• BMB Reports
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• v.50 no.9
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• pp.472-477
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• 2017

The transcription repressor Bach2 has been proposed as a regulator of T cell quiescence, but the underlying mechanism is not fully understood. Given the importance of interleukin-2 in T cell activation, we investigated whether Bach2 is a component of the network of factors that regulates interleukin-2 expression. In primary and transformed $CD4^+$ T cells, Bach2 overexpression counteracted T cell receptor/CD28- or PMA/ionomycin-driven induction of interleukin-2 expression, and silencing of Bach2 had the opposite effect. Luciferase and chromatin immunoprecipitation assays revealed that Bach2 binds to multiple Maf-recognition element-like sites on the interleukin-2 proximal promoter in a manner competitive with AP-1, and thereby represses AP-1-driven induction of interleukin-2 transcription. Thus, this study demonstrates that Bach2 is a direct repressor of the interleukin-2 gene in $CD4^+$ T cells during the immediate early phase of AP-driven activation, thereby playing an important role in the maintenance of immune quiescence in the steady state.

• Bulletin of the Korean Mathematical Society
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• v.60 no.3
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• pp.763-774
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• 2023

If a paraSasakian manifold of dimension (2n + 1) represents Bach almost solitons, then the Bach tensor is a scalar multiple of the metric tensor and the manifold is of constant scalar curvature. Additionally it is shown that the Ricci operator of the metric g has a constant norm. Next, we characterize 3-dimensional paraSasakian manifolds admitting Bach almost solitons and it is proven that if a 3-dimensional paraSasakian manifold admits Bach almost solitons, then the manifold is of constant scalar curvature. Moreover, in dimension 3 the Bach almost solitons are steady if r = -6; shrinking if r > -6; expanding if r < -6.

• Bulletin of the Korean Mathematical Society
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• v.56 no.5
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• pp.1341-1353
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• 2019

For complete Riemannian manifolds with vanishing Bach tensor and positive constant scalar curvature, we provide a rigidity theorem characterized by some pointwise inequalities. Furthermore, we prove some rigidity results under an inequality involving $L^{\frac{n}{2}}$-norm of the Weyl curvature, the traceless Ricci curvature and the Sobolev constant.

• Journal of the Korean Mathematical Society
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• v.58 no.2
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• pp.401-418
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• 2021

For complete manifolds with α-Bach tensor (which is defined by (1.2)) flat, we provide some rigidity results characterized by some point-wise inequalities involving the Weyl curvature and the traceless Ricci curvature. Moveover, some Einstein metrics have also been characterized by some $L^{\frac{n}{2}}$-integral inequalities. Furthermore, we also give some rigidity characterizations for constant sectional curvature.

• Journal of the Korean Mathematical Society
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• v.57 no.2
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• pp.539-552
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• 2020

In this paper we consider gradient almost Ricci solitons with weak conditions on Weyl and Bach tensors. We show that a gradient almost Ricci soliton has harmonic Weyl curvature if it has fourth order divergence-free Weyl tensor, or it has divergence-free Bach tensor. Furthermore, if its Weyl tensor is radially flat, we prove such a gradient almost Ricci soliton is locally a warped product with Einstein fibers. Finally, we prove a rigidity result on compact gradient almost Ricci solitons satisfying an integral condition.

• BMB Reports
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• v.50 no.11
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• pp.560-565
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• 2017

Geraniin, a hydrolysable tannin, used in traditional medicine in Southeast Asia, is known to exhibit various biological activities. As an antioxidant it is known to up-regulate phase II enzyme Heme oxygenase-1 (HO-1). However its mechanism is not clearly understood. Nuclear factor erythroid-derived 2 related factor 2 (Nrf-2) is transcriptionally up-regulated by Extracellular signal-regulated kinase (ERK) 1/2 and retained in nucleus due to inactivated Glycogen synthase kinase 3 beta ($GSK-3{\beta}$). Geraniin additionally down-regulates expression of microRNA 217 and 377 (miR-217 and miR-377) which target HO-1 mRNA. Expression of BTB and CNC homolog 1 (BACH-1), another regulator of HO-1, is also down-regulated by up-regulating microRNA 98 (miR-98), a negative regulator of BACH-1. Thus, geraniin up-regulates HO-1 expression both through activating its positive regulator Nrf-2 and by down-regulating its negative regulator BACH-1. Up-regulation of HO-1 also confers protection to HepG2 cells from tertiary butyl hydroperoxide (TBH) induced cytotoxicity.

• The Bulletin of The Korean Astronomical Society
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• v.32 no.1
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• pp.90.2-90.2
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• 2007

• The Bulletin of The Korean Astronomical Society
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• v.31 no.2
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• pp.69-69
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• 2006

• 한국생물공학회:학술대회논문집
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• 2000.04a
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• pp.295-298
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• 2000

In order to maximize the RNA accumulation and biomass production in Saccharomyces cerevisiae MTY62, a high-content RNA yeast strain, fed-bach cultures were performed with optimized industrial medium including molasses and corn steep liquor. Among the feeding modes examined, the constant feeding mode resulted in the cell concentration of 35.7 g-DCW/L and the RNA concentration of 5434 ${\mu}g-RNA/mL$, which were about 2-fold increased levels, compared to the results of bach culture. However, the RNA content (153 mg-RNA/g-DCW) in the fed-batch cultures was lower than that in the batch culture (171 mg-RNA/g-DCW).

• Proceedings of the IEEK Conference
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• 2003.07c
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• pp.2513-2516
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• 2003

This paper presents an optimal robust LQ-PID roller design method for the second-order ems with state delay to satisfy the design ification in time domain. The Sensitivity bach concept is utilized for its optimization.