• The Korea Journal of Herbology
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• v.37 no.1
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• pp.19-29
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• 2022

Objectives : Although the pharmacological effects of anti-inflammatory and antioxidant action of Atractylodes macrocephala Koidzumi water extract (AM) have been proven from many studies, reports on the antioxidant effect of AM on ulcerative colitis (UC) are scarce. Therefore, we aimed at evaluating the anti-oxidant effect of AM on the DSS-induced UC model. Methods : To induce ulcerative colitis, 8-week-old male Balb/c mice received 5% DSS in drinking water for 1 week. After 1 week of adaptation, mice were divided into four groups (n=8 each) for use as normal (Normal), DSS Control (Control), DSS + AM 100 mg/kg (AM100)-treatment, DSS + AM 200 mg/kg (AM200)-treatment. After 1 week of the experiment, the animals were sacrificed, and the extracted colon tissue was analyzed for protein through western blot. Results : As a result of confirming the macroscopic changes in colon tissues to confirm the therapeutic effects of AM, the decrease in colon length was suppressed in the AM treatment group compared to the control group. In addition, as a result of biochemical analysis, AM administration significantly reduced serum glutamic oxalacetic transaminase, glutamic pyruvate transaminase levels and tissue malondialdehyde levels. As a result of confirming the protein expression level through western blot, AM administration significantly decreased the expression of NADPH-related proteins such as NOX2, p22^phox, and iNOS, but significantly increased the expression of SOD, catalase, and GPx-1/2. Conclusions : AM may improve DSS-induced UC in mice by modulating NADPH and antioxidant-related proteins. In conclusion, AM showed an antioxidant effect through the improvement of oxidative stress on UC.

• The Journal of the Convergence on Culture Technology
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• v.5 no.2
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• pp.157-161
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• 2019

This study aims to investigate the types of popular songs and the paths to reach popular songs. Young children no longer sings for them. The popular song is deeply located around young children. Participants were 73 kindergarten children. Preliminary interviews were conducted from October 1, 2018 to October 11, 2018. Through the preliminary interview, the structured question was revised and the interview was conducted. This interview was conducted from October 22, 2018 to November 9. Based on the transferred data, I classified the types of popular songs that young children encounter into popular songs, popular singers, and genres. The path that young children touches the popular song is analyzed as place, medium, and person. As a popular song by young children, iKon as a popular singer, and k-pop as a genre. There were many kindergartens and houses in the place where young children got to know the popular songs, and they came into contact with many people through Youtube, and they got through family and friends. Through research, I have found that popular songs are already deeply embedded in the everyday life of young children. Now, it is necessary for young children to be equipped with popular song literacy.

• Journal of Internet of Things and Convergence
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• v.7 no.2
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• pp.13-19
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• 2021

It is analyzed that the energy pattern is affected by the social matters of the disease trend where the energy consumption has been reduced following the depression of the national economy. The campaign of social distance for the people has been done by voluntary or legally due to the epidemic of the Coronavirus Disease 2019 (COVID-19). Some economic stimulus policies have been done in some countries including the United States, South Korea, and some others. It is shown the susceptible, infectious, and recovered (SIR) modeling applied by system dynamics (SD) where the logical modeling is constructed with S, I, and R. Especially, the I is connected with Society including Population, Race, and Maturity. In addition, Economy and Politics are connected to Income, GDP, Resources, President, Popularity, Ruling Government, and Leadership. The graph shows the big jump on 2020 April when is the starting month of the S value multiplication. This shows the effect of the COVID-19 and its related post-pandemic trend. The trends of OECD and non-OECD are very similar and the effect of the virus hazards causes significantly to the economic depressions.

• Informatization Policy
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• v.31 no.2
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• pp.82-104
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• 2024

Smart home services are growing rapidly as the development of the Internet of Things (IoT) opens the era of the so-called "Connected Living." Although personal information leaks through smart home cameras are increasing, however, users-while concerned-tend to take passive measures to protect their personal information. This study theoretically explained and verified how to design effective software update notification messages for smart home cameras to ensure that users comply with the recommended security behavior (i.e., update installation). In a survey experiment participated in by 120 actual users, the effectiveness of both emotional appeals (i.e., security breach warning images for fear appeals) and rational appeals (i.e., loss-framed messages emphasizing the negative consequences of not installing the updates) were confirmed. The results of this study provide theoretical interpretations and practical guidelines on the message design features that are effective for threat appraisals (i.e., severity, vulnerability) of smart home camera users and their protection motivation.

• Journal of Digital Convergence
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• v.10 no.5
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• pp.105-116
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• 2012

This thesis is surveying the notions and the countermeasures of the farmers, who produce environmental-friendly crops, on a market and buyers. It ultimately tries to find out ways to increase the sale and the consumption of environmental-friendly crops from the side of the farmers. In chapter 2, analyzing the reality of consuming environmental-friendly crops and consumers inclinations. Also, on the basis of this, in chapter 3, I demonstrate how environmental-friendly producers countermeasures for the consumers are. I try to analyze the trust of the consumer buying environmental-friendly crops, which have been pointed out as a decisive factor for environmental-friendly crops by a lot of researchers, and analyze producers methods dealing with consumers approach to consume environmental-friendly crops. Regarding ways of the reconsideration about the trust, I have shown the problems about the quality authentication, forming consumers trust, and the ways of the consumer management. For the channel and method of the sale I have scrutinized not only a farmers notion about an internet homepage and his or her use but also producers principal sales route, cognition, and correspondence about it. Finally, I have examined the counter plans of the producer to increase sale and to facilitate consumption.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.12
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• pp.7292-7301
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• 2014

With the development of IT Info-Communications technology, the vehicle with a combination of wireless-communication technology has resulted in significant research into the convergence of the component of existing traffic with information, electronics and communication technology. Intelligent Vehicle Communication is a Machine-to-Machine (M2M) concept of the Vehicle-to-Vehicle. The Vehicle-to-Infrastructure communication consists of safety and the ease of transportation. Security technologies must precede the effective Intelligent Vehicle Communication Structure, unlike the existing internet environment, where high-speed vehicle communication is with the security threats of a wireless communication environment and can receive unusual vehicle messages. In this paper, the Vehicle Identification number between the V2I and the secure message communication protocol was proposed using hash functions and a time stamp, and the validity of the vehicle was assessed. The proposed system was the performance evaluation section compared to the conventional technique at a rate VPKI aspect showed an approximate 44% reduction. The safety, including authentication, confidentiality, and privacy threats, were analyzed.

• Journal of Life Science
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• v.32 no.12
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• pp.938-946
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• 2022

This study aims to evaluate the effects of antioxidant activities, protein and mRNA expressions of matrix metalloproteinase (MMP) -1 and procollagen type I C-peptide (PIP) in 70% ethanol extract from Hydnocarpus anthelmintica Pierre (HE). DPPH and ABTS⁺ radicals scavenging assays were measured for antioxidant activities and HE had 73.5% and 74.4% of scavenging activities at 1,000 ㎍/ml concentration, respectively. And we investigated the inhibition of collagenase by HE, and the result was a 78.8% inhibition effect on concentrations of 1,000 ㎍/ml. In addition, an MTT assay was performed to confirm the toxicity of the CCD-986sk fibroblasts to the HE, and as a result, the cell viability rate was about 91.7% at a concentration of 50 ㎍/ml or less, and subsequent cell experiments were performed at a concentration of 50 ㎍/ml or less. We treated the cells with UVB (20 mJ/cm²) for stimulation, treated HE at various concentrations, and performed ELISA tests and RT-PCR experiments. And HE increased the PIP and mRNA in a dose-dependent manner and showed an expression rate of about 64.2% and 83.4%, respectively, at a concentration of 50 ㎍/ml compared with Cont (50.3% and 45.8%, respectively). And HE suppressed the MMP-1 protein and mRNA in a dose-dependent manner and showed a low expression rate of about 48.7% and 35.9%, respectively, at a concentration of 50 ㎍/ml. These results can be applied to developing anti-wrinkle materials for functional food and cosmetics with HE.

• The Korea Journal of Herbology
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• v.38 no.2
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• pp.17-26
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• 2023

Objectives : A persistent inflammatory response can cause diseases such as fibrosis, cancer, and allergies. This study aimed to investigate the anti-inflammatory activity of Curcumae longae Rhizoma and Cinnamomi Ramulus Mixture (CCM) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Methods : The total polyphenol and flavonoid contents of CCM were confirmed through an in vitro experiment. Also, radical scavenging activities of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and Hydroxyl were confirmed. Moreover, ferric reducing antioxidant power (FRAP) activity were confirmed. After, CCM (50, 100, and 200 ㎍/mL) were applied to 0.1 ㎍/mL LPS-stimulated RAW264.7 cells. The levels of nitric oxide (NO) and pro-inflammatory cytokines in the supernatant fraction were determined. Also, the expressions of mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways were detected using Western blot. Results : As a result of in vitro experiments, there was an excellent antioxidant activity in CCM-treated cells. In addition, in RAW264.7 cells stimulated with LPS, the increased NO level was inhibited in a concentration-dependent manner by the treatment of CCM. In addition, inflammatory cytokines production were significantly inhibited in a concentration-dependent manner in CCM-treated group. CCM treatment significantly decreased the protein expressions of MAPKs. Moreover, the expressions of NF-κBp65 and cyclooxygenase-2 (COX-2) were significantly decreased when 200 mg/kg of CCM was applied, and phospho-inhibitor of nuclear factor kappa B-α (p-IκBα) and inducible nitric oxide synthase (iNOS) were significantly decreased at all concentrations treated with CCM. Conclusion : Our findings show that CCM exhibited excellent antioxidant activity and exhibited superior anti-inflammatory effect through the MAPKs and NF-κB pathways in LPS-stimulated RAW 264.7 macrophages.

• Journal of Microbiology and Biotechnology
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• v.30 no.4
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• pp.583-590
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• 2020

Deinococcus actinosclerus BM2^T (GenBank: KT448814) is a radio-resistant bacterium that is newly isolated from the soil of a rocky hillside in Seoul. As an extremophile, D. actinosclerus BM2^T may possess anti-inflammatory properties that may be beneficial to human health. In this study, we evaluated the anti-inflammatory effects of BM2U, an aqueous extract of D. actinosclerus BM2^T, on lipopolysaccharide (LPS)-mediated inflammatory responses in RAW264.7 macrophage cells. BM2U showed antioxidant capacity, as determined by the DPPH radical scavenging (IC₅₀ = 349.3 ㎍/ml) and ORAC (IC₅₀ = 50.24 ㎍/ml) assays. At 20 ㎍/ml, BM2U induced a significant increase in heme oxygenase-1 (HO-1) expression (p < 0.05). BM2U treatment (0.2-20 ㎍/ml) significantly suppressed LPS-induced increase in the mRNA expression of proinflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 (p < 0.05). BM2U treatment also suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), which are involved in the production of inflammatory mediators. BM2U treatment also inhibited the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs): JNK, ERK, and p-38 (p < 0.05). Collectively, BM2U exhibited anti-inflammatory potential that can be exploited in attenuating inflammatory responses.

• Journal of Korean Ophthalmic Optics Society
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• v.14 no.2
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• pp.1-8
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• 2009

Purpose: The purpose of this study is to compare degrees of asthenopia in after wearing of dispensed reading glasses with different criterion of P.D. Methods: The person who has minus near correction power (distance correction value (-)) is compared to the degree of asthenopia by wearing of dispensed reading glasses with near P.D(-B) and distance P.D. The person who has plus near correction power is compared to degree of asthenopia by wearing of dispensed reading glasses with near P.D-B, distance P.D, near P.D-A. The "Near-P.D-A" means reduced optical centre distance of reading glasses of positive correction value at which the same effect of prism B.O through near visual point in distance glasses exist at near visual point in reading glasses. Results: When near correction value is (-), dispensed reading glasses with distance P.D have caused less asthenopia than dispensed glasses with near P.D-B. When the near correction value is (+), we cannot confirm that which P.D is more useful for reading glasses. As a result of this study, dispensed reading glasses with near P.D-A have caused less asthenopia than another criterion of P.D. Conclusion: The effect of prism B.I through a near visual point in distance glasses ((-) correction value) reduce convergence demand. Therefore (-) correction value-reading glasses support convergence in near vision, because the effect of prism B.I of reading glasses is smaller than that of distance glasses. When the near correction value is (+), centration points can be determined by one of near P.D-A, near P.D-B, distance P.D.