• Toxicological Research
• /
• v.32 no.2
• /
• pp.103-108
• /
• 2016

The purpose of this study was to determine the hair growth effects of lavender oil (LO) in female C57BL/6 mice. The experimental animals were divided into a normal group (N: saline), a vehicle control group (VC: jojoba oil), a positive control group (PC: 3% minoxidil), experimental group 1 (E1: 3% LO), and experimental group 2 (E2: 5% LO). Test compound solutions were topically applied to the backs of the mice ($100{\mu}L$ per application), once per day, 5 times a week, for 4 weeks. The changes in hair follicle number, dermal thickness, and hair follicle depth were observed in skin tissues stained with hematoxylin and eosin, and the number of mast cells was measured in the dermal and hypodermal layers stained with toluidine blue. PC, E1, and E2 groups showed a significantly increased number of hair follicles, deepened hair follicle depth, and thickened dermal layer, along with a significantly decreased number of mast cells compared to the N group. These results indicated that LO has a marked hair growth-promoting effect, as observed morphologically and histologically. There was no significant difference in the weight of the thymus among the groups. However, both absolute and relative weights of the spleen were significantly higher in the PC group than in the N, VC, E1, or E2 group at week 4. Thus, LO could be practically applied as a hair growth-promoting agent.

• Journal of Ginseng Research
• /
• v.32 no.3
• /
• pp.187-193
• /
• 2008

The present study was designed to investigate the anti-diabetic effect and mechanism of Korean red ginseng in C57BL/KsJ db/db mice. The db/db mice were divided into three groups: diabetic control group (DC), Korean red ginseng group (KRG, 100 mg/kg) and metformin group (MET, 300 mg/kg), and treated with drugs once per day for 10 weeks. Compared to the DC group, fasting blood glucose levels were decreased by 19.8% in KRG-, 67.7% in MET-treated group. With decreased plasma glucose and insulin levels, the insulin resistance index of the KRG-treated group was reduced by 27.6% compared to the DC group. The HbA1c levels in KRG and MET-treated groups were also decreased by 11.0% and 18.9% compared to that of DC group, respectively. Plasma triglyceride and non-esterified fatty acid levels were decreased by 18.8% and 16.8%, respectively, and plasma adiponectin and leptin levels were increased by 20.6% and 12.1%, respectively, in the KRG-treated group compared to those in DC group. Histological analyses of the liver and fat tissue of mice treated with KRG revealed significantly decreased number of lipid droplets and decreased size of adipocytes compared to the DC group. From the pancreatic islet double-immunofluorescence staining, we observed KRG has increased insulin contents, but decreased glucagon production. To elucidate action mechanism of KRG, effects on AMP-activated protein kinase (AMPK) and its downstream target proteins responsible for fatty acid oxidation and gluconeogenesis were explored in the liver. KRG activated AMPK and acetyl-coA carboxylase (ACC) phosphorylations, resulting in stimulation of fatty acid oxidation. KRG also caused to down regulation of SREBP1a and its target gene expressions such as FAS, SCD1 and GPAT. In summary, our results suggest that KRG exerted the anti-diabetic effect through AMPK activation in the liver of db/db mice.

• The Journal of Pediatrics of Korean Medicine
• /
• v.32 no.1
• /
• pp.1-10
• /
• 2018

Objectives The purpose of this study is to understand effect on respiratory disease and satisfaction of parents about acupoint sticking in hottest period of summer. Methods A survey was conducted to the parents of their children who took acupoint sticking in Dog-days for two years in a row. 17 children (10 boys, 7 girls, 4.0-12.11 years) were attached Socheongo to BL-13, BL-15, BL-17 for 3 hours. In terms of the effectiveness of the therapy, the treatment only considered as effective when there is any improvement in respiratory symptoms. Results 11 children (64.7%) from the study group have shown positive effect. There were significant improvements in frequency of having a cold or duration of a cold; duration of rhinitis; frequency of having empyema or its duration; frequency of having bronchitis; frequency of having pneumonia; frequency of having otitis media. Respiratory health VAS (Visual Analog Scale) had significant increase from 5 to 6.71 (p<0.05). 7 parents (41.2%) were satisfied with acupoint in hottest period of summer and 16 parents (94.1%) wanted to have their children get treated again in next year. From the survey, inconveniences of acupuncture were weak attachment of the acupoint (23.5%), long attaching time (11.8%), pressure about number of treatments (5.9%), worry about side effects (5.9%). Side effects have been reported; 2 pruritus (11.8%), 1 pruritus and erythema (5.9%). Conclusions Acupoint sticking in hottest period of summer improves lung symptoms in children older than three years old. However, the ways to reduce the side effects and inconveniences are needed.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.15 no.10
• /
• pp.2209-2216
• /
• 2011

In this paper, we design a 32-bit eFuse OTP memory for PMICs using MagnaChip's $0.18{\mu}m$ process. We solve a problem of an electrical shortage between an eFuse link and the VSS of a p-substrate in programming by placing an n-well under the eFuse link. Also, we propose a WL driver circuit which activates the RWL (read word-line) or WWL (write word-line) of a dual-port eFuse OTP memory cell selectively when a decoded WERP (WL enable for read or program) signal is inputted to the eFuse OTP memory directly. Furthermore, we reduce the layout area of the control circuit by removing a delay chain in the BL precharging circuit. We'can obtain an yield of 100% at a program voltage of 5.5V on 94 manufactured sample dies when measured with memory tester equipment.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.17 no.2
• /
• pp.164-171
• /
• 1988

The composition of lipid class and fatty acid of free lipids(FL) and bound lipids(BL at low temperature and BL at high temperature) from Mungbean (Phaseolus radiatus, L) was investigated with the chromatographic procedures. The contents of neutral lipid (NL), glycol lipids(GL) and phospholipids(PL) in FL were 89.1%, 7.1%, and 3.7%, on the other hand those of BL were $49{\sim}56%,\;28{\sim}29%\;and\;15{\sim}21%$, respectively. The major components of NL fraction were triglycerides, 1,2-diglycerides and esterified sterol in the lipids of FL and BL. Esteryl steryl glycosides and monogalactosyl diglycerides were observed as major GL components of FI and BL. Of the PL in FL and BL, phosphatidyl ethanolamine, diphosphatidyl glycerides and phosphatidyl choline were the major components. The predominent fatty acids of NL, GL and PL were linoleic, palmitic and linolenic acids. There are a little difference between the compositions of BL at low and high temperature extraction.

• Journal of Environmental Health Sciences
• /
• v.32 no.6
• /
• pp.566-570
• /
• 2006

Exposure to ultraviolet B(UVB) radiation causes skin inflammation such as pigmentation and the induction of cyclooxygenase-2(COX-2) gene expression. In this study, we investigated the effect of natural extracts from Tea, EGb 761 and Korean red ginseng(KRG), on the pigmentation and expression of COX-1 and COX-2 mRNA in UVB-irradiated C57BL/6 mice. Before UVB irradiation, the skin color was significantly showed the lightening effect by topical application of natural compounds (p<.05). In the case of UVB irradiated mice, we observed a decrease in pigmentation by compounds (p<.05). In irradiated skin, COX-1 mRNA expression is not changed following UVB irradiation, but COX-2 gene increases. Also, natural compounds lowered mRNA levels of COX-2. Therefore, these results suggest that COX-2 mRNA increases by UVB irradiation. Also, Tea, EGb 761 and KRG as a topical application may inhibit skin pigmentation and modulate COX-2 mRNA level.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.26 no.2
• /
• pp.241-247
• /
• 2012

The purpose of this case study is to report the effect of electroacupuncture at acupoints Baliao (BL31 Shangliao, BL32 Ciliao, BL33 Zhongliao, BL34 Xialiao) on patients with voiding problem. Neurogenic Bladder can be classified according to whether impairment of urinary reservoir or emptying. The first case was a patient with urinary emptying impairment. He was diagnosed with areflexic neurogenic bladder, and was managed with suprapubic cystostomy. After starting of electroacupuncture on Baliao, residual urine volume was gradually decreased, at last cystostomy could be removed. The second case was a patient with urinary reservoir impairment. She complained symptoms of urinary frequency, nocturia due to overactive bladder. After starting of electroacupuncture on Baliao, urination frequency was significantly decreased. We consider electroacupuncture on Baliao may have a useful effect on voiding problem, both urinary reservoir and emptying impairment.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.27 no.3
• /
• pp.158-167
• /
• 2014

Objectives: This study aims to report the effect of Korean medicine treatments on a pelvic inflammatory disease (PID). Methods: The patient was treated with Qingbaozhuyu-tang, acupuncture at Jungwan (CV12), Gihae (CV6), Taechung (LR3), Hapgok (LI4), Sameumgyo (SP6), Sangryo (BL3), Charyou (BL32), Jungryo (BL33), Haryo (BL34), Cheonchu (ST25), Pungryung (ST40), Duyu (ST8), Taeyang (EX-HN5). And we evaluated treatment effects by visual analogue scale (VAS) and Urine analysis (UA) Finding. Results: After treatments, the symptoms such as lower abdominal pain, pelvic pain and fever were improved and there were no abnormal findings in urine analysis. Conclusions: This study suggests that Korean medicine treatments show effective on PID treatment.

• Journal of Life Science
• /
• v.32 no.7
• /
• pp.532-541
• /
• 2022

Obesity induced by high-fat diet (HFD) is verified as a strong risk factor and negative prognostic factor for prostate cancer in several genetically engineered mice although it was not examined in the normal mice. To investigate whether HFD-induced obesity can affect the development and progression of cancer in the prostate of normal mice, alterations in the weight and histological structure of the prostate as well as the expression of cancer-related proteins were analyzed in obese C57BL/6N mice fed with 60% HFD for 16 weeks. First, HFD-induced obesity, including an increase in organ weight, body weight, fat accumulation, and serum lipid profile, was successfully induced in C57BL/6N mice after HFD treatment. The total weight of the prostate significantly increased HFD-induced obesity in the model mice compared with the control group. Among the four lobes of the prostate, the weight of the ventral prostate (VP) and anterior prostate (AP) were higher in HFD-induced obesity model mice than in the control group, although the weights of the lateral prostate (DLP) and seminal vesicle (SV) were constantly maintained. In addition, the incidences of hyperplasia and non-hodgkin's lymphoma (NHL) in the histological structure were remarkably increased in HFD-induced obesity model mice, while the epithelial thickness was higher in the same group. A significant increase in the phosphorylation levels of key proteins in the AKT (protein kinase B) signaling pathway was detected in HFD-induced obesity model mice. Therefore, these results suggest that HFD-induced obesity can promote hyperplasia and NHL in the prostates of C57BL/6N mice through the activation of the AKT signaling pathway.

• The Journal of Internal Korean Medicine
• /
• v.21 no.1
• /
• pp.169-180
• /
• 2000

Objectives : To satisfy the demand of good treatment of constipation Methods : we investigated the literatures of Oriental Medicine about Constipation. Results: 1. There are three categories of etimological factors of constipation, that is, endogenous, exogenous and non-exo-endogenous factor. The endogenous factor is caused by seven emotions, called depression of Ki and stagnation of Ki. The exogenous factor is six excessive atmospheric influences, for example, wind, cold, dampness, heat and dryness. And the non-exo-endogenous factors are overfatigue, improper diet, stagnated blood and deficiency of Ki and blood that comes from old age, long disease and after delivery. 2. Classification: According to cause of disease it is classified by constipation due to cold, heat, wind, dryness, retention of undigested and phlegm. According to Internal Organs there are constipation due to deficiency syndrome of the stomach, excess syndrome of the stomach, deficiency syndrome of kidney and splenic constipation. And Differentiation of syndromes according to Ki and blood, there are constipation of deficiency type and excess type. There are constipation due to stagnation and deficiency of Ki, deficiency of blood and stagnated blood. 3. Principles and Methods of treatment 1) Herbal Medicine (1) Excess type [1] Constipation due to heat : Seunggitang(承氣湯) and Majainwhan(麻子仁丸) [2] Constipation due to stagnation of Ki : Samatang(四磨湯) and Yukmatang(六磨湯) (2) Deficiency type [1] Constipation due to deficiency of Ki : Whanggitang(黃?湯) [2] Constipation due to deficiency of blood: Yunjangwhan(潤腸丸) [3] Constipation due to cold : Jechunjun(濟川煎) and Banyuwhan(半硫丸) 2) Enema therapy: It is a method to induce defecation by honey or pig's bile juice for weak people. 3) Acupuncture and Moxibustion: Acupoints used to treat constipation are BL25, ST25 and TE6. Moxibustion at CV8, CV6 is good for constipation due to cold. (4) Diet therapy: It is very important that we eat meals regularly and defecate on the same time even if you don't. And we have to eat food like fruits, vegetables and beans. (5) finger pressure: Finger pressing around these points like ST25, SP25, BL25, BL31, BL32, BL33 and BL34 is good for it. (6) Kigong therapy: Abdominal breathing (7) Old man' s constipation: Hip bath or diet therapy is commended. Laxation with lubricant like Supungyunjangwhan(搜風潤腸丸) is used. (8) Women' s constipation: After delivery, we have to administer tonifying prescription Sipjundaebotang(十全大補湯) and enema can be used. Conclusion : We have to examine the cause of disease and bowl movement carefully. After comprehensive analysis of the data gained by the four methods of diagnosis, we diagnose and treat patients on the base of overall of symptoms and signs.