• Title/Summary/Keyword: Developmental

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Reprogramming of Cloned Embryos During Early Embryogenesis (초기 발생에 있어서 복제수정란의 리프로그래밍)

  • Han, Yong-Mahn;Kang, Yong-Kook;Koo, Deog-Bon;Lee, Kyung-Kwang
    • 대한생식의학회:학술대회논문집
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    • 2002.05a
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    • pp.11-17
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    • 2002
  • Animal clones derived from somatic cells have been successfully produced in a variety of mammalian species such as sheep, cattle, mice, goats, pigs, cat and rabbits. However, there are still many unsolved problems in the present cloning technology. Somatic cell nuclear transfer has shown several developmental aberrancies including high rate of abortion in early gestation and increased perinatal death. These developmental failures of cloned embryos may arise from abnormal reprogramming of donor genome and/or incomplete cloning procedure. We have found that overall genomic methylation status of cloned bovine embryos is quite different from that of normal embryos in various genomic regions, suggesting that the developmental failures of cloned embryos may be due to incomplete reprogramming of donor genomic DNA. Many of the advances in understanding the molecular events for reprogramming of donor genome will more clarify the developmental defects of cloned embryos.

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A study on the variation of the developmental grooves on the occlusal surface of the permanent molars in Korea (영구대구치(永久大臼齒)의 교합면상(咬合面上)에 나타난 발육구(發育溝)의 변이(變異)에 관(關)한 연구(硏究))

  • Lee, Young-Eun
    • Journal of Technologic Dentistry
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    • v.11 no.1
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    • pp.65-70
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    • 1989
  • The development of the lobe pattern in the human dentition plays a part in the form and function of each individual teeth. In order to determin the morphological categories used to describe the occlusal surfaces of the maxillary and mandibular molars, the variation of the developmental grooves which separate each lobe in the molars was examined and analysed. The obtained conclusions were as follow. 1. Most of the maxillary first molars with more distinct and more developmental grooves than the other molars but in most cases of the third molar, a heart-shaped outline due to poorly developed or abscent distolingual cusp was most frequent and in this case the third molar had the 3 cusps separated by the central developmental groove and the buccal developmental groove. 2. In most cases, the mandibular first molar had the 5-cusp type that the groove patter resembles a Y, the second molar the 4-cusp type arranged in such a way that the buccal and lingual developmental grooves meet the central developmental groove at right angle on the occlusal surface and many instances of the mandibular third molars had the 5-cusp thpe with a+groove pattern which separatess the mesiolingual cusp from the distobuccal cusp and the 4-cusp type with a+groove pattern. 3. The maxillary and mandibular third molar were most variable in the developmental groove.

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Uterotrophic Assays of Pyrethroid Insecticides in Immature Rats

  • Kim, Soon-Sun;Rhee, Gyu-Seek;Lee, Rhee-Da;Kwack, Seung-Jun;Lim, Kwon-Jo;Yhun, Hyo-Jung;Park, Kwang-Sik;Park, Kui-Lea
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.10b
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    • pp.149-149
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    • 2003
  • It is well known that many pesticides possess hormonal activity, and thus have been classified as endocrine disruptors. Currently, pyrethroid insecticides are in worldwide use to control in door pests, providing potential for environmental exposure. A few studies of hormonal activities of these pyrethroid insecticides, however, have been reported, and are controversial between studies.(omitted)

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The Effects of 5 Personality factors on Subjective Well-Being in Parents with Developmental Disabilities: The Mediating Effects of self-regulatory efficacy (발달장애인 부모의 성격 5요인이 주관적 안녕감에 미치는 영향: 자기조절효능감을 매개로)

  • Kim, MinKyeong;Kim, Min-Jung
    • The Journal of Korean Society for School & Community Health Education
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    • v.22 no.1
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    • pp.25-35
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    • 2021
  • Objectives: This study examined the relations among 5 personality factors, self-regulatory efficacy and subjective well-being in parents with developmental disabilities. This study also examined the mediating effect of self-regulatory efficacy on the relationship between 5 personality factors and subjective well-being in parents with developmental disabilities. Methods: The research subjects consisted of 114 parents with developmental disabilities. They completed questionnaires 5 personality factors, self-regulatory efficacy and subjective well-being by parents. The data were analyzed by SPSS 22.0 program. Results: The results of this study showed that 5 personality factors-neuroticism and extroversion-had a direct effect on subjective well-being in parents with developmental disabilities. Second, 5 personality factors-extroversion- had an indirect effect on the subjective well-being through self-regulatory efficacy in parents with developmental disabilities. Conclusions: These findings have implications for future research and practice by highlighting the importance of self-regulatory efficacy in subjective well-being in parents with developmental disabilities.

THE REDEFINITION OF SUPPORT SYSTEM FOR LIFELONG EDUCATION FOR THE DEVELOPMENTAL DISABLED BASED ON UNIVERSITY: LEADING THE ESTABLISHMENT OF AN INTEGRATED COMPOSITION SYSTEM BETWEEN COOPERATION WITH LOCAL RELATED ORGANIZATIONS AND FOSTERING QUALIFICATIONS FOR PROFESSIONALS THROUGH CONNECTION WITH CURRICULUM BEYOND THE LEVEL OF USE OF PHYSICAL SPACE

  • Kim, Young-Jun;Kim, Wha-Soo;Rhee, Kun-Yong
    • International Journal of Advanced Culture Technology
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    • v.9 no.4
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    • pp.52-60
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    • 2021
  • This study is conducted with the aim of redefining the university-based lifelong education support system for developmental disabled. The research method consisted of procedures in parallel with literature analysis and expert meetings. As for the contents of the study, a composition system that recognized the problems and solutions of lifelong education for the developmental disabled based on universities was primarily presented. Through this, it was suggested that universities can form an academic foundation for the establishment of a lifelong education support system for the developmental disabled along with the convergence field. In addition, a structural model related to this was presented along with the aspect that universities could develop a curriculum for lifelong education for the developmental disabled according to the school foundation. Also, a composition system was suggested that universities can develop lifelong education curriculum for people with developmental disabilities to lead the cooperation of local related organizations such as welfare centers for the disabled and lifelong education centers for the developmentally disabled. As a result of the study, it was analyzed that leadership in the university-based lifelong education support system for developmental disabled can contribute to fostering professional manpower qualifications and establishing cooperation with local related organizations in an integrated composition system.

Investigation of Quality of Life for Families with Developmental Disabilities Participating in Regular Physical Activity (규칙적 신체활동에 참여하는 발달장애인 가족의 삶의 질 검증)

  • Seung-Jun Choi
    • PNF and Movement
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    • v.22 no.1
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    • pp.81-90
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    • 2024
  • Purpose: This study examined the perceived quality of life of families of individuals with developmental disabilities who regularly participate in physical activities. It also explored differences in the quality of family life based on variables such as family relationships, family income, gender, disability type, and age. Methods: A survey was administered to 69 family members of individuals with developmental disabilities who regularly participate in physical activities. The collected data were analyzed using descriptive statistics, independent samples t-test, and one-way analysis of variance. Results: The average overall quality of life for families of individuals with developmental disabilities who participate in continuous physical activities was 3.49. After analyzing each subtype, psychological health was found to be 3.91, the burden for people with developmental disabilities was 2.75, community participation was 3.76, cohesion was 3.83, and openness was 3.49. No statistically significant differences were found in family relationships or family classes, disability type, age, or gender of the individuals with developmental disabilities across the variables. Conclusion: When planning service development and support to improve the quality of life for families of individuals with developmental disabilities, it is necessary to develop systematic programs at the family level rather than providing support based on various variables.

A Study on the Perception of the Right to Vote of Persons with Developmental Disabilities in College Students: Based on the Experience of Disability Related Education (발달장애인 선거권에 대한 대학생의 인식 연구: 장애관련 교육경험 유무를 중심으로)

  • Lee, Woo-Jin;Kim, Tae-Gang
    • Journal of Digital Convergence
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    • v.16 no.2
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    • pp.65-71
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    • 2018
  • The purpose of this study is to examine the perception of the right to vote of persons with developmental disabilities in college students. College students attending in A University and B University in Gwangju Metropolitan City were selected using convenience sampling and 370 samples were finally analyzed. The results were as follows. First, the subjects who took a disability course had high perception of the right to vote of persons with developmental disabilities. Second, it was discovered that the more times people participated in the volunteer work related to disabilities, the more recognition they had on the voting rights of people with developmental disabilities. Third, the subjects who responded for the need for the political rights of persons with developmental disabilities had more positive perception of the right to vote of persons with developmental disabilities than those who did not responded. Based on the findings, it was suggested that methods should be investigated to establish positive attitude and perception of the right to vote of persons with developmental disabilities in persons without developmental disabilities including college students.

Effect of Temperature on the Development of the Ash-gray Leaf Bug, Piesma maculata (Insecta, Hemiptera, Piesmatidae) (온도가 두줄명아주노린재의 발육에 미치는 영향 (곤충망, 매미목, 명아주노린재과))

  • Park, Pil Ryoun;Sang Ock Park
    • The Korean Journal of Ecology
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    • v.6 no.1
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    • pp.55-65
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    • 1983
  • The authors reared the ash-gray leaf bug, Piesma maculata in the growth cabinet controlled as temperature groups of $15, 20, 25, 30, 40^{\circ}C$under condition of photoperiod 16L:8D, light intensity $510{\pm}240$ lus, relative humidity $65{\pm}3%$, and analyzed the effects of temperature on the development of the insect. The results are summarized as follow: There are highly significant differences the developmental periods for the temperature groups, and between the developmental periods for the developmental stages. The egg in the temperature of 15 and $40^{\circ}C$ was hatched, but the ecdysis was impossible. The thermal threshold was $12.34^{\circ}C$and the upper lethal temperature $40.39^{\circ}C$. The total developmental periods of egg to adulate in the temperature of 20, 25, 30 and $35^{\circ}C$are 40.52, 22.37, 15.91 and 13.00 days, respectively. That is, the developmental period was decreased, as the temperature was increased. In the developmental period for the developmental stages, the developmental period of egg stage was longer than that of 25, 30 and $35^{\circ}C$, and that of 25。C was longer than that of $35^{\circ}C$. But ther was not significant differences between the developmental periods for the other temperature group. The rate of hatch at$20^{\circ}C$is the greater value as 90%, and the rates of 25, 30 and $35^{\circ}C$ are 79, 79 and 67%, respectively. That is the rate of hatch was decreased, as the temperature was increased. The mortality in the temperature of $35^{\circ}C$ is the greatest value as 68%, and those of 30, 25 and $20^{\circ}C$are 59, 59 and 41%, respectively. That is, the mortality was increased, as the temperature was increased. There was not significantly differences between the developmental period of female and male.

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Developmental disability Diagnosis Assessment Systems Implementation using Multimedia Authorizing Tool (멀티미디어 저작도구를 이용한 발달장애 진단.평가 시스템 구현연구)

  • Byun, Sang-Hea;Lee, Jae-Hyun
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.3 no.1
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    • pp.57-72
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    • 2008
  • Serve and do so that graft together specialists' view application field of computer and developmental disability diagnosis estimation data to construct developmental disability diagnosis estimation system in this Paper and constructed developmental disability diagnosis estimation system. Developmental disability diagnosis estimation must supply information of specification area that specialists are having continuously. Developmental disability diagnosis estimation specialist system need multimedia data processing that is specialized little more for developmental disability classification diagnosis and decision-making and is atomized for this. Characteristic of developmental disability diagnosis estimation system that study in this paper can supply quick feedback about result, and can reduce mistake on recording and calculation as well as can shorten examination's enforcement time, and background of training is efficient system fairly in terms of nonprofessional who is not many can use easily. But, as well as when multimedia information that is essential data of system construction for developmental disability diagnosis estimation is having various kinds attribute and a person must achieve description about all developmental disability diagnosis estimation informations, great amount of work done is accompanied, technology about equal data can become different according to management. Because of these problems, applied search technology of contents base (Content-based) that search connection information by contents of edit target data for developmental disability diagnosis estimation data processing multimedia data processing technical development. In the meantime, typical access way for conversation style data processing to support fast image search, after draw special quality of data by N-dimension vector, store to database regarding this as value of N dimension and used data structure of Tree techniques to use index structure that search relevant data based on this costs. But, these are not coincided correctly in purpose of developmental disability diagnosis estimation because is developed focusing in application field that use data of low dimension such as original space DataBase or geography information system. Therefore, studied save structure and index mechanism of new way that support fast search to search bulky good physician data.

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Assessing systemic, developmental, and reproductive toxicity and estrogenicity of Korean red ginseng extract G1899 in juvenile Sprague-Dawley Rats

  • Sangyun Kim;Ji-Seong Jeong;Woojin Kim;Onju Ham;Yixian Quah;Soontag Jung;Dong-Ju Park;Min Jae Kim;Byung-Cheol Han;Eunji Kim;Seung-Jin Lee;Wook-Joon Yu
    • Journal of Ginseng Research
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    • v.48 no.3
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    • pp.333-340
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    • 2024
  • Background: Korean red ginseng (KRG) is a product from ginseng roots, which is enriched with ginsenosides and has been utilized for a long time as an adaptogen to alleviate various physiological or disease conditions. While KRG is generally considered safe, conducting a thorough toxicological assessment of the spray-dried powder G1899 during the juvenile period is essential to establish its safety profile. This study aimed to assess the safety of G1899 during the juvenile period using Sprague-Dawley rats. Methods: Two studies were conducted separately: a juvenile toxicity study and a uterotrophic bioassay. To assess the potential toxicity at systemic, postnatal developmental, and reproductive levels, G1899 was orally gavaged once a day in post-weaning juvenile Sprague-Dawley (SD) rats at 0, 1250, 2500, or 5000 mg/kg/day. Estrogenicity was assessed by orally gavaging G1899 in immature female SD rats at 0, 2500, or 5000 mg/kg/day on postnatal days (PND) 19-21, followed by a uterotrophic bioassay. These studies were conducted in accordance with the Good Laboratory Practice (GLP) regulations and regulatory test guidelines. Results: Regarding juvenile toxicity, no abnormalities related to the G1899 treatment were observed in any group during the experiment. Moreover, no uterotrophic responses were observed in the dosed female group. Based on these results, the no observed adverse effect level (NOAEL) of G1899 was determined to be at least 5000 mg/kg/day for general systemic function, developmental/reproductive function, and estrogenic activity. Conclusion: Our results suggest that G1899 is not toxic to juveniles at doses of up to 5000 mg/kg/day.