• Korean Journal of Logic
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• v.18 no.1
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• pp.133-153
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• 2015

In his paper "Structural Equations Approach to Token Causation: The Active Route Account Revisited" Professor Sungsu Kim defends the active route account. The active route account is the theory of causation which overcomes counterexamples to the counterfactual theories of causation, while maintaining the counterfactual theorist's essential intuition that an effect depends counterfactually on a cause. Unfortunately, there are counterexamples to the active route account itself. Professor Sungsu Kim attempts to defend the active route account by rebutting those counterexamples. In this paper, I argue that his defense of the active route account is not successful.

• Korean Journal of Logic
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• v.18 no.2
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• pp.265-289
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• 2015

The idea that an effect counterfactually depends on its cause is simple and intuitive. However, this simple idea runs into various difficulties. The active route account, in order to avoid the difficulties, analyzes causation in terms of counterfactual dependence under certain control. In her recent article, Seahwa Kim criticizes Sungsu Kim's earlier attempt to defend the active route account from its counterexamples. Her criticisms are convincing, and defenders of the active route account or counterfactual analysis of causation in general need another defense. In response, a two-step defense is proposed. First, the scope of the active route account is restricted to 'proximate' causal relation. Second, a control over factors that are in proximate causal relation is offered to figure out 'distant' causal relation. The result is that with proper control, an effect indeed counterfactually depends on its cause.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.2
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• pp.136-141
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• 2009

Biological activities of enzymatic hydrolysate of spirulina (EHS) were investigated. EHS showed no significant effects on the growth-stimulating activity for lactic-acid bacteria and antioxidant activity. EHS showed slight in vitro growth-inhibitory effects (15% at 1.42 mg/L) on a human cervical cancer cell line (HeLa). In addition, the anticoagulant activities of EHS were measured based on three different pathways: common, intrinsic and extrinsic pathways. As an indication of anticoagulant activity on common pathway, thrombin time (TT) of EHS (100 mg/L) was measured as 155.6 sec. Activated partial thromboplastin time (aPTT) for intrinsic pathway of EHS (1,000 mg/L) was measured as 95.8 sec. Prothrombin time (PT) based on extrinsic pathway of EHS (1,000 mg/L) was measured as 10.6 sec. These data showed that EHS have influences on anticoagulant factors of common pathway and intrinsic pathway. Consequently it was found that EHS could be used as a functional food for blood circulation.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.2
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• pp.335-341
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• 2000

In order to search for blood anticoagulant substance from herbal extracts, we extracted with cold water (Fr. I), methanol (Fr. II) and hot water (Fr. III) from 93 commercially available herbs. The anticoagulant activity of herbal extracts was examined through the intrinsic pathway by activated partial thromboplastin time (APTT), the extriansic pathway by prothrombin time (PT) and the common pathway by thrombin time (TT). Onion, garlic, clove, fenugreek, mugwort, thyme and sage had on anticoagulant activity with intrinsic pathway and mint, italian seasoning, rosemary, turmeric, tarragon and wasabie had on anticoagulant activity with common pathway. Nobody had on anticogulant activity with extrinsic pathway. Among commerical herbs tested, clove cultivated in holland was selected because it showed the most potent anticoagulant activity among the samples investigated.

• Asian Journal of Turfgrass Science
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• v.1 no.1
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• pp.49-55
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• 1987

Zoysia japonica를 부위별로 나누어서 그들간의 amylase와 nitrate reductase의 활성을 조사한 결과는 다음과 같다. 1. Amylase의 활성은 관부에서 8.36~9.46 unit/mg.rotein/hr.로 가장 높았고 이삭에서 2.04 unit/mg.rotein/hr.로 가장 낮았다. 포복경, 뿌리, 잎에서의 amylase의 활성을 각각 5.42~5.82, 3.76, 2.32~3.16 unit/mg.rotein/hr.나타내었다. 2. Nirate reductase의 활성은 빛을 많이 받는 잎에서 0.35~0.66 n mole/mg.rotein/hr.로 가장 높았고 관부에서 0.06~0.10 n mole/mg.rotein/hr.로 가장 낮았다. 이삭과 포복경에서는 각각 0.31,0.27~0.63 n mole/mg.rotein/hr.를 나타내었다. 이러한 결과로부터 저장기관인 관부나 관부 절간에서 높은 amylase의 활성을 이용하여, 양분을 이삭으로 이동시키고 있음을 알 수 있었다. nitrate reductase의 활성은 chloroplast를 갖지 않는 기관보다 광합성기관에서 더 높았다. 잔디밭에서 같이 사는 크로버와 비교해 보면 amylase의 활성이 Zoysia japonica보다 2배가량 더 높았다. 이러한 결과로부터 잔디밭에서 크로버가 더 생장력이 큼을 알 수 있었다.

• The Journal of the Korea Contents Association
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• v.9 no.1
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• pp.285-292
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• 2009

The purpose of this study was to demonstrate immune-activities by heat therapy. To exam, furthermore, the immune effect is investigated from the healthy volunteer(male:15, female:15) by monitoring changes of immune substances such as complements(C1q, C3, and C4), a comparative study with warm water immersion($40.8{\pm}0.3^{\circ}C$) and infrared(250W) was carried out. The plasma analysis showed that the percentage of C1q, C3, and C4 was decreased in warm water immersion-stimulated group, but not in infrared-applied group, compared with control group from healthy volunteer. Therefore, these results suggest that the thermo-stimulation improved immune activity and inhibited complement-related inflammation through the warm water immersion-dependent classical pathway.

• Journal of Acupuncture Research
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• v.29 no.1
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• pp.25-35
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• 2012

목적 : 이 연구는 $Vipera$ $lebetina$ $turanica$ 사독(蛇毒)이 인간 대장암 세포주인 HCT116 세포에서 세포주기진행, death receptor 의존적 세포자멸사 경로 관련단백질 발현 및 NK-${\kappa}B$와 STAT3 활성에 미치는 영향을 규명함으로써 대장암 세포 성장에 대한 억제와 그 기전에 대하여 살펴보고자 하였다. 방법 : 사독을 처리한 후 HCT116의 세포주기를 분석하기 위해서 FACS analysis를 시행하였고, apoptosis 평가에는 TUNEL assay를 시행하였으며 death receptor 의존적 세포자멸사 경로 관련단백질 및 NF-${\kappa}B$와 STAT3 활성 변동 관찰에는 RT-PCR 및 western blot analysis를 시행하였다. 결과 : 1. 0.1, 0.5 및 $1{\mu}g/m{\ell}$ 등의 사독을 처리한 결과 농도 의존적으로 HCT116 대장암 세포활성의 억제가 나타났다. 2. 0.1, 0.5 및 $1{\mu}g/m{\ell}$ 등의 사독을 처리한 결과 농도의존적으로 세포자멸사 활성세포의 증가가 나타났고, SVT $1{\mu}g/m{\ell}$에서는 60-70%의 대장암세포 억제 효과가 나타났다. 3. 0.1, 0.5 및 $1{\mu}g/m{\ell}$ 등의 사독을 처리한 결과 약한 G1 arrest와 강한 G2/M arrest가 나타났고, G0/G1 또는 G2/M 관련 cyclin D, E 및 B1의 증가가 나타났다. 4. 0.1, 0.5 및 $1{\mu}g/m{\ell}$ 등의 사독을 처리한 결과 death receptor4, 5의 발현증가와 그에 따른 세포자멸사 촉진 Bax, PARP, caspase-3, -8, -9 발현 증가 및 세포자멸사 억제의 Bcl-2의 발현 감소 등이 나타났다. 6. 0.1, 0.5 및 $1{\mu}g/m{\ell}$ 등의 사독을 처리한 결과 NF-${\kappa}B$와 STAT3의 활성변동은 관찰되지 않았다. 결론 : 이상의 연구에서 사독은 death receptor 의존적인 세포자멸사를 촉진하여 대장암의 화학치료 내성을 극복할 수 있는 하나의 대안이 될 것으로 생각되지만 보다 심화된 연구가 필요할 것으로 사료된다.

• Journal of the Korea Institute of Building Construction
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• v.10 no.5
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• pp.37-44
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• 2010

This study examined the practical application of ground granulated blast-furnace slag (GGBS) based alkali-activated (AA) binders for the development of cementless environmental-friendly secondary products of concrete, such as brick, shore protection blocks and interlocking blocks. The addition amount and type of alkaline ion to activate GGBS varied according to the diverse qualities of the secondary products of concrete required in Korean industrial standards (KS) and other specifications. Test results showed that the secondary products of concrete using GGBS-based AA binders surpassed the demanded capacities of KS and other specifications. In addition, shore protection block had a pH value close to neutral, enabling an advantageous environment for marine life. Therefore, the GGBS-based AA binders can be effectively applied to develop eco-friendly secondary products of concrete with reduced $CO_2$.

• Korean Journal of Animal Reproduction
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• v.20 no.4
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• pp.395-412
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• 1997

Mammalian eggs are ovulated arrested at meiotic metaphase II until fertilization. Generally in mammals, fertilization results in a series of intracellular calcium oscillations that are mediated by inositol triphosphate (IP$^3$) or cyclic adenosine diphosphoribose (cADPr). The high levels of maturation promotion factor (MPF) within the cell decrease, pronuclei form, the cytoskeleton is reorganized and proteins are post-translationally modified. If all is normal, the newly formed embryo initiates the developmental program specific to that species. Artificial methods of producing these effects in pig oocytes are discussed. One potential mechanism mediated via a signal transduction pathway is present in pig oocytes. Stimulation of this pathway leads to the early events following fertilization, and electrical stimulation leads to apparently normal de v velopment to day 12. Further studies are needed to determine which mechanism(s) the sperm uses to initiate development.

• Journal of Plant Biotechnology
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• v.46 no.1
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• pp.45-55
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• 2019

TheCitrus grandis Osbeck is a special product in the Jeju island. The product has been as a remedy for liver damage and hang over. This study demonstrates how to investigate and compare the antioxidant, phenol content, tyrosinase and ${\alpha}$-glucosidase inhibitory activity, antimicrobial, and alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activity with the C. grandis leaves extracted in different ethanol concentrations. From the yield, a 20% ethanol extract demonstrated the highest results among the other extracts. The distilled water extract showed the most abundant in a total phenol content and highest ABTS radical scavenging activity and reducing power assay. In the DPPH radical scavenging activity, ${\alpha}$-glucosidase and tyrosinase inhibitory assay (used ${\text\tiny{L}}$-tyrosine as substrate), the 80% ethanol extract exhibited a higher value than other extracts. The 60% ethanol extract showed prominent activities in the tyrosinase inhibitory (used ${\text\tiny{L}}$-dopa as substrate), ADH and ALDH activity assay. In the minimum inhibitory concentration (MIC) assay, 60% and 80% ethanol extracts inhibited the bacterial growth almost similarly. Moreover, the gram-positive bacteria was more restrained than the gram-negative bacteria. The resultsrevealed that the distilled water and 80% ethanol extract showed a relatively higher antioxidant activity compared to other extracts. The 60 ~ 80% ethanol extracts demonstrated potential tyrosinase, ${\alpha}$-glucosidase inhibitory, antimicrobial, ADH and ALDH activities. Therefore, the C. grandis is suggested to be considered as a functional material for various proposes.