• Molecules and Cells
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• 제41권2호
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• pp.83-92
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• 2018

The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.

• 한국표면공학회지
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• 제32권3호
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• pp.423-427
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• 1999

Electroplating of 80%Ni permalloy thin plate for magnetic core materials. was studied The convected flow of electrolyte was used for stirring methode. The current density could be increased up to 250mA/$\textrm{cm}^2$ by flow cell. The composition of electroplated layer with vespect to current density and flow rate was investigated and experimental equation to predict the composition was made. How cell yielded more uniform thickness distribution than paddle cell did. The composition distribution was also studied. The thickness was the most important factor to the permeability. The permeability of 5$\mu\textrm{m}$plated permalloy was over 2000 at 1 MHz.

• BMB Reports
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• 제53권5호
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• pp.241-247
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• 2020

As an intracellular degradation system, autophagy is an essential and defensive cellular program required for cell survival and cellular metabolic homeostasis in response to various stresses, such as nutrient deprivation and the accumulation of damaged organelles. In general, autophagy flux consists of four steps: (1) initiation (formation of phagophore), (2) maturation and completion of autophagosome, (3) fusion of autophagosomes with lysosomes (formation of autolysosome), and (4) degradation of intravesicular components within autolysosomes. The number of genes and reagents that modulate autophagy is increasing. Investigation of their effect on autophagy flux is critical to understanding the roles of autophagy in many physiological and pathological processes. In this review, we summarize and discuss ways to analyze autophagy flux quantitatively and qualitatively with the use of imaging tools. The suggested imaging method can help estimate whether each modulator is an inhibitor or a promoter of autophagy and elucidate the mode of action of specific genes and reagents on autophagy processes.

• 반도체디스플레이기술학회지
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• 제19권4호
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• pp.94-98
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• 2020

The core/shell of nanowires (NWs) with Cu-doped CdSe quantum dots were fabricated as an electron transport layer (ETL) for perovskite solar cells, based on ZnO/TiO2 arrays. We presented CdSe with Cu2+ dopants that were synthesized by a colloidal process. An improvement of the recombination barrier, due to shell supplementation with Cu-doped CdSe quantum dots. The enhanced cell steady state was attributable to TiO2 with Cu-doped CdSe QD supplementation. The mechanism of the recombination and electron transport in the perovskite solar cells becoming the basis of ZnO/TiO2 arrays was investigated to represent the merit of core/shell as an electron transport layer in effective devices.

• BMB Reports
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• 제49권10호
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• pp.527-528
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• 2016

In embryonic stem cells (ESCs), cell cycle regulation is deeply connected to pluripotency. Especially, core transcription factors (CTFs) which are essential to maintaining the pluripotency transcription programs should be reset during M/G1 transition. However, it remains unknown about how CTFs are governed during cell cycle progression. Here, we describe that the regulation of Oct4 by Aurora kinase b (Aurkb)/protein phosphatase 1 (PP1) axis during the cell cycle is important for resetting Oct4 to pluripotency and cell cycle related target genes in determining the identity of ESCs. Aurkb starts to phosphorylate Oct4(S229) at the onset of G2/M phase, inducing the dissociation of Oct4 from chromatin, whereas PP1 binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle. Furthermore, Aurkb phosphormimetic and PP1 binding-deficient mutations in Oct4 disrupt the pluripotent cell cycle, lead to the loss of pluripotency in ESCs, and decrease the efficiency of somatic cell reprogramming. Based on our findings, we suggest that the cell cycle is directly linked to pluripotency programs in ESCs.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 추계종합학술대회 논문집(1)
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• pp.37-40
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• 2000

Multi Protocol Label Switching (MPLS) is a high performance method for forwarding packets (frames) through a network. It enables routers at the edge of a network to apply simple labels to packets (frames). we use MPLS in the core network for internet. MPLS provide high speed switching and traffic engineering in MPLS domain but at the Label Edge Router(LER) there is frequently cell discarding via congestion and buffer management method. It is one of the most important reasons retransmission and congestion. In this paper we propose advanced LER scheme that provide less cell loss rate also efficient network infrastructure.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1995년도 추계학술발표회논문집(1)
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• pp.85-90
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• 1995

A characteristic transport theory code CRX is developed and tested for cell and assembly calculations. Since the characteristic method treats explicitly (analytically) the streaming portion of the transport equation, CRX treats strong absorbers well and has no practical limitations placed on the geometry of the problem. To test the code, it was applied to three benchmark problems which consist of complex meshes and compared with other codes.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.881-882
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• 2005

• KIEE International Transactions on Electrophysics and Applications
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• 제4C권4호
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• pp.176-180
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• 2004

This paper presents the fabrication and test of a micro cell exciter actuated by an electromagnetic force for the study on the chondrogenic differentiation of rabbit mesenchymal stem cells (MSCs). The micro cell exciter is designed to apply compressive loading to the alginate gel mixed with the MSCs. The magnetic cell exciter consists of an actuator component and a cartridge-type chamber component. An actuator is composed of a permanent magnet, a core and a coil. The chamber has seven PMMA wells and a cell culture Petri dish. Two types of alginate gels were stimulated by the cell exciters for 10 minutes every 12 hours for 7 days. In order to determine the expression of these matrix components during differentiation, RT-PCR analysis was performed. Collagen type II was expressed in the MSCs subjected to the compressive stimulation.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2006년도 춘계종합학술대회
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• pp.927-930
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• 2006

마이크로프로세서 제조업체의 대명사로 불리는 인텔이 비메모리 시장을 거의 독점하고 있는 가운데, IBM, Sony, Toshiba 인 세 개의 기업이 도전적으로 힘을 합하여 차세대 엔터테인먼트 프로세서라고 불리는 멀티코어 기반의 Cell 프로세서를 개발하였다. Cell 프로세서는 기존의 Power 라는 아키텍쳐를 기반으로 하는 코어 PPE (Power processor Element)를 중심으로 8개의 데이터 처리용 코어 SPE(Synergistic processor Element)를 포함하고 있으며, SIMD(Single Input Multiple Data) 데이터 처리 방식을 지원하여 데이터 처리량이 많은 멀티미디어나 게임 어플리케이션을 처리하는데 최적화되도록 설계된 프로세서로서, 기본적으로는 Power 마이크로프로세서 아키텍쳐 및 구조에 대한 혁신적인 확장 기능을 포함하고 있다. 본 논문에서는 현존하는 프로세서 중 가장 성능이 우수하다고 평가받는 Cell 마이크로프로세서의 설계 개념과 그 구조에 대하여 분석한다.