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Effects of Natural Extracts on COX-1 and COX-2 mRNA Expression on UVB-induced Skin Inflammation in C57BL/6 Mouse  

Ahn, Ryoung-Me (Department of Health Science, Dongduk Women's University)
Publication Information
Journal of Environmental Health Sciences / v.32, no.6, 2006 , pp. 566-570 More about this Journal
Abstract
Exposure to ultraviolet B(UVB) radiation causes skin inflammation such as pigmentation and the induction of cyclooxygenase-2(COX-2) gene expression. In this study, we investigated the effect of natural extracts from Tea, EGb 761 and Korean red ginseng(KRG), on the pigmentation and expression of COX-1 and COX-2 mRNA in UVB-irradiated C57BL/6 mice. Before UVB irradiation, the skin color was significantly showed the lightening effect by topical application of natural compounds (p<.05). In the case of UVB irradiated mice, we observed a decrease in pigmentation by compounds (p<.05). In irradiated skin, COX-1 mRNA expression is not changed following UVB irradiation, but COX-2 gene increases. Also, natural compounds lowered mRNA levels of COX-2. Therefore, these results suggest that COX-2 mRNA increases by UVB irradiation. Also, Tea, EGb 761 and KRG as a topical application may inhibit skin pigmentation and modulate COX-2 mRNA level.
Keywords
UVB radiation; inflammation; pigmentation; COX-1; COX-2;
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Times Cited By KSCI : 2  (Citation Analysis)
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