Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Extract of Malus sieboldii Suppresses IgE-mediated Mast Cell Activation through Inhibition of Syk Kinase

아그배나무(Malus sieboldii)의 IgE 매개성 알레르기 반응 억제 효과 및 기전

  • Jo, So Young (College of Pharmacy, Duksung Women's University) ;
  • Kim, Young Mi (College of Pharmacy, Duksung Women's University)
  • 조소영 (덕성여자대학교 약학대학) ;
  • 김영미 (덕성여자대학교 약학대학)
  • Received : 2018.10.17
  • Accepted : 2018.11.29
  • Published : 2018.12.31
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Abstract

Malus sieboldii is a dicotyledonous plant that grows widely in Jeju Island and Ganghwa Island in Korea. Malus sieboldii has been known as a detoxifying and antioxidant plant, but study on allergic diseases is not known. In this study, we investigated the effect of Malus sieboldii extract (MSE) on the activation of mast cells, which is well known to be a critical causative cell to induce allergic diseases. As a result of our experiments, MSE inhibited the degranulation and inflammatory cytokine secretion from mast cells by antigen stimulation. As the mechanism of MSE in mast cells, it inhibited the activation of Syk kinase, a essential signaling protein activated by antigen, and further inhibited activation of $PLC{\gamma}$ and MAP kinase(P38, ERK1/2, and JNK). Furthermore, in vivo animal studies showed that MSE significantly inhibited IgE-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis in a dose-dependent manner. Taken together, the results of this study showed for the first time that MSE inhibited IgE-mediated allergic responses by suppressing Syk kinase in mast cells. Therefore, it could be considered that MSE is worth developing as an anti-allergic material.

Keywords

References

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