Browse > Article
http://dx.doi.org/10.5352/JLS.2005.15.2.287

Anti-inflammatory Activity of the Galactomannans Produced by a New Fungal Strain Trichoderma erinaceum DG-312  

Joo Ji-Hoon (Department of Biotechnology, College of Engineering, Daegu University)
Lim Jong-Min (Department of Biotechnology, College of Engineering, Daegu University)
Koo Kwang-Bon (Department of Bioindustry, College of Life & Environment, Daegu University)
Yun Jong-Won (Department of Biotechnology, College of Engineering, Daegu University)
Choi Jang Won (Department of Bioindustry, College of Life & Environment, Daegu University)
Publication Information
Journal of Life Science / v.15, no.2, 2005 , pp. 287-292 More about this Journal
Abstract
The crude galactomannans (GMs) were obtained from the culture of a newly isolated fungus Trichoderma erinaceum DG-312 and their anti-inflammatory activity was investigated in mice. The maximum concentrations of mycelial biomass and GMs reached 9.44 g/l, 2.72 g/l at day 3 in a 5-l stirred-tank bioreactor, respectively. The results of Sepharose CL-6B gel chromatography and compositional analysis revealed that the crude GMs contain heterogeneous polysaccharides consisting of $74.9\%$ mannose and $24.1\%$ galactose. The GMs was shown to possess a significant anti-inflammatory activity against acetic acid-induced inflammatory mouse model in a dose-dependent manner, when mice were treated with 100 and 200 mg GMs/kg body weight. The inhibition in vascular permeability $(60.6\%)$ and in writhing response $(62.5\%)$ evidenced an anti-inflammatory activity of the GMs. The marked anti-inflammatory and writhing-lowering properties of the GMs suggest its potential therapeutic use.
Keywords
Anti-inflammatory activity; capillary permeability; galactomannans; submerged culture; Trichoderma erinaceum;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Bohn, J.A. and J. N. BeMiller. 1995. (1-3)-,$\beta$-D-Glucans as biological response modifiers: a review of structure-functional activity relationships. Carbohydrate Polymers 28, 3-14   DOI   ScienceOn
2 Burdan, F., J. Szumilo, R. Klepacz, J. Dudka, A. Korobowicz, E. Tokarska, M. Cendrowska-Pinkosz, B. Madej and L. Klepacz. 2004. Gastrointestinal and hepatic toxicity of selective and non-selective cyclooxygenase-2 inhibitors in pregnant and non-pregnant rats. Pharmacological Research 50, 533-543   DOI   ScienceOn
3 Chia, J. E., F. Crenner, M. H. Metz-Boutigue, D. Aunis and F. Angel. 2004. The effect of a chromogranin A-derived peptide (CgA4-16) in the writhing nociceptive response induced by acetic acid in rats. Life Sciences 75, 1787-1799   DOI   ScienceOn
4 Choi, E. M. and J. K. Hwang. 2004. Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. Fitoterapia 75, 557-565   DOI   ScienceOn
5 Diniz, R. O., L. K. Garla, J. M. Schneedorf and J. C. T. Carvalho. 2003. Study of anti-inflammatory activity of Tibetan mushroom, a symbiotic culture of bacteria and fungi encapsulated into a polysaccharide matrix. Pharmacological Research 47, 49-52   DOI   ScienceOn
6 Duncan, C. J. G., N. Pugh, D. S. Pasco and S. A Ross. 2002. Isolation of a galactomannan that enhances macrophage activation from the edible fungus Morchella esculenta. J. of Agri. and Food Chem. 50, 5683-5685   DOI   ScienceOn
7 Aderem, A. and K. D. Smith. 2004. A systems approach to dissecting immunity and inflammation. Seminars in Immunology 16, 55-67
8 Adzu, B., S. Amos, S. Dzarma, I. Muazzam and K. S. GamanieL 2002. Pharmacological evidence favoring the folkloric use of Diospyros mespilijormis Hochst in the relief of pain and fever. J. of Ethnopharmacology 82, 191-195   DOI   ScienceOn
9 Theresa, A. B. and J. B. Greg. 2003. A review of the non-target effects of fungi used to biologically control plant diseases. Agriculture Ecosystems and Environment 100, 3-16   DOI   ScienceOn
10 Eufrocinio, C. M., B. Takeshi, I. K. Shin, F. Ei-ichiro and K. Akio. 2002. Biosynthetic studies of the tetramic acid antibiotic trichosetin. Tetrahedron 58, 6655-6658   DOI   ScienceOn
11 Thompson, J. D., D. G. Higgins and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalies and weight matrix choice. Nucl. Acids Res. 22, 4673-4680   DOI   ScienceOn
12 Ukawa, Y., H. Ito and M. Hisamatsu. 2000. Antitumor effects of (1$\rightarrow$3)-$\beta$-D-glucan and (1$\rightarrow$6)-$\beta$-D-glucan purified from newly cultivated mushroom, Hatakeshimeji (Lyophyllum decastes Sing.). J. of Bioscience and Bioengineering 90, 98-104   DOI   ScienceOn
13 Van der Meeren A., P. Monti, L. Lebaron-jacobs, C. Marquette and P. Gourmelon. 2001. Characterization of the acute inflammatory response after irradiation in mice and its regulation by interleukin 4 (II4). Radiation Research 155, 858-865   DOI   ScienceOn
14 Morris, E., O. P. E. Doyle and K. J. Clancy. 1995a. A profile of Trichoderma species. I. Mushroom compost production. Mushroom Science 14, 611-618
15 Warner, R. L., N. M. Bless, C. S. Lewis, E. Younkin, L. Beltran, R. F. Guo, K. J. Johnson and J. Varani. 2000. Time dependent inhibition of immune complex-induced lung injury by catalase: relationship to alterations in macrophage and neutrophil matrix metalloproteinase elaboration. Free Radical Biology and Medicine 29, 8-16   DOI   ScienceOn
16 Whittle, B.A. 1964. The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics. British J. of Pharmacology 22, 246-253
17 Yu, R., L. Song, Y. Zhao, W. Bin, L. Wang, H. Zhang, Y. Wu, W. Ye and X. Yao, 2004. Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris. Fitoterapia 75, 465-472   DOI   ScienceOn
18 Morris, E., O. P. E. Doyle and K. J. Clancy. 1995b. A profile of Trichoderma species. II. Mushroom growing units. Mushroom Science 14, 619-626
19 Navarro, P., R. M. Giner, M. C. Recio, S. Manez, M. Cerda Nicolas and J. L. Rios, 2001. In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium. Life Sciences 68, 1199-1206   DOI   ScienceOn
20 Ribeiro, R. A, M. L. Vale, S. M. Thomazzi, A B. P. Paschoalato, S. Poole, S. H. Ferreira and F. Q. Cunha. 2000. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur. J. of Pharmacol. 387, 111-118   DOI   ScienceOn
21 Somchit, N., F. Sanat, E. H. Gan, I. A. W. Shahrin and A. Zuraini. 2004. Liver injury induced by the non-steroidal anti-inflammatory drug mefenamic acid. Singapore Medical Journal 45, 530-532
22 Pereira, B. M. R., B. P. Silva, N. A Pereira and J. Parente. 2000. Anti-inflammatory and immunologically active polysaccharides of Periandra mediterranea. Phytochemistry 54, 409-413   DOI   ScienceOn
23 Silva, B. P. and J. P. Parente. 2001. An anti-inflammatory and immunomodulatory polysaccharide from Orbignya phalerata. Fitoterapia 72, 887-893   DOI   ScienceOn
24 Silva, B. P. and J. P. Parente. 2003. Bioactive polysaccharides form Costus spocatus. Carbohydrate Polymers 51, 239-242   DOI   ScienceOn
25 Schinella, G. R., H. A. Tournier, J. M. Prieto, P. Mordujovich de Buschiazzo and J. L. Rios, 2002. Antioxidant activity of anti-inflammatory plant extracts. Life Sciences 70, 1023-1033   DOI   ScienceOn
26 Shen, Y. C., C. J. Chou, Y. H. Wang, C. F. Chen, Y. C. Chou and M. K. Lu, 2004. Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species. FEMS Microbiology Letters 231, 137-143   DOI   ScienceOn
27 Gepdiremen, A., V. Mshvildadze, H. Suleyman and R. Elias. 2004. Acute and chronic anti-inflammatory effects of Hedera colchica in rats. J. of Ethnopharmacology 94, 191-195   DOI   ScienceOn
28 Jose, N., T. A. Ajith and K. K. Janardhanan. 2004. Methanol extract of the oyster mushroom, Pleurotus florida, inhibits inflammation and platelet aggregation. Psychotherapy Research 18, 43-46
29 Lakshmi, B., T. A Ajith, N. Sheena, N. Gunapalan and K. K. Janardhanan. 2003. Antiperozidative, anti-inflammatory, and antimutagenic activities of ethanol extract of the mycelium of Ganodemla lucidum occurring in south india. Teratogenesis Carcinogenesis and Mutagenesis Supplement 1, 85-97
30 Carbone, I. And L. M. Kohn. 1993. Ribosomal DNA sequence divergence within internal transcribed spacer 1 of the Selerotiniaccae. Mycologia 85, 415-427   DOI
31 Warner, T. D. and J. A. Mitchell. 2004. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB Journal 18, 790-804   DOI   ScienceOn
32 Kumar, R., G. Clermont, Y. Vodovotz and C. C. Chow. 2004. The dynamics of acute inflammation. J. of Theoretical Biology 230, 145-155   DOI   ScienceOn
33 Kim, S. W., H. J. Hwang, J. P. Park, Y. J. Cho, C. H. Song and J. W. Yun. 2002. Mycelial growth and exo-biopolymer production by submerged culture of various edible mushrooms under different media. Letters in Applied Microbiology 34, 56-61   DOI   ScienceOn
34 Kim, G. Y., H. S. Park, B. H. Nam, S. J. Lee and J. D. Lee. 2003. Purification and characterization of acidic proteoheteroglycan from the fruiting body of Phellinus linteus (Berk. & M.A. Curtis) Teng. Bioresource Technol. 89, 81-87   DOI   ScienceOn
35 Kim, S. H., Y. S. Song, S. K. Kim, B. C. Kim, C. J. Lim and E. H. Park. 2004. Anti-inflammatory and related pharmacological acitivities of the n-BuOH subfraction of mushroom Phellinus linteus. J. of Ethnopharmacology 93, 141-146   DOI   ScienceOn
36 Mifio, J., V. Moscatelli, O. Hnatyszyn, S. Gorzalczany, C. Acevedo and G. Ferraro. 2004. Antinociceptive and antiinflammatory activities of Artemisia copa extracts. Pharmacological Research 50, 59-63   DOI   ScienceOn
37 Arja, M. -O., P. Marja, L. Raija and S. Pirkko. 2005. Enhanced production of cellobiohydrolases in Trichoderma reesei and evaluation of the new preparations in biofinishing of cotton. J. of Biotechnology 116, 305-317   DOI   ScienceOn
38 Bao, X., C. Liu, J. Fang and X. Li. 2001. Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst. Carbohydrate Research 332, 67-74   DOI   ScienceOn