• 대한생식의학회:학술대회논문집
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• 대한불임학회 2002년도 제42차 춘계학술대회
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• pp.11-17
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• 2002

Animal clones derived from somatic cells have been successfully produced in a variety of mammalian species such as sheep, cattle, mice, goats, pigs, cat and rabbits. However, there are still many unsolved problems in the present cloning technology. Somatic cell nuclear transfer has shown several developmental aberrancies including high rate of abortion in early gestation and increased perinatal death. These developmental failures of cloned embryos may arise from abnormal reprogramming of donor genome and/or incomplete cloning procedure. We have found that overall genomic methylation status of cloned bovine embryos is quite different from that of normal embryos in various genomic regions, suggesting that the developmental failures of cloned embryos may be due to incomplete reprogramming of donor genomic DNA. Many of the advances in understanding the molecular events for reprogramming of donor genome will more clarify the developmental defects of cloned embryos.

• 대한치과기공학회지
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• 제11권1호
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• pp.65-70
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• 1989

The development of the lobe pattern in the human dentition plays a part in the form and function of each individual teeth. In order to determin the morphological categories used to describe the occlusal surfaces of the maxillary and mandibular molars, the variation of the developmental grooves which separate each lobe in the molars was examined and analysed. The obtained conclusions were as follow. 1. Most of the maxillary first molars with more distinct and more developmental grooves than the other molars but in most cases of the third molar, a heart-shaped outline due to poorly developed or abscent distolingual cusp was most frequent and in this case the third molar had the 3 cusps separated by the central developmental groove and the buccal developmental groove. 2. In most cases, the mandibular first molar had the 5-cusp type that the groove patter resembles a Y, the second molar the 4-cusp type arranged in such a way that the buccal and lingual developmental grooves meet the central developmental groove at right angle on the occlusal surface and many instances of the mandibular third molars had the 5-cusp thpe with a+groove pattern which separatess the mesiolingual cusp from the distobuccal cusp and the 4-cusp type with a+groove pattern. 3. The maxillary and mandibular third molar were most variable in the developmental groove.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.149-149
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• 2003

It is well known that many pesticides possess hormonal activity, and thus have been classified as endocrine disruptors. Currently, pyrethroid insecticides are in worldwide use to control in door pests, providing potential for environmental exposure. A few studies of hormonal activities of these pyrethroid insecticides, however, have been reported, and are controversial between studies.(omitted)

• 한국학교ㆍ지역보건교육학회지
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• 제22권1호
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• pp.25-35
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• 2021

Objectives: This study examined the relations among 5 personality factors, self-regulatory efficacy and subjective well-being in parents with developmental disabilities. This study also examined the mediating effect of self-regulatory efficacy on the relationship between 5 personality factors and subjective well-being in parents with developmental disabilities. Methods: The research subjects consisted of 114 parents with developmental disabilities. They completed questionnaires 5 personality factors, self-regulatory efficacy and subjective well-being by parents. The data were analyzed by SPSS 22.0 program. Results: The results of this study showed that 5 personality factors-neuroticism and extroversion-had a direct effect on subjective well-being in parents with developmental disabilities. Second, 5 personality factors-extroversion- had an indirect effect on the subjective well-being through self-regulatory efficacy in parents with developmental disabilities. Conclusions: These findings have implications for future research and practice by highlighting the importance of self-regulatory efficacy in subjective well-being in parents with developmental disabilities.

• International Journal of Advanced Culture Technology
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• 제9권4호
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• pp.52-60
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• 2021

This study is conducted with the aim of redefining the university-based lifelong education support system for developmental disabled. The research method consisted of procedures in parallel with literature analysis and expert meetings. As for the contents of the study, a composition system that recognized the problems and solutions of lifelong education for the developmental disabled based on universities was primarily presented. Through this, it was suggested that universities can form an academic foundation for the establishment of a lifelong education support system for the developmental disabled along with the convergence field. In addition, a structural model related to this was presented along with the aspect that universities could develop a curriculum for lifelong education for the developmental disabled according to the school foundation. Also, a composition system was suggested that universities can develop lifelong education curriculum for people with developmental disabilities to lead the cooperation of local related organizations such as welfare centers for the disabled and lifelong education centers for the developmentally disabled. As a result of the study, it was analyzed that leadership in the university-based lifelong education support system for developmental disabled can contribute to fostering professional manpower qualifications and establishing cooperation with local related organizations in an integrated composition system.

• PNF and Movement
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• 제22권1호
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• pp.81-90
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• 2024

Purpose: This study examined the perceived quality of life of families of individuals with developmental disabilities who regularly participate in physical activities. It also explored differences in the quality of family life based on variables such as family relationships, family income, gender, disability type, and age. Methods: A survey was administered to 69 family members of individuals with developmental disabilities who regularly participate in physical activities. The collected data were analyzed using descriptive statistics, independent samples t-test, and one-way analysis of variance. Results: The average overall quality of life for families of individuals with developmental disabilities who participate in continuous physical activities was 3.49. After analyzing each subtype, psychological health was found to be 3.91, the burden for people with developmental disabilities was 2.75, community participation was 3.76, cohesion was 3.83, and openness was 3.49. No statistically significant differences were found in family relationships or family classes, disability type, age, or gender of the individuals with developmental disabilities across the variables. Conclusion: When planning service development and support to improve the quality of life for families of individuals with developmental disabilities, it is necessary to develop systematic programs at the family level rather than providing support based on various variables.

• 디지털융복합연구
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• 제16권2호
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• pp.65-71
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• 2018

본 연구는 대학생들의 발달장애인 선거권에 대한 인식을 알아보는데 목적이 있다. 광주광역시의 A대학교와 B대학교에 재학 중인 학생들을 대상으로 편의표집을 통해 최종 370명의 자료를 분석하였다. 분석결과, 장애관련 강좌를 수강한 적이 있는 경우에 발달장애인의 선거권에 대한 인식이 높은 것으로 나타났다. 둘째, 장애관련 봉사 참여 횟수가 많을수록 발달장애인의 선거권에 대한 인식이 높은 것으로 나타났다. 셋째, 발달장애인의 참정권 필요하다고 응답한 경우가 그렇지 않은 경우보다 선거권의 인식이 긍정적인 것으로 나타났다. 이러한 결과를 통해 대학생을 포함한 비장애인들이 발달장애인의 선거권에 대한 긍정적인 태도와 인식을 확립하기 위한 방안 모색이 필요함을 제언하였다.

• The Korean Journal of Ecology
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• 제6권1호
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• pp.55-65
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• 1983

The authors reared the ash-gray leaf bug, Piesma maculata in the growth cabinet controlled as temperature groups of $15, 20, 25, 30, 40^{\circ}C$under condition of photoperiod 16L:8D, light intensity $510{\pm}240$ lus, relative humidity $65{\pm}3%$, and analyzed the effects of temperature on the development of the insect. The results are summarized as follow: There are highly significant differences the developmental periods for the temperature groups, and between the developmental periods for the developmental stages. The egg in the temperature of 15 and $40^{\circ}C$ was hatched, but the ecdysis was impossible. The thermal threshold was $12.34^{\circ}C$and the upper lethal temperature $40.39^{\circ}C$. The total developmental periods of egg to adulate in the temperature of 20, 25, 30 and $35^{\circ}C$are 40.52, 22.37, 15.91 and 13.00 days, respectively. That is, the developmental period was decreased, as the temperature was increased. In the developmental period for the developmental stages, the developmental period of egg stage was longer than that of 25, 30 and $35^{\circ}C$, and that of 25。C was longer than that of $35^{\circ}C$. But ther was not significant differences between the developmental periods for the other temperature group. The rate of hatch at$20^{\circ}C$is the greater value as 90%, and the rates of 25, 30 and $35^{\circ}C$ are 79, 79 and 67%, respectively. That is the rate of hatch was decreased, as the temperature was increased. The mortality in the temperature of $35^{\circ}C$ is the greatest value as 68%, and those of 30, 25 and $20^{\circ}C$are 59, 59 and 41%, respectively. That is, the mortality was increased, as the temperature was increased. There was not significantly differences between the developmental period of female and male.

• 벤처창업연구
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• 제3권1호
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• pp.57-72
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• 2008

본 논문에서는 그동안 부분적으로 진행된 발달장애 진단 평가에 관련된 전산처리를 멀티미디어 기법을 응용하여 발달장애 진단 평가분야에 새로운 방법을 제시한다. 발달장애 진단 평가를 위한 멀티미디어 정보는 여러 가지 속성을 지니고 있기 때문에 모든 발달장애 진단 평가 정보에 대한 기술을 사람이 수행해야 할 때는 엄청난 작업량이 수반될 뿐 아니라 동일한 데이터에 대한 기술이 주관에 따라 달라질 수도 있다는 것을 알게 되였다. 특히 발달장애 시스템 구현은 현재의 컴퓨팅 환경에서의 동영상 데이터 처리에 대한 비중의 증가, 텍스트 위주의 데이터에서 시각적인 동영상으로의 데이터 활용의 전이 등 발달장애 데이터가 멀티미디어 환경에 적합한 데이터로의 전이가 필수적이며 사용자 역시 빠른 이해를 위해 시각적 데이터를 선호하기 때문에 본 논문에서는 GUI(Graphics User Interface) 기법을 도입하여 검사 중에 텍스트 명령어는 거의 사용하지 않고도 발달장애 진단 평가를 수행할 수 있게 했다. 특히 발달장애 진단 평가에서 필요한 각종 데이터는 그 속성이 영상, 이미지, 논리연산의 필요성 및 각종 연산이 요구된다. 그래서 본 논문에서는 문제점을 해결하기 위해 편집대상 데이터(Content)에 의해 관련 정보를 검색하는 내용 기반(Content-based)의 검색 기술에 대한 연구를 적용했다.

• Journal of Ginseng Research
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• 제48권3호
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• pp.333-340
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• 2024

Background: Korean red ginseng (KRG) is a product from ginseng roots, which is enriched with ginsenosides and has been utilized for a long time as an adaptogen to alleviate various physiological or disease conditions. While KRG is generally considered safe, conducting a thorough toxicological assessment of the spray-dried powder G1899 during the juvenile period is essential to establish its safety profile. This study aimed to assess the safety of G1899 during the juvenile period using Sprague-Dawley rats. Methods: Two studies were conducted separately: a juvenile toxicity study and a uterotrophic bioassay. To assess the potential toxicity at systemic, postnatal developmental, and reproductive levels, G1899 was orally gavaged once a day in post-weaning juvenile Sprague-Dawley (SD) rats at 0, 1250, 2500, or 5000 mg/kg/day. Estrogenicity was assessed by orally gavaging G1899 in immature female SD rats at 0, 2500, or 5000 mg/kg/day on postnatal days (PND) 19-21, followed by a uterotrophic bioassay. These studies were conducted in accordance with the Good Laboratory Practice (GLP) regulations and regulatory test guidelines. Results: Regarding juvenile toxicity, no abnormalities related to the G1899 treatment were observed in any group during the experiment. Moreover, no uterotrophic responses were observed in the dosed female group. Based on these results, the no observed adverse effect level (NOAEL) of G1899 was determined to be at least 5000 mg/kg/day for general systemic function, developmental/reproductive function, and estrogenic activity. Conclusion: Our results suggest that G1899 is not toxic to juveniles at doses of up to 5000 mg/kg/day.