• The Journal of Korean Institute of Communications and Information Sciences
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• v.42 no.1
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• pp.64-76
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• 2017

Routing in mobile ad hoc networks (MANETs) is highly challenging because of the dynamic nature of network topology. AntHocNet is a bio-inspired routing protocol for MANETs that mimics the foraging behavior of ants. However, unlike many other MANET routing protocols, the paths constructed in AntHocNet are unidirectional, which requires a separate path setup if a route in the reverse direction is also required. Because most communication sessions are bidirectional, this unidirectional path setup approach is often inefficient. Moreover, AntHocNet suffers from looping problems because of its property of multiple paths and stochastic data routing. In this paper, we propose a modified path setup procedure that constructs bidirectional paths. We also propose solutions to some of the looping problems in AntHocNet. Simulation results show that performance is significantly enhanced in terms of overhead, end-to-end delay, and delivery ratio when loops are prevented. Performance is further improved, in terms of overhead, when bidirectional paths setup is employed.

• Journal of Ginseng Research
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• v.41 no.2
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• pp.201-208
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• 2017

Background: Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. Methods: VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative-hypnotic (pentobarbital-induced sleeping test), anti-stress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects. Results: VGE treatment increased the spontaneous locomotor activity, enhanced the endurance to stress, reduced the anxiety-like behavior, and ameliorated the scopolamine-induced memory impairments in mice. In addition, VGE treatment did not alter the motor balance and coordination of mice and did not potentiate pentobarbital-induced sleep, indicating that VGE has no sedative-hypnotic effects. The effects of VGE were comparable to those of the Korean Red Ginseng extract. Conclusion: VG, like other ginseng products, has significant and potentially useful psychopharmacological effects. This includes, but is not limited to, psychomotor stimulation, anxiolytic, antistress, and memory enhancing effects.

• Research in Community and Public Health Nursing
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• v.24 no.3
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• pp.264-272
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• 2013

Purpose: The aim of this study was to investigate coping styles for dysmenorrhea and explore factors related with their coping styles according to different health loci of control in middle schoolers. Methods: Data were collected by using a structured questionnaire for 572 students from three middle schools in Seoul from March 22 to April 2, 2010. The measurement included menstrual distress, coping method questionnaire and health locus of control. The data were analyzed by using t-test, ANOVA, Pearson's correlation coefficients, and multiple regression analysis. Results: Middle school students used the active behavioral coping style more often than the avoidance style. There was a significant difference in means within each coping style including levels of stress, levels of health, and regular exercise. There were also significant correlations between each coping style and health locus of control. Regression analyses indicated that the health locus of control factor is the most powerful factor in each coping style. Conclusion: We observed that various coping methods are used for dysmenorrhea in middle school students. However, the active behavioral coping style is dominant in such a condition. Based on these results, we need to develop a health locus of control to improve coping styles for dysmenorrhea.

• The Journal of the Korean dental association
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• v.51 no.7
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• pp.405-413
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• 2013

Pediatric and adolescent dental anxiety and fear have been researched in the connection with behavior modification for a long time and this dental anxiety can persist until the adult hoods resulting in extreme fear of and avoidance of dental treatments and causes oral health deterioration. However, the domestic researches regarding adolescent dental anxiety and fear are insufficient. For this reason, this study aims to examine the level of fear and the influential factors affecting their dental fear and to utilize the result as the basic materials in the dental management. The subjects were the students from a middle school located in Gyeonggi-Do. The school was selected by convenient sampling and self-answered questionnaire was filled in by the students. The distribution of responses in each category of fear was examined by frequency analysis. The analysis was conducted using cross tabulation in order to examine the difference between male students and female students and using independent sample t-test in order to compare the fear score of each category. The study results showed the fear score of female students for the category 'causing irritation during the dental treatments' was significantly higher in statistics(p<0.05). Therefore, these results should be reflected to the dental care environments in order for the adolescent to reduce the dental anxiety and fear.

• Journal of Korean Academy of Nursing
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• v.3 no.2
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• pp.81-90
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• 1973

Since there is nothing in the literature regarding how Koreans value their children, this is an exploratory study attempting to (1) generate ideas as to why women of child- bearing age want children and (2) discover aspects of the interaction between the value of children and the fertility behavior according to socio-economic class and level of education. Fifty women from the Yonhee A Citizen′s Apartment and 50 women from the slum area surrounding the Yonhee Apartment were interviewed by the investigator during the period of October 10 to October 25, 1972. All of the women interviewed were under 35 years of age and had more than one child. The questionnaire consisted of questions regarding the general characteristics of the respondents, the status of current family planning practice, the number of induced abortions and the reasons for wanting children. An open ended question followed by a forced choice question was the method used to determine the reasons for wanting children. The results of the study were as follows: 1. Half of all the respondents were between 30 and 34 years of age. 2. Four percent of the respondents had no schooling, 51 percent had graduated from primary school, and 45 percent were educated beyond middle school. 3. The most important reasons tot wanting children given by the respondents were categorized as follows: (1) carrying on the family name, (2) old age security, (3) value of life, (4) fun of rearing children, (5) avoidance of loneliness, (6) responsibility of women. 4. The number of consistent answers between the open ended and forced choice questions regarding reasons for wanting children was significantly different. Only 30 women among the total respondents gave consistent answers. Carrying on the family name was the category in which there was the highest rate of consistency. 5. The reasons for wanting children were not significantly different for age, educational level, and number of living children for all of the respondents. 6. In response to the question "If you want to have only one child, which sex , would you prefer\ulcorner" 96 percent of the respondents said they would select a son. 7. Major suggestions for further study were to differentiate. (1) between reasons women want children and reasons women have children and (2) between reasons men want children and reasons women want children.

• Biomolecules & Therapeutics
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• v.25 no.3
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• pp.249-258
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• 2017

To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naïve mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-${\zeta}$ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-${\zeta}$ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.

• Psychiatry investigation
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• v.15 no.11
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• pp.1079-1086
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• 2018

Objective The pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role in human anxiety states and anxiety-related traits. The aim of this study was to investigate the possible relationship between social anxiety symptoms and plasma oxytocin levels. Methods Twenty-three male patients with SAD and 28 healthy male controls participated in this study. All participants were assessed using the Mini International Neuropsychiatric Interview (MINI) and the Liebowitz Social Anxiety Scale (LSAS). Multivariate regression analysis was performed to identify associations between plasma oxytocin levels and SAD. Results In multiple regression models, after controlling for age and years of education, we found that higher oxytocin levels were significantly associated with higher total LSAS scores ($R^2=0.157$, coefficient=0.145, 95% CI=-0.0005-0.291, p=0.051) and fear subscale scores ($R^2=0.134$, coefficient=0.083, 95% CI=0.007-0.159, p=0.034) in the SAD group. Conclusion In this study, increased plasma oxytocin levels were associated with higher social anxiety symptoms among SAD patients, but not among controls. This might be because among SAD patients, higher oxytocin (OT) secretion is an insufficient compensatory attempt to reduce social anxiety symptoms.

• Biomolecules & Therapeutics
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• v.27 no.4
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• pp.349-356
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• 2019

Behavioral analysis in mice provided important contributions in helping understand and treat numerous neurobehavioral and neuropsychiatric disorders. The behavioral performance of animals and humans is widely different among individuals but the neurobehavioral mechanism of the innate difference is seldom investigated. Many neurologic conditions share comorbid symptoms that may have common pathophysiology and therapeutic strategy. The forced swim test (FST) has been commonly used to evaluate the "antidepressant" properties of drugs yet the individual difference analysis of this test was left scantly investigated along with the possible connection among other behavioral domains. This study conducted an FST-screening in outbred CD-1 male mice and segregated them into three groups: high performers (HP) or the active swimmers, middle performers (MP), and low performers (LP) or floaters. After which, a series of behavioral experiments were performed to measure their behavioral responses in the open field, elevated plus maze, Y maze, three-chamber social assay, novel object recognition, delay discounting task, and cliff avoidance reaction. The behavioral tests battery revealed that the three groups displayed seemingly correlated differences in locomotor activity and novel object recognition but not in other behaviors. This study suggests that the HP group in FST has higher locomotor activity and novelty-seeking tendencies compared to the other groups. These results may have important implications in creating behavior database in animal models that could be used for predicting interconnections of various behavioral domains, which eventually helps to understand the neurobiological mechanism controlling the behaviors in individual subjects.

• Journal of Microbiology and Biotechnology
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• v.31 no.1
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• pp.51-62
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• 2021

Here, we investigated the prebiotic and antioxidant effects of Actinidia arguta sprout water extract (AASWE) on lipopolysaccharide (LPS)-induced cognitive deficit mice. AASWE increased viable cell count, titratable acidity, and acetic acid production in Lactobacillus reuteri strain and showed a cytoprotective effect on LPS-induced inflammation in HT-29 cells. We assessed the behavior of LPS-induced cognitive deficit mice using Y-maze, passive avoidance and Morris water maze tests and found that administration of AASWE significantly improved learning and memory function. The AASWE group showed antioxidant activity through downregulation of malondialdehyde levels and upregulation of superoxide dismutase levels in brain tissue. In addition, the AASWE group exhibited activation of the cholinergic system with decreased acetylcholinesterase activity in brain tissue. Furthermore, AASWE effectively downregulated inflammatory mediators such as phosphorylated-JNK, phosphorylated-NF-κB, TNF-α and interleukin-6. The major bioactive compounds of AASWE were identified as quercetin-3-O-arabinopyranosyl(1→2)-rhamnopyranosyl(1→6)-glucopyranose, quercetin-3-O-apiosyl(1 → 2)-galactoside, rutin, and 3-caffeoylquinic acid. Based on these results, we suggest that AASWE not only increases the growth of beneficial bacteria in the intestines, but also shows an ameliorating effect on LPS-induced cognitive impairment.

• Journal of Apiculture
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• v.34 no.4
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• pp.315-323
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• 2019

Large amounts of sludge produced by paper mill industries represent one of the most serious environmental problems in the world. Recently, beekeepers living in the neighborhood of the paper mill in Hwasan County, Youngcheon city, GB, Korea, became alarmed that honey bee colonies were dying off suddenly across the neighborhood. A preliminary study was conducted to evaluate the toxicity (oral, fumigation, repellent) of recycled solid paper mill sludge (SPMS) and leachate paper mill sludge (LPMS) to honey bee workers under laboratory conditions, and to analyze the volatile organic compounds(VOC). The SPMS and LPMS were separately subjected to a liquid-liquid extraction (LLE) at three temperatures to extract VOC(highest VOC yields: 1.52% SPMS and 0.34% LPMS). A total of 70 chemicals were detected in the VOC of paper mill sludges, of which 49 and 21 volatile organic compounds from SPMS and LPMS, respectively. The SPMS was dominated by high degree presence of stanols (saturated sterols), such as cholestanol, cholestan-3-ol and also saturated hydrocarbons. However, LPMS was characterized by the absence of sterols. Both SPMS and LPMS showed an influence on the olfactory behavior of honey bee on Y-tube assay, with repulsion rates of 72 and 68%, respectively. Both SPMS and LPMS at concentration of 100mg/mL caused higher honey bee oral mortality than the untreated controls at 48, 72, 96 and 120 hours after treatment(highest oral mortality at 120 hr: 85.74%(SPMS); 93.51 % (LPMS)). A similar pattern was observed when honey bees were tested to fumigant toxicity. Both SPMS and LPMS caused significant higher mortality than the untreated control 24 hour after the exposure (highest fumigation mortality at 120 hr: 69.4% (SPMS); 56.8% (LPMS)). These preliminary results indicated that paper mill sludge could be partly responsible for sudden death and disappearance of honey bees, especially in hot humid summer days. With climate change, the risk of environmental chemical exposure to honey bee would pose greater attention.