• The Korea Journal of Herbology
• /
• v.35 no.6
• /
• pp.11-19
• /
• 2020

Objective : The genus Glycyrrhiza has been used in food and traditional herbal medicine. Glycyrrhiza new varieties Wongam and Sinwongam have been developed by Korea Rural Development Administration and investigated to register on Korean Pharmacopoeia of the Ministry of Food and Drug Safety. The aim of this study is to investigate the immunomodulatory effect of Wongam and Sinwongam comparing with listed Glycyrrhiza species (Glycyrrhiza uralensis Fischer and G. glabra Linne) for evaluations about pharmacological effect of Glycyrrhiza new varieties. Methods : We studied the immunomodulatory effect of Wongam and Sinwongam compared with G. uralensis and G. glabra using THP-1 cell in vitro model. The cells were treated with phorbol 12-myristate 13-acetate (PMA) for differentiation and stimulated with lipopolysaccharides (LPS) to induce immune activation. We analyzed and compared the effects Glycyrrhiza new varieties and listed Glycyrrhiza species using nitric oxide (NO) assay, western blot, and reverse transcription-quantitative polymerase chain reaction analysis. 1) Results : Wongam and Sinwongam showed no cytotoxicity in THP-1 cells. Wongam and Sinwongam, and listed Glycyrrhiza species increased NO production, and cyclooxygenase (COX)-2 expression with or without LPS in differentiated THP-1 macrophages. Furthermore, Wongam and Sinwongam and listed Glycyrrhiza species upregulated the mRNA expressions of T helper type 1 (Th 1)-associated cytokines in LPS-stimulated THP-1 macrophages. Conclusion : These results indicated that Wongam and Sinwongam would have effect of enhancing immune response through the increase of NO and COX-2 expression, and activate Th1-associated cytokines. The findings of this study suggest the wide applicability of Glycyrrhiza new varieties.

• Journal of Navigation and Port Research
• /
• v.38 no.3
• /
• pp.227-232
• /
• 2014

There are three essential components of eLoran: dLoran, data map of ASF, and the Loran data channel. Particularly, dLoran improves navigation accuracy, which is the core technology of eLoran systems. The requirement of HEA's absolute accuracy, less than 20 meters, can be satisfied via dLoran measurements and their corrections. In this study, dLoran measurements using the Pohang Loran-C (9930M) station signal were conducted at Yeongil Bay. We established a dLoran reference station at Homigot Management Office for navigation aids within the Bay. We estimated the effectiveness of the dLoran between the reference site (Homigot Management Office) and a test site (Heunghwan beach) by measuring TOAs. We verified that the TOA data measured at these two regions were highly correlated. The temporal differences in the data between the dLoran reference station and test site were about 10~30 ns per day, which is equivalent to a ranging error of 3~9 m. This result shows that eLoran can meet the requirement of 8~20 meters position accuracy for maritime HEA by correcting the ASF at the user's receiver.

• Journal of IKEEE
• /
• v.24 no.3
• /
• pp.699-705
• /
• 2020

In this study, a facial way to enhance the electrical properties of organic light-emitting diodes (OLEDs) via the solution process doping method based on the poly[(9,9-dioctylfluorenyl-2,7-diyl)-co-(4,4'-(N-(4-sec-butylphenyl) diphenylamine)] (TFB) as a hole transporting layer (HTL) is demonstrated. In the TFB solution of the hole transport material, 1,4,5,8,9,11-hexaazatriphenylene hexacarbonitrile (HAT-CN) was doped by 3 wt% to improve the electrical properties of the HTL. According, the OLED with HAT-CN doped TFB showed the increased current density and luminance at the same driving voltage on behalf of the improved conductivity of HTL, and the reduced turn-on voltage from 13 V to 9 V. Furthermore, the maximum external quantum efficiency was dramatically increased three times from 3.6 to 10.8 % compared to the reference device without appling doping methode.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.12
• /
• pp.730-736
• /
• 2019

The demand for natural gas, which is considered an environmentally friendly energy source, is increasing, and at the same time, the market share of large pipelines for natural gas supply is increasing continuously. On the other hand, the corrosion of such large pipelines reduces the efficiency of natural gas transportation. Therefore, this study aims to establish a strategy for securing the patent rights of related technologies through quantitative analysis of patents on energy-independent high-efficiency corrosion prevention technology for large-scale pipelines for natural gas supply. In this patent technology trend study, Korean, US, Japanese, and European patents filed, published, and registered by June 2018 were analyzed, and a technical classification system and classification criteria were prepared through expert discussion. To use fuel cells as an external power source to prevent the corrosion of natural gas large-scale pipelines, it is believed that rights can be claimed using an energy control system and methods having 1) branch structures of pipeline and facility designs (decompressor/compressor/heat exchanger) and 2) decompression/preheating and pressurization/cooling technology of high pressure natural gas.

• Development and Reproduction
• /
• v.13 no.4
• /
• pp.265-270
• /
• 2009

The fertilized eggs were obtained from mature adult slime flounder Microstomus achne to determine the water temperature effect on egg development. The lowest water temperature for the flounder egg development was $0.4^{\circ}C$ on average. The temperature-dependent duration from fertilization to hatching ranged 86.5 to 296.7 hours at $9\sim21^{\circ}C$ with an accelerated development at higher temperature. Agreeable hatching rates, 95.8~97.0%, were obtained at $12\sim18^{\circ}C$, while lower at both extremes, 86.9% at $9^{\circ}C$ and 9.3% at $21^{\circ}C$. The highest water temperature, $24^{\circ}C$, had the life of the fertilized eggs confined within 24 hours. Water temperature was a parameter that induced an abnormal egg development: with abnormalities of 88.3% at $21^{\circ}C$, 2.1% at $9^{\circ}C$ (P<0.05), and 0.4~0.8% at $12\sim18^{\circ}C$.

• Journal of Korean Foot and Ankle Society
• /
• v.10 no.2
• /
• pp.117-124
• /
• 2006

Purpose: This study was aimed at elucidating the pathogenesis of talar osteochondral lesion by analyzing the histopathological findings. Materials and Methods: Twenty specimens from 20 patients who underwent surgical treatment for talus osteochondral lesions were studied. Preoperative MRI images including T1, T2, and stir images were taken and cases were classified according to modification of the Anderson's classification. There were 5 cases of MRI group 1, 6 cases of group 2, 7 cases of group 3 and 2 cases of group 4. A full thickness osteochondral plug including the osteochondral lesion of the talus was harvested from each patient and reviewed histopathologic changes of osteochondral fragment using H-E staining. Mean diameter of specimens was 8.5 mm and mean depth was 10.3 mm. Pathologic changes of articular cartilage and subchondral bone were observed. Subchondral bone was divided into superficial, middle and deep zones according to depth. Cartilage formation, trabecular thickening and marrow fibrosis were observed in each zone. Results: There were detachment of the joint cartilage at the tidemark in 16 cases of 20 cases and the separated cartilages were almost necrotic on the histopathologic findings. Cartilage formation within subchondral bone was discovered beneath the tidemark in 12 cases. Trabeculae were increased and thickened in 17 cases. These pathologic changes were similar to fracture healing process and these findings were more conspicuous near the tidemark and showed transition to normal bone marrow tissue with depth. No correlation between the pathological progression and MRI stages was found. A large cyst shown on MRI's was microscopically turned out to be multiple micro-cysts accompanied by fibrovascular structure and newly formed cartilage tissue. Conclusion: The histopathologic findings of osteochondral lesions are detachment of overlying cartilage at the tidemark and subsequent changes of subchondral bone. Subchondral bone changes are summarized as cartilage formation, marrow fibrosis and trabecular thickening that mean healing process following repeated micro fractures of trabecular. These osteochondral lesions should have differed from osteochondral fractures.

• Proceedings of the KWS Conference
• /
• 2009.11a
• /
• pp.92-92
• /
• 2009

조선업을 포함한 다양한 산업 분야에서 후판 강재의 수요량 증가와 함께 사용 범위 또한 폭넓게 되고 있다. 특히, 선박의 수송효율의 극대화를 위하여 컨테이너선의 대형화가 급속하게 진행되고 있으며, 2009년 현재1,300TEU 이상의 초대형 컨테이너선이 건조되고 이다. 이처럼 용접구조물의 초대형화에 따른 사용강재 또한 고강도 극후물화 되고 있다. 현재 선박에 적용중인 고강도 강재는 EH47 강재로 YP 460MPa 급의 강재가 Hatch Coamming부에 적용중에 있으며, 강재의 두께 또한 70mm 이상이다. 이러한 고강도 극후물재의 강구조물에 적용에 따른 선급협회에서는 용접부에서의 취성균열 전파에 의한 취성파괴의 위험성이 있으므로 강재의 두께를 제한하고 더욱 엄격한 파괴인성값을 요구하고 있다. 일본선급협회(NK)를 중심으로 취성균열의 정지를 위한 모재의 요구 성능등에 관한 연구들이 진행되고 있다. 이 연구의 대부분의 전제 조건은 선박의 블럭과 블럭의 조립시에 용접부가 직선형이 아닌 계단형(Butt shift)를 하는 것으로 하고 있으므로, 국내의 조선건조 공법의 현실과는 거리감이 있다. 본 연구에서는 국내 조선사에서 수행중인 직선 이음부에 대한 시공 공법에서 취성균열이 발생하여 진전 되더라도 균열을 정지 시킬 수 있는 기술에 관한 연구를 수행하였다. 균열의 진전은 대부부의 연속면에서는 정지를 시키지 못하고 직진 전파 하여서 파괴에 도달하게 된다. 따라서 뭔가의 불연속적인 면을 임의로 생성하여야 균열을 정지 시킬 수 있다. 본 연구에서는 이러한 균열의 정지 방법으로 형상적인 측면과 재료적인 측면에서 검토를 수행하였다. 형상적인 측면에서는 균열을 정지 시키고자 하는 위치에 불연속적인 면을 만들기 위하여 일정 크기의 hole을 만들어서 균열을 정지시켰으며, 재료적인 측면에서는 고인성의 용접재료를 사용하여서 취성균열이 진행하는 경로에 인성을 높은 재료를 적용하여 불연속적인 면의 생성과 함께 인성을 높여서 균열을 정지 시키는 기술을 개발하였다. 이러한 기술의 개발을 통하여 취성균열의 전파에 의한 파괴를 방지 할 수 있으며, 용접구조물의 안전성 확보를 가능하게 하였다.

• The Korean Journal of Nuclear Medicine
• /
• v.31 no.1
• /
• pp.1-8
• /
• 1997

뇌성마비는 뇌 발달시기중 초기의 장애로 인하여 운동기능과 자세의 이상 등을 초래하는 질환으로 임상적으로 여러 유형으로 나누어진다. 뇌성마비 환자중에서 MRI 상 롤란도야의 이상소견을 보이는 경우 특이한 임상적 특징을 나타낸다고 보고되어있다. 본 논문에서는 이들을 대상으로 하여 뇌 단일광자컴퓨터촬영에서 나타나는 뇌혈류 이상 소견과 MRI 소견, 그리고 임상양상들을 비교해보고자 하였다. 임상적으로 뇌성마비로 진단된 80여명의 환자중 MRI상 롤란도야에 저산소성 뇌질환의 소견을 보인 7명을 대상으로 하였다. 이들에게 5-10mCi의 Tc-99m-ECD를 정맥주사후 뇌 단일광자컴퓨터촬영을 하였다. 뇌 단일광자컴퓨터촬영상에서는 특히 뇌피질, 선조체, 시상, 뇌간 및 소뇌의 혈류이상 소견을 분석하였고, 이를 MRI 소견 및 임상증상과 비교하였다. 모든 환자들은 만삭 또는 만삭에 가깝게 태어났고, 주산기 아사가 여섯명의 환자에서 있었다. 임상적으로는 긴장성 사지마비로 나타났다. Tc-99m ECD를 이용한 뇌 단일광자 컴퓨터촬영상 롤란도야의 혈류감소는 모두에서 확연하게 나타났다 MRI상에서 롤란도야의 이상소견은 5명에서는 확실하게 나타났고, 2명에서는 의심되었다. MRI상에서 이상소견을 보인 것보다 더 광범위한 부분에서 뇌단일광자컴퓨터촬영상 이상소견이 보였다. 결론적으로, 롤란도야에서 이상소견을 보인 환자는 임상적, 구조적, 그리고 기능적으로 특이한 소견을 보였다. Tc-99m-ECD를 이용한 뇌 단일광자컴퓨터촬영은 매우 민감하게 반영하였고, MRI보다 뇌의 더 광범위한 부위에서 이상소견을 보였다.

• Journal of The Korean Society of Grassland and Forage Science
• /
• v.27 no.4
• /
• pp.229-234
• /
• 2007

To select the most proper soil for root initiation from stem cuts of Birdsfoot trefoil (Lotus corniculatus L.), eight-week-old stem cuts were cultured on three types of soil [commercial bed soil, decomposed granite (DCG), and river sand] for one month. The results showed that the root initiation ratios on DCG (77.8%) and river sand (70.0%) were relatively high, but the ratio on commercial bed soil (41.1%) was very low. To examine the effect of rare earth (RE) and Indole-3-Butyric Acid (IBA) on root initiation from stem cuts of Birdsfoot Trefoil, stem cuts were cultured on two types of soil (DCG and river sand) with treatment of RE and IBA for one month. The root initiation ratios turned out to be 90.0% (DCG with 60 ppm of RE), 80.0% (river sand with 20 ppm of RE), 96.7% (DCG with 40 ppm of IBA), and 96.7% (river sand with 40 ppm of IBA). These results suggested that the most efficient way for root initiation of Birdsfoot trefoil was to culture the stem cuts on river sand or DCG over 30 days with IBA treatment (40 ppm).

• Journal of Life Science
• /
• v.15 no.2 s.69
• /
• pp.287-292
• /
• 2005

The crude galactomannans (GMs) were obtained from the culture of a newly isolated fungus Trichoderma erinaceum DG-312 and their anti-inflammatory activity was investigated in mice. The maximum concentrations of mycelial biomass and GMs reached 9.44 g/l, 2.72 g/l at day 3 in a 5-l stirred-tank bioreactor, respectively. The results of Sepharose CL-6B gel chromatography and compositional analysis revealed that the crude GMs contain heterogeneous polysaccharides consisting of $74.9\%$ mannose and $24.1\%$ galactose. The GMs was shown to possess a significant anti-inflammatory activity against acetic acid-induced inflammatory mouse model in a dose-dependent manner, when mice were treated with 100 and 200 mg GMs/kg body weight. The inhibition in vascular permeability $(60.6\%)$ and in writhing response $(62.5\%)$ evidenced an anti-inflammatory activity of the GMs. The marked anti-inflammatory and writhing-lowering properties of the GMs suggest its potential therapeutic use.