Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment

  • Kim, Chang-Yul (Department of Pathology, College of Oriental Medicine, Daegu Haany University) ;
  • Lee, Gil-Yong (Department of Pathology, College of Oriental Medicine, Daegu Haany University) ;
  • Park, Gyu Hwan (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University) ;
  • Lee, Jongwon (Deparment of Biochemistry, School of Medicine, Catholic University of Daegu) ;
  • Jang, Jung-Hee (Department of Pharmacology, School of Medicine, Keimyung University)
  • Received : 2014.05.29
  • Accepted : 2014.07.08
  • Published : 2014.09.30
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Abstract

The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly decreased the spontaneous alterations in Y-maze test and step-through latency in passive avoidance test, whereas increased time spent to find the hidden platform in Morris water maze test compared with the sham control group. In contrast, oral administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the expression of brain-derived neurotrophic factor (BDNF) in the cortex and hippocampus via promoting activation of cAMP response element binding protein (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning and memory impairment possibly through activation of CREB and up-regulation of BDNF levels, thereby exhibiting a cognition-enhancing potential.

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References

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