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http://dx.doi.org/10.3746/jkfn.2009.38.2.136

Investigation of Biological Activities of Enzymatic Hydrolysate of Spirulina  

Son, Min-Hee (Dept. of Food and Biotechnology, Hoseo University)
Park, Keun-Hyoung (Dept. of Food and Biotechnology, Hoseo University)
Choi, A-Reum (Dept. of Food and Biotechnology, Hoseo University)
Yoo, Gui-Jae (Dept. of Food and Biotechnology, Hoseo University)
In, Man-Jin (Chungwoon University)
Kim, Dong-Ho (Vitamin Co., Ltd.)
Chae, Hee-Jeong (Dept. of Food and Biotechnology, Hoseo University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.38, no.2, 2009 , pp. 136-141 More about this Journal
Abstract
Biological activities of enzymatic hydrolysate of spirulina (EHS) were investigated. EHS showed no significant effects on the growth-stimulating activity for lactic-acid bacteria and antioxidant activity. EHS showed slight in vitro growth-inhibitory effects (15% at 1.42 mg/L) on a human cervical cancer cell line (HeLa). In addition, the anticoagulant activities of EHS were measured based on three different pathways: common, intrinsic and extrinsic pathways. As an indication of anticoagulant activity on common pathway, thrombin time (TT) of EHS (100 mg/L) was measured as 155.6 sec. Activated partial thromboplastin time (aPTT) for intrinsic pathway of EHS (1,000 mg/L) was measured as 95.8 sec. Prothrombin time (PT) based on extrinsic pathway of EHS (1,000 mg/L) was measured as 10.6 sec. These data showed that EHS have influences on anticoagulant factors of common pathway and intrinsic pathway. Consequently it was found that EHS could be used as a functional food for blood circulation.
Keywords
spirulina hydrolsate; biological activity; anticoagulant activity;
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