• Genomics & Informatics
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• 제10권4호
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• pp.234-238
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• 2012

Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression quantitative trait loci (eQTLs), that are associated with the expression phenotypes have been identified, first in Epstein-Barr virus-transformed lymphoblastoid cell lines and later expanded to other cell and tissue types. Integration of the eQTL information and the network analysis of transcription modules may lead to a better understanding of gene expression regulation. As these network modules have relevance to biological or disease pathways, these findings may be useful in predicting disease susceptibility.

• 대한전기학회논문지
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• 제38권12호
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• pp.1022-1032
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• 1989

King Sejong's Striking Clepsydra was an elaborate timekeeping and annunciating system incorporating biological automata capable of annunciating hours, intervals and night-watches based on Shou-shih calindrical systems automatically. In this paper the author has studied the original manuscripts on the Striking Clepsydra [Sejong sillock, 65: 1a-3b ff` 16th year, 7th month(1434)] from the technical point of view undertaking a close analysis of this monumental clock and aiming to our modern understanding of the full degree of delicate mechanisms and sophisticated controls built into the night-watch and division announcing clockwork(jackwork). Based on the input/output model, timekeeping, ball-rack, ball-relay, and audible time-indicating mechanisms were synthesized reconstructing night-watch annunciating systems. It revealed that the night-watch and division announcing processes were entirely renewed automatically. Historical and philological data concerning the improvements of the proposed model were discussed.

• Journal of Plant Biotechnology
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• 제36권3호
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• pp.224-229
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• 2009

Human lactoferrin is an iron-binding glycoprotein with many biological activities, including the protection against microbial and virus infection and stimulation of the immune system. We introduced a human lactoferrin (hLf) cDNA under the control of 35S promoter into sweet potato by particle bombardment. Transgenic plants were regenerated via somatic embryogenesis. Transgenic plants were produced typical tuberous roots in soil. PCR, Southern and northern analyses confirmed that the hLf cDNA was incorporated into the plant genome and was properly expressed in plants. Western blot analysis showed that the 80 kDa full length hLf protein was produced in transgenic tuberous roots. Overall results indicated that sweet potato would be an excellent host to produce human therapeutic proteins.

• 대한심미치과학회지
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• 제13권1호
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• pp.31-39
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• 2004

For the prosthodontic results which are compatible with esthetics to be fulfilled, the first prerequisite would be periodontal intervention and stability, the second one may be functional competency and the ultimate goal should be ascribed to esthetic considerations. Other words, esthetic dentistry is a whole entity which encompasses the biological stability of the periodontium, physical accuracy of the prosthodontic structure and finally, the beauty which can be found in natural dentition. It also implies the harmonized lip line which reveals the well-balanced tooth morphology and health gum profiles (Red-White Esthetics). Largely, there lie some differences in the input system of the 3-dimentional data from the prepared abutments between respective computer-assisted systems available now. But the manufacturing systems (CAM) are very similar between them, to say, comprise numeric control systems with whole 3-dimensional milling units according to the restorations to be made. Now the author is going to present CAD/CAM Zirconia All Ceramic Restoration on the topics for the Red-White Esthetics, periodontal control and maintenance, treatment for the discolored teeth, post & core build-up works for the devitalized teeth, characteristics of the Zirconium oxide All Ceramics, fabrication procedures, clinical considerations and its application to diverse clinical situations.

• 한국생물환경조절학회:학술대회논문집
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• 한국생물환경조절학회 1999년도 학술발표논문집
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• pp.126-129
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• 1999

Natural ventilation is achieved by air exchanges through multiple openings due to natural pressure variations inside and outside the greenhouse. Wind is the primary driving force making natural ventilation systems very difficult to design properly because of variations in wind velocity and direction. The optimization of these systems for acceptable climate control requires a thorough knowledge of the airflow rates and patterns as related to weather conditions and greenhouse structural details. (omitted)

• Current Optics and Photonics
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• 제3권4호
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• pp.275-284
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• 2019

Chirality is ubiquitous in physics and biology from microscopic to macroscopic phenomena, such as fermionic interactions and DNA duplication. In photonics, chirality has traditionally represented differentiated optical responses for right and left circular polarizations. This definition of optical chirality in the polarization domain includes handedness-dependent phase velocities or optical absorption inside chiral media, which enable polarimetry for measuring the material concentration and circular dichroism spectroscopy for sensing biological or chemical enantiomers. Recently, the emerging field of non-Hermitian photonics, which explores exotic phenomena in gain or loss media, has provided a new viewpoint on chirality in photonics that is not restricted to the traditional polarization domain but is extended to other physical quantities such as the orbital angular momentum, propagation direction, and system parameter space. Here, we introduce recent milestones in chiral light-matter interactions in non-Hermitian photonics and show an enhanced degree of design freedom in photonic devices for spin and orbital angular momenta, directionality, and asymmetric modal conversion.

• Journal of Microbiology and Biotechnology
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• 제31권7호
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• pp.903-911
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• 2021

Previous studies have modified microbial genomes by introducing gene cassettes containing selectable markers and homologous DNA fragments. However, this requires several steps including homologous recombination and excision of unnecessary DNA regions, such as selectable markers from the modified genome. Further, genomic manipulation often leaves scars and traces that interfere with downstream iterative genome engineering. A decade ago, the CRISPR/Cas system (also known as the bacterial adaptive immune system) revolutionized genome editing technology. Among the various CRISPR nucleases of numerous bacteria and archaea, the Cas9 and Cas12a (Cpf1) systems have been largely adopted for genome editing in all living organisms due to their simplicity, as they consist of a single polypeptide nuclease with a target-recognizing RNA. However, accurate and fine-tuned genome editing remains challenging due to mismatch tolerance and protospacer adjacent motif (PAM)-dependent target recognition. Therefore, this review describes how to overcome the aforementioned hurdles, which especially affect genome editing in higher organisms. Additionally, the biological significance of CRISPR-mediated microbial genome editing is discussed, and future research and development directions are also proposed.

• Smart Structures and Systems
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• 제30권1호
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• pp.1-15
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• 2022

This article focuses on stability analysis and fuzzy controller synthesis for large neural network (NN) systems consisting of several interconnected subsystems represented by the NN model. Advanced and fuzzy NN differential inclusion (NNDI) for stability based on the developed algorithm with H infinity can be designed based on the evolved biological design. This representation is constructed using sector linearity for NN models. Sector linearity transforms a non-linear model into a linear model based on proposed operations. New sufficient conditions are realized in the form of LMI (linear matrix inequalities) to ensure the asymptotic stability of the trans-Lyapunov function. This transforms the nonlinear model into a linear model based on multiple rules. At last, a numerical case study with simulations is derived as illustration to prove its feasibility in real nonlinear structures.

• 센서학회지
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• 제31권5호
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• pp.286-292
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• 2022

As mobile electronics become smarter, higher-level security systems are necessary to protect private information and property from hackers. For this, biometric authentication systems have been widely studied, where the recognition of unique biological traits of an individual, such as the face, iris, fingerprint, and voice, is required to operate the device. Among them, ultrasound fingerprint imaging technology using piezoelectric materials is one of the most promising approaches adopted by Samsung Galaxy smartphones. In this review, we summarize the recent progress on piezoelectric ultrasound micro-electro-mechanical systems (MEMS) transducers with various piezoelectric materials and provide insights to achieve the highest-level biometric authentication system for mobile electronics.

• 환경생물
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• 제32권4호
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• pp.397-402
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• 2014

1992년 6월 브라질 리우데자네이루에서 생물다양성협약(Convention on Biological Diversity, CBD)에 158개국이 서명한 이후, 현재 194개국 당사국들은 자국의 이익을 위해 다양한 형태로 논의에 참여하고 있다. 그리고 생물다양성협약 유전자원에 대한 접근 및 이익 공유(Access to genetic resources and Benefit-Sharing, ABS)를 다룬 나고야의정서가 채택되어 2014년 10월 12일에 발효 되었다. 이러한 상황에서 생물다양성협약 및 나고야의정서 발효가 해양생물다양성을 연구하는 연구자들에게 어떠한 영향을 미칠 것인가는 상당히 중요한 문제이다. 그러나 지난 생물다양성총회에서 해양 및 해양생물자원에 대한 관심은 비교적 적었으며, 이에 따라, 이와 관련된 논의도 늦어졌다. 하지만 이번 제12차 평창 생물다양성총회에서 생물학적 또는 생태학적 중요해역 (Ecologi-cally or Biologically Significant marine Areas, 이하 EBSA) 및 기타 해양관련 문제를 논의하였다. 우리나라는 나고야 의정서에 아직 정식으로 가입하지 않았지만 유전자원 이용 시 사전통보승인(Prior and Informed consent, PIC) 및 상호합의조건 (Mutually Agreed Terms, MAT) 그리고 다자간 이익공유체계 (Global Multilateral Benefit-Sharing Mechanism, GMBSM)를 중심으로 다양한 논의가 이루어졌다. 우리나라는 생물자원 보유국으로서 정부는 국내 생물자원의 관리체계 및 법률을 빠르게 정비하여야 한다. 또한 이용국으로서 학계 및 산업계가 국외의 생물자원을 보다 쉽고 효율적으로 이용하도록 정보체계를 구축할 필요가 있다고 판단된다.