셀메드 (CELLMED)

  • 제8권3호
  • /
  • Pages.15.1-15.5
  • /
  • 2018
  • /
  • 3022-6805(pISSN)
  • /
  • 3022-6791(eISSN)
셀메드 세포교정의약학회 (Cellmed Orthocellular Medicine and Pharmaceutical Association)
권호 표지
DOI QR코드

DOI QR Code

In vitro anthelmintic evaluation of common Indian Ayurvedic anthelmintic drugs: Krimimudgar Ras, Kriminol and Vidangasava against intestinal helminths

  • Chen, Risa Parkordor (Department of Zoology, North-Eastern Hill University) ;
  • Yadav, Arun K. (Department of Zoology, North-Eastern Hill University)
  • 투고 : 2018.08.22
  • 심사 : 2018.08.24
  • 발행 : 2018.08.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Helminthiasis is one of the most common worm diseases which causes a range of adverse health problems in humans. Ayurveda is one of the most prominent and ancient systems of traditional medicines in India. Most Ayurvedic drugs used against intestinal helminths have been developed by traditional wisdom and therefore lack a proper validation through controlled studies. The aim of the present study was to scientifically validate the in vitro efficacy of three common Indian Ayurvedic anthelmintic drugs, viz. Krimimudgar Ras, Kriminol and Vidangasava in relation to the synthetic broad-spectrum anthelmintic drugs, praziquantel and albendazole. The in vitro testing of Ayurvedic anthelmintics was done against an intestinal cestode, Raillietina sp. and a nematode, Syphacia obvelata, employing 10 mg/ml, 30 mg/ml and 50 mg/ml concentrations of each medicine. The anthelmintic efficacy was judged on the basis of paralysis and mortality time of worms after exposing to these Ayurvedic drugs. Of the three tested Ayurvedic medicines, Krimimudgar ras (KR) showed the most prominent efficacy, against both the cestode and nematode parasites. At 50 mg/ml concentration, KR caused mortality of cestodes in $7.53{\pm}0.15hr$, and of nematodes in $7.61{\pm}0.19hr$. Vidangasava was found to be comparatively less effective against the tested helminth parasites. The results of this study indicate that Ayurvedic formulations do possess significant anthelmintic effects, however, an evidence-based research is required to validate all currently used Ayurvedic anthelmintics, using proper controlled studies.

키워드

참고문헌

  1. Abdurahiman PA. Problems and prospects of Ayurvedic medicines manufacturing units in the northern region of Kerala with special reference to marketing. Thesis. Department of Commerce and Management Studies, University of Calicut;2004.
  2. Abhilasha, Dubey VS. Combined effect of Vidanga and Kampillaka on krimi roga with respect to round worms. J Ayurveda Integr Med Sci. 2017; 2:100-106.
  3. Anonymous. The Ayurvedic Pharmacopeia of India. Part-II (Formulations). Volume 1. First Edition. Government of India, Ministry of Health & Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homeopathy, New Delhi; 2014.
  4. Anwikar S, Bhitre M. Study of the synergistic antiinflammatory activity of Solanum xanthocarpum Schrad and Wendl and Cassia fistula Linn. Int J Ayurveda Res. 2010; 1:167-171. https://doi.org/10.4103/0974-7788.72489
  5. Barik CS, Kanungo SK, Tripathy NK, Panda JR, Padhi M. A review on therapeutic potential of polyherbal formulations. Int J Pharm Sci Drug Res. 2015; 7:211-228.
  6. Bauri RK, Tigga MN, Kullu SS. A review on use of medicinal plants to control parasites. Indian J Nat Prod Resour. 2015; 6:268-277.
  7. Bhagyalakshmi BR, Galib R, Nariya M, Prajapati PK. Antitussive activity of Shwasakuthara rasa, a herbo-mineral formulation prepared with and without Kajjali (Black Sulphide of Mercury) in SO2 induced cough in Swiss albino mice. J Phytopharmacol. 2016; 5: 50-52.
  8. Bhandari U, Ansari MN. Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusioninduced focal cerebral ischemia in rats. Indian J Pharmacol. 2008; 40:215-220. https://doi.org/10.4103/0253-7613.44153
  9. Bose A, De K, Saroch V. A review on latest developments in the standardization of Ayurvedic drugs. Int J Pharm Res Biosci. 2012; 1:96-119.
  10. Challam M, Roy B, Tandon V. In vitro anthelmintic efficacy of Carex baccans (Cyperacea): ultrastructural, histochemical and biochemical alterations in the cestode Raillietina echinobothrida. J Parasit Dis. 2012; 36:81-86. https://doi.org/10.1007/s12639-011-0087-7
  11. Danga SK, Bombarde DT, Pinge CD, Gulhane CM, Shubhangi P. A clinical study of Khadiradi Kashaya in Purishaj krimi with special reference to worm infestation. Int J Ayurveda Med. 2014; 5:315-320.
  12. Das C, Ghosh G, Das D. Ayurvedic liquid dosage form Asava and Arishta: An overview. Indian J Pharma Educ Res. 2017;51:169-176. https://doi.org/10.5530/ijper.51.2.22
  13. Dunn JC, Turner HC, Tun S, Anderson RM. Epidemiological surveys of, and research on, soil-transmitted helminths in Southeast Asia: a systematic review. Parasit Vectors. 2016;9:31. https://doi.org/10.1186/s13071-016-1310-2
  14. Dwivedi A, Dwivedi S, Sitoke AK, Patel R, Jhade D. Anthelmintic activity of a polyherbal preparation. Ethnobotanical Leaflets. 2009; 13:259-262.
  15. Dwivedi V, Anandan EM, Mony RS, Muraleedharan TS, Valiathan MS, Mutsuddi M, Lakhotia SC. In vivo effects of traditional ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications. PloS ONE 2012; 7:e37113. https://doi.org/10.1371/journal.pone.0037113
  16. Gogoi S, Yadav AK. In vitro and in vivo anthelmintic effects of Caesalpinia bonducella (L.) Roxb. leaf extract on Hymenolepis diminuta (Cestoda) and Syphacia obvelata (Nematoda). J Intercult Ethnopharmacol 2016; 5:427-433. https://doi.org/10.5455/jice.20160821024821
  17. Jabbar A, Zaman MA, Iqbal Z, Yaseen M, Shamim A. Anthelmintic activity of Chenopodium album (L) and Caesalpinia crista (L) against trichostrongylid nematodes of sheep. J Ethnopharmcol. 2007; 114:86-91. https://doi.org/10.1016/j.jep.2007.07.027
  18. Katoch D, Sharma JS, Banerjee S, Biswas R, Das B, Goswami, D, Harwansh RK, Katiyar CK, Mukherjee PK. Government policies and initiatives for development of Ayurveda. J Ethnopharmacol. 2017; 197:25-31. https://doi.org/10.1016/j.jep.2016.08.018
  19. Kattula D, Sarkar R, Ajjampur SSR, Minz S, Levecke B, Muliyil J, Kang G. Prevalence & risk factors for soiltransmitted helminth infection among school children in South India. Indian J Med Res. 2014; 139:76-82.
  20. Lobo DA, Velayudhan R, Chatterjee P, Kohli H, Hotez PJ. The neglected tropical diseases of India and South Asia: Review of their prevalence, distribution and control or elimination. PLoS Negl Trop Dis. 2011; 5: e1222. https://doi.org/10.1371/journal.pntd.0001222
  21. Mohandas S, Sreekumar TR, Prakash V. Anthelmintic activity of Vidangadi churna. Asian J Pharm Clin Res. 2013; 6:94-95.
  22. Nirmal SA, Gagare PB, Dighe SB, Kadam SL, Ishatake SH. Anthelmintic activity of some existing polyherbal Ayurvedic formulations. Pharmacologyonline. 2008; 3:76-79.
  23. Rajput A, Pal SC, Patel B. Phytochemical screening, antibacterial activity and physicochemical evaluation of leaves of Butea monosperma. Int J Pharm Pharm Sci. 2011; 3:189-191.
  24. Reddy BU, Seetharam YN. Anthelmintic activity of Trikatu churna and its ingredients. Ethnobotanical Leaflets. 2009; 13:532-539.
  25. Sayyad R, Wagh S, Virkar S, Ubale G. Anthelmintic activity of aqueous and methanolic extract of krumina tablet- a polyherbal formulation. Int J Pharm Lif Sci. 2014; 5:3813-3816.
  26. Singh K, Verma B. Scope of Herbal Anthelmintics: An Ayurvedic perspective. Int J Res Ayurveda Pharm. 2013; 4:589-594. https://doi.org/10.7897/2277-4343.04428
  27. Singh RK, Rajagopala S, Patel KS. Krimighna Dashemani - An Ayurvedic Anthelmintic Compound for Hymenolepis nana- A Case Study. A Case Study. http://docplayer.net/47406919-Krimighna-dashemani-an-ayurvedic-anthelmintic-compoundfor-hymenolepis-nana-a-case-study-rakesh-kumar-singhrajagopala-s-k-s.html. Punarnav: Int Peer Rev Ayurveda J. 2014; 2:1-6.
  28. Srinivasulu B, Dev PB, Murthy PHC. X-ray diffraction analysis of samaguna balijarita kajjali (Black sulphide of mercury). Int J Res Ayurveda Pharm. 2012; 3: 524-527.
  29. Thite SV, Chavan YR, Aparadh VT, Kore BA. Preliminary phytochemical screening of some medicinal plants. Int J Pharm Chem Biol Sci. 2013; 3:87-90.
  30. Thooyavan G, Kathikeyan J, Govindarajalu B. Anthelmintic activity of Abutilon indicum leaf extract on sheep tapeworm Moniezia expansa in vitro. J Pharmacogn Phytochem. 2018; 7:317-321.
  31. Verma NS, Gupta P, Shah P. Investigation of anthelmintic activity of polyherbal preparation. Int J Pharm Lif Sci. 2011; 2:590-591.
  32. Vijaya, Yadav AK. In vitro anthelmintic assessment of selected phytochemicals against Hymenolepis diminuta, a zoonotic tapeworm. J Parasit Dis. 2016; 40:1082-1086. https://doi.org/10.1007/s12639-014-0560-1

피인용 문헌

  1. Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies vol.49, pp.20, 2018, https://doi.org/10.1080/00397911.2019.1639754