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http://dx.doi.org/10.9713/kcer.2019.57.3.305

Nitric Oxide Delivery using Nanostructures and Its Biomedical Applications  

Choi, Yunseo (Bio-Convergence Major Integrated Science and Engineering Division (ISED), Underwood International College, Yonsei University)
Jeong, Hyejoong (Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University)
Park, Kyungtae (Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University)
Hong, Jinkee (Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University)
Publication Information
Korean Chemical Engineering Research / v.57, no.3, 2019 , pp. 305-312 More about this Journal
Abstract
The discovery of nitric oxide (NO) as a major signaling molecule in a number of pathophysiological processes - vasodilation, immune response, platelet aggregation, wound repair, and cancer biology - has led to the development of various exogeneous NO delivery systems. However, the development of ideal delivery system for human body application is still left as a challenge due to its high reactivity and short half-life in physiological condition. In this article, an overview of several nano-structures as potential NO delivery system will be presented, along with their recent research results and biomedical applications. Nano-size delivery system has immense advantages compared to others due to its high surface-to-volume ratio and capability for surface modification; thus, it has been proven to be effective in delivering nitric oxide with enhanced performance. Through this novel nano-structure delivery system, we are expecting to achieve sustained release of nitric oxide within adequate range of concentration, which ensures desired drug effects at the target site. Among different nano-structures, in particular, nanoparticle, microemulsion and nanofilm will be reviewed and compared to each other in respect of nitric oxide release profile. The proposed nano-structures for exogeneous NO delivery have a biological significance in that it can be further utilized in diverse biomedical fields as a highly promising therapeutic method.
Keywords
Nano structure; Nitric oxide; Release profile; Biomedical;
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