• BMB Reports
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• 제51권2호
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• pp.73-78
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• 2018

Vascular endothelial growth factor and its receptor (VEGF-VEGFR) system play a critical role in the regulation of angiogenesis and lymphangiogenesis in vertebrates. Each of the VEGF has specific receptors, which it activates by binding to the extracellular domain of the receptors, and, thus, regulates the angiogenic balance in the early embryonic and adult stages. However, de-regulation of the VEGF-VEGFR implicates directly in various diseases, particularly cancer. Moreover, tumor growth needs a dedicated blood supply to provide oxygen and other essential nutrients. Tumor metastasis requires blood vessels to carry tumors to distant sites, where they can implant and begin the growth of secondary tumors. Thus, investigation of signaling systems related to the human disease, such as VEGF-VEGFR, will facilitate the development of treatments for such illnesses.

• 한국건강관리협회지
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• 제3권1호
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• pp.97-109
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• 2005

Chronic fatigue syndrome(CFS) is a complex, debilitating disorder characterized by at least 6 months of severe persistent of relapsing fatigue and a group of characteristic but nonspecific symptoms. Many researchers have proposed that CFS has a specific cause. However currently no evidence exists that proves either a specific cause of CFS. And there is no diagnostic test for CFS. The diagnosis of chronic fatigue syndrome is based on the patient's history, excluding other illnesses In the absence of consistent biological markers, the diagnosis of CFS arises from operational criteria that do not afford validity. The prognosis is poor and often disability and impairment of daily function and performance are prolonged. A limited understanding of the CFS has complicated the management of this disorder. Therefore, treatment of CFS may be variable and should be tailored to each patient. Therapy should include exercise, diet, good sleep hygiene, antidepressants, and other medications, depending on the patient's presentation. Regular follow-up is key to continue to exclude other medical problems and provide support for patients. Chronic fatigue syndrome is a challenging illness to manage and requires a team approach of caring providers. For the majority of patients this is a chronic illness with the goals of therapy being to improve functional status and to prevent disability. Further understanding of the etiology and pathogenesis of this illness should lead to better specific therapy.

• 보건교육건강증진학회지
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• 제19권3호
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• pp.35-49
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• 2002

The purpose of this study is to provide an effective program contents of information supplied by broadcasting media with the aim of developing health program models. Health programs which have been aired and are being aired on KBS I radio, KBS, EBS, Cable TV and SBS radio were analyzed in order to understand the issues of current health programs and to design a plan for improvement. In order to address current issues of health programs, the range of health information should be extended to meet various expectations from the public audience, in addition to dealing with diagnosis and treatment of illnesses. Programs should be capable of encompassing various issues such as health practice, prevention, information on medical facilities, public health policies, daily health information, and the role of patients. As health programs function as major information sources for health services, it is necessary to raise the quality and credibility of broadcasting. Broadcasting agencies has a responsible role for public health promotion through health programs. In order to make it possible for broadcasting to fulfill its social responsibility, it is advisable to develop programs that have a clear understanding of what is the cognition of the public and the level of demand in regard to health programs.

• 대한한방소아과학회지
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• 제35권1호
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• pp.104-121
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• 2021

Objectives The purpose of this study is to evaluate the efficacy and safety of herbal medication for the treatment of functional abdominal pain in children by analyzing randomized controlled trials conducted in China. Methods Literatures from China National Knowledge Infrastructure published up to 23 November, 2020 were searched. Then they were collected and analyzed by their publication year, demographic information, treatment methods used, duration of illnesses, duration of treatments, follow-up periods, outcome measurement and adverse events. Results A total of 27 studies were selected for the analysis. In all studies, the total efficacy of the herbal medicine treatment group was reported to be higher than that of the control group. The most frequently used medical herb was Root of Glycyrrhiza uralensis Fischer (甘草). The most frequently used classes of herbal medications are Qi regulating medicine (理氣藥), Qi tonics (補氣藥), Aromatic wet medicine (芳香化濕藥), and Digestant (消食藥). The adverse events rate for the herbal medicine treatment group were significantly lower than those in the Western medicine treatment group. Conclusions This study showed that herbal medicine treatment can be effective and safe option for treating pediatric functional abdominal pain. However, additional well-designed clinical studies are needed to solidify the findings.

• Journal of Hospice and Palliative Care
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• 제26권1호
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• pp.22-25
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• 2023

Although most patients prefer dying at home, patients whose condition rapidly becomes critical need care in the intensive care unit (ICU), and it is rare for them to die at home with their families. Therefore, interest in hospice and palliative care for patients in the ICU is increasing. Hospice and palliative care (PC) is necessary for all patients with life-threatening diseases. The following patients need palliative care in the ICU: patients with chronic critical illnesses who need tracheostomy, percutaneous gastrostomy tube, and extracorporeal life support; patients aged 80 years or older; stage 4 cancer patients; patients with specific acute diseases with a poor prognosis (e.g., anoxic brain injury and intracerebral hemorrhage requiring mechanical ventilation); and patients for whom the attending physician expects a poor prognosis. There are two PC models-a consultative model and an integrative model-in the ICU setting. Since these two models have advantages and disadvantages, it is necessary to apply the model that best fits each hospital's circumstances. Furthermore, interdisciplinary decision-making between the ICU care team and PC specialists should be strengthened to increase the provision of hospice and palliative care services for patients expected to have poor outcomes and their families.

• 보건의료생명과학 논문지
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• 제11권1호
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• pp.135-140
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• 2023

고령화 시대로 인하여 시니어인구의 비중이 급격히 증가하고 있다. 자연적으로 시니어의 정신적 건강관리가 중요하게 되었으며 행복한 여생을 누릴 수 있는 프로그램 지원이 절실한 상황이다. 제안 논문에서는 우울증 및 치매를 앓고 있는 시니어의 다양한 정신 질환에 대하여 정신건강 예방차원에서 시니어의 자서전적 회상 능력을 향상시키기 위한 방안을 제시한다. 시니어 정신건강 상담 지원을 위한 정신적 디지털 헬스케어 프로그램 설계를 통하여 과거의 데이터를 회상할 수 있는 상담 내용을 중심으로 점차 치유되어질 수 있도록 프로그램을 설계한다.

• Korean Circulation Journal
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• 제52권9호
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• pp.659-679
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• 2022

Efforts to improve end-of-life (EOL) care have generally been focused on cancer patients, but high-quality EOL care is also important for patients with other serious medical illnesses including heart failure (HF). Recent HF guidelines offer more clinical considerations for palliative care including EOL care than ever before. Because HF patients can experience rapid, unexpected clinical deterioration or sudden death throughout the disease trajectory, choosing an appropriate time to discuss issues such as advance directives or hospice can be challenging in real clinical situations. Therefore, EOL issues should be discussed early. Conversations are important for understanding patient and family expectations and developing mutually agreed goals of care. In particular, high-quality communication with patient and family through a multidisciplinary team is necessary to define patient-centered goals of care and establish treatment based on goals. Control of symptoms such as dyspnea, pain, anxiety/depression, fatigue, nausea, anorexia, and altered mental status throughout the dying process is an important issue that is often overlooked. When quality-of-life outweighs expanding quantity-of-life, the transition to EOL care should be considered. Advanced care planning including resuscitation (i.e., do-not resuscitate order), device deactivation, site for last days and bereavement support for the family should focus on ensuring a good death and be reviewed regularly. It is essential to ensure that treatment for all HF patients incorporates discussions about the overall goals of care and individual patient preferences at both the EOL and sudden changes in health status. In this review, we focus on EOL care for end-stage HF patients.

• 대한예방한의학회지
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• 제19권3호
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• pp.29-43
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• 2015

Objective : The purpose of this study was to identify characteristics of patients' self-perceived health in traditional Korean medical facilities. Method : This research was conducted based on the survey on patients whom have visited traditional Korean medical facilities in 2011 by the Ministry of Health and Welfares and Korean Institute for Health and Social Affairs. Using a sample of 3,931 (1,180 male and 2,751 female) outpatients' self-perceived health based on the data from usage and consumption of Korean Medicine. 'Healthy', 'Fair', and 'Poor Health' were used to measure patients' self-perceived health status. The data was analyzed by frequency, t-test, cross correlation analysis and multiple logistics regression analysis using the SPSS program package. Results : Sex(P<0.001), age(P<0.001), marital status(P<0.001), education(P<0.001), employment status(P<0.001), occupation(P<0.001), health insurance(P<0.001) and income level(P<0.0001) showed statistical significance. Main Treatment Facilities(P<0.001), experience of taking Korean medicine(P=0.032), experience of receiving acupuncture treatment(P<0.001), number of visits(P<0.001), medical expense (P=0.005), and subjective health status after the treatments showed statistical significance for Korean herbal medicine(P=0.038), acupuncture (P=0.001), cupping therapy(P=0.006), oriental physiotherapy(P=0.003), and treatment satisfaction(P<0.001). For subjective health status based on suffering disorders in the past three months, the response of poor health was higher in the group suffering recent illnesses. Statistical significance was seen in hypertension (P=0.002), arthritis(P<0.001), lumbar pain(P<0.001), diabetes mellitus(P=0.001), stroke(P<0.001), hwa-byung (P=0.001), gastric disorders(P=0.021), common cold(P<0.001), ankle sprain(P<0.001), muscular injury(P<0.001), lumbar sprain(p=0.009) and fracture(P=0.03). Also the number of diseases during the past three months showed statistical significance(P<0.001). Statistical significance was also seen in Level of knowledge(P<0.001), route of information(P<0.001), reliability of Korean medicine(P=0.003), insurance coverage(P=0.005), medical costs(P<0.001), and future willingness to use Korean medicine(P<0.001). As a result of the multiple logistics regression analysis, risks of subjective poor health statistically increased in female population, elderlies, medicaid beneficiaries, less educated, higher medical expense, and more disorders during the past three months. Conclusion : Patients' self-perceived health status has significant differences with each variables such as sex, age, marital status, education, health insurance, medical expense, number of diseases.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2165-2168
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• 2014

Background: Today, survival rate of patients with chronic renal failure/hemodialysis has increased so that chronic illnesses are more likely to occur. Cancer is the main cause of morbidity and mortality in such patients. Aim: In this study, physician attitudes were examined about cancer screening in patients with renal failure. Materials and Methods: This study was done by face to face questionnaire in the $27^{th}$ National Nephrology Congress to determine if the physicians dealing with chronic renal failure, hemodialysis or renal transplanted patients, recommend cancer screening or not and the methods of screening for cervix, prostate, breast and colon cancer. Results: One hundred and fifty six physicians were included in the survey. A total of 105 (67%) participants were male and the age of responders was $48{\pm}9$ years. About 29% were specialists in nephrology, 28% internal medicine, and 5% were other areas of expertise. Some 48% of participants were hemodialysis certified general practitioners. Patients were grouped as compensated chronic renal failure, hemodialysis or renal transplanted. Of the 156 responders, 128 (82%) physicians recommended breast cancer screening and the most recommended subgroup was hemodialysis patients (15%). The most preferred methods of screening were combinations of mammography, self breast examination and physicianbreast examination. 112 (72%) physicians recommended cervix cancer screening, and the most preferred method of screening was pap-smear. Colon cancer screening was recommended by 102 (65%) physicians and prostate screening by 109 (70%) physicians. The most preferred methods of screening were fecal occult blood test and PSA plus rectal digital test, respectively. Conclusions: It is not obvious whether cancer screening in renal failure patients is different from the rest of society. There is a variety of screening methods. An answer can be found to these questions as a result of studies by a common follow-up protocol and cooperation of nephrologists and oncologists.

• 의료법학
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• 제24권3호
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• pp.105-124
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• 2023

현대 사회는 뜻밖의 사고와 위험 상황으로 불안정한 환경에 직면하고 있다. 예를 들어 분당 다리 붕괴사고와 이태원 압사사고 등이 그 예가 될 것이다. 이와 함께 급성심정지나 뇌졸중과 같은 중대한 응급상황이 발생하였을 때, 신속한 조치와 전문 의료 기관으로의 원활한 이송이 필요한 경우 또한 빈번하게 발생하고 있다. 이러한 위험 요소에 대응하기 위해 국가는 국민의 생명과 안전을 보호하기 위한 다양한 시스템을 구축하고 있는데, 119구급대는 응급 의료 시스템 중 핵심적인 역할을 수행한다. 중대한 외상 환자나 중증 질환 환자의 응급 상황에 즉각적으로 대응하여 손상을 최소화하고, 응급의료 기관으로 신속하게 이송하여 전문적인 치료를 제공함으로써 환자의 생명과 안전을 보호하는 것이 그 목표이다. 이와 관련된 핵심 활동이 구급활동인 것이다. 특히, 119구급시스템은 응급 환자의 병원 이송을 책임지는 핵심 기관이나, 구급대원들은 업무수행 중 구급활동 방해 사례에 여전히 직면하고 있다. 이러한 방해 사례는 경찰의 협조 노력에도 불구하고 줄어들지 않고 있고, 구급활동은 공무집행 방해죄와 유사한 특성을 지니며, 응급의료 시스템 내에서 근무하는 응급의료 종사자에 대한 폭행 및 장비 파손과 같은 사례와도 유사한 형태를 보인다. 따라서 119구급시스템을 포함한 응급 의료 활동을 수행하는 과정에서 발생하는 방해 문제에 대한 심층적인 이해와 개선 노력이 필요하다. 이러한 문제에 대한 해결책은 "소방기본법"과 "119구조·구급에 관한 법률"을 중심으로 구급활동 방해죄의 조건을 정립하고 개선하는 것이다.