• 성인간호학회지
• /
• 제17권4호
• /
• pp.539-547
• /
• 2005

Purpose: To examine an estimate factor and grasp the relation of difference for Type A Behavior Pattern(TABP), Perceived Stress Questionnaire, Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the $19^{th}$ of October to 10th of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP).These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.

• 대한본초학회지
• /
• 제32권1호
• /
• pp.1-13
• /
• 2017

Objective : Soybeans of Canavalia gladiata(CG) and root of Arctium lappa(AL) have been reported to have anti-inflammatory, antioxidant effect. However, the immunoregulatory mechanisms of its combinational prescription remain a matter of considerable debate. In the current study, we investigated whether CG and AL and its combinational prescription(CG+AL) regulate immune system using chronic immobilization-stress mouse model. Methods : C57BL/6J mice fixed for 2 hours into immobilization tube after CG, AL, CG+AL oral administration after 2 hours daily for 21 days. After every experiment has ended the C57BL/6J mice were sacrificed on 22 days. The production of Serotonin and Cortisol, lgA were observed by ELISA method, The proportion of immune cells such as T/B cell and macrophage, NK cell were measured by FACS. Then, Real-time PCR was performed to measure the mRNA expression of Inflammatory cytokines(IL-1beta, IL-6, TNF-a) and T cell activation cytokines(IL-2, IL-10, IFN-gamma, IL-12p35 / p40). Result : When chronic immobilization-stress mouse model were treated with CG+AL(1:4), the expression of mRNA were significantly decreased at the Inflammatory cytokines(IL-1beta, IL-6, TNF-a). While, the levels of mRNA were significantly increased at immune T cell activation cytokines. Additionally, CG+AL(1:4) combinational prescription group enhanced immune cells such as T/B cell and macrophage, NK cell. Furthermore, the Immuno-fluorescence result of brain tissue can confirm that CG+AL(1:4) group significantly increased the BDNF expression. Conclusion : These result suggest that CG+AL(1:4) combinational prescription has Immune System enhancement via stress-mediated immunocyte.

• Clinical and Experimental Pediatrics
• /
• 제61권5호
• /
• pp.150-155
• /
• 2018

Purpose: Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms. Methods: We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their behaviors were observed 75 minutes after injection. The expression of KCC2 and GAD67 was also determined using immunohistochemistry. Results: Exposure to long-term prenatal stress increased the frequency of spasms and decreased the latency to onset of spasms compared with offspring exposed to short-term prenatal stress. Expression of KCC2 and GAD67 also decreased in the group exposed to long-term prenatal stress compared with the group exposed to short-term prenatal stress. Conclusion: Our study suggests that exposure to long-term prenatal stress results in increased susceptibility to seizures.

• 기본간호학회지
• /
• 제16권3호
• /
• pp.353-361
• /
• 2009

Purpose: The purpose of this study was to examine the relationship of adult the women's satisfaction with their appearance, self-esteem, depression and stress to health related quality of life (HRQOL) across the lifespan. Method: In this study a convenience sample of Korean women aged 20 years and over was used. There were 1152 women and data were collected from November 2007 to February 2008. Results: There was no difference in satisfaction with appearance in all age group. Elderly women reported lowest self esteem and HRQOL and highest depression and stress. There were statistical significances between satisfaction with appearance, self-esteem, depression, stress and HRQOL for all age groups. The most significant predictors of HRQOL in early adulthood women were stress and depression. The most significant predictors of HRQOL in middle adulthood women were stress, disease, depression, self-esteem, and monthly income. The most significant predictors of HRQOL in elderly women were stress, disease, depression, and satisfaction with appearance. Conclusion: The results indicate that HRQOL of Korean women is associated with psychological distress as with stress and depression. When developing programs to enhance health in elderly women, consideration should be given to body image as well as psychological distress and chronic conditions.

• The Korean Journal of Physiology and Pharmacology
• /
• 제17권5호
• /
• pp.393-403
• /
• 2013

Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated that repeated restraint stress disrupts the activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. The behavioral and neurochemical basis of the BA effect on depression remain unclear. The present study used the forced swimming test (FST) and changes in brain neurotransmitter levels to confirm the impact of BA on repeated restraint stress-induced behavioral and neurochemical changes in rats. Male rats received 10, 20, or 40 mg/kg BA (i.p.) 30 min prior to daily exposure to repeated restraint stress (2 h/day) for 14 days. Activation of the HPA axis in response to repeated restraint stress was confirmed by measuring serum corticosterone levels and the expression of corticotrophin-releasing factor in the hypothalamus. Daily BA administration significantly decreased the duration of immobility in the FST, increased sucrose consumption, and restored the stress-related decreases in dopamine concentrations in the hippocampus to near normal levels. BA significantly inhibited the stress-induced decrease in neuronal tyrosine hydroxylase immunoreactivity in the ventral tegmental area and the expression of brain-derived neurotrophic factor (BDNF) mRNA in the hippocampus. Taken together, these findings indicate that administration of BA prior to the repeated restraint stress significantly improves helpless behaviors and depressive symptoms, possibly by preventing the decrease in dopamine and BDNF expression. Thus, BA may be a useful agent for the treatment or alleviation of the complex symptoms associated with depression.

• Journal of Preventive Medicine and Public Health
• /
• 제25권4호
• /
• pp.429-447
• /
• 1992

The effects and roles of social support and stressors (stressful life events and chronic strains) on psychosocial distress were examined in a model with data from a sample of the white-collar workers (N=416) in Korea. The findings of this study present that mean levels of psychosocial distress were higher in the female, youth, unmarried and divorced, and low economic status (monthly income). The analysis also shows that, as expected, stressful life and chronic strains as stressors are positively related to occurrence of psychosocial distress, and social support is negatively related to psychosocial distress. Further, the contribution of social support to predicting psychosocial distress is greater in magnitude than that of stressful events, chronic strains, and seciodemographic variables. There is no evidence that social support buffers the impacts of stressors on psychosocial distress, rather social support takes a role of mai or direct effects on psychosocial distress. Therefore, the strength of the social support is an important and meaningful strategy to prevent from stress and mental, physical illness.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제11권2호
• /
• pp.252-261
• /
• 2000

목 적：만성 신체 질환 아동의 우울, 자기 개념 및 스트레스에 대한 지각과 대처 양상에 대해 알아보고자 하였다. 방 법：연구 대상자는 서울대학교 병원 어린이 병원에 입원해 있거나 외래에 다니는 환아 13명과 정상아동 13명으로 구성되었다. 만성 질환 아동군은 Schiffer 등(1963)이 만성 환자군으로 정의한 조작적 정의에 근거하여 최소한 3개월 이상 질환을 앓고 있거나 앓았던 적이 있으며, 현재도 그 질환으로 인해 지속적인 치료를 받고 있는 정형외과, 소아과 아동을 대상으로 하였다. 정상 아동군은 그러한 병력이 없는 아동 13명을 대상으로 하였다. 검사 도구는 피어스-해리스 자기 개념 척도, 소아 우울 척도, 투사적 검사(나의 기분을 색으로 표현하기, 다른 사람으로 인한 나의 기분을 색으로 표현하기, 비속의 아이)를 실시하였다. 결 과：만성 질환 아동군과 정상 아동군을 비교한 결과, 만성 질환 아동군이 소아 우울 척도에서 유의미하게 높은 점수를 보였으며, 자기 개념 척도에서는 보다 유의미하게 낮은 점수를 보였다. 또한 자기 개념 척도의 하위 항목인'인기도' 및 '학습 상태'에서 유의미하게 점수가 낮았다. 투사 과제의 경우,'색으로 표현하기' 과제에서는 집단간의 유의한 차이를 보이지 않았으나, 스트레스에 대한 지각 및 대처를 평가하는 '비속의 아이' 과제에서는 하위 항목(비의 양, 기간, 도구, 효율성) 모두에서 집단간의 차이를 보였다. 비속의 아이 과제와 우울 점수, 자기 개념 점수와의 상관 계수를 구한 결과, '비가 오는 기간' 항목이 우울 점수와는 정적 상관을, 자기 개념 점수와는 높은 부적 상관을 보였다. 결 론：만성 질환 아동군이 정상 아동군 보다 더 우울하며, 자기 개념이 더 부정적이었다. 또한, 이들이 지각하는 스트레스는 상당히 지속적이고 장기적이며, 이에 대해 대처할 수 있는 스스로의 능력이나 전략을 사용하는 데 있어서는 매우 무기력한 것으로 나타났다. 이러한 결과는 만성적인 신체 질환이 아동의 정신 건강 및 심리적 적응에 있어서 위험 요인이 될 수 있음을 시사해 준다.

• Toxicological Research
• /
• 제35권1호
• /
• pp.25-35
• /
• 2019

The extracts of Plathymenia reticulata and Connarus favosus are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast Saccharomyces cerevisiae, and against mercurial contamination in zebrafish Danio rerio. In yeast, both extracts efficiently protected the ${\Delta}ycf1$ mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.

• Journal of Preventive Medicine and Public Health
• /
• 제55권6호
• /
• pp.499-505
• /
• 2022

Despite advances in medicine and preventive strategies, fewer than 1 in 5 people with hypertension have the problem under control. This could partly be due to gaps in fully elucidating the etiology of hypertension. Genetics and conventional lifestyle risk factors, such as the lack of exercise, unhealthy diet, excess salt intake, and alcohol consumption, do not fully explain the pathogenesis of hypertension. Thus, it is necessary to revisit other suggested risk factors that have not been paid due attention. One such factor is psychosocial stress. This paper explores the evidence for the association of psychosocial stressors with hypertension and shows that robust evidence supports the role of a chronic stressful environment at work or in marriage, low socioeconomic status, lack of social support, depression, anxiety, post-traumatic stress, childhood psychological trauma, and racial discrimination in the development or progression of hypertension. Furthermore, the potential pathophysiological mechanisms that link psychosocial stress to hypertension are explained to address the ambiguity in this area and set the stage for further research.

• 대한불안의학회지
• /
• 제5권1호
• /
• pp.14-20
• /
• 2009

Objective : The objective of this study was to examine the relationship between plasma serotonin concentration and posttraumatic stress disorder (PTSD) symptoms in chronic PTSD patients who have been taking medication. Methods : Plasma serotonin level of 14 PTSD patients and a control group of 28 Vietnam War veterans was measured by HPLC (high performance liquid chromatography). The Combat Exposure Scale (CES), Mississippi Scale for Combat-Related Posttraumatic Stress Disorder (M-PTSD), Clinician Administered PTSD Scale (CAPS), Hamilton Rating Scale for Depression (HRSD), and Hamiltion Anxiety Scale (HAS) were used to evaluate PTSD symptom severity. Results : Serotonin level was significantly higher in the PTSD group than in the control group (p=0.036, p=0.006, respectively). M-PTSD (p<0.001), CAPS (p<0.001), HRSD (p<0.001), and HAS (p<0.001) scale scores were significantly higher in the PTSD group than in the control group; however, the CES score failed to show a significant improvement (p=0.964). There were no significant differences between plasma serotonin and PTSD symptoms. Conclusion : In chronic PTSD patients who have been taking medications, we can not predict treatment effect and symptom severity by measuring only plasma serotonin levels. PTSD is a complicated disorder which may likely be related to a variety of neurotransmitter systems. Therefore, further research which investigate relationships with norepinephrine, dopamine, and other neurotransmitters as well as serotonin is needed to improve the treatment of PTSD.