• Journal of Chest Surgery
• /
• v.17 no.1
• /
• pp.101-109
• /
• 1984

The influences of acute respiratory and metabolic acid-base disturbances on the carotid, renal and coronary blood flow were measured in dogs. Respiratory acidosis was induced by artificial respiration with 8% CO2 -02 gas mixture and respiratory alkalosis was induced by hyperventilation under the control of respirator. Metabolic acidosis and metabolic alkalosis were induced by intravenous infusion of 0.3N hydrochloric acid and 0.6M sodium bicarbonate solution. To observe the effect of hyperkalemia, isotonic potassium chloride solution was infused. CVI electromagnetic flowmeter probes were placed on the left common carotid artery, left renal artery and left circumflex coronary artery. Each flow was recorded on polygraph. 1. The carotid blood flow showed rapid showed rapid and marked increase in acute respiratory acidosis. Even in the cases when arterial blood pressure was lowered during the state of respiratory acidosis, carotid blood flow increased. By the infusion of hydrochloric acid, carotid blood flow increased slowly and returned to the previous label after discontinuation of the infusion. Carotid blood flow also increased by the infusion of large amount of sodium bicarbonate, but it might be the combined effect of expansion of extracellular fluid and compensatory elevation of carbon dioxide tension. 2.The renal blood flow remained unchanged during the acute acid-base disturbances, suggesting effective autoregulation. Renal blood flow, however, increased very slowly when the infusion of potassium chloride continued for a long period. 3.Although less marked than the carotid blood flow, the coronary blood flow increased in the acute respiratory and metabolic acidosis. In asphyxiated condition, coronary blood flow increased most markedly and this might be the combined effect of hypoxia, hypercapnea, and lowering of pH. In summary, the carotid blowflow showed more marked change in the acute respiratory and metabolic acidosis than the renal and coronary blood flow. Respiratory and metabolic components of acid-base disturbances may influence the local blood flow concomitantly, there being more differences in the individual responses, but respiratory component manifested more rapid and marked effect than metabolic component.

• Journal of Pharmaceutical Investigation
• /
• v.24 no.1
• /
• pp.41-48
• /
• 1994

A new local drug delivery device to treat otitis media (OM) has been developed. This device consists of a biodegradable poly(L-lactic acid) (PLLA) film containing antibiotic (ampicillin, AMP), which can be placed into the middle ear cavity and release the therapeutic concentration of AMP for prolonged period. Biodegradable films containing AMP (10 w/w%) were prepared by solution casting method using a suspension of the drug in a $PLLA/CH_{2}Cl_{2}$ solution (molecular weight of PLLA, 100,000 (100 K) and 300,000 (300 K), respectively). PLLA-AMP films were characterized by FTIR, DSC, and SEM. In vitro release of AMP from AMP-PLLA films were examined. The release pattern of AMP from AMP-PLLA films remained consistent from 1 day to 14 days, and the release rates of AMP from AMP-100K-PLLA film and AMP-300K-PLLA film were $0.7384\;{\mu}g/ml/day$, $0.4107\;{\mu}g/ml/day$, respectively.

• The Transactions of the Korean Institute of Electrical Engineers A
• /
• v.54 no.8
• /
• pp.375-387
• /
• 2005

This paper presents an application of parallel Genetic Algorithm-Tabu Search (GA-TS) algorithm to search an optimal solution of a service restoration in distribution systems. The main objective of service restoration of distribution systems is, when a fault or overload occurs, to restore as much load as possible by transferring the do-energized load in the out of service area via network reconfiguration to the appropriate adjacent feeders at minimum operational cost without violating operating constraints, which is a combinatorial optimization problem. This problem has many constraints with many local minima to solve the optimal switch position. This paper develops parallel GA-TS algorithm for service restoration of distribution systems. In parallel GA-TS, GA operators are executed for each processor. To prevent solutions of low fitness from appearing in the next generation, strings below the average fitness are saved in the tabu list. If best fitness of the GA is not changed for several generations, TS operators are executed for the upper $10\%$ of the population to enhance the local searching capabilities. With migration operation, best string of each node is transferred to the neighboring node after predetermined iterations are executed. For parallel computing, we developed a PC cluster system consists of 8 PCs. Each PC employs the 2 GHz Pentium IV CPU and is connected with others through ethernet switch based fast ethernet. To show the validity of the proposed method, proposed algorithm has been tested with a practical distribution system in Korea. From the simulation results, we can find that the proposed algorithm is efficient for the distribution system service restoration in terms of the solution quality, speedup, efficiency and computation time.

• The KIPS Transactions:PartC
• /
• v.8C no.5
• /
• pp.637-646
• /
• 2001

The multicasting telecommunication is an important research as an applicable technique in the development of adaptable technique for modern mobile computing and mobile IP, because that is supposed to be a solution for transferring the large-size information on the mobile and wireless network with the narrow bandwidth. This paper will suggest one solution for the bidirectional tunneling and the local re-registration problems to support transferring mobile multicasting datagram by the partitioned network. The bidirectional tunneling technique is in use for mobile host moving around in a region and the local re-registration technique for crossing regions to reduce traffic load caused by transferring datagram along a long distance, and we compare those models with our suggested model by simulation.

• The Transactions of the Korea Information Processing Society
• /
• v.6 no.4
• /
• pp.959-968
• /
• 1999

several papers have reported that parallel heuristics or hybrid approaches combining several heuristics can get better results. However, the parallelization and hybridization of any search methods on the single CPU type computer need enormous computation time. that case, we need more elegant combination method. For this purpose, we propose Fast Model of Parallel Heuristics(FMPH). FMPH is based on the island model of parallel genetic algorithms and takes local search to the elite solution obtained form each island(sub group). In this paper we introduce how can we adapt FMPH to the job-shop scheduling problem notorious as the most difficult NP-hard problem and report the excellent results of several famous benchmark problems.

• Journal of the Institute of Electronics Engineers of Korea CI
• /
• v.41 no.4
• /
• pp.67-72
• /
• 2004

This paper proposes a method improving the convergence speed of optimal solution for parallel genetic algorithm in the network based client-server model. Unlike the existing methods of obtaining global elite only by evaluating local elites in server, the proposed method obtains it by evaluating local elites and improving its fitness by applying genetic algorithm during idle time of the server. By using the improved chromosome in server for the client's genetic algorithm processing, the convergence speed of the optimal solution is increased. The improvement of fitness at the server during the interval of chromosome migration is (equation omitted)(F$_{max}$(g)-F$_{max}$(g-1)), whole F$_{max}$(g) is a max fitness of the g-th generation and G is the number of improved generation by the server. As the number of clients increases and G decreases, the improvement of fitness goes down. However the improvement of fitness is better than existing methods..

• Journal of the Korean Mathematical Society
• /
• v.54 no.5
• /
• pp.1483-1504
• /
• 2017

We consider weak solutions of the instationary Navier-Stokes system in a smooth bounded domain ${\Omega}{\subset}{\mathbb{R}}^3$ with initial value $u_0{\in}L^2_{\sigma}({\Omega})$. It is known that a weak solution is a local strong solution in the sense of Serrin if $u_0$ satisfies the optimal initial value condition $u_0{\in}B^{-1+3/q}_{q,s_q}$ with Serrin exponents $s_q$ > 2, q > 3 such that ${\frac{2}{s_q}}+{\frac{3}{q}}=1$. This result has recently been generalized by the authors to weighted Serrin conditions such that u is contained in the weighted Serrin class ${{\int}_0^T}({\tau}^{\alpha}{\parallel}u({\tau}){\parallel}_q)^s$ $d{\tau}$ < ${\infty}$ with ${\frac{2}{s}}+{\frac{3}{q}}=1-2{\alpha}$, 0 < ${\alpha}$ < ${\frac{1}{2}}$. This regularity is guaranteed if and only if $u_0$ is contained in the Besov space $B^{-1+3/q}_{q,s}$. In this article we consider the limit case of initial values in the Besov space $B^{-1+3/q}_{q,{\infty}}$ and in its subspace ${{\circ}\atop{B}}^{-1+3/q}_{q,{\infty}}$ based on the continuous interpolation functor. Special emphasis is put on questions of uniqueness within the class of weak solutions.

• Journal of the Korea Society of Computer and Information
• /
• v.25 no.8
• /
• pp.151-157
• /
• 2020

The first thing we can consider to prevent juvenile delinquency is to punish those criminals. However, this is not always the proper solution. In consideration to the feature of juvenile period when they lack in proper judgment it is better to provide education than punishment so that they are not branded as criminals in our society. Also, by returning to the society, they can obtain social techniques and obtain the opportunity of making contribution to the society, which is also good for their career development. Combining international examples on juvenile delinquency prevention, there is a need to comprehensively evaluate level of probation and risk exposure of juvenile based on placement matrix of comprehensive strategy program in the US. Also, control solution by juvenile crime development phase should be made. In terms of control treatment based on crime phase, crime history should be considered when applying control. For the subject of preventing juvenile crime, it shouldn't be legal organizations like before but shall be home, school, local society, and legal organization together.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.40 no.2
• /
• pp.92-98
• /
• 2017

Data clustering determines a group of patterns using similarity measure in a dataset and is one of the most important and difficult technique in data mining. Clustering can be formally considered as a particular kind of NP-hard grouping problem. K-means algorithm which is popular and efficient, is sensitive for initialization and has the possibility to be stuck in local optimum because of hill climbing clustering method. This method is also not computationally feasible in practice, especially for large datasets and large number of clusters. Therefore, we need a robust and efficient clustering algorithm to find the global optimum (not local optimum) especially when much data is collected from many IoT (Internet of Things) devices in these days. The objective of this paper is to propose new Hybrid Simulated Annealing (HSA) which is combined simulated annealing with K-means for non-hierarchical clustering of big data. Simulated annealing (SA) is useful for diversified search in large search space and K-means is useful for converged search in predetermined search space. Our proposed method can balance the intensification and diversification to find the global optimal solution in big data clustering. The performance of HSA is validated using Iris, Wine, Glass, and Vowel UCI machine learning repository datasets comparing to previous studies by experiment and analysis. Our proposed KSAK (K-means+SA+K-means) and SAK (SA+K-means) are better than KSA(K-means+SA), SA, and K-means in our simulations. Our method has significantly improved accuracy and efficiency to find the global optimal data clustering solution for complex, real time, and costly data mining process.

• Bulletin of the Society of Naval Architects of Korea
• /
• v.27 no.1
• /
• pp.24-34
• /
• 1990

In this paper, the formulation of a new simplified finite element is made to analyze the ultimate strength of damaged tubular members subjected to combined axial force and end moment. A damaged tubular member that has the bending deformation and the local dent is modeled by beam elements. Tangent elastic stiffness matrix of a beam element which contains the effect of the geometric nonlinearity is derived by using the updated Lagrangian approach. Here the contribution of the stiffness in the dented area is neglected since its resistance against the external loads is considered to be small. A fully plastic interaction curve of the element under combined loads taking account of the local dent effect is selected as a yielding criterion at each nodal point. Also tangent elasto-plastic stiffness matrix of the element is formulated by plastic node method. Comparison with the present solution and the existing experimental results is made showing that the present method gives quite an accurate solution.