhancing the safety of nuclear power plants and, especially, the development of passive cooling systems, such as passive containment cooling system (PCCS) and passive residual heat removal system, is increasingly important, where condensation is a crucial heat transfer mechanism. Recently, Ahn & Yun et al. developed a horizontal in-tube condensation heat transfer model as one of the activities for the PCCS development. In this work, we implemented the Ahn & Yun 's condensation heat transfer model into the MARS code and assessed it using the PASCAL experimental data. Based on the results of the assessment, we identified the limitations of the Ahn & Yun 's model and suggested a modified Ahn & Yun 's model, and assessed the model using various experimental data.