• Communications for Statistical Applications and Methods
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• 제29권2호
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• pp.239-250
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• 2022

In many applications, we frequently encounter correlated multiple outcomes measured on the same subject. Joint modeling of such multiple outcomes can improve efficiency of inference compared to independent modeling. For instance, in developmental toxicity studies, fetal weight and number of malformed pups are measured on the pregnant dams exposed to different levels of a toxic substance, in which the association between such outcomes should be taken into account in the model. The number of malformations may possibly have many zeros, which should be analyzed via zero-inflated count models. Motivated by applications in developmental toxicity studies, we propose a Bayesian joint modeling framework for continuous and count outcomes with excess zeros. In our model, zero-inflated Poisson (ZIP) regression model would be used to describe count data, and a subject-specific random effects would account for the correlation across the two outcomes. We implement a Bayesian approach using MCMC procedure with data augmentation method and adaptive rejection sampling. We apply our proposed model to dose-response analysis in a developmental toxicity study to estimate the benchmark dose in a risk assessment.

• 대한물리의학회지
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• 제2권1호
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• pp.85-91
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• 2007

Purpose : The purpose of this study is understanding of Rett Syndrome. Rett Syndrome is a common developmental - neurologic disorder that has been reported almost exclusively in female. Recently mutations in the gene encoding X-linked methyl-CpG binding protein 2 (MECP2) have been identified as the cause of Rett syndrome. Consistent with the diagnostic criteria, hand skills, verbal or non - verbal communication skills and common motor skills were lost during regression. Regression most commonly occurred between 12 and 18 months of age. Methods : This is a literature study with books, articles, web site for Rett syndrome international association. Results : There is a continuing need to further elucidate the pre- and post - regression features of Rett syndrome. Rett syndrome need to physical therapy, musical therapy, special education and medical interventions. Conclusion : There has not been therapeutic method to the root of Rett syndrome but our goal is relaxation of symptom and physical therapist's study of Rett syndrome.

• Journal of Interdisciplinary Genomics
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• 제3권1호
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• pp.13-20
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• 2021

Developmental and epileptic encephalopathies are the most devastating early-onset epilepsies, characterized by early-onset seizures that are often intractable, electroencephalographic abnormalities, developmental delay or regression, and various comorbidities. A large number of underlying genetic variants of developmental and epileptic encephalopathies have been identified over the past few decades. However, the most thorough sequencing studies leave 60-65% of patients without a molecular diagnosis. This review explores the genetic basis of developmental and epileptic encephalopathies that start within the first year of life, including Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, infantile spasms, and Dravet syndrome. The purpose of this review is to give an overview and encourage the clinicians to start considering genetic testing as an important investigation along with electroencephalogram for better understanding and management of developmental and epileptic encephalopathies.

• Child Health Nursing Research
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• 제26권2호
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• pp.131-139
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• 2020

Purpose: This study was conducted to identify factors related to developmental care performance among neonatal intensive care units (NICU) nurses. Methods: The participants were 139 nurses who had provided care to premature infants for more than 6 months and were recruited from the NICU of 8 hospitals. Data were collected from September 1 to December 1, 2017 through questionnaires that encompassed developmental care performance, developmental care perceptions, and the nursing work environment. Results: More than half (51.8%) of the participants responded that they had never received developmental care education, and for 89.6% of those who had received developmental care education, it was a one-time event. The average developmental care performance of NICU nurses was 0.81, with a range of 0.5~1 point. Multiple regression analysis, demonstrated that the nursing work environment (β=.27, p=.001) and developmental care perceptions (β=.23, p=.004) influenced developmental care performance, with a total explanatory power of 14%. Conclusion: Based on these results, developmental care education for the NICU nurses must be provided systematically. In addition, strategies to improve nurses' perceptions of developmental care and to provide appropriate support for the nursing work environment can promote developmental care performance.

• 한국융합학회논문지
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• 제11권4호
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• pp.333-341
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• 2020

이 연구는 발달장애인의 평생교육 참여의사에 영향을 미치는 변인을 탐색함으로써 발달장애인 평생교육 활성화를 위한 기초 자료를 제시하기 위해 수행되었다. 2017년 장애인실태조사 원자료 중 발달장애인을 대상으로 한 자료를 활용하였고, 발달장애인의 평생교육 참여의사를 종속변수로 발달장애인의 평생교육 참여의사에 영향을 미칠 수 있는 16개 변인을 독립변수로 각각 설정하여 로지스틱 회귀분석을 실시하였다. 연구결과, 발달장애인의 성, 연령, 장애정도, 가족지지, 생활만족도, 수단적일상생활수행능력이 발달장애인의 평생교육 참여의사에 유의미한 영향을 미치는 변인으로 탐색되었다. 따라서 발달장애인 평생교육 활성화를 위해서는 기관, 관련 인력 및 프로그램 확대와 같은 인프라 구축뿐만 아니라 발달장애인이 평생교육에 참여하고자 하는 의지를 향상시킬 수 있는 방안도 함께 마련될 필요가 있다.

• Child Health Nursing Research
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• 제14권3호
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• pp.261-268
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• 2008

Purpose: This study was conducted to estimate the prevalence of questionable development according to developmental screening testing for children, and to explore biological and environmental risk factors of developmental delays. Method: The study participants were 153 children under two years of age. A questionnaire and Home Observation for measurement of the Environment (HOME) inventory were used to collect data, and Korean Denver II was administered. Results: The overall prevalence of questionable development was 11.1%. Significant differences in biological factors between the normal development group and questionable development group were the rate of prematurity, twins, the educational level of mother and father's and the presence of an illness in the mother (p<.10). Maternal acceptance in HOME was significantly different between the two groups. The factors related to questionable development that were significant in the logistic regression analysis were prematurity (OR=3.56, p=.026), and maternal acceptance in HOME score (OR=.629, p=.028). Conclusion: Early developmental screening tests seem necessary for all children, especially for prematurely born children. Also, child rearing environments were identified as significant factors in the development of all children. These findings suggest that the HOME scores might be useful in identifying children at risk for developmental delays, and that interventions for these children will probably be more effective if their mothers are helped to provide a more appropriate social environment.

• 가정과삶의질연구
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• 제22권2호
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• pp.13-21
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• 2004

This study examined the role of maternal attribution in parenting behaviors of mothers who have a child with developmental disabilities. Using an attributional model, it assessed whether maternal attributions about the child's knowledge, capacity, expectation, and responsibility for behavior problems have effects on maternal behaviors of affect, authoritarian control, and overprotect. The sample consisted of 161 mothers of elementary children with developmental disabilities. Multivariate regression analysis revealed that maternal attribution about the child's capacity for misbehavior had positive influence on maternal affect and negative influence on authoritarian control behaviors, and that maternal attribution of responsibility for misbehavior positively influenced maternal authoritarian control and overprotect behaviors. Also, maternal attribution about the child's knowledge for misbehavior had negative influence on maternal overprotect behaviors. In addition, such background factors as number of disability, maternal education, and job of mother were significant predictors for maternal attribution, while maternal self-esteem was a strong significant predictor for mothering behaviors. The findings suggest the importance of maternal attributions in parenting.

• Imaging Science in Dentistry
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• 제44권3호
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• pp.185-191
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• 2014

Purpose: This study investigated the developmental stages of third molars in relation to chronological age and compared third molar development according to location and gender. Materials and Methods: A retrospective analysis of panoramic radiographs of 2490 patients aged between 6 and 24 years was conducted, and the developmental stages of the third molars were evaluated using the modified Demirjian's classification. The mean age, standard deviation, minimal and maximal age, and percentile distributions were recorded for each stage of development. A Mann-Whitney U test was performed to test the developmental differences in the third molars between the maxillary and mandibular arches and between genders. A linear regression analysis was used for assessing the correlation between the third molar development and chronological age. Results: The developmental stages of the third molars were more advanced in the maxillary arch than the mandibular arch. Males reached the developmental stages earlier than females. The average age of the initial mineralization of the third molars was 8.57 years, and the average age at apex closure was 21.96 years. The mean age of crown completion was 14.52 and 15.04 years for the maxillary and the mandibular third molars, respectively. Conclusion: The developmental stages of the third molars clearly showed a strong correlation with age. The third molars developed earlier in the upper arch than the lower arch; further, they developed earlier in males than in females.

• 한국보육지원학회지
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• 제17권1호
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• pp.19-37
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• 2021

Objective: This study aimed to explore the effect of the national preschool curriculum on children's development in Korea, focusing on teachers' daily practice. By comparing the effect of the teachers' curriculum practice to that of quantitatively measured free play, it tried to add practical implications beyond the statistical significance. Methods: Participants were 512 three-year-old children who participated in the Panel Study of Korean Children and their teachers. National curriculum practice and free play time at the age of three was put in the hierarchical linear regression models to discover children's developmental outcomes at the age of four, in domains of language, cognitive development, and social development. Results: Results demonstrated the significant positive influence of national curriculum practice on every domain of developmental outcomes. However, no facilitative influence of free play time was observed. Conclusion/Implications: The importance of teachers' practice of the national curriculum was emphasized. It was implied that the quantity of free play time itself did not assure the sound development of children. Policy implications were discussed regarding teacher practice and education.

• International Journal of Industrial Entomology and Biomaterials
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• 제33권2호
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• pp.50-53
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• 2016

The size of head capsule is one of the most important factors for identifying developmental stage. In order to understand the developmental characteristics of the butterfly Atrophaneura alcinous, we examined fluctuations in larval head capsule size under three different temperature conditions (20, 25, and $30^{\circ}C$) and 60% humidity. As a result, larvae developed to the fifth instar at all three temperatures. The head capsule size of larvae tended to be larger at the lowest temperature and smaller at the highest temperature. The development rate showed a regular change, consistent with Dyar's rule regarding head capsule size development. Furthermore, the development of head capsule size was found to correspond to a second degree polynomial regression better than to a linear regression. On the basis of these results, it would appear to be possible to perform an accurate assessment of instar status during the development of A. alcinous.