Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells |
An, Byung Chull
(Department of Anatomy, Chonnam National University Medical School)
Jung, Nak-Kyun (Department of Anatomy, Chonnam National University Medical School) Park, Chun Young (Department of Pathology, Chonnam National University Medical School) Oh, In-Jae (Department of Internal Medicine, Chonnam National University Medical School) Choi, Yoo-Duk (Department of Pathology, Chonnam National University Medical School) Park, Jae-Il (Animal Facility of Aging Science, Korea Basic Science Institute) Lee, Seung-won (Department of Anatomy, Chonnam National University Medical School) |
1 | Polman, J.A., Welten, J.E., Bosch, D.S., de Jonge, R.T., Balog, J., van der Maarel, S.M., de Kloet, E.R., and Datson, N.A. (2012). A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells. BMC Neurosci. 13, 118. DOI |
2 | Qi, X., Ng, K.T.P., Lian, Q.Z., Liu, X.B., Li, C.X., Geng, W., Ling, C.C., Ma, Y.Y., Yeung, W.H., Tu, W.W., et al. (2014). Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma. Oncotarget 5, 11103-11120. DOI |
3 | Ramamoorthy, S., and Cidlowski, J.A. (2013). Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements. Mol. Cell. Biol. 33, 1711-1722. DOI |
4 | Reddy, T.E., Pauli, F., Sprouse, R.O., Neff, N.F., Newberry, K.M., Garabedian, M.J., and Myers, R.M. (2009). Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. Genome Res. 19, 2163-2171. DOI |
5 | Saga, Y., Ohwada, M., Suzuki, M., Konno, R., Kigawa, J., Ueno, S., and Mano, H. (2008). Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncol. Rep. 20, 1299-1303. |
6 | Taylor, K.M., Ray, D.W., and Sommer, P. (2016). Glucocorticoid receptors in lung cancer: new perspectives. J. Endocrinol. 229, R17-28. DOI |
7 | Tothova, V., Isola, J., Parkkila, S., Kopacek, J., Pastorek, J., Pastorekova, S., and Gibadulinova, A. (2011). Glucocorticoid receptor-mediated transcriptional activation of S100P gene coding for cancer-related calcium-binding protein. J. Cell. Biochem. 112, 3373-3384. DOI |
8 | Voetsch, B., Jin, R.C., Bierl, C., Benke, K.S., Kenet, G., Simioni, P., Ottaviano, F., Damasceno, B.P., Annichino-Bizacchi, J.M., Handy, D.E., and Loscalzo, J. (2007). Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke 38, 41-49. DOI |
9 | Wang, J.C., Derynck, M.K., Nonaka, D.F., Khodabakhsh, D.B., Haqq, C., and Yamamoto, K.R. (2004). Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes. Proc. Natl. Acad. Sci. U SA 101, 15603-15608. DOI |
10 | Wang, H., Luo, K., Tan, L.Z., Ren, B.G., Gu, L.Q., Michalopoulos, G., Luo, J.H., and Yu, Y.P. (2012). p53-induced gene 3 mediates cell death induced by glutathione peroxidase 3. J. Biol. Chem. 287, 16890-16902. DOI |
11 | Weber, M., Hellmann, I., Stadler, M.B., Ramos, L., Paabo, S., Rebhan, M., and Schubeler, D. (2007). Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat. Genet. 7, 457-466. |
12 | Yao, D.M., Zhou, J.D., Zhang, Y.Y., Yang, L., Wen, X.M., Yang, J., Guo, H., Chen, Q., Lin, J., and Qian, J. (2015). GPX3 promoter is methylated in chronic myeloid leukemia. Int. J. Clin. Exp. Pathol. 8, 6450-6457. |
13 | Ying, C.Y., Dominguez-Sola, D., Fabi, M., Lorenz, I.C., Hussein, S., Bansal, M., Califano, A., Pasqualucci, L., Basso, K., and Dalla-Favera, R. (2013). MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma. Nat Immunol. 14, 1084-1092. DOI |
14 | Yu, Y.P., Yu, G., Tseng, G., Cieply, K., Nelson, J., Defrances, M., Zarnegar, R., Michalopoulos, G., and Luo, J.H. (2007). Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Res. 67, 8043-8050. DOI |
15 | Bierl, C., Voetsch, B., Jin, R.C., Handy, D.E., and Loscalzo, J. (2004). Determinants of human plasma glutathione peroxidase (GPx-3) expression. J. Biol. Chem. 279, 26839-26845. DOI |
16 | Zhang, X., Yang, J.J., Kim, Y.S., Kim, K.Y., Ahn, W.S., and Yang, S. (2010). An 8-gene signature, including methylated and downregulated glutathione peroxidase 3, of gastric cancer. Int. J. Oncol. 36, 405-414 |
17 | An, B.C., Lee, S.S., Lee, J.T., Hong, S.H., Wi, S.G., and Chung, B.Y. (2011). Engineering of 2-Cys peroxiredoxin for enhanced stresstolerance. Mol. Cells 32, 257-264. DOI |
18 | An, B.C., Lee, S.S., Jung, H.S., Kim, J.Y., Lee, Y., Lee, K.W., Lee, S.Y., Tripathi, B.N., and Chung, B.Y. (2015). An additional cysteine in a typical 2-Cys peroxiredoxin of Pseudomonas promotes functional switching between peroxidase and molecular chaperone. FEBS Lett. 589, 2831-2840. DOI |
19 | Barrett, C.W., Ning, W., Chen, X., Smith, J.J., Washington, M.K., Hill, K.E., Coburn, L.A., Peek, R.M., Chaturvedi, R., Wilson, K.T., et al. (2013). Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res. 73, 1245-1255. DOI |
20 | Bibikova, M., Barnes, B., Tsan, C., Ho, V., Klotzle, B., Le, J.M., Delano, D., Zhang, L., Schroth, G.P., Gunderson, K.L., et al. (2011). High density DNA methylation array with single CpG site resolution. Genomics 98, 288-295. DOI |
21 | Chen, B., Rao, X., House, M.G., Nephew, K.P., Cullen, K.J., and Guo, Z. (2011). GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response. Cancer Lett. 309, 37-45. DOI |
22 | Cheng, K.C., Cahill, D.S., Kasai, H., Nishimura, S., and Loeb, L.A. (1992). 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem. 267, 166-172. |
23 | Greenberg, A.K., Hu, J., Basu, S., Hay, J., Reibman, J., Yie, T.A., Tchou-Wong, K.M., Rom, W.N., and Lee, T.C. (2002). Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators. Am. J. Respir. Cell Mol. Biol. 27, 320-328. DOI |
24 | Chung, S.S., Kim, M., Youn, B.S., Lee, N.S., Park, J.W., Lee, I.K., Lee, Y.S., Kim, J.B., Cho, Y.M., Lee, H.K., et al. (2009). Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells. Mol. Cell. Biol. 29, 20-30. DOI |
25 | Do, H., Wong, N.C., Murone, C., John, T., Solomon, B., Mitchell, L., and Dobrovic, A. (2014). A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma. Sci. Rep. 4, 4186. |
26 | Drini, M., Wong, N.C., Scott, H.S., Craig, J.M., Dobrovic, A., Hewitt, C.A., Dow, C., Young, J.P., Jenkins, M.A., Saffery, R., et al. (2011). Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome. PLoS One 6, e16831. DOI |
27 | Hayano, T., Garg, M., Yin, D., Sudo, M., Kawamata, N., Shi, S., Chien, W., Ding, L.W., Leong, G., Mori, S., et al. (2013). SOX7 is down-regulated in lung cancer. J. Exp. Clin. Cancer Res. 32, 17. DOI |
28 | He, Y., Wang, Y., Li, P., Zhu, S., Wang, J., and Zhang, S. (2011). Identification of GPx3 epigenetically silenced by CpG methylation in human esophageal squamous cell carcinoma. Dig. Dis. Sci. 56, 681-688. DOI |
29 | Hussain, S.P., and Harris, C.C. (1998). Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res. 58, 4023-4037. |
30 | Ingawale, D.K., Mandlik, S.K., and Patel, S.S. (2015). An emphasis on molecular mechanisms of anti-inflammatory effects and glucocorticoid resistance. J. Complement. Integr. Med. 12, 1-13. DOI |
31 | Jee, C.D., Kim, M.A., Jung, E.J., Kim, J., and Kim, W.H. (2009). Identification of genes epigenetically silenced by CpG methylation in human gastric carcinoma. Eur. J. Cancer 45, 1282-1293. DOI |
32 | Kay, P., Schlossmacher, G., Matthews, L., Sommer, P., Singh, D., White, A., and Ray, D. (2011). Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells. PLoS One 6, e24839. DOI |
33 | Kim, Y.S., Park, J.S., Jee, Y.K., and Lee, K.Y. (2004). Dexamethasone inhibits TRAIL- and anti-cancer drugs-induced cell death in A549 cells through inducing NF-kappaB-independent cIAP2 expression. Cancer Res. Treat. 36, 330-337. DOI |
34 | Kino, T., Souvatzoglou, E., De Martino, M.U., Tsopanomihalu, M., Wan, Y., and Chrousos, G.P. (2003). Protein 14-3-3s interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. J. Biol. Chem. 278, 25651-25656. DOI |
35 | Lassar, A.B., Davis, R.L., Wright, W.E., Kadesch, T., Murre, C., Voronova, A., Baltimore, D., and Weintraub, H. (1991). Functional activity of myogenic HLH proteins requires hetero-oligomeri- zation with E12/E47-like proteins in vivo. Cell 66, 305-315. DOI |
36 | Lee, O.J., Schneider-Stock, R., McChesney, P.A., Kuester, D., Roessner, A., Vieth, M., Moskaluk, C.A., and El-Rifai, W. (2005). Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Neoplasia 7, 854-861. DOI |
37 |
McKay, L.I., and Cidlowski, J.A. (1999). Molecular control of immune/inflammatory responses: interactions between nuclear factor- |
38 | Leggas, M., Kuo, K.L., Robert, F., Cloud, G., deShazo, M., Zhang, R., Li, M., Wang, H., Davidson, S., and Rinehart, J. (2009). Intensive anti-inflammatory therapy with dexamethasone in patients with non-small cell lung cancer: effect on chemotherapy toxicity and efficacy. Cancer Chemother. Pharmacol. 63, 731-743. DOI |
39 | Liu, Q., Jin, J., Ying, J., Sun, M., Cui, Y., Zhang, L., Xu, B., Fan, Y., and Zhang, Q. (2015). Frequent epigenetic suppression of tumor suppressor gene glutathione peroxidase 3 by promoter hypermethylation and its clinical implication in clear cell renal cell carcinoma. Int. J. Mol. Sci. 16, 10636-10649. DOI |
40 | Lodygin, D., Epanchintsev, A., Menssen, A., Diebold, J., and Hermeking, H. (2005). Functional epigenomics identifies genes frequently silenced in prostate cancer. Cancer Res. 65, 4218-4227. DOI |
41 | Mohamed, M.M., Sabet, S., Peng, D.F., Nouh, M.A., El-Shinawi, M., and El-Rifai, W. (2014). Promoter hypermethylation and suppression of glutathione peroxidase 3 are associated with inflammatory breast carcinogenesis. Oxid. Med. Cell Longev. 2014, 787195. |
42 | Oh, I.-J., Kim, H.-E., Song, S.-Y., Na, K.-J., Kim, K.-S., Kim, Y.-C., and Lee, S.-W. (2014). Diagnostic value of serum glutathione peroxidase 3 levels in patients with lung cancer. Thoracic Cancer 5, 425-430. DOI |
43 | Peng, D.F., Hu, T.L., Schneider, B.G., Chen, Z., Xu, Z.K., and El-Rifai, W. (2012). Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. PLoS One 7, e46214. DOI |
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