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http://dx.doi.org/10.5487/TR.2019.35.1.025

Protective Effects of Plathymenia reticulata and Connarus favosus Aqueous Extracts against Cadmium- and Mercury-Induced Toxicities  

Gombeau, Kewin (University of Bordeaux)
de Oliveira, Ricardo Bezerra (Federal University of Western Para - UFOPA, PPGRNA, LABBEX, Tapajos Campus)
Sarrazin, Sandra Layse Ferreira (Federal University of Western Para - UFOPA, PPGRNA, LABBEX, Tapajos Campus)
Mourao, Rosa Helena Veras (Federal University of Western Para - UFOPA, PPGRNA, LABBEX, Tapajos Campus)
Bourdineaud, Jean-Paul (University of Bordeaux)
Publication Information
Toxicological Research / v.35, no.1, 2019 , pp. 25-35 More about this Journal
Abstract
The extracts of Plathymenia reticulata and Connarus favosus are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast Saccharomyces cerevisiae, and against mercurial contamination in zebrafish Danio rerio. In yeast, both extracts efficiently protected the ${\Delta}ycf1$ mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.
Keywords
Plant extract; Methylmercury; Cadmium; Saccharomyces cerevisiae; Danio rerio; Oxidative stress;
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