• Journal of the Korea Convergence Society
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• v.8 no.4
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• pp.19-24
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• 2017

The growing number of electronic financial transactions (e-banking) has entailed the rapid increase in security threats such as extortion and falsification of financial transaction data. Against such background, rigid security and countermeasures to hedge against such problems have risen as urgent tasks. Thus, this study aims to implement an improved case model by applying the Fraud Detection System (hereinafter, FDS) in a financial corporation 'A' using big data technique (e.g. the function to collect/store various types of typical/atypical financial transaction event data in real time regarding the external intrusion, outflow of internal data, and fraud financial transactions). As a result, There was reduction effect in terms of previous scenario detection target by minimizing false alarm via advanced scenario analysis. And further suggest the future direction of the enhanced FDS.

• KIEAE Journal
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• v.10 no.5
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• pp.165-170
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• 2010

Super high-rise mixed use buildings require a longer period for construction. Especially finishing work takes up about 40% of the whole construction period. Thus, finishing work is becoming an important factor in determining the construction period along with earth work and frame work. As the expected returns added by the reduction of the period and cost in constructing super high-rise mixed use buildings are huge, the expectations are now increasing for the possible gains. In this respect, as the period of finishing work is easier to be shortened than that of frame work, the efforts to acquire the technical knowledge to reduce the finishing work period are now being required. Accordingly, in this study, we aimed at suggesting the basic data for designing an economic plan for finishing-work procedure by analyzing the productivity of each work type of finishing work procedure on the basis of the execution and results of a construction method as a time-flexible finishing work plan. For this, we categorized the work types of finishing work procedure into each work unit and provided a work-system for each of them. Also, with case studies, we calculated the detailed amounts of the work-loads, required materials, productivity, and productivity index of the main work types of finishing work procedure and each of their separate work units as well as analyzed the relationship between the value results to suggest a better way to improve its productivity.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.6
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• pp.1678-1689
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• 2008

Recently, OOM(Object-Oriented Method) access method which begins to apply to software development is emphasizing development cost and time reduction through independent software reuse. But because of planning to the exclusion of the lack of knowledge and expansion or performance for development technology many problems are coming out. Therefore, this thesis suggests Effective Object-Oriented Modeling methods considering the plan for higher productivity enhancement of software in the software development life cycle. Effective Object-Oriented Modeling method includes, methods, Use Case modeling methods, Analysis Modeling methods, Design Modeling methods and others. This thesis suggests Framework model method read in characteristics as follows. First, suggestion about effective object-oriented standard model development, Second, retrenchment of software development or maintenance cost, Third, solution about uncertain problems of projects in line with the application of new technology.

• Journal of radiological science and technology
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• v.28 no.1
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• pp.19-24
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• 2005

The purpose of this study was to design and implement a useful annotation-based Radiological image retrieval system to accurately determine on education and image information for Radiological technologists. For better retrieval performance based on large image databases, we presented an indexing technique that integrated $B^+-tree$ proposed by Bayer for indexing simple attributes and inverted file structure for text medical keywords acquired from additional description information about Radiological images. In our results, we implemented proposed retrieval system with Delphi under Windows XP environment. End users, Radiological technologists, are able to store simple attributes information such as doctor name, operator name, body parts, disease and so on, additional text-based description information, and Radiological image itself as well as to retrieve wanted results by using simple attributes and text keywords from large image databases by graphic user interface. Consequently proposed system can be used for effective clinical decision on Radiological image, reduction of education time by organizing the knowledge, and well organized education in the clinical fields. In addition, It can be expected to develop as decision support system by constructing web-based integrated imaging system included general image and special contrast image for the future.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.2
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• pp.207-212
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• 2011

A hydraulic breaker is an attachment installed at the end of excavator arm and is used for breaking. As per the authors' knowledge, there have been no research results on reducing the weight of the hydraulic breaker even though this weight reduction is very important for improving the performance of the excavator. In this study, we minimize the weight of the housing of the hydraulic breaker under normal operating conditions, while the maximum stress of the housing is lower than the allowable stress. A meta-model, which is generated by using the CAE results for the sampling design points determined by an orthogonal array, is used to solve the minimization problem. The weight of the housing according to the optimal design is found to be lower than the original weight by 4.8% while satisfying the constraint on the maximum stress.

• Biomolecules & Therapeutics
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• v.20 no.4
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• pp.357-370
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• 2012

Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major significance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large field or whole brain radiation every year in the United States. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional deficits in brain several months to years after treatment. In particular, whole brain radiation therapy results in a significant reduction in learning and memory in brain tumor patients as long-term consequences of treatment. Although a number of in vitro and in vivo studies have demonstrated the pathogenesis of radiation-mediated brain injury, the cellular and molecular mechanisms by which radiation induces damage to normal tissue in brain remain largely unknown. Therefore, this review focuses on the pathophysiological mechanisms of whole brain radiation-induced cognitive impairment and the identification of novel therapeutic targets. Specifically, we review the current knowledge about the effects of whole brain radiation on pro-oxidative and pro-inflammatory pathways, matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) system and extracellular matrix (ECM), and physiological angiogenesis in brain. These studies may provide a foundation for defining a new cellular and molecular basis related to the etiology of cognitive impairment that occurs among patients in response to whole brain radiation therapy. It may also lead to new opportunities for therapeutic interventions for brain tumor patients who are undergoing whole brain radiation therapy.

• 모자간호학회지
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• v.1
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• pp.16-22
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• 1991

Various minor discomforts are reported to be complained by the pregnant women. but what were and how much were they complained has not been revealed until recently. So, These lack of knowledge have given nurses difficulties in planning of care to promote the health during the pregnancy. Objectives of this study were to identify the rate of complaints in each minor discomforts and to explore the influencing factor on reduction of complaints of minor discomforts. The subjects were 120 mothers, who delivered their babies in hospital, from September to December 1990 and the reason why the postpartum mothers were selected as the subjects were minor discomforts could develope during the entire period of pregnancy. Data were gathered by the questionnares and analized statistically using SAS and SPSS program. Results were as follows. 1. More than one third of the subjects complained frequent urination, fatigue, increase of the vaginal discharge, morning sickness, the increased urination at night, pain in leg, backache, edema in leg, constipation, dyspnea, varicose vein, flatulence, headache. 2. Minor discomforts complained to be severe in more than one third of the subjects were frequent urination and increased urination at night. 3. The influencing factor to reduce the complaints of minor discomfort was revealed to be the perceived family support (r=0.030431, t=0.0007). We suggest that nurses should emphasize the importance of the family support to the pregnant women and their family, and to explore the relationships among the locus of control, the perceived family support and the complaints of minor discomforts.

• Journal of Menopausal Medicine
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• v.24 no.3
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• pp.183-187
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• 2018

Objectives: The present mini review aimed to summarize the existing knowledge regarding the beneficial and adverse effects of raloxifene in menopausal women. Methods: This study is a review of relevant publications about the effects of raloxifene on sleep disorder, depression, venous thromboembolism, the plasma concentration of lipoprotein, breast cancer, and cognitive function among menopausal women. Results: Raloxifene showed no significant effect on depression and sleep disorder. Verbal memory improved with administration of 60 mg/day of raloxifene while a mild cognitive impairment risk reduction by 33% was observed with administration of 120 mg/day of raloxifene. Raloxifene was associated with a 50% decrease in the need for prolapse surgery. The result of a meta-analysis showed a significant decline in the plasma concentration of lipoprotein in the raloxifene group compared to placebo (standardized mean difference, -0.43; 10 trials). A network meta-analysis showed that raloxifene significantly decreased the risk of breast cancer (relative risk, 0.572; 95% confidence interval, 0.327-0.881; P = 0.01). In terms of adverse effects of raloxifene, the odds ratio (OR) was observed to be 1.54 (P = 0.006), indicating 54% increase in the risk of deep vein thrombosis (DVT) while the OR for pulmonary embolism (PE) was 1.05, suggesting a 91% increase in the risk of PE alone (P = 0.03). Conclusions: Raloxifene had no significant effect on depression and sleep disorder but decreased the concentration of lipoprotein. Raloxifene administration was associated with an increased risk of DVT and PE and a decreased risk of breast cancer and pelvic organ prolapse in postmenopausal women.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.5
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• pp.644-651
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• 2021

Viral hemorrhagic septicemia virus (VHSV) is a fish pathogen responsible for causing enormous economic loss to the aquaculture industry not only in Korea but worldwide. Thus, it is necessary to identify natural compounds that can be used to control the spread of VHSV. In this study, the anti-VHSV activities of five catechol derivatives, i.e., catechol, pyrogallol, 3-methyl catechol, veratrole, and 3-methyl veratrole-extracted from green tea-were assessed. The antiviral activities of these derivatives were found to be dependent on their structure, i.e., the hydroxyl or methoxyl group and their substituent groups-on the benzene ring. Catechol, pyrogallol, and 3-methyl catechol exhibited relatively high 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities than veratrole, and 3-methyl veratrole. Moreover, 3-methyl catechol harboring a methyl substituent group increased the viability of the virus-infected cells and resulted in a 2.86 log reduction in the gene copies of VHSV N (per mL) in real-time PCR analysis. In conclusion, the catechol derivatives harboring hydroxyl groups in their benzene ring exhibited higher antioxidant activities than those harboring the methoxyl groups. However, catechol derivatives with a methyl group at the 3'-position of the benzene ring exhibited higher antiviral activity than those harboring a hydroxyl group. To our knowledge, this is the first study to evaluate the relationship between the structure and the anti-VHSV activity of catechol derivatives.

• Journal of dental hygiene science
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• v.19 no.2
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• pp.141-146
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• 2019

Background: Oral cancer has a high incidence worldwide and has been closely associated with smoking, alcohol, and infection by the human papillomavirus. Metastasis is highly important for oral cancer survival. Lysophosphatidic acid (LPA) is a bioactive lipid mediator that promotes various cellular processes, including cell survival, proliferation, metastasis, and invasion. Signal transducer and activator of transcription (STATs) are transcription factors that mediate gene expression. Among the seven types of STATs in mammals, STAT3 is involved in invasion and metastasis of numerous tumors. However, little is known about the role of STAT3 in oral tumor invasion. In the present study, we hypothesized that STAT3 mediates LPA-induced oral cancer invasion. Methods: Immunoblotting was performed to analyze LPA-induced STAT3 activation. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was performed to assess the survival rates of YD-10B cells. STAT3 levels in LPA-treated oral tumor cells were evaluated by performing in vitro invasion assay. Results: To the best of our knowledge, this is the first study to demonstrate that LPA enhances STAT3 phosphorylation in oral cancer. In addition, treatment with WP1066, a selective inhibitor of STAT3, at a concentration that does not cause severe reduction in cell viability, significantly attenuated LPA-induced YD-10B cancer cell invasion. Conclusion: The results suggested that LPA induces oral tumor cells with greater invasive potential via STAT3 activation. Our findings provided important insights into the mechanisms underlying mouth neoplasms.