• Proceedings of the Korean Society for Bioinformatics Conference
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• 2002.06a
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• pp.89-104
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• 2002

유전체연구사업단은 국내에서 발병 및 사망빈도가 가장 높은 위암과 간암의 퇴치를 목적으로 국가적 특목전략사업으로 연구를 추진하고 있다. 이와 별도로 보건복지부에서는 22개의 중요 질병별 유전체 연구센터를 전국적으로 추진하고 있다. 따라서, 연구가 성공적으로 진행되면 각 연구소에서 독자적으로 개발하여 제공하는 생명정보의 양은 거의 무한에 이를 것이다. 그러나 생명정보는 환자진료에 도움을 주기 위해서는 궁극적으로 임상정보와 함께 유기적으로 통합되어야 한다. 임상정보와의 통합을 위해서는 의료기관의 진료정보와 연구소의 생명정보가 연계되어 엄밀한 임상실험이 추가적으로 실시되어야 한다. 뿐만 아니라 생명정보학의 발전을 위해서는 연구대상의 임상정보가 공유되어야 한다. 유전체정보를 이용하는 생명정보학(Bioinformatics)은 각 국가마다 전략사업으로 간주하여 막대한 투자가 이루어지는 새로운 분야이다. 현재 선진국에서 개발 사용 중인 시스템의 연간 사용료가 고가이므로 국내 도입은 거의 불가능하거나 또는 매우 비효율적이다. 유전체 또는 생명정보의 임상활용 및 생명정보연구를 위한 임상정보 공유를 위해서는 우선 다음의 사항이 개발되어야 한다. 1) 다음과 같은 개별환자의 정보를 각 의료기관에서 제공 받아 저장 활용한다. - 진찰 및 임상소견, 수술기록, 경과기록, 검사결과 (임상병리, 해부병리, 방사선 등), - 영상정보 (X-ray, CT, MRI, 초음파, 전자현미경, 그래픽 등), - 환자개인기록(병력, 과거력, 가족력, 알러지 등), - 예방접종 기록 2) 각 연구소에서 첨단기술을 이용하여 개발되는 생명정보를 임상에 활용하기 위해서는 유전체연구센타와 병원간에 임상정보와 유전체 분석정보의 공유가 필수적으로 발생하게 됨으로, 유전체 정보와 임상정보의 통합은 미래 의료환경에 필수기능이 될 것이다. 3) 각 생명공학 연구소에서 사용하는 첨단 분석 장비와 생명공학 정보시스템의 자동 연계가 필요하다. 현재 국내에는 전국적인 초고속정보망이 가동되어 웹을 기반으로 하는 생명정보의 공유는 기술적으로 문제가 될 수 없으나 임상정보의 유전체연구에 그리고 유전체연구정보의 임상활용은 다양한 문제를 내포하고 있다. 이에 영상을 포함한 환자정보의 유전체연구센터와 병원정보시스템과의 효율적인 연계통합 운영을 위해 국내에서는 초기 도입단계에 있는 국제적인 보건의료정보의 표준인 Health Level 7 (textural information 공유), DICOM (image 및 wave 공유), 관련 ISO표준, WHO의 ICD9/10 (질병분류), LOINC (검사 및 관련용어), SNOMED International (의학용어) 등을 활용하여야 한다.

• The Journal of the Acoustical Society of Korea
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• v.14 no.6
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• pp.21-26
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• 1995

In this paper integral equations are derived and simulated numerically for the mutual radiation impedance of an acoustic transducer in a Plane array. It is assumed that the pistons are mounted in the rigid infinite baffle. The mutual radiation impedance is separated into resistance and reactance and plotted as a function of ka and kd. Mutual radiation resistance is decreased and perturbed according to increase of ka. Mutual radiation reactance is decreased along to increase of ka. Mutual impedance is decreased when kd is increased. However, when ka is 6, 13, and 19 the interaction effect is decayed. When the relative piston position of the two pistons is 45 degree, the amount of interaction becomes minimized.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.18 no.10
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• pp.1454-1460
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• 1993

The scattering pattern, due to an E-Polarized wave incident on M circular parallel dielectric cylinders, is computed. The multiply-scattered fields between the cylinders are considered. Modeling of infinite cylindrical scatterer of arbitrary cross sections by a number of circular cylinders is executed. By enforcing the boundary conditions on the surface of each cylinder, an infinite set of equations is obtained. The first order of scattering results from the excitation of each cylinder by only the incident wave. The second order results from the excitation of each cylinder by the first order of scattering from the remaining cylinders, and so no to an infinite order of scattering. Although the resulting equation is of infinite size, proper truncation yields very accurate numerical results.

• Journal of the Korean Society for Railway
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• v.19 no.1
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• pp.67-76
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• 2016

The asphalt-concrete trackbed system has many advantages in terms of maintenance and economics. However, methods to investigate practical use corresponding to the development of the trackbed system must be developed. The primary objective of this study was to evaluate the dynamic performance of the asphalt system in accordance with both the elastic and viscoelastic material characteristics and design thickness of the asphalt trackbed. More specifically, in order to reduce the uncertainty error of the Finite Element(FE) model, a three-dimensional full scale FE model was developed and then the infinite foundation model was considered. Finally, to compare the condition of viscoelastic materials, performance evaluation of the asphalt-concrete trackbed system was used to deal with the dynamic amplification factors; numerical results using isotropic-elastic materials in the FE analysis are presented.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.13 no.4
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• pp.437-448
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• 2000

In this study, a numerical analysis method for soil-pile interaction in frequency domain problem is presented. The total soil-pile interaction system is divided into two parts so called near field and far field. In the near field, beam elements are used lot a pile and plain strain finite elements for soil. In the far field, dynamic fundamental solution for multi-layered half planes based on boundary element formulation is adopted lot soil. These two fields are coupled using FE-BE coupling technique. In order to verify the proposed soil-pile interaction analysis, the dynamic responses of pile on multi-layered half planes are simulated and the results are compared with the experimental results. Also, various numerical analyses of piles considering different conditions of soil-pile interaction system are performed to examine the dynamic behavior of the system. It has been found that the developed method which satisfies the radiation conditions of multi-layered half planes can be applied to various structure systems effectively in frequency domain.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.12 no.1
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• pp.1-8
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• 1992

A method analizing contact pressure between plate and elastic half space is presented by using F.E.M. With the method, the pressure intensities at surface nodes of half space cae be directly calculated by using flexibility matrix of half space. The method is originally presented by Y.K. Cheung et al.(3) Insted of Y.K. Cheung's method, which use a conception of equi-contact pressure area around each surface nodes of half space in the noded rectanqular element area. We use the equi-contact pressure area around the Gaussian integration points of half space surface in the noded isoparametric element area. Numarical examples are presented and compared with other's studies.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.10 no.2
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• pp.103-112
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• 1990

This study examines the characteristics of soil behavior which includes many uncertainties in seismic design, evaluates the dynamic soil properties and studies the soil-structure interaction to generalize the applicability and economy of the available sites. An example analysis is performed for soil-structure system response assuming a containment structure built on site which includes soil layers using both elastic halfspace analysis and FEM analysis against the seismic loads from the actual design. This exercise is performed as a part of the safety analysis and economic assessment of the nuclear power plant built on soils. It includes the preparation of computer program capable of incorporating large nonlinearity in the analysis, resonable evaluation procedures to determine input soil data. Nonlinear FEM analysis of Seed and Idriss model is found suitable for the accurate analysis of dynamic response of soils. Linear FEM analysis using dynamic soil properties at strain level obtained by one-dimensional seismic response, and elastic half-space analysis using dynamic soil properties at strain level under static loads are recommended to evaluate the dynamic soil properties.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2002.11a
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• pp.55-58
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• 2002

This study is to analyze the influence of correction factor and specimen thickness on the fundamental properties of porous concrete. Results of this study were shown as follows; 1) As correction factor decrease, compaction time according to correction factor and specimen thickness decrease. Also, though correction factor is same, as specimen thickness increase, compaction time increase. So It mutt be considered that the influence of compaction time according to correction factor and specimen thickness. 2) As correction factor decrease, difference of measured thickness and designed thickness according to correction factor and specimen thickness decrease. Also, correction factor of aggregate of 10~l5mm is smaller than that of 5~l0mm. So It must be considered that the influence of correction factor according to size of aggregate.

• The Journal of the Acoustical Society of Korea
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• v.22 no.1
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• pp.54-60
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• 2003

The characteristics of radiation impedance for piston source on a spherical baffle are analyzed by algorithms which consists of Finite Element Method (FEM) and Hybrid type Infinite Element Method (HIEM). The results of self-radiation impedance for radiation angle and mutual radiation impedance between piston sources coincided with other reports on the spherical rigid baffle. For the spherical non-rigid baffles, the variations of self-radiation impedance and mutual-radiation impedance are identified. Therefore, these results can be applied to design and radiation characteristics analysis of acoustic transducers.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.581-584
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• 2008

In this study, it is willing to present that fundamental data for proposing quantitatively shrinkage cracking evaluation method such as plat-ring type restrained test method. To examine suitable size of specimen of plat-ring type restrained test method, Evaluated concrete about restrained shrinkage crack properties of numerical analysis of 3D solid element using the MIDAS program, drying shrinkage deformation, restrained shrinkage stress, crack area and crack point with inside ring diameter of specimen in 100mm, 150mm, 200mm and high of Specimen in 30mm, 50mm after curing in condition of constant temperature and usual habit of temperature 20${\pm}$3$^{\circ}$C, humidity 60${\pm}$5%. As a result, it was available about suitable estimation with inside ring diameter of specimen in more than 150mm and high of Specimen in 50mm. Hereafter, it is considered that the study concerning environmental condition and mixing factor in plat-ring type restrained test method is need.