Increasing safety requirements of automobile are asking companies to find out solutions, based on the ISO 26262 which is a functional safety standard. ISO 26262 is an adaptation of the IEC 61508 for automotive electric/electronic systems. ISO 26262 provides a V model for ECU (Electronic Control Unit) development process to secure safety against vehicle. It well describes the requirements, necessary works and their resulting products for each development phase. However, it is difficult to apply to product development for achieving functional safety in the electric/electronic systems of an automobile because it lacks explanation on the working steps to follow and the methodologies and tools to be used in each step. In this paper, we introduce the outline of the ISO 26262 product development process and present a DFSS (Design For Six Sigma) road-map based on the ISO 26262 product development process as a way to operate efficiently the ISO 26262 product development process. The DFSS road-map consists of five phases: Define, Measure, Analyze, Design, and Verify. The detailed activities, tools, inputs, and work products are given for each phase.