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Effects of Allium Hookeri on Glucose Metabolism in Type II Diabetic Mice  

Kim, Nam-Seok (Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration)
Choi, Bong-Kyoum (Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration)
Lee, Seon-Hye (Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration)
Jang, Hwan-Hee (Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration)
Kim, Jung-Bong (Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration)
Kim, Haeng-Ran (Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration)
Kim, Dae Keun (College of Pharmacy, Woosuk University)
Kim, You-Suk (Sunchang County Agricultural Research Center)
Yang, Jae-Heon (Center For Healthcare Technology Development, Chonbuk National University)
Kim, Hyun-Ju (Research Department, World Institute of Kimchi)
Lee, Sung-Hyen (Functional Food & Nutrition Division, Department of Agrofood Resources, Rural Development Administration)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.1, 2015 , pp. 78-83 More about this Journal
Abstract
This study was conducted to verify the potential of Allium hookeri to control glucose metabolism in a diabetes model. We fed the experimental diets (AL, AR, Dex) supplemented with the powder of leaf, root, or dextrin as a positive control, respectively at 3% of diet to the diabetic mice (C57BLKS/J, db/db) for 8 weeks. Control mice were fed with the diet supplemented with cornstarch (Cont) at 3% level of diet. At 8th week of feeding the diets, we measured body weight, blood glucose, HbA1c, and plasma insulin levels and conducted an oral glucose tolerance test (OGTT) and staining insulin immunoreactive cells in islets of pancreas. AL group treated with the leaf of A. hookeri showed significantly lower blood glucose and HbA1c levels, higher plasma insulin levels, and increased density of insulin immunoreactive cells compared with the Cont group. During the OGTT, AL group showed lower blood glucose levels than the Cont group for 120 min. Based on these results, leaf of A. hookeri is considered to be effective in improving glucose tolerance by partially affecting insulin secretion and it may be used to prevent and treat diabetic disease.
Keywords
Allium Hookeri; Diabetic mice; Glucose; HbA1c; Insulin;
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