• Journal of Broadcast Engineering
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• v.17 no.6
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• pp.1080-1090
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• 2012

This study investigates the users' preference of frequency reallocation and frequency auction after digital transition of terrestrial broadcasting and it focuses on the relationships between media using pattern, reception environment of broadcasting telecommunication, and expectation for the universal service and requirement for the public interest. The results show that the longer DMB viewing hours, people prefer to frequency allocation for the telecommunication side. The technical aspects such as perception on the reception environment of broadcasting don't make effect on the users' preference of frequency allocation. In addition, the more people think the universal service of terrestrial broadcasting important, the more people think it unnecessary to adopt auction system to the broadcasting frequency. These results give implication that it is the most basic condition to improve the reception environment in order to accomplish universal service duty of terrestrial broadcasting.

• Molecules and Cells
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• v.39 no.8
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• pp.631-638
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• 2016

Glutathione peroxidase 3 (GPx3), an antioxidant enzyme, acts as a modulator of redox signaling, has immunomodulatory function, and catalyzes the detoxification of reactive oxygen species (ROS). GPx3 has been identified as a tumor suppressor in many cancers. Although hyper-methylation of the GPx3 promoter has been shown to down-regulate its expression, other mechanisms by which GPx3 expression is regulated have not been reported. The aim of this study was to further elucidate the mechanisms of GPx3 regulation. GPx3 gene analysis predicted the presence of ten glucocorticoid response elements (GREs) on the GPx3 gene. This result prompted us to investigate whether GPx3 expression is regulated by the glucocorticoid receptor (GR), which is implicated in tumor response to chemotherapy. The corticosteroid dexamethasone (Dex) was used to examine the possible relationship between GR and GPx3 expression. Dex significantly induced GPx3 expression in H1299, H1650, and H1975 cell lines, which exhibit low levels of GPx3 expression under normal conditions. The results of EMSA and ChIP-PCR suggest that GR binds directly to GRE 6 and 7, both of which are located near the GPx3 promoter. Assessment of GPx3 transcription efficiency using a luciferase reporter system showed that blocking formation of the GR-GRE complexes reduced luciferase activity by 7-8-fold. Suppression of GR expression by siRNA transfection also induced down-regulation of GPx3. These data indicate that GPx3 expression can be regulated independently via epigenetic or GR-mediated mechanisms in lung cancer cells, and suggest that GPx3 could potentiate glucocorticoid (GC)-mediated anti-infla-mmatory signaling in lung cancer cells.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.2
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• pp.86-94
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• 2007

The NoC (network-on-chip) approach is a promising solution to the increasing complexity of on-chip communication problems because of its high scalability. But, NoC applications generally consume a lot of power, because they require a large design space to accommodate many parallel IPs and network communication channels. It is not easy to analyze the power consumption of NoC applications with conventional simulation methods using simple power models. In addition, there are also many limitations in using sophisticated simulation models because they require long execution time and large efforts. In this paper, we apply a cycle-accurate energy measurement technique and tool to the FPGA prototypes, which are generally used to verify the correctness of SoC designs, as a practical indication of the power consumption of real NoC applications. An NoC-based JPEG encoder implementation is used as a case study to demonstrate the effectiveness of our approach.

• Korean Journal of Veterinary Research
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• v.29 no.4
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• pp.549-558
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• 1989

This experiment was carried out to investigate the influence of Aloe vera in the pancreatic islets of streptozotocin diabetic mice. Experimental diabetes was induced in ICR mice with a single injection of SZ(140mg/kg body weight, ip). The mice demonstrating hyperglycemia 48 hours after SZ injection were treated for 16 days with Aloe vera(300, 800mg/kg). Plasma glucose was measured, and for morphological studies of the islets specimens were stained with hematoxylin-eosin and by immunocytochemical methods. Then we observed the morphological changes of islets. Polymorphonuclear cells were infiltrated at the periphery of the islets 48 hours after SZ injection in SZ-treated ICR mice, but no prominent WBC infiltration was observed throughout the experiment. Blood glucose in mice treated with Aloe vera after SZ injection was higher than that of SZ injected mice, and mononuclear cells were heavily infiltrated at the islets 16 days after Aloe vera treatment(300mg/kg), and significant islets infiltration of mononuclear cells was observed 30 days after Aloe vera treatment(800mg/kg). Islets of ICR mice treated with Aloe vera after SZ injection showed severer insulitis, degranulation and necrosis of B cells than those of SZ injected mice. These studies indicate that Aloe vera in SZ injected mice increases vascular permeability and number of WBC in pancreatic islets, and potentiates destruction of B cells by cell-mediated immune system.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.8
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• pp.10-17
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• 2015

A satellite communication system is one of viable solutions for Internet applications running in wide areas. However, the performance of TCP can be seriously degraded in the satellite networks due to long round-trip time (RTT) and high bit error rate (BER) over satellite links. Therefore, a performance enhancing proxy(PEP) based TCP splitting connection scheme is used in the satellite link to improve the TCP performance. In this paper, we implement PEP testbed and conduct experiment to evaluate the performance of TCP splitting connection by comparing with high-speed TCP solutions in various environments. In our experimental environment, we consider multiple connections, high packet loss, and limited bandwidth. The experiment results show that PEP improves the TCP throughput than high-speed TCP variants in various environments. However, there is no improvement of the TCP throughput with the limited bandwidth because there is packet loss caused by both the congestion and the channel error.

• Asia pacific journal of information systems
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• v.12 no.4
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• pp.193-213
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• 2002

The sales activity of most of small manufacturing companies is based on orders of buyers. The process of promotion, negotiation, receipt and selection of orders of the manufacturers is closely coupled with the load status of the production lines. The decision on whether to accept an order or not, or the selection of optimal order set among excessive orders is entirely dependent on the schedule of production lines. However, in the real world, since the production scheduling activity is mainly performed by human experts, most of small manufacturers are suffer from being unable to meet due dates, lack of rapid decision on the acceptance of new order. Recently, Internet based Electronic Commerce is recognized as one of the alternatives for strengthening sales power of small and medium companies. However, small and medium manufacturers can't adjust properly to the new environment because they are in short of money, personnel, and technology. To cope with this problem, this paper deals with development of part sales agent coupled with virtual manufacturing in Internet environment that consist of selection agent, advertisement agent, selection agent, negotiation agent, and virtual manufacturing system. This paper develops a time-bounded negotiation mechanism for small and medium manufacturers in agent-based automated negotiation between customers and negotiation agents. Furthermore, to select optimal order set maximized profit, we first formulate the order selection problem with mixed integer programming, but the computation time of IP is not acceptable for real world scale problem. To overcome this problem and dynamic nature of virtual manufacturing, we suggest a genetic algorithm approach, which shows a reasonable computation time for real world case and good incremental problem solving capability.

• The Journal of the Korea Contents Association
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• v.11 no.10
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• pp.115-127
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• 2011

As broadcasting contents are recognized as a key competition means, there are issues raised such as improvement of terrestrial retransmission system, introduction of PAR in broadcasting market and so forth. Especially, in pay broadcasting market, strategic partership between SP and PP leads to contents exclusivity for competitors, which causes to hinder normal competition and limit viewers' right of access. Consequently, not only is it claimed that essential facilities doctrine should be adopted in broadcasting market, but also clause of content equal access in IP TV law and adoption of prohibited acts regulation can be viewed in the same context. However, adoption of essential facilities doctrine in broadcasting market is likely to be counterproductive because of the differences of philosophies, economies and legal systems on which general facilities and contents are based. Therefore, it is time for a essential facilities concept, a fundamental concept of a refusal to dealing of essential facilities, and basic works to review specific cases and precedents implemented in competition laws market This study aims to review and propose beforehand if adoption of essential facilities doctrine is appropriate for broadcasting contents.

• The Journal of Information Systems
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• v.12 no.2
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• pp.57-72
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• 2003

The purpose of this paper is to propose the modeling of multiagent based SCM and implement the prototype in the Internet environment. SCM process follows the supply chain operations reference (SCOR) model which has been suggested by Supply Chain Counsil. SCOR model has been positioned to become the industry standard for describing and improving operational process in SCM. Five basic processes, plan, source, matte, deliver and return are defined in the SCOR model, through which a company establishes its supply chain competitive objectives. A supply chain is a world wide network of suppliers, factories, warehouses, distribution centers and retailers through which raw materials are acquired, transformed or manufactured and delivered to customers by autonomous or semiautonomous process. With the pressure from the higher standard of customer compliance, a frequent model change, product complexity and globalization, the combination of supply chain process with an advanced infrastructure in terms of multiagent systems have been highly required. Since SCM is fundamentally concerned with coherence among multiple decision makers, a multiagent framework based on explicit communication between constituent agents such as suppliers, manufacturers, and distributors is a natural choice. Multiagent framework is defined to perform different activities within a supply chain. Dynamic and changing functions of supply chain can be dealt with multi-agent by cooperating with other agents. In the areas of inventory management, remote diagnostics, communications with field workers, order fulfillment including tracking and monitoring, stock visibility, real-time shop floor data collection, asset tracking and warehousing, customer-centric supply chain can be applied and implemented utilizing multiagent. In this paper, for the order processing event between the buyer and seller relationship, multiagent were defined corresponding to the SCOR process. A prototype system was developed and implemented on the actual TCP/IP environment for the purchase order processing event. The implementation result assures that multiagent based SCM enhances the speed, visibility, proactiveness and responsiveness of activities in the supply chain.

• BMB Reports
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• v.46 no.6
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• pp.322-327
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• 2013

The ATP-binding cassette transporters ABCG5 and ABCG8 form heterodimers that limit absorption of dietary sterols in the intestine and promote cholesterol elimination from the body through hepatobiliary secretion. To identify cis-regulatory elements of the two genes, we have cloned and analyzed twenty-three evolutionary conserved region (ECR) fragments using the CMV-luciferase reporter system in HepG2 cells. Two ECRs were found to be responsive to the Liver-X-Receptor (LXR). Through elaborate deletion studies, regions containing putative LXREs were identified and the binding of $LXR{\alpha}$ was demonstrated by EMSA and ChIP assay. When the LXREs were inserted upstream of the intergenic promoter, synergistic activation by $LXR{\alpha}/RXR{\alpha}$ in combination with GATA4, $HNF4{\alpha}$, and LRH-1, which had been shown to bind to the intergenic region, was observed. In conclusion, we have identified two LXREs in ABCG5/ABCG8 genes for the first time and propose that these LXREs, especially in the ECR20, play major roles in regulating these genes.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.1B
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• pp.26-38
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• 2006

To construct seamless collaborative environments, what all participants intent should be delivered, and visual elements such gesture, facial expression, and ambiance should be shared with all participants. In this paper, we propose high-quality video service to support DV(digital video) and HDV(high-definition DV) based on Access Grid(AG) which is a prevalent collaborative system. The proposed service is designed for employing versatile media tools and codecs with SDP(session description protocol) and SAP(session announcement protocol). We also design network-adaptive video transmission module to mitigate the impact of network fluctuation. This periodically monitors multicast performance and controls frame rate on sender side considering network condition. The experimental results over the test bed show that proposed service enhances quality of AG video service and provides seamless high-quality video transport by mitigating the impact of network fluctuation.