• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1467-1472
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• 2013

Metabolomics is a field that studies systematic dynamics and secretion of metabolites from cells to understand biological pathways based on metabolite changes. The metabolic profiling of intact human colorectal tissues was performed using high-resolution magic angle spinning (HR-MAS) NMR spectroscopy, which was unnecessary to extract metabolites from tissues. We used two different groups of samples, which were defined as normal and cancer, from 9 patients with colorectal cancer and investigated the samples in NMR experiments with a water suppression pulse sequence. We applied target profiling and multivariative statistical analysis to the analyzed 1D NMR spectra to identify the metabolites and discriminate between normal and cancer tissues. Cancer tissue showed higher levels of arginine, betaine, glutamate, lysine, taurine and lower levels of glutamine, hypoxanthine, isoleucine, lactate, methionine, pyruvate, tyrosine relative to normal tissue. In the OPLS-DA (orthogonal partial least square discriminant analysis), the score plot showed good separation between the normal and cancer groups. These results suggest that metabolic profiling of colorectal cancer could provide new biomarkers.

• 한국태양에너지학회:학술대회논문집
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• 2009.11a
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• pp.342-349
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• 2009

The purpose of this study is to estimate efficiently an odor dispersion from waste treatment facility for a crematory and a neighborhood facility, then propose planning, a location of an opening or the arrangement of the trees. Hence, offer a comfortable environment for a resident. For this, first the research data about estimating odor dispersion from waste treatment facility and odor are analyzed, then research an ingredient, characteristic, a direct effect for human and a method of measurement. Second, with on-site survey, check odorimetry and the source of odor dispersion, then apply this to the boundary condition of CFD simulation. Third, analyse by the hour for the 2008 standard weather data of Cheon-an, then apply summer data that odor dispersion is active, winter data relatively slow and an annual mean velocity and wind to the simulation. Even if a crematory and neighborhood facility located on south and north from waste treatment facility are at the low rate, the south and north wind will be applied to the simulation. Fourth, with CFD simulation result, predict an odor dispersion, then propose a solution which is considered an odor dispersion, a location of an opening and the arrangement of the trees. Consequently, this study will have an effect on an environment of a resident.

• The KSFM Journal of Fluid Machinery
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• v.14 no.3
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• pp.33-38
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• 2011

Medicated water electrolysis apparatus, which electrolyzes water into acidic water and alkaline water, was in the spotlight as becoming known the effect of alkaline water. It is known as good for health as removing active oxygen in the human's body and promoting digestion. But, the customers could not get that desired water temperature because these apparatuses are directly connected with a water pipe. So, the cooling system was developed for controlling the temperature of the alkaline water. One of the typical way is to store water in water tank and control the temperature. But, in this way, storing water can be polluted impurities coming from outside. For protecting this pollution, the cooling system based on indirect heat exchange method through phase change between water and ice was developed. In this study, we have calculated efficiency of the cooling system with phase change by experiment and commercial CFD(Computational Fluid Dynamics) code, ANSYS CFX. To consider the effect of latent heat that is generated by melting ice, we have simulated two phase numerical analyses used enthalpy method and found the temperature, velocity, and ice mass distribution for calculating the efficiency of cooling. From the results of numerical analysis, we have obtained the relationship between the cooling efficiency and each design factor.

• Human Ecology Research
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• v.56 no.3
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• pp.317-330
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• 2018

Objectives: This study explores the characteristics of family migration for North Korean defectors and classifies family migration by examining who initiated the migration and who followed. Method: We analyzed the family migration using detailed stories from fifty-five North Korean defectors who were interviewed between 2005 and 2011. Results: We found that 43 out of 55 cases were family migration and the remaining 12 cases were single person migration. We also found several characteristics typical of migration. First, family migration followed the process of step migration, which indicated a serial migration in numbers. Second, migration relied heavily on informal social networks. Finally, the process of earlier migration by North Koreans was incidental and unexpected; however, unexpectedness has diminished in recent migration. Looking at who initiated the migration, the most common type was 'mother-initiated' cases (14 cases) followed by 'child-initiated' cases (10 cases). The third most common type was 'mother-child accompanied' cases (7 cases). The migration process was various; however the most common type was when a married woman initiated the family migration process. This is most likely because married women have the responsibility to support families in the informal economy of North Korea. According to the range of family migrated, the most common type was 'nuclear-family only' cases (22 cases) followed by 'maternal extended family migration' cases (12 cases). Conclusions: The findings of this study provide information on the family dynamics of North Korean defectors.

• Korean Journal of Applied Biomechanics
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• v.23 no.2
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• pp.169-177
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• 2013

The purpose of this study is to investigate the effect of aging and dual tasking to the postural control during quiet standing. It was hypothesized that the center of pressure (COP) dynamics would be differently affected by aging and characteristics of the task. Total 60 adults (35 young adults and 25 older adults) participated in this study. They conducted two different standing tasks (dual vs. Nondual) twice in a random order. Variability, complexity, coupling and symmetric index from the left, right and overall COPs were measured by various parameters in nonlinear, linear and frequency analyses methods. Results demonstrated that older adults had worse performance in postural control with decreased complexity in overall sway movement, and increased coupling between left and right limb COP movement, even though there was no significant difference in symmetric index. These tendencies are generally clearer in nonlinear measures at the dual task condition. Results implied that older adults had compensatory strategy in dual tasking which results in simple and combined postural movement patterns.

• Journal of Preventive Medicine and Public Health
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• v.40 no.2
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• pp.185-190
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• 2007

Objectives : Since the first human infection from avian influenza was reported in Hong Kong in 1997, many Asian countries have confirmed outbreaks of highly pathogenic H5N1 avian influenza viruses. In addition to Asian countries, the EU authorities also held an urgent meeting in February 2006 at which it was agreed that Europe could also become the next target for H5N1 avian influenza in the near future. In this paper, we provide the general and applicable information on the avian influenza in the bioinformatics field to assist future studies in preventive medicine. Methods : We introduced some up-to-date analytical tools in bioinformatics research, and discussed the current trends of avian influenza outbreaks. Among the bioinformatics methods, we focused our interests on two topics: pattern analysis using the secondary database of avian influenza, and structural analysis using the molecular dynamics simulations in vaccine design. Results : Use of the public genome databases available in the bioinformatics field enabled intensive analysis of the genetic patterns. Moreover, molecular dynamic simulations have also undergone remarkable development on the basis of the high performance supercomputing infrastructure these days. Conclusions : The bioinformatics techniques we introduced in this study may be useful in preventive medicine, especially in vaccine and drug discovery.

• Journal of the Korean Mathematical Society
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• v.49 no.4
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• pp.779-794
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• 2012

In this paper, we study the global stability of two mathematical models for human immunodeficiency virus (HIV) infection with intra-cellular delays. The first model is a 5-dimensional nonlinear delay ODEs that describes the interaction of the HIV with two classes of target cells, $CD4^+$ T cells and macrophages taking into account the saturation infection rate. The second model generalizes the first one by assuming that the infection rate is given by Beddington-DeAngelis functional response. Two time delays are used to describe the time periods between viral entry the two classes of target cells and the production of new virus particles. Lyapunov functionals are constructed and LaSalle-type theorem for delay differential equation is used to establish the global asymptotic stability of the uninfected and infected steady states of the HIV infection models. We have proven that if the basic reproduction number $R_0$ is less than unity, then the uninfected steady state is globally asymptotically stable, and if the infected steady state exists, then it is globally asymptotically stable for all time delays.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.2
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• pp.231-238
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• 2019

This study aims is to analyze of existing concepts of gender stereotypes and gender differences in wages, defining of gender pay gap determinants, and to evaluate the level of discrimination against women in Kazakhstan. This paper begins by reviewing trends in gender stereotypes and gender segregation during the past several decades. In this research, authors propose the methodological tools for presenting a standard form of evaluation of gender pay gap. The developed methodological tools will allow providing authentic and formal analysis on gender pay gap and identifying the main determinants of gender pay differences. Further, the obtained results showed the distribution of wage gap in Kazakhstan's regions and the Duncan's dissimilation index allows us to trace the dynamics of changes in the professional structure between men and women. According to the results, gender pay gap is narrowing with the reduction of the job level and discrimination is related to differences in human capital and education. Wages in the industrial sector are higher for men than for women, because men's professions are characterized by severe and unhealthy working conditions. In addition, employers prefer male managers, but if they take woman managers, they give them salary 3 times less.

• Nuclear Engineering and Technology
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• v.53 no.3
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• pp.825-832
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• 2021

A simulation-based approach is proposed to study the protective actions taken by residents during nuclear emergencies using cognitive findings. Human perception-based behaviors are not heavily incorporated in the evacuation study for nuclear emergencies despite their known importance. This study proposes a generic framework of perception-based behavior simulation, in accordance with the ecological concept of affordance theory and a formal representation of affordance-based finite state automata. Based on the generic framework, a simulation model is developed to allow an evacuee to perceive available actions and execute one of them according to Newton's laws of motion. The case of a shadow evacuation under nuclear emergency is utilized to demonstrate the applicability of the proposed framework. The illustrated planning algorithm enables residents to compute not only prior knowledge of the environmental map, but also the perception of dynamic surroundings, using widely observed heuristics. The simulation results show that the temporal and spatial dynamics of the evacuation behaviors can be analyzed based on individual perception of circumstances, while utilizing the findings in cognitive science under unavoidable data restriction of nuclear emergencies. The perception-based analysis of the proposed framework is expected to enhance nuclear safety technology by complementing macroscopic analyses for advanced protective measures.

• Parasites, Hosts and Diseases
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• v.56 no.6
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• pp.545-552
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• 2018

Plasmodium vivax is more challenging to control and eliminate than P. falciparum due to its more asymptomatic infections with low parasite densities making diagnosis more difficult, in addition to its unique biological characteristics. The potential re-introduction of incidence cases, either through borders or via human migrations, is another major hurdle to sustained control and elimination. The Republic of Korea has experienced re-emergence of vivax malaria in 1993 but is one of the 32 malaria-eliminating countries to-date. Despite achieving successful nationwide control and elimination of vivax malaria, the evolutionary characteristics of vivax malaria isolates in the Republic of Korea have not been fully understood. In this review, we present an overview of the genetic variability of such isolates to increase understanding of the epidemiology, diversity, and dynamics of vivax populations in the Republic of Korea.