The heavy duty diesel engine must have a large output for maintaining excellent mobility. In this study, a three dimensional finite element model of a heavy-duty diesel engine was developed to conduct the stress analysis. The FE model of the heavy duty diesel engine main parts consisting with four half cylinder was selected. The heavy duty diesel engine parts includes with cylinder block, cylinder head, gasket, liner, bearing cap, bearing and bolts. The loading conditions of engine were pre-fit load, assembly load, and gas load. As the results of structural analysis, because the stress values of cylinder block and bearing cap did not exceed the basic design can be satisfied. But on the part which contacts with cylinder block and bearing cap the stress value exceeds the allowable strength of material. In order to decrease the stress at that part, it was optimized with parametric study.