• KIPS Transactions on Computer and Communication Systems
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• v.7 no.12
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• pp.295-300
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• 2018

The rapid development of IT, many conventional passive jobs have been automated. This automation increases the leisure time of many people and various services are being developed for them. In addition, with the advent of smart devices that are compact and portable, it is possible to use various internet services without any time and place discretion. Various studies based on virtualization are under way to efficiently store and process large data generated by many devices and services. Desktop Storage Virtualization (DSV), which integrates and provides users with on-premise-based distributed desktop resources during these studies, uses virtualization to consolidate unused resources within distributed, legacy desktops. This DSV is very important for providing high reliability to users. In addition, research on hierarchical structure and resource integration for efficient data distribution storage processing in a distributed desktop-based resource integration environment is underway. However, there is a lack of research on efficient operation in case of server failure in on-premise resource integration environment. In this paper, we propose Non-disruptive Server Management (NSM) which can actively cope with the failure of desktop server in distributed desktop storage environment based on on-premise. NSM is easy to add and remove desktops in a desktop-based integrated environment. In addition, an alternative server is actively performed in response to a failure occurrence.

• Korean Chemical Engineering Research
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• v.57 no.3
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• pp.305-312
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• 2019

The discovery of nitric oxide (NO) as a major signaling molecule in a number of pathophysiological processes - vasodilation, immune response, platelet aggregation, wound repair, and cancer biology - has led to the development of various exogeneous NO delivery systems. However, the development of ideal delivery system for human body application is still left as a challenge due to its high reactivity and short half-life in physiological condition. In this article, an overview of several nano-structures as potential NO delivery system will be presented, along with their recent research results and biomedical applications. Nano-size delivery system has immense advantages compared to others due to its high surface-to-volume ratio and capability for surface modification; thus, it has been proven to be effective in delivering nitric oxide with enhanced performance. Through this novel nano-structure delivery system, we are expecting to achieve sustained release of nitric oxide within adequate range of concentration, which ensures desired drug effects at the target site. Among different nano-structures, in particular, nanoparticle, microemulsion and nanofilm will be reviewed and compared to each other in respect of nitric oxide release profile. The proposed nano-structures for exogeneous NO delivery have a biological significance in that it can be further utilized in diverse biomedical fields as a highly promising therapeutic method.

• 한국체육학회지인문사회과학편
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• v.58 no.1
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• pp.295-308
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• 2019

The purpose of the present study is to apply a health belief model to the serious perception of an increase in youth obesity, and to develop and validate a measurement tool for youth obesity prevention among this group who are experiencing increasing rates of obesity. The specific goals of this study are to 1) apply a health belief model to develop a measurement tool for obesity prevention among youth who are seeing rising rates of obesity, and 2) provide an integrated validation procedure and foundation for developing this measurement tool. A total of 1801 high school students[sample1: 902(male:464,female:438); sample2: 899(male:464,female:438)] were recruited and collected data from 12 high school in Seoul and Kyonggi area. For this study the analytic framework of unified validity was developed which can comprehensively reflect unified validity be Messick(1995), framework for conducting a strong program of construct validation by Benson(1998), the unified validity implementation method of Rasch model suggested by Wolfe and Smith(2007a, 2007b). Furthermore, after dividing the developed analytic framework into each stage(the substantive domain), the evidence of validity of Youth Obesity Prevention Scale(YOPS) applying Health Belief Model was systematically suggested. The YOPS suggested the evidence about the substantive domain of unified validity. The developed YOPS was consist of Susceptibility, Severity, Benefits, Barriers and Cues to Action. After 3 stage in substantive domain, the components of YOPS(5factors and 28items) satisfied the unidimensionality, and the 5 point Likert scale had the significant discrimination of the respondents' response.

• Korean Journal of Psychosomatic Medicine
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• v.28 no.2
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• pp.99-107
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• 2020

Fibromyalgia is a disorder characterized by the core symptom of chronic widespread pain, along with fatigue, sleep disturbances, mood changes, and cognitive difficulties. The etiology of fibromyalgia involves a combination of biological factors, such as genetic vulnerability, alterations in pain processing and stress response system ; psychological factors, such as anxiety, depression, anger, and perceived stress ; environmental factors, such as infections, febrile diseases, and trauma. Central sensitization, which is amplified in the process of sensory stimulation, has been emphasized as a key etiological factor, as supported by enhanced wind-up, delayed aftersensation, decreased nociceptive flexion reflex threshold and functional imaging studies. Several guidelines recommend that a multimodal approach be used to treat fibromyalgia, including both pharmacological and non-pharmacological treatments, tailored to each individual, and that clinicians should provide an intellectual framework through sufficient education and emphasis on the importance of self-management. The prevalence of mood disorders, anxiety disorders, and other psychiatric problems is 7-9 times higher in patients with fibromyalgia than in the general population ; moreover, the association between fibromyalgia and certain psychopathologies or sleep problems has also been suggested. Since psychiatric problems, with shared vulnerabilities and risk factors, interact with fibromyalgia bidirectionally and also affect the disease course, an integrated management approach is needed to determine the risk of comorbidities.

• Journal of Life Science
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• v.31 no.1
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• pp.28-36
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• 2021

Edwardsiella piscicida is a significant cause of hemorrhagic septicemia in fish and gastrointestinal infections in humans. Survival bacteria require specialized mechanisms to adapt to environmental fluctuations. Hence, to understand the mechanism through which E. piscicida senses and responds to environmental osmolarity changes, we determined the protein expression profile and physiological properties under various salinity conditions in this study. The OmpR protein is a part of the Env-ZOmpR two-component system that has been implicated in sensing salt stress in bacteria. However, the physiological role played by this protein in E. piscicida remains to be elucidated. Therefore, in this work, the function of the OmpR protein in response to salt stress was investigated. Phenotypic analysis revealed that, in the mutant, three of the biochemical phenotypes were different from the wild type, including, citrate utilization, hydrogen sulfide, and indole production. Introduction of the plasmid containing the entire ompR gene to the mutant strain returned it to its parental phenotype. The retarded growth rate also partially recovered. Furthermore, in our studies, OmpR was not found to be related to cell motility. Taken together, our results from the mutational analysis, the growth assay, MALDI-TOF MS, qRT-PCR, and the phenotype studies suggest that the OmpR of E. piscicida is implicated in osmoregulation, growth, expression of porins (ETAE_1826), virulence-related genes (EseC, EseD and EvpC), and certain genes of unknown function (ETAE_1540 and ETAE_2706).

• Korean Journal of Construction Engineering and Management
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• v.22 no.2
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• pp.106-118
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• 2021

Global governments and initiatives have attempted and integrated various organizational efforts to implement the 17 Sustainable Development Goals (SDGs), presenting a new paradigm of sustainable development to address global issues (climate change, poverty eradication, and human rights). Recently, investment in sustainable finance has expanded to finance the attainment of goals set out in the Paris Agreement and SDGs. Non-financial factors such as environment, social responsibility, and governance (ESG) have become intangible assets that determine the future competitiveness and profitability of companies. Domestic and foreign institutional investors and asset management companies have been expanding their investments based on the ESG performance of companies. In this study, we aim to derive international standards and initiatives that require disclosure of information on corporate social responsibility activities and ESG performance and analyze construction companies' ESG activities and performance levels. The results of this study can be used as the basis to develop platforms for the construction industry ESG ecosystem and the measurement and management of intangible assets. These could ultimately contribute to overcoming the crisis in the future due to the outbreak of the COVID-19 pandemic, fostering net-zero emissions, and preventing fatal workplace accidents in the construction industry.

• Applied Chemistry for Engineering
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• v.32 no.4
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• pp.461-466
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• 2021

In this article, a portable and cost-effective voltammetric biosensor with nanoparticles was developed for the measurements of heterogeneous nuclear ribonucleoprotein A1 protein (hnRNP A1) biomarker which can potentially be used for lung cancer diagnosis. Gold nanoparticles were first electrodeposited onto screen printed carbon electrode (SPCE) followed by immobilizing a single stranded DNA aptamer specific to hnRNP A1 onto the electrode surface. Ethanolamine was also used when immobilizing DNA aptamer on the surface to prevent signals from non-specific adsorption events. Sequential injection of hnRNP A1 biomarker and anti-hnRNP A1 conjugated with alkaline phosphatase (ALP) onto the aptamer chip surface allows to form the sandwich complex of DNA aptamer/hnRNP A1/ALP-anti-hnRNP A1 on the electrode surface which further reacted with 4-aminophenyl phosphate (APP). The electrocatalytic reaction of the enzyme, ALP, and the substrate, APP, resulting in the oxidative current response changes at -0.05 and -0.17 V (vs. Ag/AgCl) against the hnRNP A1 concentration was measured using cyclic and differential pulse voltammetry, respectively. The Au nanoparticles-integrated voltammetric biosensor was applied to analyze human normal serum solutions possibly suggesting potential applicability for lung cancer diagnosis.

• The Journal of the Convergence on Culture Technology
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• v.7 no.4
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• pp.879-892
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• 2021

In a make-to-order manufacturing environment, the manufacturer's quotation information is important information used as basic information for bidding, receiving orders, and producing products in response to various customer demands. This quotation information is changed according to various factors such as customer demands, changes in product production environment, changes in drawing information of technical partners, and technological improvement of products. Due to this change, various changes occur in the quotation information that the manufacturer is preparing to reflect the customer's requirements. The change of quotation information according to these various change factors puts a lot of burden on the quotation management work from the standpoint of a make-to-order manufacturing company. In particular, the change of quotation information due to the change factors of quotation is inevitable and frequently occurs due to the requirements of the customer in the customer-oriented make-to-order production environment. In this paper, we propose a quotation change process based on the quotation creation process and propose a consistent and efficient quotation change processing method. To this end, the factors causing the change of quotation were defined, and the types of changes for each factor were defined. And it shows the procedure of applying the quotation change process to the quotation management system through the cases of each cause of the quotation change. In addition, in order to show the usefulness of the quotation change factors, the type of quotation change, the quotation change process, and the quotation system management, the proposed quotation change process and function was applied in the integrated quotation management system for the ship engine division of a typical make-to-order manufacturing company 'H'. As a result, it was confirmed that the proposed quotation change process and management system according to the quotation change factors were efficiently performed.

• Journal of the Society of Disaster Information
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• v.18 no.1
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• pp.129-145
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• 2022

Purpose: This study aims at preparing an external evacuation system by setting up situation that may occur outside buildings in case of large-scale fire at buildings such as multiuse facilities and presenting appropriate response procedures and action instructions for evacuees and facility managers. Method: Major matters are summarized based on various situations which may occur outside in case of fire and the contents of fire manual. Necessary factors including risk alert standards in the event of fire and the role of building occupants are classified and then important issues are summarized. In addition, the definition of fire-related outside shelters and external evacuation routes are showed, and then the applicability to the shelters and the routes are reviewed for old apartments in Jung-gu among multi-dense facilities. Result: Four stages (attention, caution, alert, serious) for standards of fire risk warning are established with the results of the investigation and analysis, and guidelines for behavior for evacuees, facility owners, residents, managers are summarized and presented. In addition, the concept and role of external shelters are divided into primary to the third shelters, and matters related to the definition of each shelter and the establishment of evacuation routes are presented, and then considered them carefully. Conclusion: This study has highlighted the importance of suggesting a systematic plan to secure the safety for evacuees outside space of buildings with disorder and difficulty to control in the event of fire. Therefore, we are confident that it will be useful in making an integrated manual for inside and outside buildings.

• Journal of Dental Anesthesia and Pain Medicine
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• v.22 no.4
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• pp.277-287
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• 2022

Background: Inflammatory dental diseases that occur during pregnancy can cause preterm labor and/or intrauterine growth restriction. Therefore, proactive treatment of dental diseases is necessary during pregnancy. Dexmedetomidine (DEX) is a widely used sedative in the dental field, but research on the effect of DEX on pregnancy is currently insufficient. In this study, we investigated the effects of co-treatment with DEX and lipopolysaccharide (LPS) on inflammatory responses in human amnion-derived WISH cells. Methods: Human amnion-derived WISH cells were treated with 0.001, 0.01, 0.1, and 1 ㎍/mL DEX with 1 ㎍/mL LPS for 24 h. Cytotoxicity of WISH cells was evaluated by 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay. The protein expression of cyclooxygenase-2 (COX-2), prostaglandin E₂ (PGE₂), p38, and nuclear factor kappa B (NF-𝜅B) was examined by western blot analysis. The mRNA expression of pro-inflammatory cytokines such as interleukin (IL)-1𝛽 and tumor necrosis factor (TNF)-𝛼 was analyzed by real-time quantitative polymerase chain reaction. Results: Co-treatment with DEX and LPS showed no cytotoxicity in the WISH cells. The mRNA expression of IL-1𝛽 and TNF-𝛼 decreased after co-treatment with DEX and LPS. DEX and LPS co-treatment decreased the protein expression of COX-2, PGE₂, phospho-p38, and phospho-NF-𝛋B in WISH cells. Conclusion: Co-treatment with DEX and LPS suppressed the expression of COX-2 and PGE₂, as well as pro-inflammatory cytokines such as IL-1𝛽 and TNF-𝛼 in WISH cells. In addition, the anti-inflammatory effect of DEX and LPS co-treatment was mediated by the inhibition of p38/NF-𝜅B activation.