• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
• /
• v.16 no.4
• /
• pp.212-222
• /
• 2011

Estuaries have been used competitively and exploited for the past decades in Korea. To preserve the environment of the estuaries from the integrated perspective, new policies have started to change such exploitative development in 2000s. Due to the poor knowledge-base, however, there has been a lack of support system which enables to execute such policies effectively. The present study was conducted to figure out the limits of the estuarine management research projects in Korea, which is being performed to overcome these limitations. It was studied through Gap Analysis between domestic and foreign advanced practices as well as Analytical Hierarchy Process on expert survey in terms of the three aspects: how well the estuarine management research projects in Korea meets the demands of policy making and administration; raises the awareness of citizens about the merit of environmental preservation; and establishes knowledge-based support system. This project turned out to reflect adequately the development of programs for building estuarine management systems. But consideration of other ministries was relatively scarce. But the contents which directly support community-based activities and educational programs to improve citizens' awareness were judged to be insufficient. According to the results of Gap Analysis, research about the structure and function of estuarine ecosystems, which can support to develop policy alternatives in detail, was relatively more necessary. Therefore, to support estuarine policy management effectively, the development of a realistic plan, which can overcome fundamental issues inherent in the Korean environmental management system and the limitation of the estuarine management research projects in Korea itself, is needed.

• Biomolecules & Therapeutics
• /
• v.18 no.1
• /
• pp.32-38
• /
• 2010

Activation of JNK has long been associated with the apoptotic response induced by various anti-cancer drugs including doxorubicin, vinblastine, and etoposide. In this study, we examined and compared patterns of apoptosis and JNK activation according to three different anti-cancer drugs (daunorubicin, vinblastine, and etoposide) and two different sources of HL60 cells (Jackson Laboratory and ATCC). HL60 cells from Jackson Laboratory (HL60/RPMI) were maintained in RPMI 1640 containing 5% fetal bovine serum and those from ATCC (HL60/IMDM) in IMDM containing 20% fetal bovine serum as to each manufacture's guideline. In general, HL60/RPMI cells were more sensitive to anti-cancer drugs compared to HL60/IMDM cells, demonstrated by the XTT and flow cytometric analyses. Apoptotic pathways after treatment with anti-cancer drugs seemed to be different between HL60/RPMI (daunorubicin and etoposide, caspase 3 dependent, but caspase 8 or 9 independent; vinblastine, caspase 3 independent) and HL60/IMDM (caspase 3 and caspase 9 dependent). The expression of apoptotic protein, BID, was consistent with caspase 3 activation. Immunoblotting of phospho-JNK and JNK kinase assay showed JNK activation by all three anti-cancer drugs in HL60/RPMI, while JNK activation was observed only in vinblastine-treated cells in HL60/IMDM. Our study results suggest that in vitro environmental conditions have a significant influence on JNK mediated apoptosis of HL60 cells by anti-cancer drugs and in vitro culture conditions are important factors in JNK or possibly other MAPK related studies.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.42 no.9 s.339
• /
• pp.1-8
• /
• 2005

A $0.35\mu$m SiGe BiCMOS fabrication process has been timely developed, which is aiming at wireless RF ICs development and fast growing SiGe RF market. With non-selective SiGe epilayer, SiGe HBTs in this process used trapezoidal Ge base profile for the enhanced AC performance via Ge induced bandgap niuoin. The characteristics of hFE 100, $f_{T}\;45GHz,\;F_{max}\;50GHz,\;NF_{min}\;0.8dB$ have been obtained by optimizing not only SiGe base profile but also RTA condition after emitter polysilicon deposition, which enables the SiGe technology competition against the worldwide cutting edge SiGe BiCMOS technology. In addition, the process incorporates the CMOS logic, which is fully compatible with $0.35\mu$m pure logic technology. High Q passive elements are also provided for high precision analog circuit designs, and their quality factors of W(1pF) and inductor(2nH) are 80, 12.5, respectively.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.29 no.4
• /
• pp.592-599
• /
• 2002

Objective : The purpose of this study was to evaluate the effects of several light curing methods and several adhesives on the microleakage of composite resin restorations in primary teeth. Materials and methods : In 150 extracted human primary anterior teeth, O-shaped cavities were prepared in the labial surface ; the cavity diameter and depth were 1.6mm. The cavities were filled with light-activated composite resin, Compoglass. Four kinds of adhesives were used. Each filling materials were polymerized with three light cure methods. The restorations were polished using Sof-Lex discs(3M Co., USA). The samples were thermocycled 1,000 times between $5^{\circ}C$ and $55^{\circ}C$ with a 1-minute dwell time. Then, they were immersed in a 2% methylene blue solution(pH 7) for 12hours. Subsequently they were sectioned labio-lingually through the center of the restoration with a diamond saw at low speed with a water coolant, and evaluated by stereomicroscopy. Microleakage analyses were done, using scores from 0 to 4. Results : Results showed the least microleakage in Compoglass group(P<0.05). There were less microleakage in SBMP group among the adhesive groups, but no significant difference was observed(P>0.05). And there were no significant differences among the groups depending on curing methods(P>0.05).

• Journal of the korean academy of Pediatric Dentistry
• /
• v.27 no.2
• /
• pp.202-207
• /
• 2000

The purpose of study was to compare the caries experience between the mentally retarded(MR) and the normal(N) children and adolescents and to survey the dental visit frequency. preventive dental care, and tooth-brushing behavior of the mentally retarded. Two hundred and fifty MR and two hundred and ten N subjects were selected for the study. 1. The number of teeth which had experienced caries was 3.28 in MR and 4.66 in N. The number of decayed teeth was 2.24 in MR and 1.50 in N. The number of filled teeth was 0.71 in MR and 3.06 in N Filled teeth rate was 19.78% in MR and 58.89% in N The differences between MR and N were all significant(P<0.01). 2. Dental visit frequency of MR was 1.15 per year, and the 51.2% of MR did not visit the dental clinic for the last one year. 38.0% of MR had received the preventive dental care. 3. Toothbrushing frequency per day was 2.16 and the toothbrushing time for 78.3% of MR was less than two minutes. 51.2% of MR brushed their teeth by themselves, 13.3% did with the help of the carers, and 35.5% totally depended on the carers. In conclusion, MR experienced less dental caries than N, had more untreated caries than N, and had need for regular preventive dental care.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.30 no.2
• /
• pp.210-216
• /
• 2003

The double teeth include gemination and fusion. The congenital missing tooth is the absence of the tooth. The purpose of this study was to investigate the prevalence of double teeth and congenital missing teeth in preschool children of Iksan city. The study population consisted of 1,031 children, 569 boys and 462 girls, aged from 17 to 84 months. The double teeth possess a variety of diagnostic and treatment problems. Gemination is the partial splitting of a single bud into two distinct entities that remain joined in a Siamese twin fashion. Fusion is the joining of two buds. Both may be normal, or one may be a supernumerary tooth. Congenital missing is the absence of one or a few teeth. Twenty three(11 boys and 12 girls) of the 1,031 children had double teeth and 17(8 boys and 9 girls) exhibited congenital missing of teeth. The prevalence of double primary teeth was 2.2%. The prevalence of congenital missing teeth was 1.6%. One subject had double teeth and congenital missing tooth at the same time. Of the 17 cases of congenital missing teeth, one girl showed it in the maxilla and aye boys and six girls had them in the unilateral side of the mandible. There were no significant differences in the prevalence of double teeth and congenital missing teeth between the boys and the girls.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.43 no.2
• /
• pp.231-237
• /
• 2014

This research showed that delphinidin, an anthocyanin present in blueberry, induced apoptosis in MDA-MB-231 breast cancer cells as well as mediated anti-cancer effects in vivo. As a result, growth of cancer cells as assessed by MTT assay decreased in a concentration-dependent manner. Chromatin condensation by DAPI staining significantly increased in a concentration-dependent manner, indicating apoptosis. The level of p53-protein increased while those of anti-apoptotic molecules (Bcl-2, p-$GSK3{\beta}$) decreased in the western blot. Tumor size decreased in cells treated with 10 mg/kg of delphinidin compared with the control group in vivo. Cell apoptosis assessed by TUNEL assay significantly increased, and tumor inhibitory effect was confirmed. Therefore, delphinidin can be developed for cancer preventive medicine due to its growth inhibitory effects and induction of apoptosis in human breast cancer cells.

• KSBB Journal
• /
• v.27 no.5
• /
• pp.308-312
• /
• 2012

Argon-plasma jet (Ar-PJ) is generated by ionizing Ar gas, and the resulting Ar-PJ consists of a mixture of neutral particles, positive ions, negative electrons, and various reactive species. Although Ar-PJ has been used in various biomedical applications, little is known about the biological effects on cells located near the plasma-exposed region. Here, we investigated the effects of the Ar-PJ on actin cytoskeleton of mouse embryonic fibroblasts (MEFs) in response to indirect as well as direct exposure to Ar-PJ. This Ar-PJ was generated at 500 mL/min of flow rate and 100 V electric power by our device mainly consisting of electrodes, dielectrics, and a high-voltage power supply. Because actin cytoskeleton is the key cellular machinery involved in cellular movement and is implicated in regulation of cancer metastasis and thus resulting in a highly desirable cancer therapeutic target, we examined the actin filament architectures in Ar-PJ-treated MEFs by staining with an actin-specific phalloidin labeled with fluorescent dye. Interestingly, the Ar-PJ treatment causes destabilization of actin filament architectures in the regions indirectly exposed to Ar-PJ, but no differences in MEFs treated with Ar gas alone and in untreated cell control, indicating that this phenomenon is a specific cellular response against Ar-PJ in the live cells, which are indirectly exposed to Ar-PJ. Collectively, our study raises the possibility that Ar-PJ may have potential as anti-cancer drug effect through direct destabilization of the actin cytoskeleton.

• Journal of Conservation Science
• /
• v.27 no.4
• /
• pp.345-356
• /
• 2011

To remove metal stains of the ceramics, chemical cleaning is essential case by case. This study investigated the removal characteristics of iron stains by oxalic acid and citric acid including their application methods of soaking and poultice. The soaking method in cleaning agents showed removal process by color difference and released iron contents from iron stains on ceramics. Iron stains were removed successfully from ceramics, which soaked in oxalic acid for 60 hours. However, it is recommendable to soak in 0.25M oxalic acid for one to three hours because most iron stains were disappeared in 3 hours soaking. Citric acid is less effective than oxalic acid in removing iron stains because of heavy molecular weight and low acidity. Poultices (bentonite, sepiolite, activated carbon fiber and celite) with oxalic acid were applied on contaminated ceramics. After ten hours, iron stains on ceramics were removed successfully by poultice. Among them, bentonite and sepiolite have better application. Therefore, sepiolite with 0.25M oxalic acid was applied on the iron stains of whiteware and celadon from Ma Island, and then stains were removed. However, it is judged that the application methods can be varied according to the form and depth of contaminant. In addition, the residues of poultice on the ceramics will be considered for preventing contamination.

• Korean Journal of Pharmacognosy
• /
• v.46 no.1
• /
• pp.78-83
• /
• 2015

This study was conducted to verify the potential of Allium hookeri to control glucose metabolism in a diabetes model. We fed the experimental diets (AL, AR, Dex) supplemented with the powder of leaf, root, or dextrin as a positive control, respectively at 3% of diet to the diabetic mice (C57BLKS/J, db/db) for 8 weeks. Control mice were fed with the diet supplemented with cornstarch (Cont) at 3% level of diet. At 8th week of feeding the diets, we measured body weight, blood glucose, HbA1c, and plasma insulin levels and conducted an oral glucose tolerance test (OGTT) and staining insulin immunoreactive cells in islets of pancreas. AL group treated with the leaf of A. hookeri showed significantly lower blood glucose and HbA1c levels, higher plasma insulin levels, and increased density of insulin immunoreactive cells compared with the Cont group. During the OGTT, AL group showed lower blood glucose levels than the Cont group for 120 min. Based on these results, leaf of A. hookeri is considered to be effective in improving glucose tolerance by partially affecting insulin secretion and it may be used to prevent and treat diabetic disease.