• Journal of Pharmaceutical Investigation
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• v.33 no.3
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• pp.201-208
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• 2003

Pharmacokinetics and oral bioavailability of levosulpiride was determined in Korean healthy male volunteers. Thirty subjects received a single oral dose (25 mg) of a tablet in a randomized $2{\times}2$ cross-over design. The plasma concentrations of levosulpiride were measured by HPLC and compared with those reported in the literature. Pharmacokinetic parameters for $Isomeric^{\circledR}$ tablet (levosulpiride 25 mg) were revealed as follows: $AUC_{inf}\;737.1{\pm}176.9\;ng{\cdot}hr/ml,\;C_{max}\;56.4{\pm}20.1\;ng/ml,\;T_{max}\;4.2{\pm}1.6\;hr,\;K_a\;1.00{\pm}1.09\;hr^{-1},\;K_{el}\;0.08{\pm}0.02\;hr^{-1},\;and\;t_{1/2}\;8.8{\pm}1.9\;hr$. The rate constant of the absorption phase was obtained based on the first-order kinetics. In the aspect of bioavailability, $Isomeric^{\circledR}$ tablet was bioequivalent to the other product $(Levopride^{\circledR}\;tablet)$ available in the Korea market. Intersubject variations and race differences were show in comparison with the published data in the literature, even though there was a linear relationship between dose ad extent of bioavailability.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.2
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• pp.371-380
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• 2004

The history of the glasses can say that we began with the development of the typography. Glasses were made for the first time from the skin which they tied. We came to make the rim as the horn tree afterwards or bone. And the snail glasses make the lens as the modification or glass and to put to connect the two to large snail was developed. The rim after he brought lots of style change. The development of the Bridge and eyewear form of the Temple of an entry today began to come out. The development of and various design and material. We reached practical style. development of design concentration new fashion trend lead can make it eyewear company and designer's. A rim of various style through historical development course because we have a present time's rim analysis. We try to try to investigate a method element of the glass design with a final cause form of the design in the viewpoint of the facility.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.599_600
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• 2009

In superconducting magnetic energy storage (SMES) systems, the current leads are usually divided into two parts. Normal metals like brass or copper are often used in the first part from the room temperature to the 1st stage of the cryocooler. Their dimensions were decided to minimize the conduction heat penetration and Ohm's heat generation. The second part down to the cryogenic coil is made of high temperature superconductor (HTS). HTS current leads can reduce the conductive heat penetration because they have poor thermal conductivity and generate no Ohm's heat generation. The brass current lead and the HTS current lead were designed and fabricated for application to the 10kJ class SMES system. The HTS current lead is 300A class. The HTS current lead was stacked with 2 HTS layers using the $Bi_2Sr_2Ca_2Cu_3O_x$ (BSCCO)/Ag. In this paper, we introduce the design procedure of the current leads and discuss the test results of the current leads.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.9 no.1
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• pp.59-69
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• 2001

The rotor blade is modeled using a composite box beam with arbitrary wall. The active constrained damping layers are bonded to the upper and lower surfaces of the box beam to provide active and passive damping. A finite element model, based on a hybrid displacement theory, is used in the structural analysis. The theory is capable of accurately capturing the transverse shear effects in the composite primary structure, the viscoelastic and the piezoelectric layers within the ACLs. A reduced order model is derived based on the Hankel singular value. A linear quadratic Gaussian (LQG) controller is designed based on the reduced order model and the available measurement output. However, the LQG control system fails to stabilize the perturbed system although it shows good control performance at the nominal operating condition. To improve the robust stability of LQG controller, the loop transfer recovery (LTR) method is applied. Numerical results show that the proposed controller significantly improves rotor aeromechanical stability and suppresses rotor response over large variations in rotating speed by increasing lead-lag modal damping in the coupled rotor-body system.

• Archives of design research
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• v.16 no.2
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• pp.171-178
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• 2003

The visual, sensible and social situation that the modern digital technologies create became the background for the works of architects in extreme modernism and their space modeling suggested another possibility that was emancipated from the restriction of a property of matter and gravity in the existing space. The architecture design process using the digital technology has been attempted in diverse ways and summarized with several characteristics such as displacement, nonlinear space, flexibility of space and non-Euclidean geometry system. However, the conceptual and very technical design process that is called as digital architecture has been indiscriminately used with mixed meanings and the common features and differences between works and theories are not studied. This study aims to classify and identify the digital architecture by type as analyzing the non-linear composition process that is common in the digital architecture.

• Journal of The Korean Society of Grassland and Forage Science
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• v.20 no.4
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• pp.303-308
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• 2000

The objective of this experiment was to evaluate chemical composition, dry matter(DM) digestibility, DM intake, relative feed value(RFV) and hay grade of imported roughage which was collected by wholesale dealer at Chungnam province in 1999. Experimental roughages includes 8 kinds of imported hays(com stover bale, tall fescue straw, green cell, bermudagrass straw, reed carnarygrass straw, alfalfa bale, sugarcane bale and oat hay) and mixture hay(control) which was harvested at Chungnam National University experimental field. Compared with mixture hay(control) except for alfalfa bale, crude protein of most imported roughage was low, but NDF, ADF, cellulose and lignin compound were high. Futhermore, DM digestibility, DM intake, RFV and hay grade of imported roughage except for alfalfa bale was significantly lower than those of mixture hay(control)(P<0.05). Therefore, it is necessary to evaluate the economic value in the aspect of quality for the imported roughages.

• Journal of the Korean Society for Advanced Composite Structures
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• v.1 no.2
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• pp.51-58
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• 2010

This work examines the identification of stiffness reduction in damaged reinforced concrete bridges under moving loads, and carries out the performance assessment after repairing using advanced composite materials. In particular, the change of stiffness in each element before and after repairing, based on the Microgenetic algorithm as an advanced inverse analysis, is described and discussed by using a modified bivariate Gaussian distribution function. The proposed method in the study is more feasible than the conventional element-based method from computation efficiency point of view. The validity of the technique is numerically verified using a set of dynamic data obtained from a simulation of the actual bridge modeled with a three-dimensional solid element. The numerical examples show that the proposed technique is a feasible and practical method which can inspect the complex distribution of deteriorated stiffness although there is a difference between actual bridge and numerical model as well as uncertain noise occurred in the measured data.

• Journal of the Korean Society for Advanced Composite Structures
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• v.1 no.2
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• pp.1-13
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• 2010

Delamination reduces an elastic buckling load of the laminated composite structures and lead to global structural failure at loads below the design level. Therefore, the problem of the delamination buckling of laminated composite structures has generated significant research interest and has been the subject of many theoretical and experimental investigations. However, questions still remain regarding a complete understanding and details of the phenomena involved. In this paper an efficient finite element model is presented for analyzing the elastic buckling behavior of laminated composite plates with square embedded delamination using a solid element based on a three-dimensional theory. The solid finite element, named by EAS-SOLID8, based on an enhanced assumed strain method is developed. The study for elastic buckling behavior of laminated composite plates with embedded square delaminations are focused on various parameters, such as support condition and width-to-thickness ratio. Both graphs and buckling modes in this paper are good guide for design of the laminated composite plates with embedded square delamination.

• Journal of Pharmaceutical Investigation
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• v.31 no.3
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• pp.191-196
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• 2001

Biodegradable polymeric microspheres were studied for their usefulness as carriers for the delivery of vaccine antigens. However, protein antigen could be denatured during microencapsulation processes due to the exposure to the organic phase and stress condition of cavitation and shear force. Therefore this study was carried out to re-evaluate the degree of protein denaturation during microencapsulation with poly(lactide-co-glycolide) (PLGA) copolymer. PLGA microspheres containing ovalbumin (OVA), prepared by W/O/W multiple emulsification method, were suspended in pH 7.4 PBS and incubated with shaking at $37.5^{\circ}C$. Drug released medium was collected periodically and analyzed for protein contents by micro-BCA protein assay. In order to evaluate the protein integrity, release medium was subjected to the analyses of SDS-PAGE and size exclusion chromatography (SEC). And enzyme-linked immunosorbent assay (ELISA) was introduced to measure the immunoreactivity of entrapped OVA and to get an insight into the three-dimensional structure of epitope. The structures of entrapped protein were not affected significantly by the results of SDS-PAGE and SEC. However, immunoreactivity of released antigen was varied, revealing the possibility of protein denaturation in some microspheres when it was evaluate by ELISA method. Therefore, in order to express the degree of protein denaturation, antigenicity ratio (AR) was obtained as follows: amount of immunoreactivity of OVA/total amount of OVA released ${\times}100(%)$. ELISA method was an efficient tool to detect a protein denaturation during microencapsulation and the comparison of AR values resulted in more accurate evaluation for immunoreactivity of entrapped protein.

• Journal of Pharmaceutical Investigation
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• v.32 no.3
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• pp.199-207
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• 2002

In order to develop a sustained release formulation of bovine somatotropin (BST), which has been used to increase the body weight of oxen or the milk production of dairy cows, poly(D,L-lactide-co-glyceride)(PLGA) microspheres were made by W/O/W multiple emulsification method and solvent extraction method. Physical properties including particle size, drug entrapment, drug release, protein denaturation, and in vivo body weight increase in rats were characterized. The size of the microspheres was increased as the molecular weight of PLGA increased. When Span 65 and stearic acid during preparation were added, the size was decreased but the amount of surface protein was increased, resulting in a high loading efficiency, with fast release of BST from the microspheres. Aggregation or fragmentation of BST by SDS-PAGE during microsphere preparation and drug release study was not observed. Body weight of Sprague-Dawley's male rats was significantly increased after subcutaneous administrations of BST-loaded PLGA microspheres. There was a good correlation between in vivo weight gain and in vitro release rate of microspheres. PLGA microspheres with a high surface protein ratio could be a good candidate for the sustained delivery of BST.