• Title/Summary/Keyword: Efficacy testing

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Respiratory Review of 2014: Pulmonary Thromboembolism

  • Lee, Jae Seung
    • Tuberculosis and Respiratory Diseases
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    • v.77 no.3
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    • pp.105-110
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    • 2014
  • Venous thromboembolism (VTE), which includes pulmonary embolism and deep vein thrombosis, is an important cause of morbidity and mortality. The aim of this review is to summarize the findings from clinically important publications over the last year in the area of VTE. In this review, we discuss 11 randomized controlled trials published from March 2013 to April 2014. The COAG and the EU-PACT trials indicate that pharmacogenetic testing has either no usefulness in the initial dosing of vitamin K antagonists or marginal usefulness in the Caucasian population. Recent clinical trials with novel oral anticoagulants (NOACs) have demonstrated that the efficacy and safety of rivaroxaban, apixaban, edoxaban, and dabigatran are not inferior to those of conventional anticoagulants for the treatment of VTE. The PEITHO and ULTIMA trials suggested that rescue thrombolysis or catheter-directed thrombolysis may maximize the clinical benefits and minimize the bleeding risk. Lastly, riociguat has a proven efficacy in treating chronic thromboembolic pulmonary hypertension. In the future, NOACs, riociguat, and catheter-directed thrombolysis have the potential to revolutionize the management of patients with VTE.

Comparison of Differences in Levels per Group on Math Self-Regulated Learning Factors of High School Students (고등학생의 수학 자기조절 학습 요인에 대한 집단별 수준 차이 비교)

  • Yoo, Ki Jong
    • Journal for History of Mathematics
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    • v.34 no.1
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    • pp.21-37
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    • 2021
  • The purpose of the present study is to compare the differences in levels per group of high school students regarding the self-regulated learning factors for mathematics. For this purpose, a self-regulated learning measurement tool was developed and surveys were conducted. And the statistical analysis was completed using the frequency analysis, Kolmogorov-Smirnov normality test, Mann-Whitney U test and the Kruskal-Wallis H test. As a result, it is found that self-efficacy is of statistically significant differences in self-regulated learning levels regardless of the group classifications but test anxiety does not show statistically significant differences in self-regulated learning levels regardless of the group classifications.

In vitro anthelmintic evaluation of common Indian Ayurvedic anthelmintic drugs: Krimimudgar Ras, Kriminol and Vidangasava against intestinal helminths

  • Chen, Risa Parkordor;Yadav, Arun K.
    • CELLMED
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    • v.8 no.3
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    • pp.15.1-15.5
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    • 2018
  • Helminthiasis is one of the most common worm diseases which causes a range of adverse health problems in humans. Ayurveda is one of the most prominent and ancient systems of traditional medicines in India. Most Ayurvedic drugs used against intestinal helminths have been developed by traditional wisdom and therefore lack a proper validation through controlled studies. The aim of the present study was to scientifically validate the in vitro efficacy of three common Indian Ayurvedic anthelmintic drugs, viz. Krimimudgar Ras, Kriminol and Vidangasava in relation to the synthetic broad-spectrum anthelmintic drugs, praziquantel and albendazole. The in vitro testing of Ayurvedic anthelmintics was done against an intestinal cestode, Raillietina sp. and a nematode, Syphacia obvelata, employing 10 mg/ml, 30 mg/ml and 50 mg/ml concentrations of each medicine. The anthelmintic efficacy was judged on the basis of paralysis and mortality time of worms after exposing to these Ayurvedic drugs. Of the three tested Ayurvedic medicines, Krimimudgar ras (KR) showed the most prominent efficacy, against both the cestode and nematode parasites. At 50 mg/ml concentration, KR caused mortality of cestodes in $7.53{\pm}0.15hr$, and of nematodes in $7.61{\pm}0.19hr$. Vidangasava was found to be comparatively less effective against the tested helminth parasites. The results of this study indicate that Ayurvedic formulations do possess significant anthelmintic effects, however, an evidence-based research is required to validate all currently used Ayurvedic anthelmintics, using proper controlled studies.

Effects of Transformational and Authentic Leadership on Crew Member's Job Satisfaction and Organizational Commitment: Mediating Effects of Crew Member's Self-efficacy and LMX (항공사 객실팀장의 변혁적 리더십과 진성 리더십이 직무만족 및 조직몰입에 미치는 영향: 자기 효능감과 LMX의 매개효과)

  • Kang, Seh hyeon;Lee, Yun-Cheol
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.27 no.3
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    • pp.54-69
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    • 2019
  • Transformational and authentic leadership are known to create positive effects on follower's various outcomes, like job satisfaction and organizational commitment. We're mostly interested in testing positive effects of transformational and authentic leadership of cabin team leaders in airline industry, because their leadership tends to have strong and immediate impact on cabin crew's quality of customer services. We figured that cabin team leader's transformational and authentic leadership had positive effects on crew member's job satisfaction and organizational commitment. And, these positive relationships were at least partially mediated through crew member's self-efficacy and LMX. Based on these positive results, we discussed several theoretical and practical implications for developing effective leadership across cabin team leaders in airline services industry.

In vivo and in vitro efficacy of florfenicol, terbinafine, and mometasone furoate topical otic solution for the treatment of canine otitis externa

  • Bae, Seulgi;Jin, Yunseok;Oh, Taeho
    • Korean Journal of Veterinary Research
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    • v.61 no.4
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    • pp.37.1-37.6
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    • 2021
  • This study evaluated the efficacy of a new, single-dose otic solution combining florfenicol, terbinafine, and mometasone furoate for the treatment of canine otitis externa (OE) in vitro and in vivo. Forty-one client-owned dogs with OE were included in the study and divided into a treatment group that received the test solution and a negative control group that received a normal saline solution. On day 0, the dogs were treated either with the test or the control solution and evaluated over 30 days. Clinical efficacy was evaluated by clinical signs and cytological organism counts. In vitro antimicrobial susceptibility was evaluated by the minimum inhibitory concentration (MIC). After treatment with the test solution, clinical signs continuously decreased and cytological scores were significantly reduced. The results of MIC testing showed that the test solution was potent against the common pathogenic causes of canine OE. In this study, the most common causative pathogens were Staphylococcus pseudintermedius, Pseudomonas spp. and Malassezia pachydermatis. No issues related to safety were identified. Based on these results, this new ototopical drug can be used as first line treatment for canine OE.

The Effect of Empowering Leadership on Work Engagement and Job Performance through Employees' Self-Efficacy and Belonging (임파워링 리더십이 구성원의 자기효능감과 소속감, 그리고 직무열의와 직무성과에 미치는 영향)

  • Seo, JungKyu;Kwon, HyeokGi
    • Journal of Korea Society of Industrial Information Systems
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    • v.25 no.5
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    • pp.103-117
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    • 2020
  • The importance of empowering leadership has emerged, which inspires confidence and attachment to members' task capabilities through delegation of authority between leaders and members. The purpose of this study is to analyze the effect of empowering leadership on work engagement and job performance through self-efficacy and sense of belonging in construction companies. Hypothesis testing of 271 copies of the questionnaire from Busan, Ulsan and Gyeongnam areas was conducted using the structural equation model. First, in the order of information sharing and participatory decision-making, there was a significant positive effect on self-efficacy, whereas the lead and coaching factors were not significant. Second, it was shown that all 4 factors of empowering leadership had a significant positive effect on belonging. Third, the sense of self-efficacy and belonging had a significant positive effect on both work engagement and job performance.

A Study on the Relationships between College Students' NCS Basic Capability Group and Career Preparation Behavior : Focused on Communication Capability and Mathematical Capability (전문대학생의 NCS기초능력군과 진로준비행동과의 관계에 관한 연구 : 의사소통능력과 수리능력을 중심으로)

  • Sung, Haengnam;Cho, Donghwan
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.15 no.2
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    • pp.71-85
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    • 2019
  • The importance of the NCS(National Competitiveness Standards) is growing as the job market shrinks and more institutions require hiring based on NCS. Of the ten domains of NCS', the most relevant one with the performance of all tasks is basic capability group. The purpose of this study is to investigate the effect of college students' basic capability group(communication capability, mathematical capability) on their career preparation behavior. In this study, we set up a process model to comprehend the effect of college students' basic capability group on career preparation behavior based on social cognitive career theory. For research model testing, 561 questionnaires were used for empirical analysis through structural equations modeling. Empirical analysis showed that communication capability positively influenced college students' career preparation behaviors for employment. But, mathematical capability don't influenced college students' career preparation behaviors for employment. Next, career self-efficacy and career outcome expectation each positively influenced college students' career preparation behaviors for employment. Also, interest in the major positively influenced college students' career preparation behaviors for employment. The academic implications are as follows: Career self-efficacy and interest in the major were important factors in the communication capability. The process of communication capability affecting career preparation behavior and interest in the major was explained through social cognitive career theory and self-efficacy. The practical implications are as follows: Administrative assistance should be provided to improve the career self-efficacy of college students.

Diagnostic/prognostic health monitoring system and evaluation of a composite bridge

  • Mosallam, A.;Miraj, R.;Abdi, F.
    • Smart Structures and Systems
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    • v.5 no.4
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    • pp.397-413
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    • 2009
  • Composite bridges offer many advantages compared to current steel and aluminum bridges. This paper presents the results of a comprehensive on-going research program to develop innovative Diagnostic Prognostic System (DPS) and a structural evaluation of Composite Army Bridge (CAB) system. The DPS is founded on three technologies: optical fiber sensing, remote data transmission, and virtual testing. In developing this system, both laboratory and virtual test were used in different damage scenarios. Health monitoring with DPS entailed comparing live strain data to archived strained data in various bridge locations. For field repairs, a family of composite chords was subjected to simple ramp loads in search of ultimate strength. As such, composite bridge specimens showcased their strengths, heralded the viability of virtual testing, highlighted the efficacy of field repair, and confirmed the merits of health monitoring.

Biopsy and Mutation Detection Strategies in Non-Small Cell Lung Cancer

  • Jung, Chi Young
    • Tuberculosis and Respiratory Diseases
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    • v.75 no.5
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    • pp.181-187
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    • 2013
  • The emergence of new therapeutic agents for non-small cell lung cancer (NSCLC) implies that histologic subtyping and molecular predictive testing are now essential for therapeutic decisions. Histologic subtype predicts the efficacy and toxicity of some treatment agents, as do genetic alterations, which can be important predictive factors in treatment selection. Molecular markers, such as epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement, are the best predictors of response to specific tyrosine kinase inhibitor treatment agents. As the majority of patients with NSCLC present with unresectable disease, it is therefore crucial to optimize the use of tissue samples for diagnostic and predictive examinations, particularly for small biopsy and cytology specimens. Therefore, each institution needs to develop a diagnostic approach requiring close communication between the pulmonologist, radiologist, pathologist, and oncologist in order to preserve sufficient biopsy materials for molecular analysis as well as to ensure rapid diagnosis. Currently, personalized medicine in NSCLC is based on the histologic subtype and molecular status. This review summarizes strategies for tissue acquisition, histologic subtyping and molecular analysis for predictive testing in NSCLC.

Psychometrics of Task Self-Efficacy Scale for Korean Elderly (노인의 일상활동수행에 대한 자기효능척도의 신뢰도 및 타당도 평가)

  • ;;;;Beverly L. Roberts
    • Journal of Korean Academy of Nursing
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    • v.27 no.4
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    • pp.831-842
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    • 1997
  • The purpose of the study was to test the reliability and validity of the Korean version of Task Self-Efficacy Scale for activities of dally living (ADL). The Task Self-Efficacy Scale was developed by Roberts(1996) for low-intensity exercise study with older people to predict their performance of ADL. The scale was translated and back translated by bilingual persons, and then was modified to resolve variations in the translations. The Korean version of Self-Efficacy Scale for ADL was then administered to 193 elderly people including 95 hospitalized patients and 98 outpatients or healthy people. Face to face interview was used to fill out the structured questionnaire, and each interview took approximately 30 minutes. The subjects for the study were 80 women and 112 men with an age range of 65 to 95 years(M=71 years) of whom 82.6% classified themselves as moderate or quite active Most subjects(80.2%) had an education level of elementary school or less. The Self-Efficacy Scale for ADL is measured on a 0 to 10 VAS, assessing three areas of ADL : self care activities, household tasks, and motor tasks. The higher the score is, the higher person's confidence in performing ADL. Psychometric testing revealed that the scale was found to be internally consistent, showing a Cronbach's alpha of .97 The scale was significantly correlated with subjects' level of activity and subjective assessment of their health status. Moderate correlation with health-related hardiness scale also supported the validity. Factor analysis was performed to confirm whether the scale represents the three sub-areas as suggested in the literature. The results of the factor analysis led to a three factor solution according to Kaiser's criterion, but the items were not strongly and cleanly loaded for the third factor. This can be explained in that, among the three sub-ADL areas of the self-efficacy scale, the areas of self care activities and household tasks seem to have similar levels of difficulty in performance with not enough differences for the self-efficacy scale to distinguish between the two areas. Therefore, one factor solution was suggested since ADL can be seen as a unit of activities at similar level of difficulty in performance. One factor solution explained 68.1% of variance of the 19-item scale and all items were correlated over .6 with the factor, showing that the selected factor solution fits the model. The results indicated that the Korean version of Task Self-Efficacy Scale for ADL was reliable and valid in producing useful information to evaluate the effects of various interventions toward promoting health and quality of life for elderly people.

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