• Asian-Australasian Journal of Animal Sciences
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• 제29권11호
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• pp.1608-1615
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• 2016

This study was conducted to determine the solubility of copper (Cu) in two sources of copper(II) sulfate ($CuSO_4$) including monohydrate and pentahydrate and three sources of dicopper chloride trihydroxide (dCCTH) including ${\alpha}$-form (dCCTH-${\alpha}$), ${\beta}$-form (dCCTH-${\beta}$), and a mixture of ${\alpha}$- and ${\beta}$-form (dCCTH-${\alpha}{\beta}$) at different pH and a 3-step in vitro digestion assay for pigs. In Exp. 1, Cu sources were incubated in water-based buffers at pH 2.0, 3.0, 4.8, and 6.8 for 4 h using a shaking incubator at $39^{\circ}C$. The $CuSO_4$ sources were completely dissolved within 15 min except at pH 6.8. The solubility of Cu in dCCTH-${\alpha}$ was greater (p<0.05) than dCCTH-${\beta}$ but was not different from dCCTH-${\alpha}{\beta}$ during 3-h incubation at pH 2.0 and during 2-h incubation at pH 3.0. At pH 4.8, there were no significant differences in solubility of Cu in dCCTH sources. Copper in dCCTH sources were non-soluble at pH 6.8. In Exp. 2, the solubility of Cu was determined during the 3-step in vitro digestion assay for pigs. All sources of Cu were completely dissolved in step 1 which simulated digestion in the stomach. In Exp. 3, the solubility of Cu in experimental diets including a control diet and diets containing 250 mg/kg of additional Cu from five Cu sources was determined during the in vitro digestion assay. The solubility of Cu in diets containing additional Cu sources were greater (p<0.05) than the control diet in step 1. In conclusion, the solubility of Cu was influenced by pH of digesta but was not different among sources based on the in vitro digestion assay.

• Bulletin of the Korean Chemical Society
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• 제33권4호
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• pp.1123-1127
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• 2012

P-gp (P-glycoprotein) is a member of the ATP binding cassette (ABC) family of transporters. It transports many kinds of anticancer drugs out of the cell. It plays a major role as a cause of multidrug resistance (MDR). MDR function may be a cause of the failure of chemotherapy in cancer and influence pharmacokinetic properties of many drugs. Hence classification of candidate drugs as substrates or nonsubstrate of the P-gp is important in drug development. Therefore to identify whether a compound is a P-gp substrate or not, in silico method is promising. Recursive Partitioning (RP) method was explored for prediction of P-gp substrate. A set of 261 compounds, including 146 substrates and 115 nonsubstrates of P-gp, was used to training and validation. Using molecular descriptors that we can interpret their own meaning, we have established two models for prediction of P-gp substrates. In the first model, we chose only 6 descriptors which have simple physical meaning. In the training set, the overall predictability of our model is 78.95%. In case of test set, overall predictability is 69.23%. Second model with 2D and 3D descriptors shows a little better predictability (overall predictability of training set is 79.29%, test set is 79.37%), the second model with 2D and 3D descriptors shows better discriminating power than first model with only 2D descriptors. This approach will be used to reduce the number of compounds required to be run in the P-gp efflux assay.

• Journal of Animal Science and Technology
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• 제45권2호
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• pp.265-272
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• 2003

본 연구는 평균체중 60.0$\pm$1.5kg인 육성비육돈 30두를 대조구, 죽초액 2% 급여구 및 죽초액 4% 급여구의 3개 처리구로 10두씩 배치하여 4개월간 사양시험을 실시한 후 도축하여 등심육을 시료로 채취하여 저장 중 육질특성 변화를 알아보고자 실시하였다. pH는 저장 3일 이후 죽초액 2%와 4% 급여구가 대조구에 비해 유의적(P<0.05)으로 감소함을 나타냈다. 명도(L)는 저장 1일과 3일에 2%와 4% 급여구가 대조구에 비해 유의적(P<0.05)으로 높게 나타났다. 적색도는 저장 1일과 3일에 죽초액 4% 급여구가 대조구에 비해 유의적(P<0.05)으로 낮게 나타났다. 황색도는 저장기간 동안 죽초액 2%와 4% 급여구가 대조구에 비해 유의적(P<0.05)으로 높게 나타났다. 가열감량은 저장 3일 이후 죽초액 2%와 4%급여구가 대조구에 비해 유의적(P<0.05)으로 높게 나타났다. 전단력은 저장 1일과 3일에 죽초액 2%와 4% 급여구가 대조구에 비해 유의적(P<0.05)으로 낮게 나타나 연도 개선효과를 보였다. 지방산패도는 저장 6일과 9일에 죽초액 2%와 4% 급여구가 유의적(P<0.05)으로 감소하였다. 총균수는 죽초액 2%와 4% 급여구가 대조구에 유의적(p<0.05)으로 낮게 나타났다. 냄새는 저장 1일과 3일에 죽초액 2%와 4% 급여구가 대조구에 비해 유의적(P<0.05)으로 높은 점수를 받아 돼지 특유의 이취가 감소하는 효과를 나타냈다. 외관은 저장 1일에 죽초액 2%와 4% 급여구가 대조구에 비해 유의적(P<0.05)으로 증가함을 나타냈다. 맛은 저장 1일과 3일, 6일에 죽초액 2%와 4% 급여구가 대조구에 비해 유의적(P<0.05)으로 높게 나타났다. 이상의 결과를 종합해보면 죽초액 2%와 4% 급여된 돼지고기는 육질특성과 저장안정성이 개선된 것으로 사료된다.

• 대한치과기공학회지
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• 제23권1호
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• pp.107-114
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• 2001

R.P.D fabrication can be made if the skills already is properly used in the manufacturing press. You may feel extremely comfortable to wear it. The material used has high elasticity that it can endure the hole process of Acetal Wax pattern casting without any deformation moreover its adaptability is not bad. Because of the poor financial condition of patterns and health insurance, Acetal R.P.D Framework can be one of the best alternatives used for setting clasp partial denture cheaply. R.P.D Framework is aesthetically excellent. The color caused by saliva is so similar to that of the rest of teeth that even dentists as well as patients can not recognize clasp arm. Clasp also helps to secure prosthesis ideally without damaging teeth due to its deep position downward. Since dentists and patients have a good reaction to clasp so far, we are encouraged to apply it to other technical fields.

• 대한수학회논문집
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• 제39권3호
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• pp.785-802
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• 2024

Given M a monoid with a neutral element e. We show that the solutions of d'Alembert's functional equation for n × n matrices Φ(pr, qs) + Φ(sp, rq) = 2Φ(r, s)Φ(p, q), p, q, r, s ∈ M are abelian. Furthermore, we prove under additional assumption that the solutions of the n-dimensional mixed vector-matrix Wilson's functional equation $$\begin{cases}f(pr, qs) + f(sp, rq) = 2\phi(r, s)f(p, q),\\Φ(p, q) = \phi(q, p),{\quad}p, q, r, s {\in} M\end{cases}$$ are abelian. As an application we solve the first functional equation on groups for the particular case of n = 3.

• Asian-Australasian Journal of Animal Sciences
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• 제20권6호
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• pp.832-841
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• 2007

Rectal Temperature;Thermoregulation;Sows;Breed;The effects of season (hot vs. warm) in a tropical humid climate, parity (primiparous vs. multiparous) and breed (Creole: CR, Large White: LW) on rectal temperature (RT) were studied for a total of 222 lactations obtained in 85 sows (43 CR and 42 LW; 56 primiparous and 166 multiparous) over a 28-d lactation, between June 2002 and April 2005. Mean daily ambient temperature was higher during the hot season than during the warm season (26.0 vs. $24.1^{\circ}C$) and relative humidity was high and similar in both seasons (89% on average). At farrowing, BW was lower (172 vs. 233 kg) and backfat thickness was higher (37 vs. 21 mm) in CR than in LW sows (p<0.01). During the hot season, the reduction of average daily feed intake (ADFI) was more pronounced in LW than in CR sows (-920 vs. -480 g/d, p<0.05). Rectal temperature was higher at 1200 than at 0700hr, which coincides with the maximum and the minimum values of daily ambient temperature. The daily RT increased ($+0.9^{\circ}C$; p<0.01) between d -3 and d 7 (d 0: farrowing day), remained constant between d 7 and d 25 and decreased (p<0.01) thereafter (i.e. $-0.6^{\circ}C$ between d 25 and d 32). The average daily RT was significantly higher during the hot than during the warm season (38.9 vs. $38.6^{\circ}C$; p<0.01). It was not affected by breed, but the difference in RT between the hot and warm seasons was more pronounced in LW than in CR sows (+0.4 vs. $+0.2^{\circ}C$; p<0.05). Parity influenced the RT response; it was greater in primiparous than in multiparous sows (38.9 vs. $38.7^{\circ}C$; p<0.01). This study suggests that thermoregulatory responses to heat stress can differ between breeds and between parities.

• Asian-Australasian Journal of Animal Sciences
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• 제11권6호
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• pp.732-738
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• 1998

Three crossbred gilts weighing $61{\pm}2kg$ ($mean{\pm}SD$) and three gilts weighing $52{\pm}3kg $ on the day before the first treatment began (d -1) were used for each of two experiments (Exp. 1 and Exp. 2), respectively. In Exp. 1, all pigs were fed the experimental diet (CP 19%) from d -7 to the end of study (d 21) to verify that nitrogen retention is constant during the 21 -d period. In Exp. 2, pigs were fed the control diet (CP 15.5 %) from d -7 to d 8 and then the low-lysine diet from d 9 to d 16 in order to determine how rapidly dietary changes in amino acid composition results in a new equilibrium for nitrogen metabolism. The amount of urine nitrogen loss was not different over 21 days (p > 0.10). Rates of nitrogen retention were not different among pigs (p > 0.10) nor over time (p > 0.10). Average nitrogen retention during the period was 1.00 g/kg $BW^{0.75}$ per day. The apparent biological value was 41%, which did not change over the 3-week period (p > 0.10). The overall efficiency of nitrogen use for nitrogen retention was 35% (Exp. 1). The amount of nitrogen loss in urine and the efficiency of nitrogen utilization for nitrogen gain reached a new equilibrium within 2 to 3 d after the diet was changed. The low-lysine diet resulted in a 20% increase of nitrogen loss in urine (p < 0.001) and a 9% decline in efficiency of nitrogen use for nitrogen retention (p < 0.001). Nitrogen retention while the pigs were fed the control diet was also higher than the retention when pigs were fed the low lysine diet (p < 0.001). The efficiency of nitrogen use for nitrogen retention in pigs fed the control diet was 57% (Exp. 2), which was higher (p < 0.001) than that from pigs fed the low-lysine diets (52%).

• Journal of Microbiology and Biotechnology
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• 제27권11호
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• pp.2060-2069
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• 2017

Newcastle disease is a serious infectious disease in the poultry industry. The commercial vaccines can only offer limited protection and some of them are expensive and need adjuvants. At present, DNA vaccines are widely used. However, the immune responses induced by DNA vaccines are too slow and low. Here, we constructed the transfer vectors with a different number of C3d as molecular adjuvants (n = 1, 2, 4, or 6), and the vectors were cloned into the optimal eukaryotic expression plasmid (pVAXI-optiF) that expressed the F gene of Newcastle disease virus (NDV), and named pVAXI-F(o)-C3d1, pVAXI -F(o)-C3d2, pVAXI-F(o)-C3d4, and pVAXI-F(o)-C3d6, respectively. Cell transfection test indicated that pVAXI-F(o)-C3d6 showed the highest expression. In vivo immunization showed that the chickens immunized with pVAXI-F(o)-C3d6 intramuscularly induced better immune responses than the chickens immunized with the other plasmids. The protective efficacy of pVAXI-F(o)-C3d6 was 80% after challenge with the highly virulent NDV strain F48E9. The results in this study showed that C3d6 could be used as a molecular adjuvant to quickly induce an effective immune response to control NDV.

• 한국잠사곤충학회지
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• 제14권1호
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• pp.9-13
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• 1972

상족후 7일째 수견하고 자웅을 감별하여 일부는 방사선(${\gamma}$-선) 1,000${\gamma}$에서 40분간 조사시켜 화아 교미후 산란후 시간을 5분, 15분, 45분, 90분, 720분, 2,400분의 6구로 나누어 란내 acid soluble phosphorus의 변동을 분석 검토한 결과 다음과 같은 결과를 얻었다. 1. 표준구(대조구)에서는 산란후 90분에 1,288${\gamma}$/100 mg D.P.로 점차 감소하여 720분에 1,232${\gamma}$/100mg D.P.로 가장 적은량을 나타냈으나 2,400분에 1,456${\gamma}$/100mg D.P.로 가장 많은 량을 나타냄을 알 수 있었다. 2. 방사선처리한 ♀에 표준구(무처리) ♂놈을 교미시킨 구에서는 표준구(대조구)에 비하여 산란초기 5분에 1,288${\gamma}$/100mg D.P. 15분에 1,299${\gamma}$/100mg D.P.로 다소 적은량을 나타냈으나 45분에 1,484${\gamma}$/100mg D.P.로 증가된 량을 보이다가 2,400분에 1,400${\gamma}$/100mg D.P.로 표준구(대조구)보다 적은량을 나타냈다. 그러나 표준구에 ♀놈에 방사선처리구에 ♂놈을 교미시킨 구와 비교할 때 초기에는 다소 적은 량이었으나 큰 차리는 확인할 수 없었으며 양구 다같이 산란후 15분에서 720분까지 양적으로 표준구(대조구) 많았음을 인정할 수 있고, 방사선처리한 ♀놈에 표준구(무처리)의 ♂놈을 교미시킨 구보다 표준구의 ♀놈에 방사선처리한 ♂놈을 교미시킨 구에서 변동이 크고, lipid phosphorus(Part I)의 경우와 상반된 변동이 이루어지는것을 알 수 있었다. 3. ♀.♂ 다같이 방사선을 처리하여 교미시킨 구에서 산란후 90분에 1,736${\gamma}$/100mg D.P, 2,400분에 1,760 ${\gamma}$/100mg D.P.로 많은 량을 나타냈고 5분에 1,288${\gamma}$/100mg D.P.로 가장 적은량을 나타냈으며 전반적으로 보아 산란초기에는 표준구보다 적었으나 그 후에는 표준구보다 크게 증가하고 변동이 심한것을 확인할 수 있었다.

• 한국안광학회지
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• 제18권4호
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• pp.399-404
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• 2013

목적: 본 연구에서는 누진렌즈 안경 착용자의 굴절이상 변화를 연구하였다. 방법: 2003년부터 2013년까지 광주광역시 소재의 안경원을 방문한 43~69세의 노안인 사람 중에 안질환이 없고, 누진렌즈 안경을 처방받은 244명을 대상으로 원거리 굴절상태와 연령대에 따른 원용굴절력과 가입도의 굴절이상 변화를 각각 분석하였다. 결과: 굴절이상에 따른 원용굴절력의 변화는 정시안 +0.10 D, 근시안 +0.07 D, 원시안 +0.23 D로 나타났고(p=0.000), 가입도의 변화는 정시안 +0.22 D, 근시안 +0.29 D, 원시안 +0.17 D로 나타났다(p=0.003). 연령대에 따른 굴절력 변화는 43~49세의 경우 원용굴절력 +0.08 D, 가입도 +0.30 D로 나타났고, 50~59세의 경우 원용굴절력, +0.17 D, 가입도 +0.20 D로 나타났으며, 60~69세의 경우는 원용굴절력 +0.15 D, 가입도 +0.14 D로 나타났다(p=0.046, p=0.006). 결론: 누진안경 착용자의 원용굴절력과 가입도의 변화는 모든 굴절상태와 연령대에서 점점 (+)방향으로 증가됨을 나타내었다.